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Q6N344

- GCSP_RHOPA

UniProt

Q6N344 - GCSP_RHOPA

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Protein
Glycine dehydrogenase (decarboxylating)
Gene
gcvP, RPA3850
Organism
Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcvP
Ordered Locus Names:RPA3850
OrganismiRhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)
Taxonomic identifieri258594 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeRhodopseudomonas
ProteomesiUP000001426: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 990990Glycine dehydrogenase (decarboxylating)UniRule annotation
PRO_0000227125Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei726 – 7261N6-(pyridoxal phosphate)lysine By similarity

Proteomic databases

PRIDEiQ6N344.

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi258594.RPA3850.

Structurei

3D structure databases

ProteinModelPortaliQ6N344.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiTAYLTHP.
OrthoDBiEOG6HMXDX.
PhylomeDBiQ6N344.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6N344-1 [UniParc]FASTAAdd to Basket

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MTPLRFPSNL PLRAVAFDED QSMPHRRPID AANDFVRRHI GPSPQDIAAM    50
LATAGAGSLE QLVAETLPYA IRHREPLKLG APLTESEALA HMSELGAQNQ 100
VFTSLIGQGY YGTILPTVIQ RNILENPAWY TAYTPYQPEI SQGRLEALFN 150
FQTMICDLTG LDVANASLLD EGTAAAEAMA LAERAAAKNA KAFFVDADTH 200
PQTIAVLRTR AEPLGWRIIV GNPETGLEGA DVFGALLQYP GSSGRLSDPR 250
AVIAALRKKG ALAVVAADLL ALTLITPPGE LGADIAIGSA QRFGVPMGYG 300
GPHAAYMAVR DSLKRSLPGR IVGLSIDSHG QPAYRLALQT REQHIRREKA 350
TSNICTAQVL LAVINAMYAV YHGPDGLAAI ARRVHRRTAV LAAGLQQLGF 400
APTHGNYFDT LTIEVGDRRD AIVARAEAEN INLRINASSL GISLDETTTP 450
ATVEALWRAF GGSLDYAAVE RDAGDALGTA LPAALKRTSD YLTQPAFQDY 500
RSETELLRYM RKLSDRDLAL DRAMIPLGSC TMKLNATTEM MPLTWPEFGS 550
LHPFVPKAQA AGYHALFERL ETWLAEITGY DAVSLQPNSG AQGEYAGLLT 600
IRGYHLSRGE PHRKVCLIPS SAHGTNPASA AMAGMDVVVV ACDAHGDVDV 650
DDLRAKAEAH SADLAAVMIT YPSTHGVFEE HIREICDIVH AHGGQVYLDG 700
ANLNAQVGLA RPGSYGADVS HLNLHKTFCI PHGGGGPGMG PIGVKAHLAP 750
FLPGHPAEGE PLNGGLHGGG TVSAAPWGSA SILTISYIYI LMMGAAGLKR 800
ATEIAILNAN YIAAKLHPHF PVLYRNPRGR VAHECIIDPR ALKTSTGVTV 850
DDIAKRLIDY GFHAPTMSFP VPGTLMIEPT ESESKAEIDR FCDAMIAIRR 900
EIAQVEAGRY PIEQSPLRHA PHTAHDVTSA EWTRPYPRTE GCFPAPNSRT 950
DKYWSPVGRV DNVYGDRNLI CSCPPVEDYA LAADYARAAE 990
Length:990
Mass (Da):106,401
Last modified:July 5, 2004 - v1
Checksum:iBB35BA120F969DFF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX572605 Genomic DNA. Translation: CAE29291.1.
RefSeqiNP_949187.1. NC_005296.1.

Genome annotation databases

EnsemblBacteriaiCAE29291; CAE29291; RPA3850.
GeneIDi2691977.
KEGGirpa:RPA3850.
PATRICi23292255. VBIRhoPal84835_4043.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX572605 Genomic DNA. Translation: CAE29291.1 .
RefSeqi NP_949187.1. NC_005296.1.

3D structure databases

ProteinModelPortali Q6N344.
ModBasei Search...

Protein-protein interaction databases

STRINGi 258594.RPA3850.

Proteomic databases

PRIDEi Q6N344.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAE29291 ; CAE29291 ; RPA3850 .
GeneIDi 2691977.
KEGGi rpa:RPA3850.
PATRICi 23292255. VBIRhoPal84835_4043.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi TAYLTHP.
OrthoDBi EOG6HMXDX.
PhylomeDBi Q6N344.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-98 / CGA009.

Entry informationi

Entry nameiGCSP_RHOPA
AccessioniPrimary (citable) accession number: Q6N344
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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