Q6N5R2 (LPXB_RHOPA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Lipid-A-disaccharide synthase
EC=2.4.1.182

Gene names

Name:	lpxB
Ordered Locus Names:	RPA2909

Organism

Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009) [Complete proteome] [HAMAP]

Taxonomic identifier

258594 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bradyrhizobiaceae › Rhodopseudomonas › Rhodopseudomonas palustris

Protein attributes

Sequence length	393 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP-Rule MF_00392
Catalytic activity	UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. HAMAP-Rule MF_00392
Pathway	Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 5/6. HAMAP-Rule MF_00392
Sequence similarities	Belongs to the LpxB family.

Ontologies

Keywords
Biological process	Lipid A biosynthesis Lipid biosynthesis Lipid metabolism
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	lipid A biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	lipid-A-disaccharide synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 393	393	Lipid-A-disaccharide synthase HAMAP-Rule MF_00392		PRO_0000255214

Sequences

	Sequence		Length	Mass (Da)
	Q6N5R2 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 301A25B00E36408F	FASTA	393	42,699
	10 20 30 40 50 60 MSGAAKTGDR VRTVYLIATE ESGDRLGAAL MRELRARLGS KVRFAGVGGH CMAGEGLASL 70 80 90 100 110 120 FPIEELSIIG FAAVVQRLPM ILKLIRRAVD AVLTAKPDIL VIIDSPDFTH RVARRVRQRD 130 140 150 160 170 180 PSIPIVDYVS PTVWAWRPGR ARAMLGYVDH VLALLPFEPA EYRRLQGPPC SYVGHPLTEQ 190 200 210 220 230 240 FGSLRPDAAE QARREASPPV LLVLPGSRRS EVRHHAAAFG DTLARLKHEG VAFEAVLPTT 250 260 270 280 290 300 PHLEGLVRAA VASWEVQPRI VVGEQDKRAA FRIAHAALAK SGTVTLELAI AGVPMVTAYR 310 320 330 340 350 360 AGSVEIWIAR RVVRPGTVIL ANLVMGDDVI PEFIQEDCVP DKLVPAVRDL LGNTPARRRQ 370 380 390 LAGFAKIDDI LSTGEQTPSG RAADIVLDVM RHA

References

[1]

"Complete genome sequence of the metabolically versatile photosynthetic bacterium Rhodopseudomonas palustris." Larimer F.W., Chain P., Hauser L., Lamerdin J.E., Malfatti S., Do L., Land M.L., Pelletier D.A., Beatty J.T., Lang A.S., Tabita F.R., Gibson J.L., Hanson T.E., Bobst C., Torres y Torres J.L., Peres C., Harrison F.H., Gibson J., Harwood C.S. Nat. Biotechnol. 22:55-61(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-98 / CGA009.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX572602 Genomic DNA. Translation: CAE28350.1.
RefSeq	NP_948250.1. NC_005296.1.
3D structure databases
ProteinModelPortal	Q6N5R2.
ModBase	Search...
Protein-protein interaction databases
STRING	258594.RPA2909.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAE28350; CAE28350; RPA2909.
GeneID	2691083.
KEGG	rpa:RPA2909.
PATRIC	23290255. VBIRhoPal84835_3054.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0763.
HOGENOM	HOG000018004.
KO	K00748.
OMA	PTVWAWR.
ProtClustDB	CLSK911278.
Enzyme and pathway databases
UniPathway	UPA00359; UER00481.
Family and domain databases
HAMAP	MF_00392. LpxB.
InterPro	IPR003835. Glyco_trans_19. [Graphical view]
Pfam	PF02684. LpxB. 1 hit. [Graphical view]
TIGRFAMs	TIGR00215. lpxB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

LPXB_RHOPA

Accession

Primary (citable) accession number: Q6N5R2

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	July 5, 2004
Last modified:	May 29, 2013
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program