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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:RPA3850
OrganismiRhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)
Taxonomic identifieri258594 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeRhodopseudomonas
ProteomesiUP000001426 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 990990Glycine dehydrogenase (decarboxylating)PRO_0000227125Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei726 – 7261N6-(pyridoxal phosphate)lysineUniRule annotation

Proteomic databases

PRIDEiQ6N344.

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi258594.RPA3850.

Structurei

3D structure databases

ProteinModelPortaliQ6N344.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiRAESEMT.
OrthoDBiEOG6HMXDX.
PhylomeDBiQ6N344.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6N344-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTPLRFPSNL PLRAVAFDED QSMPHRRPID AANDFVRRHI GPSPQDIAAM
60 70 80 90 100
LATAGAGSLE QLVAETLPYA IRHREPLKLG APLTESEALA HMSELGAQNQ
110 120 130 140 150
VFTSLIGQGY YGTILPTVIQ RNILENPAWY TAYTPYQPEI SQGRLEALFN
160 170 180 190 200
FQTMICDLTG LDVANASLLD EGTAAAEAMA LAERAAAKNA KAFFVDADTH
210 220 230 240 250
PQTIAVLRTR AEPLGWRIIV GNPETGLEGA DVFGALLQYP GSSGRLSDPR
260 270 280 290 300
AVIAALRKKG ALAVVAADLL ALTLITPPGE LGADIAIGSA QRFGVPMGYG
310 320 330 340 350
GPHAAYMAVR DSLKRSLPGR IVGLSIDSHG QPAYRLALQT REQHIRREKA
360 370 380 390 400
TSNICTAQVL LAVINAMYAV YHGPDGLAAI ARRVHRRTAV LAAGLQQLGF
410 420 430 440 450
APTHGNYFDT LTIEVGDRRD AIVARAEAEN INLRINASSL GISLDETTTP
460 470 480 490 500
ATVEALWRAF GGSLDYAAVE RDAGDALGTA LPAALKRTSD YLTQPAFQDY
510 520 530 540 550
RSETELLRYM RKLSDRDLAL DRAMIPLGSC TMKLNATTEM MPLTWPEFGS
560 570 580 590 600
LHPFVPKAQA AGYHALFERL ETWLAEITGY DAVSLQPNSG AQGEYAGLLT
610 620 630 640 650
IRGYHLSRGE PHRKVCLIPS SAHGTNPASA AMAGMDVVVV ACDAHGDVDV
660 670 680 690 700
DDLRAKAEAH SADLAAVMIT YPSTHGVFEE HIREICDIVH AHGGQVYLDG
710 720 730 740 750
ANLNAQVGLA RPGSYGADVS HLNLHKTFCI PHGGGGPGMG PIGVKAHLAP
760 770 780 790 800
FLPGHPAEGE PLNGGLHGGG TVSAAPWGSA SILTISYIYI LMMGAAGLKR
810 820 830 840 850
ATEIAILNAN YIAAKLHPHF PVLYRNPRGR VAHECIIDPR ALKTSTGVTV
860 870 880 890 900
DDIAKRLIDY GFHAPTMSFP VPGTLMIEPT ESESKAEIDR FCDAMIAIRR
910 920 930 940 950
EIAQVEAGRY PIEQSPLRHA PHTAHDVTSA EWTRPYPRTE GCFPAPNSRT
960 970 980 990
DKYWSPVGRV DNVYGDRNLI CSCPPVEDYA LAADYARAAE
Length:990
Mass (Da):106,401
Last modified:July 4, 2004 - v1
Checksum:iBB35BA120F969DFF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX572605 Genomic DNA. Translation: CAE29291.1.
RefSeqiNP_949187.1. NC_005296.1.
WP_011159386.1. NC_005296.1.

Genome annotation databases

KEGGirpa:RPA3850.
PATRICi23292255. VBIRhoPal84835_4043.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX572605 Genomic DNA. Translation: CAE29291.1.
RefSeqiNP_949187.1. NC_005296.1.
WP_011159386.1. NC_005296.1.

3D structure databases

ProteinModelPortaliQ6N344.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi258594.RPA3850.

Proteomic databases

PRIDEiQ6N344.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

KEGGirpa:RPA3850.
PATRICi23292255. VBIRhoPal84835_4043.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiRAESEMT.
OrthoDBiEOG6HMXDX.
PhylomeDBiQ6N344.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-98 / CGA009.

Entry informationi

Entry nameiGCSP_RHOPA
AccessioniPrimary (citable) accession number: Q6N344
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 6, 2006
Last sequence update: July 4, 2004
Last modified: March 31, 2015
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.