Q6N5C8 (PUR5_RHOPA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligase
EC=6.3.3.1

Alternative name(s):
AIR synthase
AIRS
Phosphoribosyl-aminoimidazole synthetase

Gene names

Name:	purM
Ordered Locus Names:	RPA3051

Organism

Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009) [Complete proteome] [HAMAP]

Taxonomic identifier

258594 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bradyrhizobiaceae › Rhodopseudomonas › Rhodopseudomonas palustris

Protein attributes

Sequence length	357 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole. HAMAP-Rule MF_00741
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2. HAMAP-Rule MF_00741
Subcellular location	Cytoplasm By similarity HAMAP-Rule MF_00741.
Sequence similarities	Belongs to the AIR synthase family.

Ontologies

Keywords
Biological process	Purine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	'de novo' IMP biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosylformylglycinamidine cyclo-ligase activity Inferred from electronic annotation. Source: UniProtKB-HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 357	357	Phosphoribosylformylglycinamidine cyclo-ligase HAMAP-Rule MF_00741		PRO_0000258395

Sequences

	Sequence		Length	Mass (Da)
	Q6N5C8 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: D1B043E66DD18807	FASTA	357	37,033
	10 20 30 40 50 60 MTERKHGLTY ADSGVDIDAG NRLVDLIKPM VRATARAGAD SEIGGFGGLF DLKAAGFKDP 70 80 90 100 110 120 VLVAATDGVG TKIKVAIDAG LHTGIGIDLV AMSVNDLVVQ GAEPLFFLDY FACGKLDPEA 130 140 150 160 170 180 AAEIVAGVAE ACRESGCALI GGETAEMPGL YKDGDYDLAG FSVGAAERGT LLPSKDIAEG 190 200 210 220 230 240 DAVIGLASSG VHSNGFSLVR KIVEKSGLPY DAPAPFSPVM TLGGALLAPT KLYVKSCLQA 250 260 270 280 290 300 IRDTGAVKGL AHITGGGFTE NIPRVLPKHL GVGIDLPRIP VLPVFKWLAE QGEIAELELL 310 320 330 340 350 RTFNCGIGMV IIVKADAVDQ VTESLTASGE SVHLLGQVIA AKGEQRVVYD GHLDLAW

References

[1]

"Complete genome sequence of the metabolically versatile photosynthetic bacterium Rhodopseudomonas palustris." Larimer F.W., Chain P., Hauser L., Lamerdin J.E., Malfatti S., Do L., Land M.L., Pelletier D.A., Beatty J.T., Lang A.S., Tabita F.R., Gibson J.L., Hanson T.E., Bobst C., Torres y Torres J.L., Peres C., Harrison F.H., Gibson J., Harwood C.S. Nat. Biotechnol. 22:55-61(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-98 / CGA009.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX572602 Genomic DNA. Translation: CAE28492.1.
RefSeq	NP_948390.1. NC_005296.1.
3D structure databases
ProteinModelPortal	Q6N5C8.
SMR	Q6N5C8. Positions 7-349.
ModBase	Search...
Protein-protein interaction databases
STRING	258594.RPA3051.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAE28492; CAE28492; RPA3051.
GeneID	2691510.
KEGG	rpa:RPA3051.
PATRIC	23290567. VBIRhoPal84835_3207.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0150.
HOGENOM	HOG000229090.
KO	K01933.
OMA	HCVNDIL.
OrthoDB	EOG61CM1V.
ProtClustDB	PRK05385.
Enzyme and pathway databases
UniPathway	UPA00074; UER00129.
Family and domain databases
Gene3D	3.90.650.10. 1 hit.
HAMAP	MF_00741_B. AIRS_B.
InterPro	IPR010918. AIR_synth_C_dom. IPR000728. AIR_synth_N_dom. IPR004733. PurM_cligase. IPR016188. PurM_N-like. [Graphical view]
Pfam	PF00586. AIRS. 1 hit. PF02769. AIRS_C. 1 hit. [Graphical view]
SUPFAM	SSF55326. SSF55326. 1 hit. SSF56042. SSF56042. 1 hit.
TIGRFAMs	TIGR00878. purM. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PUR5_RHOPA

Accession

Primary (citable) accession number: Q6N5C8

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	July 5, 2004
Last modified:	November 13, 2013
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program