Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA

Gene

cpdA

Organism
Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes.UniRule annotation

Catalytic activityi

Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.UniRule annotation

Cofactori

a metal cationUniRule annotationNote: Binds 2 metal cations per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi8 – 81Metal cation 1UniRule annotation
Metal bindingi10 – 101Metal cation 1UniRule annotation
Binding sitei10 – 101cAMPUniRule annotation
Metal bindingi49 – 491Metal cation 1UniRule annotation
Metal bindingi49 – 491Metal cation 2UniRule annotation
Binding sitei49 – 491cAMPUniRule annotation
Metal bindingi79 – 791Metal cation 2UniRule annotation
Metal bindingi155 – 1551Metal cation 2UniRule annotation
Metal bindingi194 – 1941Metal cation 2UniRule annotation
Metal bindingi196 – 1961Metal cation 1UniRule annotation
Binding sitei196 – 1961cAMPUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi79 – 802cAMPUniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

cAMP, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
3',5'-cyclic adenosine monophosphate phosphodiesterase CpdAUniRule annotation (EC:3.1.4.17UniRule annotation)
Short name:
3',5'-cyclic AMP phosphodiesteraseUniRule annotation
Short name:
cAMP phosphodiesteraseUniRule annotation
Gene namesi
Name:cpdAUniRule annotation
Ordered Locus Names:RPA0124
OrganismiRhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)
Taxonomic identifieri258594 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeRhodopseudomonas
ProteomesiUP000001426 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2742743',5'-cyclic adenosine monophosphate phosphodiesterase CpdAPRO_0000413377Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi258594.RPA0124.

Structurei

3D structure databases

ProteinModelPortaliQ6NDI4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cAMP phosphodiesterase class-III family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000238352.
OMAiIWAMGNH.
OrthoDBiEOG6DG2VB.
PhylomeDBiQ6NDI4.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
HAMAPiMF_00905. cAMP_phophodiest_CpdA.
InterProiIPR024654. Calcineurin-like_PHP_lpxH.
IPR026575. cAMP_Pdiest_CpdA.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PfamiPF12850. Metallophos_2. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6NDI4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFVVLTDTH FVARGRRIYG LDPAERLSAA VARINREHPD IAFVIVTGDL
60 70 80 90 100
AHWGEEPAYD NLASVLAGLR APTILMMGNH DKREAFAKFF PGVPRDASGF
110 120 130 140 150
VQTVQVFEAA TIVTLDTLNE AAPNHEGFLC EARLAFLEHA LAEAPADRPL
160 170 180 190 200
LLFQHHPPFD TGLRYMDTIR LANPDAEWEV IARTRKPDYL FMGHLHRPIS
210 220 230 240 250
GVWRGIPFHI QRGLAHQVAF DLVAEGHIPG SHEPPDYAHV SVEADRIVIH
260 270
QCSFMYDGPL FSLHDSVALH RVSF
Length:274
Mass (Da):30,646
Last modified:July 5, 2004 - v1
Checksum:i2144858507B12CCE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX572593 Genomic DNA. Translation: CAE25568.1.
RefSeqiNP_945477.1. NC_005296.1.
WP_011155692.1. NC_005296.1.

Genome annotation databases

EnsemblBacteriaiCAE25568; CAE25568; RPA0124.
KEGGirpa:RPA0124.
PATRICi23284351. VBIRhoPal84835_0128.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX572593 Genomic DNA. Translation: CAE25568.1.
RefSeqiNP_945477.1. NC_005296.1.
WP_011155692.1. NC_005296.1.

3D structure databases

ProteinModelPortaliQ6NDI4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi258594.RPA0124.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAE25568; CAE25568; RPA0124.
KEGGirpa:RPA0124.
PATRICi23284351. VBIRhoPal84835_0128.

Phylogenomic databases

HOGENOMiHOG000238352.
OMAiIWAMGNH.
OrthoDBiEOG6DG2VB.
PhylomeDBiQ6NDI4.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
HAMAPiMF_00905. cAMP_phophodiest_CpdA.
InterProiIPR024654. Calcineurin-like_PHP_lpxH.
IPR026575. cAMP_Pdiest_CpdA.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PfamiPF12850. Metallophos_2. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-98 / CGA009.

Entry informationi

Entry nameiCPDA_RHOPA
AccessioniPrimary (citable) accession number: Q6NDI4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: July 5, 2004
Last modified: May 27, 2015
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.