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Protein

Adenosylhomocysteinase

Gene

ahcY

Organism
Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.

Catalytic activityi

S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine.

Cofactori

NAD+Note: Binds 1 NAD+ per subunit.

Pathwayi: L-homocysteine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-homocysteine from S-adenosyl-L-homocysteine.
Proteins known to be involved in this subpathway in this organism are:
  1. Adenosylhomocysteinase (ahcY)
This subpathway is part of the pathway L-homocysteine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-homocysteine from S-adenosyl-L-homocysteine, the pathway L-homocysteine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei58Substrate1
Binding sitei133Substrate1
Binding sitei195Substrate1
Binding sitei225Substrate1
Binding sitei229Substrate1
Binding sitei230NAD1
Binding sitei282NAD1
Binding sitei317NAD1
Binding sitei383NAD1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi196 – 198NAD3
Nucleotide bindingi259 – 264NAD6
Nucleotide bindingi338 – 340NAD3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processOne-carbon metabolism
LigandNAD

Enzyme and pathway databases

UniPathwayiUPA00314; UER00076.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenosylhomocysteinase (EC:3.3.1.1)
Alternative name(s):
S-adenosyl-L-homocysteine hydrolase
Short name:
AdoHcyase
Gene namesi
Name:ahcY
Ordered Locus Names:RPA4015
OrganismiRhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)
Taxonomic identifieri258594 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeRhodopseudomonas
Proteomesi
  • UP000001426 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001169841 – 469AdenosylhomocysteinaseAdd BLAST469

Interactioni

Protein-protein interaction databases

STRINGi258594.RPA4015.

Structurei

3D structure databases

ProteinModelPortaliQ6N2N5.
SMRiQ6N2N5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the adenosylhomocysteinase family.

Phylogenomic databases

eggNOGiENOG4105C3E. Bacteria.
COG0499. LUCA.
HOGENOMiHOG000227986.
KOiK01251.
OMAiTGNRDII.
OrthoDBiPOG091H00W2.
PhylomeDBiQ6N2N5.

Family and domain databases

CDDicd00401. SAHH. 1 hit.
HAMAPiMF_00563. AdoHcyase. 1 hit.
InterProiView protein in InterPro
IPR034373. Adenosylhomocysteinase.
IPR000043. Adenosylhomocysteinase-like.
IPR015878. Ado_hCys_hydrolase_NAD-bd.
IPR036291. NAD(P)-bd_dom_sf.
IPR020082. S-Ado-L-homoCys_hydrolase_CS.
PANTHERiPTHR23420. PTHR23420. 1 hit.
PfamiView protein in Pfam
PF05221. AdoHcyase. 1 hit.
PF00670. AdoHcyase_NAD. 1 hit.
PIRSFiPIRSF001109. Ad_hcy_hydrolase. 1 hit.
SMARTiView protein in SMART
SM00996. AdoHcyase. 1 hit.
SM00997. AdoHcyase_NAD. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR00936. ahcY. 1 hit.
PROSITEiView protein in PROSITE
PS00738. ADOHCYASE_1. 1 hit.
PS00739. ADOHCYASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6N2N5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTAKFTDYIV KDIGLAEFGR KEISLAETEM PGLMATREEY GPKQPLKGAK
60 70 80 90 100
IAGSLHMTIQ TAVLIETLVA LGAEVRWVSC NIYSTQDHAA AAIAAAGIPV
110 120 130 140 150
FAVKGETLKD YWDYTAKLFD WSDGGTPNMI LDDGGDATMF VHQGLRAENG
160 170 180 190 200
DTMFLDQHNS EEEEIFFALI KRILKEKPKG YFATLAKNIK GVSEETTTGV
210 220 230 240 250
HRLYDMEKAG KLLFPAINVN DSVTKSKFDN LYGCRESLVD GIRRGTDVML
260 270 280 290 300
SGKVAMVAGF GDVGKGSAAS LRQAGCRVMV SEVDPICALQ AAMEGYQVVT
310 320 330 340 350
MEDAAPIADI FVTATGNKDI ITIEHMRAMK DRAIVCNIGH FDNEIQVATL
360 370 380 390 400
KNMKWDNIKP QVDEITFPDG KRMILLSEGR LVNLGNAMGH PSFVMSASFT
410 420 430 440 450
NQTLAQIELF QNQGKYEKKV YVLPKTLDEK VARLHLAKIG VKLTELRKDQ
460
ADYIGVKVEG PFKADHYRY
Length:469
Mass (Da):51,699
Last modified:July 5, 2004 - v1
Checksum:i65C3E800744B4A4C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX572606 Genomic DNA. Translation: CAE29456.1.
RefSeqiWP_011159550.1. NC_005296.1.

Genome annotation databases

EnsemblBacteriaiCAE29456; CAE29456; RPA4015.
KEGGirpa:RPA4015.

Similar proteinsi

Entry informationi

Entry nameiSAHH_RHOPA
AccessioniPrimary (citable) accession number: Q6N2N5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: July 5, 2004
Last modified: October 25, 2017
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families