purM

Functionⁱ

Catalytic activityⁱ

ATP + 2-(formamido)-N₁-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayⁱ: IMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:

Phosphoribosylformylglycinamidine synthase subunit PurS (purS), Phosphoribosylformylglycinamidine synthase subunit PurL (purL), Phosphoribosylformylglycinamidine synthase subunit PurQ (purQ)
Phosphoribosylformylglycinamidine cyclo-ligase (purM)

This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-EC

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Ligase
Biological process	Purine biosynthesis
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCycⁱ	RPAL258594:TX73_RS15565-MONOMER
UniPathwayⁱ	UPA00074; UER00129

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation (EC:6.3.3.1UniRule annotation) Alternative name(s): AIR synthaseUniRule annotation AIRSUniRule annotation Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
Gene namesⁱ	Name:purMUniRule annotation Ordered Locus Names:RPA3051
Organismⁱ	Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)
Taxonomic identifierⁱ	258594 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bradyrhizobiaceae › Rhodopseudomonas › Rhodopseudomonas palustris
Proteomesⁱ	UP000001426 Componentⁱ: Chromosome

Subcellular locationⁱ

Cytoplasm
UniRule annotation
Manual assertion according to rulesⁱ
- HAMAP-Rule:MF_00741

GO - Cellular componentⁱ

cytoplasm Source: UniProtKB-SubCell

View the complete GO annotation on QuickGO ...

Keywords - Cellular componentⁱ

Cytoplasm

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000258395	1 – 357	Phosphoribosylformylglycinamidine cyclo-ligaseAdd BLAST		357

Proteomic databases

PRIDEⁱ	Q6N5C8

PRIDEⁱ

Q6N5C8

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	258594.RPA3051

STRINGⁱ

258594.RPA3051

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q6N5C8
SMRⁱ	Q6N5C8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the AIR synthase family.UniRule annotation

Phylogenomic databases

eggNOGⁱ	ENOG4105CXB Bacteria COG0150 LUCA
HOGENOMⁱ	HOG000229090
KEGG Orthology (KO) More...KOⁱ	K01933
OMAⁱ	NHCVNDI
Database of Orthologous Groups More...OrthoDBⁱ	POG091H0128
PhylomeDBⁱ	Q6N5C8

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd02196 PurM, 1 hit
Gene3Dⁱ	3.30.1330.10, 1 hit 3.90.650.10, 1 hit
HAMAPⁱ	MF_00741 AIRS, 1 hit
InterProⁱ	View protein in InterPro IPR010918 PurM-like_C_dom IPR036676 PurM-like_C_sf IPR016188 PurM-like_N IPR036921 PurM-like_N_sf IPR004733 PurM_cligase
PANTHERⁱ	PTHR10520 PTHR10520, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00586 AIRS, 1 hit PF02769 AIRS_C, 1 hit
SUPFAMⁱ	SSF55326 SSF55326, 1 hit SSF56042 SSF56042, 1 hit
TIGRFAMsⁱ	TIGR00878 purM, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q6N5C8-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MTERKHGLTY ADSGVDIDAG NRLVDLIKPM VRATARAGAD SEIGGFGGLF 
        60         70         80         90        100
DLKAAGFKDP VLVAATDGVG TKIKVAIDAG LHTGIGIDLV AMSVNDLVVQ 
       110        120        130        140        150
GAEPLFFLDY FACGKLDPEA AAEIVAGVAE ACRESGCALI GGETAEMPGL 
       160        170        180        190        200
YKDGDYDLAG FSVGAAERGT LLPSKDIAEG DAVIGLASSG VHSNGFSLVR 
       210        220        230        240        250
KIVEKSGLPY DAPAPFSPVM TLGGALLAPT KLYVKSCLQA IRDTGAVKGL 
       260        270        280        290        300
AHITGGGFTE NIPRVLPKHL GVGIDLPRIP VLPVFKWLAE QGEIAELELL 
       310        320        330        340        350
RTFNCGIGMV IIVKADAVDQ VTESLTASGE SVHLLGQVIA AKGEQRVVYD 

GHLDLAW

Length:357

Mass (Da):37,033

Last modified:July 5, 2004 - v1

Checksum:ⁱD1B043E66DD18807

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BX572602 Genomic DNA Translation: CAE28492.1
NCBI Reference Sequences More...RefSeqⁱ	WP_011158597.1, NC_005296.1

Genome annotation databases

EnsemblBacteriaⁱ	CAE28492; CAE28492; RPA3051
KEGGⁱ	rpa:RPA3051

Protein	Similar proteins		Species	Score	Length
Q6N5C8	Phosphoribosylformylglycinamidine cyclo-ligase		RHOPT		357
Phosphoribosylformylglycinamidine cyclo-ligase		RHOP2		357
Phosphoribosylformylglycinamidine cyclo-ligase		Rhodopseudomonas sp. AAP120		357
Phosphoribosylformylglycinamidine cyclo-ligase		RHOPS		357
Phosphoribosylformylglycinamidine cyclo-ligase		Rhodopseudomonas pseudopalustris		357
+3

Protein	Similar proteins		Species	Score	Length
Q6N5C8	Phosphoribosylformylglycinamidine cyclo-ligase		SACD2		352
Phosphoribosylformylglycinamidine cyclo-ligase		Desulfuromonas soudanensis		349
Phosphoribosylformylglycinamidine cyclo-ligase		Halomonas sp. WRN001		357
Phosphoribosylformylglycinamidine cyclo-ligase		Halomonas sp. 1513		360
Phosphoribosylformylglycinamidine cyclo-ligase		Halomonas pantelleriensis		360
+7294

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BX572602 Genomic DNA Translation: CAE28492.1
NCBI Reference Sequences More...RefSeqⁱ	WP_011158597.1, NC_005296.1

3D structure databases

ProteinModelPortalⁱ	Q6N5C8
SMRⁱ	Q6N5C8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	258594.RPA3051

STRINGⁱ

258594.RPA3051

Proteomic databases

PRIDEⁱ	Q6N5C8

PRIDEⁱ

Q6N5C8

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	CAE28492; CAE28492; RPA3051
KEGGⁱ	rpa:RPA3051

Phylogenomic databases

eggNOGⁱ	ENOG4105CXB Bacteria COG0150 LUCA
HOGENOMⁱ	HOG000229090
KEGG Orthology (KO) More...KOⁱ	K01933
OMAⁱ	NHCVNDI
Database of Orthologous Groups More...OrthoDBⁱ	POG091H0128
PhylomeDBⁱ	Q6N5C8

Enzyme and pathway databases

UniPathwayⁱ	UPA00074; UER00129
BioCycⁱ	RPAL258594:TX73_RS15565-MONOMER

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd02196 PurM, 1 hit
Gene3Dⁱ	3.30.1330.10, 1 hit 3.90.650.10, 1 hit
HAMAPⁱ	MF_00741 AIRS, 1 hit
InterProⁱ	View protein in InterPro IPR010918 PurM-like_C_dom IPR036676 PurM-like_C_sf IPR016188 PurM-like_N IPR036921 PurM-like_N_sf IPR004733 PurM_cligase
PANTHERⁱ	PTHR10520 PTHR10520, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00586 AIRS, 1 hit PF02769 AIRS_C, 1 hit
SUPFAMⁱ	SSF55326 SSF55326, 1 hit SSF56042 SSF56042, 1 hit
TIGRFAMsⁱ	TIGR00878 purM, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PUR5_RHOPA
Accessionⁱ	Q6N5C8Primary (citable) accession number: Q6N5C8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
	Last sequence update:	July 5, 2004
	Last modified:	June 20, 2018
	This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q6N5C8 (PUR5_RHOPA)

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Phosphoribosylformylglycinamidine cyclo-ligase

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: IMP biosynthesis via de novo pathway

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

Pathwayⁱ: IMP biosynthesis via de novo pathway

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ