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Q6NDI4

- CPDA_RHOPA

UniProt

Q6NDI4 - CPDA_RHOPA

Protein

3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA

Gene

cpdA

Organism
Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes.UniRule annotation

    Catalytic activityi

    Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.UniRule annotation

    Cofactori

    Binds 2 metal cations per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi8 – 81Metal cation 1UniRule annotation
    Metal bindingi10 – 101Metal cation 1UniRule annotation
    Binding sitei10 – 101cAMPUniRule annotation
    Metal bindingi49 – 491Metal cation 1UniRule annotation
    Metal bindingi49 – 491Metal cation 2UniRule annotation
    Binding sitei49 – 491cAMPUniRule annotation
    Metal bindingi79 – 791Metal cation 2UniRule annotation
    Metal bindingi155 – 1551Metal cation 2UniRule annotation
    Metal bindingi194 – 1941Metal cation 2UniRule annotation
    Metal bindingi196 – 1961Metal cation 1UniRule annotation
    Binding sitei196 – 1961cAMPUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi79 – 802cAMPUniRule annotation

    GO - Molecular functioni

    1. 3',5'-cyclic-AMP phosphodiesterase activity Source: UniProtKB-HAMAP
    2. metal ion binding Source: UniProtKB-HAMAP
    3. nucleotide binding Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    cAMP, Metal-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    3',5'-cyclic adenosine monophosphate phosphodiesterase CpdAUniRule annotation (EC:3.1.4.17UniRule annotation)
    Short name:
    3',5'-cyclic AMP phosphodiesteraseUniRule annotation
    Short name:
    cAMP phosphodiesteraseUniRule annotation
    Gene namesi
    Name:cpdAUniRule annotation
    Ordered Locus Names:RPA0124
    OrganismiRhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)
    Taxonomic identifieri258594 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeRhodopseudomonas
    ProteomesiUP000001426: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 2742743',5'-cyclic adenosine monophosphate phosphodiesterase CpdAPRO_0000413377Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi258594.RPA0124.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6NDI4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cAMP phosphodiesterase class-III family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000238352.
    OMAiAAPNHEG.
    OrthoDBiEOG6DG2VB.
    PhylomeDBiQ6NDI4.

    Family and domain databases

    Gene3Di3.60.21.10. 1 hit.
    HAMAPiMF_00905. cAMP_phophodiest_CpdA.
    InterProiIPR024654. Calcineurin-like_PHP_lpxH.
    IPR026575. cAMP_Pdiest_CpdA.
    IPR029052. Metallo-depent_PP-like.
    [Graphical view]
    PfamiPF12850. Metallophos_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF56300. SSF56300. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q6NDI4-1 [UniParc]FASTAAdd to Basket

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    MKFVVLTDTH FVARGRRIYG LDPAERLSAA VARINREHPD IAFVIVTGDL    50
    AHWGEEPAYD NLASVLAGLR APTILMMGNH DKREAFAKFF PGVPRDASGF 100
    VQTVQVFEAA TIVTLDTLNE AAPNHEGFLC EARLAFLEHA LAEAPADRPL 150
    LLFQHHPPFD TGLRYMDTIR LANPDAEWEV IARTRKPDYL FMGHLHRPIS 200
    GVWRGIPFHI QRGLAHQVAF DLVAEGHIPG SHEPPDYAHV SVEADRIVIH 250
    QCSFMYDGPL FSLHDSVALH RVSF 274
    Length:274
    Mass (Da):30,646
    Last modified:July 5, 2004 - v1
    Checksum:i2144858507B12CCE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX572593 Genomic DNA. Translation: CAE25568.1.
    RefSeqiNP_945477.1. NC_005296.1.

    Genome annotation databases

    EnsemblBacteriaiCAE25568; CAE25568; RPA0124.
    GeneIDi2689514.
    KEGGirpa:RPA0124.
    PATRICi23284351. VBIRhoPal84835_0128.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX572593 Genomic DNA. Translation: CAE25568.1 .
    RefSeqi NP_945477.1. NC_005296.1.

    3D structure databases

    ProteinModelPortali Q6NDI4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 258594.RPA0124.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAE25568 ; CAE25568 ; RPA0124 .
    GeneIDi 2689514.
    KEGGi rpa:RPA0124.
    PATRICi 23284351. VBIRhoPal84835_0128.

    Phylogenomic databases

    HOGENOMi HOG000238352.
    OMAi AAPNHEG.
    OrthoDBi EOG6DG2VB.
    PhylomeDBi Q6NDI4.

    Family and domain databases

    Gene3Di 3.60.21.10. 1 hit.
    HAMAPi MF_00905. cAMP_phophodiest_CpdA.
    InterProi IPR024654. Calcineurin-like_PHP_lpxH.
    IPR026575. cAMP_Pdiest_CpdA.
    IPR029052. Metallo-depent_PP-like.
    [Graphical view ]
    Pfami PF12850. Metallophos_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56300. SSF56300. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-98 / CGA009.

    Entry informationi

    Entry nameiCPDA_RHOPA
    AccessioniPrimary (citable) accession number: Q6NDI4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 19, 2011
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3