Q6N2A3 (TYPH_RHOPA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative thymidine phosphorylase
EC=2.4.2.4

Alternative name(s):
TdRPase

Gene names

Ordered Locus Names:

RPA4147

Organism

Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009) [Complete proteome] [HAMAP]

Taxonomic identifier

258594 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bradyrhizobiaceae › Rhodopseudomonas › Rhodopseudomonas palustris

Protein attributes

Sequence length	514 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate. HAMAP-Rule MF_00703
Sequence similarities	Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.
Sequence caution	The sequence CAE29588.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	pyrimidine nucleobase metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleoside metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	phosphorylase activity Inferred from electronic annotation. Source: InterPro thymidine phosphorylase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 514	514	Putative thymidine phosphorylase HAMAP-Rule MF_00703		PRO_0000314713

Sequences

	Sequence		Length	Mass (Da)
	Q6N2A3 [UniParc]. Last modified January 15, 2008. Version 2. Checksum: A2FD6F004F8FFE9C	FASTA	514	54,680
	10 20 30 40 50 60 MNAPDLTRPP LTIRRISLDT GRENVAVISR RSRALRPEVF RGFSRVELRI NSKVLLATLM 70 80 90 100 110 120 ITDDDAMIGP DEVGLSEPAF RRFNEPVGSA VSVTPARSPA SLDAVRAKIQ GHTLSAAEIT 130 140 150 160 170 180 AIVDDLAHFR YSDMEIAAFL ISAARFTTTD ELLALVGAMA SVGTKLTWDT PIVVDKHCIG 190 200 210 220 230 240 GIPGNRTTMI VVPIVAAHGL MIPKTSSRAI TSPAGTADTM ELLARVDLDV EQMKQVVHAC 250 260 270 280 290 300 GGCLVWGGHV NLSPADDILI SVERPLSLDT PEQMVASIMS KKLAAGSTRL LIDFPVGPSA 310 320 330 340 350 360 KVTNANEAMR LRKLFEFVGD HFGISVEVVT TDGRQPIGRG IGPVLEARDV MAVLGNEPGA 370 380 390 400 410 420 PADLREKSLR LAAHLLEYDP KLRGGTGYAR AKELLDSGAA LKKMQQIIDA QGPSPCPAEL 430 440 450 460 470 480 GSYAADVLAA ADGVVNGIDC LRINRLARSA GAPVAKGAGI DLFKKIGDRV EKGEPLYRVY 490 500 510 ASDRSEFDLA LAAAQAESGF AINHHTPADV DLVS

References

[1]

"Complete genome sequence of the metabolically versatile photosynthetic bacterium Rhodopseudomonas palustris." Larimer F.W., Chain P., Hauser L., Lamerdin J.E., Malfatti S., Do L., Land M.L., Pelletier D.A., Beatty J.T., Lang A.S., Tabita F.R., Gibson J.L., Hanson T.E., Bobst C., Torres y Torres J.L., Peres C., Harrison F.H., Gibson J., Harwood C.S. Nat. Biotechnol. 22:55-61(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-98 / CGA009.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX572606 Genomic DNA. Translation: CAE29588.1. Different initiation.
RefSeq	NP_949483.1. NC_005296.1.
3D structure databases
HSSP	HSSP built from PDB template 1BRW based on UniProtKB P77836.
ProteinModelPortal	Q6N2A3.
ModBase	Search...
Protein-protein interaction databases
STRING	258594.RPA4147.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAE29588; CAE29588; RPA4147.
GeneID	2690431.
KEGG	rpa:RPA4147.
PATRIC	23292875. VBIRhoPal84835_4351.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0213.
HOGENOM	HOG000252767.
KO	K00758.
ProtClustDB	PRK04350.
Family and domain databases
Gene3D	3.40.1030.10. 1 hit. 3.90.1170.30. 1 hit.
HAMAP	MF_00703. Thymid_phosp_2.
InterPro	IPR000312. Glycosyl_Trfase_fam3. IPR017459. Glycosyl_Trfase_fam3_N_dom. IPR013102. PYNP_C. IPR000053. Pyrmidine_PPase. IPR017872. Pyrmidine_PPase_CS. IPR013466. Thymidine_Pase_type2. [Graphical view]
PANTHER	PTHR10515. PTHR10515. 1 hit.
Pfam	PF02885. Glycos_trans_3N. 1 hit. PF00591. Glycos_transf_3. 1 hit. PF07831. PYNP_C. 1 hit. [Graphical view]
PIRSF	PIRSF000478. TP_PyNP. 1 hit.
SMART	SM00941. PYNP_C. 1 hit. [Graphical view]
SUPFAM	SSF47648. Glyco_trans_3. 1 hit. SSF52418. Glyco_trans_3. 1 hit. SSF54680. PYNP_C. 1 hit.
TIGRFAMs	TIGR02645. ARCH_P_rylase. 1 hit.
PROSITE	PS00647. THYMID_PHOSPHORYLASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TYPH_RHOPA

Accession

Primary (citable) accession number: Q6N2A3

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	January 15, 2008
Last modified:	May 1, 2013
This is version 56 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program