Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA

Gene

cpdA

Organism
Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes.UniRule annotation

Catalytic activityi

Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.UniRule annotation

Cofactori

a metal cationUniRule annotationNote: Binds 2 metal cations per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi8Metal cation 1UniRule annotation1
Metal bindingi10Metal cation 1UniRule annotation1
Binding sitei10cAMPUniRule annotation1
Metal bindingi49Metal cation 1UniRule annotation1
Metal bindingi49Metal cation 2UniRule annotation1
Binding sitei49cAMPUniRule annotation1
Metal bindingi79Metal cation 2UniRule annotation1
Metal bindingi155Metal cation 2UniRule annotation1
Metal bindingi194Metal cation 2UniRule annotation1
Metal bindingi196Metal cation 1UniRule annotation1
Binding sitei196cAMPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi79 – 80cAMPUniRule annotation2

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
LigandcAMP, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRPAL258594:G1GT2-128-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
3',5'-cyclic adenosine monophosphate phosphodiesterase CpdAUniRule annotation (EC:3.1.4.53UniRule annotation)
Short name:
3',5'-cyclic AMP phosphodiesteraseUniRule annotation
Short name:
cAMP phosphodiesteraseUniRule annotation
Gene namesi
Name:cpdAUniRule annotation
Ordered Locus Names:RPA0124
OrganismiRhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)
Taxonomic identifieri258594 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeRhodopseudomonas
Proteomesi
  • UP000001426 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004133771 – 2743',5'-cyclic adenosine monophosphate phosphodiesterase CpdAAdd BLAST274

Interactioni

Protein-protein interaction databases

STRINGi258594.RPA0124

Structurei

3D structure databases

ProteinModelPortaliQ6NDI4
SMRiQ6NDI4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cAMP phosphodiesterase class-III family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108X4D Bacteria
COG1409 LUCA
HOGENOMiHOG000238352
OMAiAAPNHEG
OrthoDBiPOG091H05L5
PhylomeDBiQ6NDI4

Family and domain databases

CDDicd07402 MPP_GpdQ, 1 hit
Gene3Di3.60.21.10, 1 hit
HAMAPiMF_00905 cAMP_phophodiest_CpdA, 1 hit
InterProiView protein in InterPro
IPR004843 Calcineurin-like_PHP_ApaH
IPR026575 cAMP_Pdiest_CpdA
IPR029052 Metallo-depent_PP-like
PfamiView protein in Pfam
PF00149 Metallophos, 1 hit

Sequencei

Sequence statusi: Complete.

Q6NDI4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFVVLTDTH FVARGRRIYG LDPAERLSAA VARINREHPD IAFVIVTGDL
60 70 80 90 100
AHWGEEPAYD NLASVLAGLR APTILMMGNH DKREAFAKFF PGVPRDASGF
110 120 130 140 150
VQTVQVFEAA TIVTLDTLNE AAPNHEGFLC EARLAFLEHA LAEAPADRPL
160 170 180 190 200
LLFQHHPPFD TGLRYMDTIR LANPDAEWEV IARTRKPDYL FMGHLHRPIS
210 220 230 240 250
GVWRGIPFHI QRGLAHQVAF DLVAEGHIPG SHEPPDYAHV SVEADRIVIH
260 270
QCSFMYDGPL FSLHDSVALH RVSF
Length:274
Mass (Da):30,646
Last modified:July 5, 2004 - v1
Checksum:i2144858507B12CCE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX572593 Genomic DNA Translation: CAE25568.1
RefSeqiWP_011155692.1, NC_005296.1

Genome annotation databases

EnsemblBacteriaiCAE25568; CAE25568; RPA0124
KEGGirpa:RPA0124

Similar proteinsi

Entry informationi

Entry nameiCPDA_RHOPA
AccessioniPrimary (citable) accession number: Q6NDI4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: July 5, 2004
Last modified: March 28, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health