Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei635ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRPAL258594:G1GT2-298-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:RPA0287
OrganismiRhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)
Taxonomic identifieri258594 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeRhodopseudomonas
Proteomesi
  • UP000001426 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001520731 – 876Leucine--tRNA ligaseAdd BLAST876

Proteomic databases

PRIDEiQ6ND22

Interactioni

Protein-protein interaction databases

STRINGi258594.RPA0287

Structurei

3D structure databases

ProteinModelPortaliQ6ND22
SMRiQ6ND22
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi43 – 53"HIGH" regionAdd BLAST11
Motifi632 – 636"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
HOGENOMiHOG000200747
KOiK01869
OMAiTFMVLAP
OrthoDBiPOG091H01JZ
PhylomeDBiQ6ND22

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 2 hits
PF13603 tRNA-synt_1_2, 1 hit
PF09334 tRNA-synt_1g, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q6ND22-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNERYNARE SEPKWQAKWD EAKIFATRND DLRKKYYVLE MFPYPSGRIH
60 70 80 90 100
MGHVRNYTMG DVVARTMRAR GYNVLHPMGW DAFGLPAENA AIERKVAPKA
110 120 130 140 150
WTYDNIAAMK KQLQTMGLSL DWAREFATCD PSYYKHQQKM FLDFLKVGLV
160 170 180 190 200
EREKRKLNWD PVDMTVLANE QVIDGRGWRS GAVVELREMN QWVFKITKYA
210 220 230 240 250
QELLDALDTL DRWPDKVRLM QRNWIGRSEG LMVRFALDSA TTPAGETELK
260 270 280 290 300
IFTTRPDTLF GAKFMAIAAD HPLAQAAAAK APKVAAFIDD CKKRGTAQAE
310 320 330 340 350
IDTAEKQGID TGIRAVHPFD PSWKLPVYVA NFVLMEYGTG AIFGCPAHDQ
360 370 380 390 400
RDLDFVNKYQ LGNTPVVCPE GQDPASFVIT DTAYDGEGRM INSRFLDGKT
410 420 430 440 450
IAEAKEEVAK RLETEQLAGA PVGARKVNFR LRDWGISRQR YWGCPIPIIH
460 470 480 490 500
CPTCDVVPVP DADLPVVLPE DVSFDKPGNA LDHHPTWKHV TCPKCGGKAV
510 520 530 540 550
RETDTMDTFV DSSWYFARFT DPWNTEAPTT PDVVNRMMPV DQYIGGVEHA
560 570 580 590 600
ILHLLYSRFF TRAMKAAGHI DIQHDEPFAG LFTQGMVVHE TYRKADGHFA
610 620 630 640 650
SPAEISITVE GDTRRATLLD GGSPVEIGPI EKMSKSKRNT VDPDDIIGTY
660 670 680 690 700
GADTARWFML SDSPPDRDVI WSEEGVKGAS RFVQRLWRMV NDAAPIAASA
710 720 730 740 750
PAERPASFGA DALTLRKAAH GALDKVLSGI ERLAFNVSLA HIREFSNTLG
760 770 780 790 800
DALARSQTPS PDLAWAIRES TVILVQLFHP MMPHLAEECW TVLGQTGLVS
810 820 830 840 850
EALWPPIEQD LLVEDSITLP VQVNGKKRGD VTVPRDAPTS EIEAAVLALD
860 870
TVKQALGGKP VRKVIVVPQR IVNVVG
Length:876
Mass (Da):97,725
Last modified:July 5, 2004 - v1
Checksum:i8FDD1478FE408442
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX572593 Genomic DNA Translation: CAE25731.1
RefSeqiWP_011155855.1, NC_005296.1

Genome annotation databases

EnsemblBacteriaiCAE25731; CAE25731; RPA0287
KEGGirpa:RPA0287

Similar proteinsi

Entry informationi

Entry nameiSYL_RHOPA
AccessioniPrimary (citable) accession number: Q6ND22
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health