Q6N1S9 (AROE_RHOPA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Shikimate dehydrogenase
EC=1.1.1.25

Gene names

Name:	aroE
Ordered Locus Names:	RPA4325

Organism

Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009) [Complete proteome] [HAMAP]

Taxonomic identifier

258594 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bradyrhizobiaceae › Rhodopseudomonas

Protein attributes

Sequence length	278 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Shikimate + NADP+ = 3-dehydroshikimate + NADPH. HAMAP MF_00222
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7. HAMAP MF_00222
Sequence similarities	Belongs to the shikimate dehydrogenase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NADP binding Inferred from electronic annotation. Source: InterPro shikimate 3-dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 278	278	Shikimate dehydrogenase HAMAP MF_00222		PRO_1000021322
Regions
	Nucleotide binding	129 – 133	5	NADP By similarity
Sites
	Active site	69	1	Proton acceptor Potential

Sequences

	Sequence		Length	Mass (Da)
	Q6N1S9 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 22C349ED09B74266	FASTA	278	29,554
	10 20 30 40 50 60 MAATKRAACL IGCPAAHSRS PLIHHYWLRQ LGIEGGYSIE AVPPEGFAEF VLHLKTHGYV 70 80 90 100 110 120 GANVTIPHKE RALQLTEPDE RACAVGAANT LYYDGDLLRS TNTDIEGFIG NLDASAPGWD 130 140 150 160 170 180 RSAHALVLGA GGSSRAVVFG LLERGVQRIA LANRSIERAQ ALRDLFGERV VPIAWSDIPA 190 200 210 220 230 240 ALPGAGLLVN TTSLGMKGQP PLQIDLSALP ADAVVSDLVY VPLETDLLAA AKARGLRTAD 250 260 270 GLGMLLHQAV RGFDLWFGAR PHVTPELRAL VEADLAPK

References

[1]

"Complete genome sequence of the metabolically versatile photosynthetic bacterium Rhodopseudomonas palustris." Larimer F.W., Chain P., Hauser L., Lamerdin J.E., Malfatti S., Do L., Land M.L., Pelletier D.A., Beatty J.T., Lang A.S., Tabita F.R., Gibson J.L., Hanson T.E., Bobst C., Torres y Torres J.L., Peres C., Harrison F.H., Gibson J., Harwood C.S. Nat. Biotechnol. 22:55-61(2004) [PubMed: 14704707] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-98 / CGA009.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX572606 Genomic DNA. Translation: CAE29766.1.
RefSeq	NP_949661.1. NC_005296.1.
3D structure databases
HSSP	HSSP built from PDB template 1NYT based on UniProtKB P15770.
ProteinModelPortal	Q6N1S9.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2689759.
GenomeReviews	Gene locus RPA4325 in contig BX571963_GR.
KEGG	rpa:RPA4325.
NMPDR	fig|258594.1.peg.4304.
PATRIC	23293245. VBIRhoPal84835_4536.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG553408.
OMA	LHLKTHG.
ProtClustDB	CLSK820486.
Enzyme and pathway databases
BioCyc	RPAL258594:RPA4325-MONOMER.
Family and domain databases
HAMAP	MF_00222. Shikimate_DH_AroE. [Tree]
InterPro	IPR016040. NAD(P)-bd_dom. IPR011342. Shikimate_DH. IPR013708. Shikimate_DH-bd_N. IPR022893. Shikimate_quinate_DH. IPR006151. Shikm_DH/Glu-tRNA_Rdtase. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00014.
Pfam	PF01488. Shikimate_DH. 1 hit. PF08501. Shikimate_dh_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR00507. AroE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROE_RHOPA

Accession

Primary (citable) accession number: Q6N1S9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	July 5, 2004
Last modified:	January 25, 2012
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program