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Q6NEB8 (PANC_CORDI) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pantothenate synthetase

Short name=PS
EC=6.3.2.1
Alternative name(s):
Pantoate--beta-alanine ligase
Pantoate-activating enzyme
Gene names
Name:panC
Ordered Locus Names:DIP2357
OrganismCorynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis) [Complete proteome] [HAMAP]
Taxonomic identifier257309 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium

Protein attributes

Sequence length286 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate By similarity. HAMAP-Rule MF_00158

Catalytic activity

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate. HAMAP-Rule MF_00158

Pathway

Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1. HAMAP-Rule MF_00158

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00158

Subcellular location

Cytoplasm Potential HAMAP-Rule MF_00158.

Miscellaneous

The reaction proceeds by a bi uni uni bi ping pong mechanism By similarity.

Sequence similarities

Belongs to the pantothenate synthetase family.

Ontologies

Keywords
   Biological processPantothenate biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processpantothenate biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

pantoate-beta-alanine ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 286286Pantothenate synthetase HAMAP-Rule MF_00158
PRO_0000305429

Regions

Nucleotide binding31 – 388ATP By similarity
Nucleotide binding153 – 1564ATP By similarity
Nucleotide binding190 – 1934ATP By similarity

Sites

Active site381Proton donor By similarity
Binding site651Beta-alanine By similarity
Binding site651Pantoate By similarity
Binding site1591Pantoate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6NEB8 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: F28A56A36ADC2E2F

FASTA28631,128
        10         20         30         40         50         60 
MTSITHTISE IQKLTRQAIS DARPVVLIPT MGALHEGHLS LVDTAYSLEL DNPFVIMSIF 

        70         80         90        100        110        120 
VNPLQFAAGE DLDSYPRTLD ADAAKLATHN HQVHAIFAPS PAEMYPLGPR TTITPGAAAL 

       130        140        150        160        170        180 
RFEGATRPTH FAGVLTVVNK LFQITQCQHA IFGEKDFQQL ALIRQMVADF NLPVHVHGSP 

       190        200        210        220        230        240 
LMRDHDGVAL SSRNAYLSDT ERVEARRISA ALRQAAMFHV KHDIIAAAIN AMAGMDIDYI 

       250        260        270        280 
DVVAPDFSEP TAGNELYGDA RIITAVKVGS TRLLDNMAVN VEKPNA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX248361 Genomic DNA. Translation: CAE50880.1.
RefSeqNP_940658.1. NC_002935.2.

3D structure databases

ProteinModelPortalQ6NEB8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING257309.DIP2357.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAE50880; CAE50880; DIP2357.
GeneID2649180.
KEGGcdi:DIP2357.
PATRIC21486033. VBICorDip47633_2368.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0414.
HOGENOMHOG000175516.
KOK01918.
OMAALHKGHQ.
OrthoDBEOG6Z6FZ4.

Enzyme and pathway databases

UniPathwayUPA00028; UER00005.

Family and domain databases

Gene3D3.40.50.620. 1 hit.
HAMAPMF_00158. PanC.
InterProIPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERPTHR21299:SF1. PTHR21299:SF1. 1 hit.
PfamPF02569. Pantoate_ligase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00018. panC. 1 hit.
ProtoNetSearch...

Entry information

Entry namePANC_CORDI
AccessionPrimary (citable) accession number: Q6NEB8
Entry history
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: July 5, 2004
Last modified: February 19, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways