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Q6N5R2

- LPXB_RHOPA

UniProt

Q6N5R2 - LPXB_RHOPA

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Protein
Lipid-A-disaccharide synthase
Gene
lpxB, RPA2909
Organism
Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciRETL1328306-WGS:GSTH-1983-MONOMER.
UniPathwayiUPA00359; UER00481.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthase (EC:2.4.1.182)
Gene namesi
Name:lpxB
Ordered Locus Names:RPA2909
OrganismiRhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)
Taxonomic identifieri258594 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeRhodopseudomonas
ProteomesiUP000001426: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 393393Lipid-A-disaccharide synthaseUniRule annotation
PRO_0000255214Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi258594.RPA2909.

Structurei

3D structure databases

ProteinModelPortaliQ6N5R2.

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018004.
KOiK00748.
OMAiRRSEIRH.
OrthoDBiEOG6FBWZR.
PhylomeDBiQ6N5R2.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6N5R2-1 [UniParc]FASTAAdd to Basket

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MSGAAKTGDR VRTVYLIATE ESGDRLGAAL MRELRARLGS KVRFAGVGGH    50
CMAGEGLASL FPIEELSIIG FAAVVQRLPM ILKLIRRAVD AVLTAKPDIL 100
VIIDSPDFTH RVARRVRQRD PSIPIVDYVS PTVWAWRPGR ARAMLGYVDH 150
VLALLPFEPA EYRRLQGPPC SYVGHPLTEQ FGSLRPDAAE QARREASPPV 200
LLVLPGSRRS EVRHHAAAFG DTLARLKHEG VAFEAVLPTT PHLEGLVRAA 250
VASWEVQPRI VVGEQDKRAA FRIAHAALAK SGTVTLELAI AGVPMVTAYR 300
AGSVEIWIAR RVVRPGTVIL ANLVMGDDVI PEFIQEDCVP DKLVPAVRDL 350
LGNTPARRRQ LAGFAKIDDI LSTGEQTPSG RAADIVLDVM RHA 393
Length:393
Mass (Da):42,699
Last modified:July 5, 2004 - v1
Checksum:i301A25B00E36408F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX572602 Genomic DNA. Translation: CAE28350.1.
RefSeqiNP_948250.1. NC_005296.1.

Genome annotation databases

EnsemblBacteriaiCAE28350; CAE28350; RPA2909.
GeneIDi2691083.
KEGGirpa:RPA2909.
PATRICi23290255. VBIRhoPal84835_3054.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX572602 Genomic DNA. Translation: CAE28350.1 .
RefSeqi NP_948250.1. NC_005296.1.

3D structure databases

ProteinModelPortali Q6N5R2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 258594.RPA2909.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAE28350 ; CAE28350 ; RPA2909 .
GeneIDi 2691083.
KEGGi rpa:RPA2909.
PATRICi 23290255. VBIRhoPal84835_3054.

Phylogenomic databases

eggNOGi COG0763.
HOGENOMi HOG000018004.
KOi K00748.
OMAi RRSEIRH.
OrthoDBi EOG6FBWZR.
PhylomeDBi Q6N5R2.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci RETL1328306-WGS:GSTH-1983-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-98 / CGA009.

Entry informationi

Entry nameiLPXB_RHOPA
AccessioniPrimary (citable) accession number: Q6N5R2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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