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Q6N344

- GCSP_RHOPA

UniProt

Q6N344 - GCSP_RHOPA

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Ordered Locus Names:RPA3850
    OrganismiRhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)
    Taxonomic identifieri258594 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeRhodopseudomonas
    ProteomesiUP000001426: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 990990Glycine dehydrogenase (decarboxylating)PRO_0000227125Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei726 – 7261N6-(pyridoxal phosphate)lysineUniRule annotation

    Proteomic databases

    PRIDEiQ6N344.

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi258594.RPA3850.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6N344.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239369.
    KOiK00281.
    OMAiTAYLTHP.
    OrthoDBiEOG6HMXDX.
    PhylomeDBiQ6N344.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q6N344-1 [UniParc]FASTAAdd to Basket

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    MTPLRFPSNL PLRAVAFDED QSMPHRRPID AANDFVRRHI GPSPQDIAAM    50
    LATAGAGSLE QLVAETLPYA IRHREPLKLG APLTESEALA HMSELGAQNQ 100
    VFTSLIGQGY YGTILPTVIQ RNILENPAWY TAYTPYQPEI SQGRLEALFN 150
    FQTMICDLTG LDVANASLLD EGTAAAEAMA LAERAAAKNA KAFFVDADTH 200
    PQTIAVLRTR AEPLGWRIIV GNPETGLEGA DVFGALLQYP GSSGRLSDPR 250
    AVIAALRKKG ALAVVAADLL ALTLITPPGE LGADIAIGSA QRFGVPMGYG 300
    GPHAAYMAVR DSLKRSLPGR IVGLSIDSHG QPAYRLALQT REQHIRREKA 350
    TSNICTAQVL LAVINAMYAV YHGPDGLAAI ARRVHRRTAV LAAGLQQLGF 400
    APTHGNYFDT LTIEVGDRRD AIVARAEAEN INLRINASSL GISLDETTTP 450
    ATVEALWRAF GGSLDYAAVE RDAGDALGTA LPAALKRTSD YLTQPAFQDY 500
    RSETELLRYM RKLSDRDLAL DRAMIPLGSC TMKLNATTEM MPLTWPEFGS 550
    LHPFVPKAQA AGYHALFERL ETWLAEITGY DAVSLQPNSG AQGEYAGLLT 600
    IRGYHLSRGE PHRKVCLIPS SAHGTNPASA AMAGMDVVVV ACDAHGDVDV 650
    DDLRAKAEAH SADLAAVMIT YPSTHGVFEE HIREICDIVH AHGGQVYLDG 700
    ANLNAQVGLA RPGSYGADVS HLNLHKTFCI PHGGGGPGMG PIGVKAHLAP 750
    FLPGHPAEGE PLNGGLHGGG TVSAAPWGSA SILTISYIYI LMMGAAGLKR 800
    ATEIAILNAN YIAAKLHPHF PVLYRNPRGR VAHECIIDPR ALKTSTGVTV 850
    DDIAKRLIDY GFHAPTMSFP VPGTLMIEPT ESESKAEIDR FCDAMIAIRR 900
    EIAQVEAGRY PIEQSPLRHA PHTAHDVTSA EWTRPYPRTE GCFPAPNSRT 950
    DKYWSPVGRV DNVYGDRNLI CSCPPVEDYA LAADYARAAE 990
    Length:990
    Mass (Da):106,401
    Last modified:July 5, 2004 - v1
    Checksum:iBB35BA120F969DFF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX572605 Genomic DNA. Translation: CAE29291.1.
    RefSeqiNP_949187.1. NC_005296.1.

    Genome annotation databases

    EnsemblBacteriaiCAE29291; CAE29291; RPA3850.
    GeneIDi2691977.
    KEGGirpa:RPA3850.
    PATRICi23292255. VBIRhoPal84835_4043.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX572605 Genomic DNA. Translation: CAE29291.1 .
    RefSeqi NP_949187.1. NC_005296.1.

    3D structure databases

    ProteinModelPortali Q6N344.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 258594.RPA3850.

    Proteomic databases

    PRIDEi Q6N344.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAE29291 ; CAE29291 ; RPA3850 .
    GeneIDi 2691977.
    KEGGi rpa:RPA3850.
    PATRICi 23292255. VBIRhoPal84835_4043.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239369.
    KOi K00281.
    OMAi TAYLTHP.
    OrthoDBi EOG6HMXDX.
    PhylomeDBi Q6N344.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-98 / CGA009.

    Entry informationi

    Entry nameiGCSP_RHOPA
    AccessioniPrimary (citable) accession number: Q6N344
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 7, 2006
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3