Q6ND98 (Q6ND98_RHOPA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Acetyl-coenzyme A synthetase HAMAP MF_01123
EC=6.2.1.1 HAMAP MF_01123

Alternative name(s):
Acetate--CoA ligase HAMAP MF_01123
Acyl-activating enzyme HAMAP MF_01123

Gene names

Name:	acsA HAMAP MF_01123
Ordered Locus Names:	RPA0211

Organism

Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009) [Complete proteome] [HAMAP]

Taxonomic identifier

258594 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bradyrhizobiaceae › Rhodopseudomonas

Protein attributes

Sequence length	650 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA. HAMAP MF_01123
Post-translational modification	Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme By similarity. HAMAP MF_01123
Sequence similarities	Belongs to the ATP-dependent AMP-binding enzyme family. HAMAP MF_01123

Ontologies

Keywords
Ligand	ATP-binding HAMAP MF_01123 Nucleotide-binding
Molecular function	Ligase HAMAP MF_01123 EMBL CAE25655.1
PTM	Acetylation HAMAP MF_01123
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	AMP binding Inferred from electronic annotation. Source: InterPro ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetate-CoA ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	514	1	By similarity HAMAP MF_01123
Amino acid modifications
	Modified residue	606	1	N6-acetyllysine By similarity HAMAP MF_01123

Sequences

	Sequence		Length	Mass (Da)
	Q6ND98 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 147F71D6F21C3E6F	FASTA	650	72,459
	10 20 30 40 50 60 MSEKIYDVPA EWASRAFVDD AKYRQMYERS VTDPTGFWAE HAKRVDWIKA PTKIDNWSFA 70 80 90 100 110 120 PGNVSIKWFE DGVLNAAYNC IDRHLDKRGD QVAIIWEGDD PSQSRSITYR ELHDEVCKFA 130 140 150 160 170 180 NILRNRNVGK GDRVTIYLPM IPEAAFAMLA CARIGAIHSV VFAGFSPDSL AGRINDCNSK 190 200 210 220 230 240 IVITADEGLR GGRKVPLKAN VDAALKKCEG VDWVMVVKRT GAAVEMDDVR DFWYHEAAEV 250 260 270 280 290 300 VTTECPVEHM HAEDPLFILY TSGSTGQPKG VLHTTGGYLV FASMTHQYVF DYHDGDIYWC 310 320 330 340 350 360 TADVGWVTGH SYILYGPLAN GATTLMFEGV PNYPTNSRFW EVIDKHKVNI FYTAPTAIRA 370 380 390 400 410 420 LMQAGDEPVK KTSRKSLRLL GSVGEPINPE AWEWYHRVVG EDRCPIVDTW WQTETGGILI 430 440 450 460 470 480 TPLPGATKLK PGSATRPFFG VVPEILDPEG NVLEGECTGN LCLARSWPGQ MRTVYGDHAR 490 500 510 520 530 540 FEQTYFSAYK GKYFTGDGCR RDTDGFYWIT GRVDDVINVS GHRMGTAEVE SSLVAHPKVS 550 560 570 580 590 600 EAAVVGYPHD IKGQGIYAYV TLMAGEEPTE ELRKELVAWV RKDIGPIASP DLIQFAPGLP 610 620 630 640 650 KTRSGKIMRR ILRKIAEDEP SSLGDTSTLA DPAVVDDLVE HRQNKHHKAS

References

[1]

"Complete genome sequence of the metabolically versatile photosynthetic bacterium Rhodopseudomonas palustris." Larimer F.W., Chain P., Hauser L., Lamerdin J.E., Malfatti S., Do L., Land M.L., Pelletier D.A., Beatty J.T., Lang A.S., Tabita F.R., Gibson J.L., Hanson T.E., Bobst C., Torres y Torres J.L., Peres C., Harrison F.H., Gibson J., Harwood C.S. Nat. Biotechnol. 22:55-61(2004) [PubMed: 14704707] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-98 / CGA009.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX572593 Genomic DNA. Translation: CAE25655.1.
RefSeq	NP_945564.1. NC_005296.1.
3D structure databases
ProteinModelPortal	Q6ND98.
SMR	Q6ND98. Positions 8-643.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2693110.
GenomeReviews	Gene locus RPA0211 in contig BX571963_GR.
KEGG	rpa:RPA0211.
NMPDR	fig|258594.1.peg.208.
PATRIC	23284537. VBIRhoPal84835_0220.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG547964.
OMA	TRGTEES.
ProtClustDB	PRK00174.
Enzyme and pathway databases
BioCyc	RPAL258594:RPA0211-MONOMER.
Family and domain databases
HAMAP	MF_01123. Ac_CoA_synth. [Tree]
InterPro	IPR011904. Ac_CoA_lig. IPR024597. Acyl-CoA_synth_DUF3448. IPR020845. AMP-binding_CS. IPR000873. AMP-dep_Synth/Lig. [Graphical view]
KO	K01895.
PANTHER	PTHR24095:SF42. PTHR24095:SF42. 1 hit.
Pfam	PF00501. AMP-binding. 1 hit. PF11930. DUF3448. 1 hit. [Graphical view]
TIGRFAMs	TIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITE	PS00455. AMP_BINDING. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q6ND98_RHOPA

Accession

Primary (citable) accession number: Q6ND98

Entry history

Integrated into UniProtKB/TrEMBL:	July 5, 2004
Last sequence update:	July 5, 2004
Last modified:	December 14, 2011
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)