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Q6ND22

- SYL_RHOPA

UniProt

Q6ND22 - SYL_RHOPA

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei635 – 6351ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:RPA0287
    OrganismiRhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)
    Taxonomic identifieri258594 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeRhodopseudomonas
    ProteomesiUP000001426: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 876876Leucine--tRNA ligasePRO_0000152073Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi258594.RPA0287.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6ND22.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi43 – 5311"HIGH" regionAdd
    BLAST
    Motifi632 – 6365"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiPVIHCPK.
    OrthoDBiEOG63Z74X.
    PhylomeDBiQ6ND22.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6ND22-1 [UniParc]FASTAAdd to Basket

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    MSNERYNARE SEPKWQAKWD EAKIFATRND DLRKKYYVLE MFPYPSGRIH    50
    MGHVRNYTMG DVVARTMRAR GYNVLHPMGW DAFGLPAENA AIERKVAPKA 100
    WTYDNIAAMK KQLQTMGLSL DWAREFATCD PSYYKHQQKM FLDFLKVGLV 150
    EREKRKLNWD PVDMTVLANE QVIDGRGWRS GAVVELREMN QWVFKITKYA 200
    QELLDALDTL DRWPDKVRLM QRNWIGRSEG LMVRFALDSA TTPAGETELK 250
    IFTTRPDTLF GAKFMAIAAD HPLAQAAAAK APKVAAFIDD CKKRGTAQAE 300
    IDTAEKQGID TGIRAVHPFD PSWKLPVYVA NFVLMEYGTG AIFGCPAHDQ 350
    RDLDFVNKYQ LGNTPVVCPE GQDPASFVIT DTAYDGEGRM INSRFLDGKT 400
    IAEAKEEVAK RLETEQLAGA PVGARKVNFR LRDWGISRQR YWGCPIPIIH 450
    CPTCDVVPVP DADLPVVLPE DVSFDKPGNA LDHHPTWKHV TCPKCGGKAV 500
    RETDTMDTFV DSSWYFARFT DPWNTEAPTT PDVVNRMMPV DQYIGGVEHA 550
    ILHLLYSRFF TRAMKAAGHI DIQHDEPFAG LFTQGMVVHE TYRKADGHFA 600
    SPAEISITVE GDTRRATLLD GGSPVEIGPI EKMSKSKRNT VDPDDIIGTY 650
    GADTARWFML SDSPPDRDVI WSEEGVKGAS RFVQRLWRMV NDAAPIAASA 700
    PAERPASFGA DALTLRKAAH GALDKVLSGI ERLAFNVSLA HIREFSNTLG 750
    DALARSQTPS PDLAWAIRES TVILVQLFHP MMPHLAEECW TVLGQTGLVS 800
    EALWPPIEQD LLVEDSITLP VQVNGKKRGD VTVPRDAPTS EIEAAVLALD 850
    TVKQALGGKP VRKVIVVPQR IVNVVG 876
    Length:876
    Mass (Da):97,725
    Last modified:July 5, 2004 - v1
    Checksum:i8FDD1478FE408442
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX572593 Genomic DNA. Translation: CAE25731.1.
    RefSeqiNP_945640.1. NC_005296.1.
    WP_011155855.1. NC_005296.1.

    Genome annotation databases

    EnsemblBacteriaiCAE25731; CAE25731; RPA0287.
    GeneIDi2689342.
    KEGGirpa:RPA0287.
    PATRICi23284707. VBIRhoPal84835_0303.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX572593 Genomic DNA. Translation: CAE25731.1 .
    RefSeqi NP_945640.1. NC_005296.1.
    WP_011155855.1. NC_005296.1.

    3D structure databases

    ProteinModelPortali Q6ND22.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 258594.RPA0287.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAE25731 ; CAE25731 ; RPA0287 .
    GeneIDi 2689342.
    KEGGi rpa:RPA0287.
    PATRICi 23284707. VBIRhoPal84835_0303.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi PVIHCPK.
    OrthoDBi EOG63Z74X.
    PhylomeDBi Q6ND22.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-98 / CGA009.

    Entry informationi

    Entry nameiSYL_RHOPA
    AccessioniPrimary (citable) accession number: Q6ND22
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 2005
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3