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Q6NEF5

- SYL_CORDI

UniProt

Q6NEF5 - SYL_CORDI

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Protein
Leucine--tRNA ligase
Gene
leuS, DIP2320
Organism
Corynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei732 – 7321ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:DIP2320
OrganismiCorynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis)
Taxonomic identifieri257309 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
ProteomesiUP000002198: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 960960Leucine--tRNA ligaseUniRule annotation
PRO_0000152005Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi257309.DIP2320.

Structurei

3D structure databases

ProteinModelPortaliQ6NEF5.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi71 – 8212"HIGH" regionUniRule annotation
Add
BLAST
Motifi729 – 7335"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiYARYHRM.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 4 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6NEF5-1 [UniParc]FASTAAdd to Basket

« Hide

MTMTNPSGNT PDTSAGPAFR YTAELAGEIE RSWQQYWIDN GTFNAPNPVG    50
DLAVSGDKLP EDKLFVQDMF PYPSGAGLHV GHPLGYIATD VFARFNRMLG 100
KNVLHTLGYD AFGLPAEQYA IQTGTHPRTT TMANIANMQR QLGALGLGHD 150
PRRSVATTDP EFYKWTQWIF LQIFNAWFDT KQQKARPISE LIPLLESGEV 200
ALPEGFEGSA DSYSELDAVE KAKVVDEFRL VYRSHSMVNW CPGLGTVLAN 250
EEVTADGRSE RGNFPVFRKK LSQWMMRITA YSDRLIDDLD LLDWPDKVKS 300
MQRNWIGRSR GAEVDFDALG HTITVFTTRP DTLFGASYMV LAPEHELVDA 350
LVAAGTNSYE GIDPRWTFGQ ATPAEAVKAY RASIAAKSDL ERQENKEKTG 400
VYLGVNAVNP VNGESIPVFI GDYVLTGYGT GAIMAVPAHD TRDYEFATEF 450
GLPIREVVAG GNIAEAAYTE SGAAVNSAND QGLDINGLDK QEAIAQVIEW 500
LVDKQKGSEK IQYKLRDWLF ARQRYWGEPF PVVYDENGLA HALPESMLPV 550
ELPEVEDYKP VSFDPDDADS EPHPPLAKAT EWTQVELDLG DGLKKYTRDT 600
NVMPQWAGSS WYQLRYIDPT NSEAFCDIEN ERYWTGPRSA EDSGGVDLYV 650
GGVEHAVLHL LYSRFWHKVL FDLGFVTSRE PYRRLFNQGY IQAFAYTDSR 700
GVYVPAEEVE EKDGKFYYQG EEVNQEYGKM GKSLKNAVAP DDICRDFGAD 750
TLRVYEMAMG PLDTSRPWST KDVIGAHRFL QRLWRLVVSE DDGSIVVTDA 800
ALTDDDLKQL HRTIAGMRDD YEGLRINTVV AKAIEYVNYL TKAYGSTGAP 850
RAAVEPLVIM VAAVAPHIAE ELWKRLGHND TITFVPFPEY EDKWLVDDEV 900
EMPVQINGKV RARIMVPADA SQDQISEIAL ASEAVATHIE GKNVIKKIVV 950
SGRMVNLVVK 960
Length:960
Mass (Da):107,162
Last modified:July 5, 2004 - v1
Checksum:i51819FA7BEB071F8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX248360 Genomic DNA. Translation: CAE50842.1.
RefSeqiNP_940621.1. NC_002935.2.
WP_010935757.1. NC_002935.2.

Genome annotation databases

EnsemblBacteriaiCAE50842; CAE50842; DIP2320.
GeneIDi2649143.
KEGGicdi:DIP2320.
PATRICi21485957. VBICorDip47633_2329.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX248360 Genomic DNA. Translation: CAE50842.1 .
RefSeqi NP_940621.1. NC_002935.2.
WP_010935757.1. NC_002935.2.

3D structure databases

ProteinModelPortali Q6NEF5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 257309.DIP2320.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAE50842 ; CAE50842 ; DIP2320 .
GeneIDi 2649143.
KEGGi cdi:DIP2320.
PATRICi 21485957. VBICorDip47633_2329.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi YARYHRM.
OrthoDBi EOG63Z74X.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 4 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700971 / NCTC 13129 / Biotype gravis.

Entry informationi

Entry nameiSYL_CORDI
AccessioniPrimary (citable) accession number: Q6NEF5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: July 5, 2004
Last modified: September 3, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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