Q6N1Y2 (KHSE_RHOPA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homoserine kinase
Short name=HK
Short name=HSK
EC=2.7.1.39

Gene names

Name:	thrB
Ordered Locus Names:	RPA4270

Organism

Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009) [Complete proteome] [HAMAP]

Taxonomic identifier

258594 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bradyrhizobiaceae › Rhodopseudomonas

Protein attributes

Sequence length	327 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + L-homoserine = ADP + O-phospho-L-homoserine. HAMAP MF_00301
Pathway	Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5. HAMAP MF_00301
Sequence similarities	Belongs to the pseudomonas-type thrB family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Threonine biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	threonine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW homoserine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 327	327	Homoserine kinase HAMAP MF_00301		PRO_0000172198

Sequences

	Sequence		Length	Mass (Da)
	Q6N1Y2 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 6574668FDE5BAD81	FASTA	327	35,821
	10 20 30 40 50 60 MAVYTDVAAD ELADFLSRYD IGDLLSYKGI AEGVENSNFL LHTSRGYFIL TLYEKRVARD 70 80 90 100 110 120 DLPFFLSLMT HLADSGINCP QPVADREGRT LATLAGRPAA IISFLDGVWP RKPSVVHCAG 130 140 150 160 170 180 VGQALAKMHL AGRDFAMKRA NALSVAGWRP LFAAAEARAD EVQPGLRDFL AAELSYLESG 190 200 210 220 230 240 VWPSDLPQGL IHADLFPDNV FFIGDEVSGI IDFTFACNDL LAYDVAICLN AWCFEADHAF 250 260 270 280 290 300 NVTKARALLS AYTRERPLDA AEQAALPLLA RGAALRFLLT RLVDWLNVPE GALVKPKDPM 310 320 EYVRKLRFQQ NVAGIRDYGV EIAGAVA

References

[1]

"Complete genome sequence of the metabolically versatile photosynthetic bacterium Rhodopseudomonas palustris." Larimer F.W., Chain P., Hauser L., Lamerdin J.E., Malfatti S., Do L., Land M.L., Pelletier D.A., Beatty J.T., Lang A.S., Tabita F.R., Gibson J.L., Hanson T.E., Bobst C., Torres y Torres J.L., Peres C., Harrison F.H., Gibson J., Harwood C.S. Nat. Biotechnol. 22:55-61(2004) [PubMed: 14704707] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-98 / CGA009.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX572606 Genomic DNA. Translation: CAE29711.1.
RefSeq	NP_949606.1. NC_005296.1.
3D structure databases
ProteinModelPortal	Q6N1Y2.
SMR	Q6N1Y2. Positions 5-320.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2692412.
GenomeReviews	Gene locus RPA4270 in contig BX571963_GR.
KEGG	rpa:RPA4270.
NMPDR	fig|258594.1.peg.4249.
PATRIC	23293135. VBIRhoPal84835_4481.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG309377.
OMA	ICLNAWC.
ProtClustDB	PRK05231.
Enzyme and pathway databases
BioCyc	RPAL258594:RPA4270-MONOMER.
Family and domain databases
HAMAP	MF_00301. Homoser_kinase_2. [Tree]
InterPro	IPR002575. Aminoglycoside_PTrfase. IPR005280. Homoserine_kinase_ThrB. IPR011009. Kinase-like_dom. [Graphical view]
KO	K02204.
Pfam	PF01636. APH. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
TIGRFAMs	TIGR00938. ThrB_alt. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KHSE_RHOPA

Accession

Primary (citable) accession number: Q6N1Y2

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 15, 2005
Last sequence update:	July 5, 2004
Last modified:	January 25, 2012
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program