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Q6NDI4

- CPDA_RHOPA

UniProt

Q6NDI4 - CPDA_RHOPA

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Protein
3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA
Gene
cpdA, RPA0124
Organism
Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes By similarity.UniRule annotation

Catalytic activityi

Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.UniRule annotation

Cofactori

Binds 2 metal cations per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi8 – 81Metal cation 1 By similarity
Metal bindingi10 – 101Metal cation 1 By similarity
Binding sitei10 – 101cAMP By similarity
Metal bindingi49 – 491Metal cation 1 By similarity
Metal bindingi49 – 491Metal cation 2 By similarity
Binding sitei49 – 491cAMP By similarity
Metal bindingi79 – 791Metal cation 2 By similarity
Metal bindingi155 – 1551Metal cation 2 By similarity
Metal bindingi194 – 1941Metal cation 2 By similarity
Metal bindingi196 – 1961Metal cation 1 By similarity
Binding sitei196 – 1961cAMP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi79 – 802cAMP By similarity

GO - Molecular functioni

  1. 3',5'-cyclic-AMP phosphodiesterase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-HAMAP
  3. nucleotide binding Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

cAMP, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA (EC:3.1.4.17)
Short name:
3',5'-cyclic AMP phosphodiesterase
Short name:
cAMP phosphodiesterase
Gene namesi
Name:cpdA
Ordered Locus Names:RPA0124
OrganismiRhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)
Taxonomic identifieri258594 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeRhodopseudomonas
ProteomesiUP000001426: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2742743',5'-cyclic adenosine monophosphate phosphodiesterase CpdAUniRule annotation
PRO_0000413377Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi258594.RPA0124.

Structurei

3D structure databases

ProteinModelPortaliQ6NDI4.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000238352.
OMAiAAPNHEG.
OrthoDBiEOG6DG2VB.
PhylomeDBiQ6NDI4.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
HAMAPiMF_00905. cAMP_phophodiest_CpdA.
InterProiIPR024654. Calcineurin-like_PHP_lpxH.
IPR026575. cAMP_Pdiest_CpdA.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PfamiPF12850. Metallophos_2. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6NDI4-1 [UniParc]FASTAAdd to Basket

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MKFVVLTDTH FVARGRRIYG LDPAERLSAA VARINREHPD IAFVIVTGDL    50
AHWGEEPAYD NLASVLAGLR APTILMMGNH DKREAFAKFF PGVPRDASGF 100
VQTVQVFEAA TIVTLDTLNE AAPNHEGFLC EARLAFLEHA LAEAPADRPL 150
LLFQHHPPFD TGLRYMDTIR LANPDAEWEV IARTRKPDYL FMGHLHRPIS 200
GVWRGIPFHI QRGLAHQVAF DLVAEGHIPG SHEPPDYAHV SVEADRIVIH 250
QCSFMYDGPL FSLHDSVALH RVSF 274
Length:274
Mass (Da):30,646
Last modified:July 5, 2004 - v1
Checksum:i2144858507B12CCE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX572593 Genomic DNA. Translation: CAE25568.1.
RefSeqiNP_945477.1. NC_005296.1.

Genome annotation databases

EnsemblBacteriaiCAE25568; CAE25568; RPA0124.
GeneIDi2689514.
KEGGirpa:RPA0124.
PATRICi23284351. VBIRhoPal84835_0128.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX572593 Genomic DNA. Translation: CAE25568.1 .
RefSeqi NP_945477.1. NC_005296.1.

3D structure databases

ProteinModelPortali Q6NDI4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 258594.RPA0124.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAE25568 ; CAE25568 ; RPA0124 .
GeneIDi 2689514.
KEGGi rpa:RPA0124.
PATRICi 23284351. VBIRhoPal84835_0128.

Phylogenomic databases

HOGENOMi HOG000238352.
OMAi AAPNHEG.
OrthoDBi EOG6DG2VB.
PhylomeDBi Q6NDI4.

Family and domain databases

Gene3Di 3.60.21.10. 1 hit.
HAMAPi MF_00905. cAMP_phophodiest_CpdA.
InterProi IPR024654. Calcineurin-like_PHP_lpxH.
IPR026575. cAMP_Pdiest_CpdA.
IPR029052. Metallo-depent_PP-like.
[Graphical view ]
Pfami PF12850. Metallophos_2. 1 hit.
[Graphical view ]
SUPFAMi SSF56300. SSF56300. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-98 / CGA009.

Entry informationi

Entry nameiCPDA_RHOPA
AccessioniPrimary (citable) accession number: Q6NDI4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi