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Protein

Chorismate synthase

Gene

aroC

Organism
Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.UniRule annotation

Catalytic activityi

5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate.UniRule annotation

Cofactori

FMNH2UniRule annotationNote: Reduced FMN (FMNH(2)).UniRule annotation

Pathwayi: chorismate biosynthesis

This protein is involved in step 7 of the subpathway that synthesizes chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate.UniRule annotation
Proteins known to be involved in the 7 steps of the subpathway in this organism are:
  1. Phospho-2-dehydro-3-deoxyheptonate aldolase (aroG1)
  2. 3-dehydroquinate synthase (aroB)
  3. 3-dehydroquinate dehydratase (aroQ)
  4. Shikimate dehydrogenase (NADP(+)) (aroE)
  5. Shikimate kinase (aroK), Shikimate kinase (aroK)
  6. 3-phosphoshikimate 1-carboxyvinyltransferase (aroA)
  7. Chorismate synthase (aroC)
This subpathway is part of the pathway chorismate biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate, the pathway chorismate biosynthesis and in Metabolic intermediate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei48NADPUniRule annotation1
Binding sitei54NADPUniRule annotation1
Binding sitei287FMN; via amide nitrogenUniRule annotation1
Binding sitei328FMNUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi131 – 133FMNUniRule annotation3
Nucleotide bindingi243 – 244FMNUniRule annotation2
Nucleotide bindingi302 – 306FMNUniRule annotation5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis
LigandFAD, Flavoprotein, FMN, NADP

Enzyme and pathway databases

BioCyciRPAL258594:G1GT2-1235-MONOMER
UniPathwayiUPA00053; UER00090

Names & Taxonomyi

Protein namesi
Recommended name:
Chorismate synthaseUniRule annotation (EC:4.2.3.5UniRule annotation)
Short name:
CSUniRule annotation
Alternative name(s):
5-enolpyruvylshikimate-3-phosphate phospholyaseUniRule annotation
Gene namesi
Name:aroCUniRule annotation
Ordered Locus Names:RPA1201
OrganismiRhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)
Taxonomic identifieri258594 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeRhodopseudomonas
Proteomesi
  • UP000001426 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001406351 – 362Chorismate synthaseAdd BLAST362

Proteomic databases

PRIDEiQ6NAI4

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi258594.RPA1201

Structurei

3D structure databases

ProteinModelPortaliQ6NAI4
SMRiQ6NAI4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chorismate synthase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D10 Bacteria
COG0082 LUCA
HOGENOMiHOG000060335
KOiK01736
OMAiMLSINAV
OrthoDBiPOG091H00EG
PhylomeDBiQ6NAI4

Family and domain databases

CDDicd07304 Chorismate_synthase, 1 hit
Gene3Di3.60.150.10, 1 hit
HAMAPiMF_00300 Chorismate_synth, 1 hit
InterProiView protein in InterPro
IPR000453 Chorismate_synth
IPR035904 Chorismate_synth_AroC_sf
IPR020541 Chorismate_synthase_CS
PANTHERiPTHR21085 PTHR21085, 1 hit
PfamiView protein in Pfam
PF01264 Chorismate_synt, 1 hit
PIRSFiPIRSF001456 Chorismate_synth, 1 hit
SUPFAMiSSF103263 SSF103263, 1 hit
TIGRFAMsiTIGR00033 aroC, 1 hit
PROSITEiView protein in PROSITE
PS00787 CHORISMATE_SYNTHASE_1, 1 hit
PS00788 CHORISMATE_SYNTHASE_2, 1 hit
PS00789 CHORISMATE_SYNTHASE_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q6NAI4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFNTFGHLF RVTTFGESHG VAIGCVVDGC PPLIPLTEAD IQGDLDRRRP
60 70 80 90 100
GQSRFTTQRQ EADQVKILSG VMVHPETGVQ VTTGTPIALL IENTDQRSKD
110 120 130 140 150
YSDIQNKFRP GHADFTYEAK YGIRDYRGGG RSSARETASR VAAGAIARKV
160 170 180 190 200
IAGMTVRGAL VQIGPHKIDR DKWDWDEIGN NPFFCPDKDK AAFYADYLDG
210 220 230 240 250
IRKSGSSIGA VVEIVAEGVP AGLGAPIYAK LDGDLAAALM SINAVKGVEI
260 270 280 290 300
GDGFASAELT GEQNADEMRT GNHGPAFLSN HAGGILGGIS TGQPVVARFA
310 320 330 340 350
VKPTSSILTP RKTVDRTGHD TEILTKGRHD PCVGIRAVPV GEAMVACVLA
360
DHLLRHRGQV GG
Length:362
Mass (Da):38,513
Last modified:July 5, 2004 - v1
Checksum:iEEF5DB431202349A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX572596 Genomic DNA Translation: CAE26644.1
RefSeqiWP_011156765.1, NC_005296.1

Genome annotation databases

EnsemblBacteriaiCAE26644; CAE26644; RPA1201
KEGGirpa:RPA1201

Similar proteinsi

Entry informationi

Entry nameiAROC_RHOPA
AccessioniPrimary (citable) accession number: Q6NAI4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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