purM

Functionⁱ

Catalytic activityⁱ

ATP + 2-(formamido)-N₁-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayⁱ: IMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:

Phosphoribosylformylglycinamidine synthase subunit PurS (purS), Phosphoribosylformylglycinamidine synthase subunit PurL (purL), Phosphoribosylformylglycinamidine synthase subunit PurQ (purQ)
Phosphoribosylformylglycinamidine cyclo-ligase (purM)

This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-EC

Complete GO annotation...

GO - Biological processⁱ

'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway

Complete GO annotation...

Keywordsⁱ

Molecular function	Ligase
Biological process	Purine biosynthesis
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayⁱ	UPA00074; UER00129.

UniPathwayⁱ

UPA00074; UER00129.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation (EC:6.3.3.1UniRule annotation) Alternative name(s): AIR synthaseUniRule annotation AIRSUniRule annotation Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
Gene namesⁱ	Name:purMUniRule annotation Ordered Locus Names:RPA3051
Organismⁱ	Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)
Taxonomic identifierⁱ	258594 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bradyrhizobiaceae › Rhodopseudomonas › Rhodopseudomonas palustris
Proteomesⁱ	UP000001426 Componentⁱ: Chromosome

Subcellular locationⁱ

Cytoplasm
UniRule annotation
Manual assertion according to rulesⁱ
- HAMAP-Rule:MF_00741

GO - Cellular componentⁱ

cytoplasm Source: UniProtKB-SubCell

Complete GO annotation...

Keywords - Cellular componentⁱ

Cytoplasm

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000258395	1 – 357	Phosphoribosylformylglycinamidine cyclo-ligaseAdd BLAST		357

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	258594.RPA3051.

STRINGⁱ

258594.RPA3051.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q6N5C8.
SMRⁱ	Q6N5C8.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the AIR synthase family.UniRule annotation

Phylogenomic databases

eggNOGⁱ	ENOG4105CXB. Bacteria. COG0150. LUCA.
HOGENOMⁱ	HOG000229090.
KEGG Orthology (KO) More...KOⁱ	K01933.
OMAⁱ	NHCVNDI.
Database of Orthologous Groups More...OrthoDBⁱ	POG091H0128.
PhylomeDBⁱ	Q6N5C8.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd02196. PurM. 1 hit.
Gene3Dⁱ	3.30.1330.10. 1 hit. 3.90.650.10. 1 hit.
HAMAPⁱ	MF_00741. AIRS. 1 hit.
InterProⁱ	View protein in InterPro IPR010918. AIR_synth_C_dom. IPR016188. PurM-like_N. IPR004733. PurM_cligase.
PANTHERⁱ	PTHR10520:SF42. PTHR10520:SF42. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00586. AIRS. 1 hit. PF02769. AIRS_C. 1 hit.
SUPFAMⁱ	SSF55326. SSF55326. 1 hit. SSF56042. SSF56042. 1 hit.
TIGRFAMsⁱ	TIGR00878. purM. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q6N5C8-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MTERKHGLTY ADSGVDIDAG NRLVDLIKPM VRATARAGAD SEIGGFGGLF 
        60         70         80         90        100
DLKAAGFKDP VLVAATDGVG TKIKVAIDAG LHTGIGIDLV AMSVNDLVVQ 
       110        120        130        140        150
GAEPLFFLDY FACGKLDPEA AAEIVAGVAE ACRESGCALI GGETAEMPGL 
       160        170        180        190        200
YKDGDYDLAG FSVGAAERGT LLPSKDIAEG DAVIGLASSG VHSNGFSLVR 
       210        220        230        240        250
KIVEKSGLPY DAPAPFSPVM TLGGALLAPT KLYVKSCLQA IRDTGAVKGL 
       260        270        280        290        300
AHITGGGFTE NIPRVLPKHL GVGIDLPRIP VLPVFKWLAE QGEIAELELL 
       310        320        330        340        350
RTFNCGIGMV IIVKADAVDQ VTESLTASGE SVHLLGQVIA AKGEQRVVYD 

GHLDLAW

Length:357

Mass (Da):37,033

Last modified:July 5, 2004 - v1

Checksum:ⁱD1B043E66DD18807

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BX572602 Genomic DNA. Translation: CAE28492.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_011158597.1. NC_005296.1.

Genome annotation databases

EnsemblBacteriaⁱ	CAE28492; CAE28492; RPA3051.
KEGGⁱ	rpa:RPA3051.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BX572602 Genomic DNA. Translation: CAE28492.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_011158597.1. NC_005296.1.

3D structure databases

ProteinModelPortalⁱ	Q6N5C8.
SMRⁱ	Q6N5C8.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	258594.RPA3051.

STRINGⁱ

258594.RPA3051.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	CAE28492; CAE28492; RPA3051.
KEGGⁱ	rpa:RPA3051.

Phylogenomic databases

eggNOGⁱ	ENOG4105CXB. Bacteria. COG0150. LUCA.
HOGENOMⁱ	HOG000229090.
KEGG Orthology (KO) More...KOⁱ	K01933.
OMAⁱ	NHCVNDI.
Database of Orthologous Groups More...OrthoDBⁱ	POG091H0128.
PhylomeDBⁱ	Q6N5C8.

Enzyme and pathway databases

UniPathwayⁱ	UPA00074; UER00129.

UniPathwayⁱ

UPA00074; UER00129.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd02196. PurM. 1 hit.
Gene3Dⁱ	3.30.1330.10. 1 hit. 3.90.650.10. 1 hit.
HAMAPⁱ	MF_00741. AIRS. 1 hit.
InterProⁱ	View protein in InterPro IPR010918. AIR_synth_C_dom. IPR016188. PurM-like_N. IPR004733. PurM_cligase.
PANTHERⁱ	PTHR10520:SF42. PTHR10520:SF42. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00586. AIRS. 1 hit. PF02769. AIRS_C. 1 hit.
SUPFAMⁱ	SSF55326. SSF55326. 1 hit. SSF56042. SSF56042. 1 hit.
TIGRFAMsⁱ	TIGR00878. purM. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PUR5_RHOPA
Accessionⁱ	Q6N5C8Primary (citable) accession number: Q6N5C8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
	Last sequence update:	July 5, 2004
	Last modified:	June 7, 2017
	This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q6N5C8 (PUR5_RHOPA)

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Phosphoribosylformylglycinamidine cyclo-ligase

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">‘Function’</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: IMP biosynthesis via de novo pathway

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

Pathwayⁱ: IMP biosynthesis via de novo pathway

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ