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Q6NEF5

- SYL_CORDI

UniProt

Q6NEF5 - SYL_CORDI

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Corynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei732 – 7321ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:DIP2320
OrganismiCorynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis)
Taxonomic identifieri257309 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
ProteomesiUP000002198: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 960960Leucine--tRNA ligasePRO_0000152005Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi257309.DIP2320.

Structurei

3D structure databases

ProteinModelPortaliQ6NEF5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi71 – 8212"HIGH" regionAdd
BLAST
Motifi729 – 7335"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiYARYHRM.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 4 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6NEF5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTMTNPSGNT PDTSAGPAFR YTAELAGEIE RSWQQYWIDN GTFNAPNPVG
60 70 80 90 100
DLAVSGDKLP EDKLFVQDMF PYPSGAGLHV GHPLGYIATD VFARFNRMLG
110 120 130 140 150
KNVLHTLGYD AFGLPAEQYA IQTGTHPRTT TMANIANMQR QLGALGLGHD
160 170 180 190 200
PRRSVATTDP EFYKWTQWIF LQIFNAWFDT KQQKARPISE LIPLLESGEV
210 220 230 240 250
ALPEGFEGSA DSYSELDAVE KAKVVDEFRL VYRSHSMVNW CPGLGTVLAN
260 270 280 290 300
EEVTADGRSE RGNFPVFRKK LSQWMMRITA YSDRLIDDLD LLDWPDKVKS
310 320 330 340 350
MQRNWIGRSR GAEVDFDALG HTITVFTTRP DTLFGASYMV LAPEHELVDA
360 370 380 390 400
LVAAGTNSYE GIDPRWTFGQ ATPAEAVKAY RASIAAKSDL ERQENKEKTG
410 420 430 440 450
VYLGVNAVNP VNGESIPVFI GDYVLTGYGT GAIMAVPAHD TRDYEFATEF
460 470 480 490 500
GLPIREVVAG GNIAEAAYTE SGAAVNSAND QGLDINGLDK QEAIAQVIEW
510 520 530 540 550
LVDKQKGSEK IQYKLRDWLF ARQRYWGEPF PVVYDENGLA HALPESMLPV
560 570 580 590 600
ELPEVEDYKP VSFDPDDADS EPHPPLAKAT EWTQVELDLG DGLKKYTRDT
610 620 630 640 650
NVMPQWAGSS WYQLRYIDPT NSEAFCDIEN ERYWTGPRSA EDSGGVDLYV
660 670 680 690 700
GGVEHAVLHL LYSRFWHKVL FDLGFVTSRE PYRRLFNQGY IQAFAYTDSR
710 720 730 740 750
GVYVPAEEVE EKDGKFYYQG EEVNQEYGKM GKSLKNAVAP DDICRDFGAD
760 770 780 790 800
TLRVYEMAMG PLDTSRPWST KDVIGAHRFL QRLWRLVVSE DDGSIVVTDA
810 820 830 840 850
ALTDDDLKQL HRTIAGMRDD YEGLRINTVV AKAIEYVNYL TKAYGSTGAP
860 870 880 890 900
RAAVEPLVIM VAAVAPHIAE ELWKRLGHND TITFVPFPEY EDKWLVDDEV
910 920 930 940 950
EMPVQINGKV RARIMVPADA SQDQISEIAL ASEAVATHIE GKNVIKKIVV
960
SGRMVNLVVK
Length:960
Mass (Da):107,162
Last modified:July 5, 2004 - v1
Checksum:i51819FA7BEB071F8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX248360 Genomic DNA. Translation: CAE50842.1.
RefSeqiNP_940621.1. NC_002935.2.
WP_010935757.1. NC_002935.2.

Genome annotation databases

EnsemblBacteriaiCAE50842; CAE50842; DIP2320.
GeneIDi2649143.
KEGGicdi:DIP2320.
PATRICi21485957. VBICorDip47633_2329.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX248360 Genomic DNA. Translation: CAE50842.1 .
RefSeqi NP_940621.1. NC_002935.2.
WP_010935757.1. NC_002935.2.

3D structure databases

ProteinModelPortali Q6NEF5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 257309.DIP2320.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAE50842 ; CAE50842 ; DIP2320 .
GeneIDi 2649143.
KEGGi cdi:DIP2320.
PATRICi 21485957. VBICorDip47633_2329.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi YARYHRM.
OrthoDBi EOG63Z74X.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 4 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700971 / NCTC 13129 / Biotype gravis.

Entry informationi

Entry nameiSYL_CORDI
AccessioniPrimary (citable) accession number: Q6NEF5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3