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Q6N344 (GCSP_RHOPA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating)

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:gcvP
Ordered Locus Names:RPA3850
OrganismRhodopseudomonas palustris (strain ATCC BAA-98 / CGA009) [Complete proteome] [HAMAP]
Taxonomic identifier258594 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeRhodopseudomonas

Protein attributes

Sequence length990 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 990990Glycine dehydrogenase (decarboxylating) HAMAP-Rule MF_00711
PRO_0000227125

Amino acid modifications

Modified residue7261N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6N344 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: BB35BA120F969DFF

FASTA990106,401
        10         20         30         40         50         60 
MTPLRFPSNL PLRAVAFDED QSMPHRRPID AANDFVRRHI GPSPQDIAAM LATAGAGSLE 

        70         80         90        100        110        120 
QLVAETLPYA IRHREPLKLG APLTESEALA HMSELGAQNQ VFTSLIGQGY YGTILPTVIQ 

       130        140        150        160        170        180 
RNILENPAWY TAYTPYQPEI SQGRLEALFN FQTMICDLTG LDVANASLLD EGTAAAEAMA 

       190        200        210        220        230        240 
LAERAAAKNA KAFFVDADTH PQTIAVLRTR AEPLGWRIIV GNPETGLEGA DVFGALLQYP 

       250        260        270        280        290        300 
GSSGRLSDPR AVIAALRKKG ALAVVAADLL ALTLITPPGE LGADIAIGSA QRFGVPMGYG 

       310        320        330        340        350        360 
GPHAAYMAVR DSLKRSLPGR IVGLSIDSHG QPAYRLALQT REQHIRREKA TSNICTAQVL 

       370        380        390        400        410        420 
LAVINAMYAV YHGPDGLAAI ARRVHRRTAV LAAGLQQLGF APTHGNYFDT LTIEVGDRRD 

       430        440        450        460        470        480 
AIVARAEAEN INLRINASSL GISLDETTTP ATVEALWRAF GGSLDYAAVE RDAGDALGTA 

       490        500        510        520        530        540 
LPAALKRTSD YLTQPAFQDY RSETELLRYM RKLSDRDLAL DRAMIPLGSC TMKLNATTEM 

       550        560        570        580        590        600 
MPLTWPEFGS LHPFVPKAQA AGYHALFERL ETWLAEITGY DAVSLQPNSG AQGEYAGLLT 

       610        620        630        640        650        660 
IRGYHLSRGE PHRKVCLIPS SAHGTNPASA AMAGMDVVVV ACDAHGDVDV DDLRAKAEAH 

       670        680        690        700        710        720 
SADLAAVMIT YPSTHGVFEE HIREICDIVH AHGGQVYLDG ANLNAQVGLA RPGSYGADVS 

       730        740        750        760        770        780 
HLNLHKTFCI PHGGGGPGMG PIGVKAHLAP FLPGHPAEGE PLNGGLHGGG TVSAAPWGSA 

       790        800        810        820        830        840 
SILTISYIYI LMMGAAGLKR ATEIAILNAN YIAAKLHPHF PVLYRNPRGR VAHECIIDPR 

       850        860        870        880        890        900 
ALKTSTGVTV DDIAKRLIDY GFHAPTMSFP VPGTLMIEPT ESESKAEIDR FCDAMIAIRR 

       910        920        930        940        950        960 
EIAQVEAGRY PIEQSPLRHA PHTAHDVTSA EWTRPYPRTE GCFPAPNSRT DKYWSPVGRV 

       970        980        990 
DNVYGDRNLI CSCPPVEDYA LAADYARAAE 

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References

[1]"Complete genome sequence of the metabolically versatile photosynthetic bacterium Rhodopseudomonas palustris."
Larimer F.W., Chain P., Hauser L., Lamerdin J.E., Malfatti S., Do L., Land M.L., Pelletier D.A., Beatty J.T., Lang A.S., Tabita F.R., Gibson J.L., Hanson T.E., Bobst C., Torres y Torres J.L., Peres C., Harrison F.H., Gibson J., Harwood C.S.
Nat. Biotechnol. 22:55-61(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-98 / CGA009.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX572605 Genomic DNA. Translation: CAE29291.1.
RefSeqNP_949187.1. NC_005296.1.

3D structure databases

ProteinModelPortalQ6N344.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING258594.RPA3850.

Proteomic databases

PRIDEQ6N344.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAE29291; CAE29291; RPA3850.
GeneID2691977.
KEGGrpa:RPA3850.
PATRIC23292255. VBIRhoPal84835_4043.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239369.
KOK00281.
OMAQTMVCDL.
OrthoDBEOG6HMXDX.
ProtClustDBPRK05367.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP_RHOPA
AccessionPrimary (citable) accession number: Q6N344
Entry history
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: July 5, 2004
Last modified: February 19, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families