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Q6N0T9

- HGD_RHOPA

UniProt

Q6N0T9 - HGD_RHOPA

Protein

Homogentisate 1,2-dioxygenase

Gene

hmgA

Organism
Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Involved in the catabolism of homogentisate (2,5-dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate.UniRule annotation

    Catalytic activityi

    Homogentisate + O2 = 4-maleylacetoacetate.UniRule annotation

    Cofactori

    Iron.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei303 – 3031Proton acceptorUniRule annotation
    Metal bindingi346 – 3461IronUniRule annotation
    Metal bindingi352 – 3521IronUniRule annotation
    Binding sitei361 – 3611homogentisateUniRule annotation
    Metal bindingi382 – 3821IronUniRule annotation
    Binding sitei382 – 3821homogentisateUniRule annotation

    GO - Molecular functioni

    1. homogentisate 1,2-dioxygenase activity Source: UniProtKB-HAMAP
    2. iron ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. L-phenylalanine catabolic process Source: UniProtKB-HAMAP
    2. tyrosine catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Dioxygenase, Oxidoreductase

    Keywords - Biological processi

    Phenylalanine catabolism, Tyrosine catabolism

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00139; UER00339.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homogentisate 1,2-dioxygenaseUniRule annotation (EC:1.13.11.5UniRule annotation)
    Short name:
    HGDOUniRule annotation
    Alternative name(s):
    Homogentisate oxygenaseUniRule annotation
    Homogentisic acid oxidaseUniRule annotation
    HomogentisicaseUniRule annotation
    Gene namesi
    Name:hmgAUniRule annotation
    Ordered Locus Names:RPA4672
    OrganismiRhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)
    Taxonomic identifieri258594 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeRhodopseudomonas
    ProteomesiUP000001426: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 448448Homogentisate 1,2-dioxygenasePRO_0000225795Add
    BLAST

    Interactioni

    Subunit structurei

    Hexamer; dimer of trimers.UniRule annotation

    Protein-protein interaction databases

    STRINGi258594.RPA4672.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6N0T9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the homogentisate dioxygenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG3508.
    HOGENOMiHOG000139824.
    KOiK00451.
    OMAiFQSPVAC.
    OrthoDBiEOG6D5FZK.
    PhylomeDBiQ6N0T9.

    Family and domain databases

    Gene3Di2.60.120.10. 2 hits.
    HAMAPiMF_00334. Homogentis_dioxygen.
    InterProiIPR005708. Homogentis_dOase.
    IPR022950. Homogentis_dOase_bac.
    IPR014710. RmlC-like_jellyroll.
    IPR011051. RmlC_Cupin.
    [Graphical view]
    PANTHERiPTHR11056. PTHR11056. 1 hit.
    PfamiPF04209. HgmA. 1 hit.
    [Graphical view]
    SUPFAMiSSF51182. SSF51182. 1 hit.
    TIGRFAMsiTIGR01015. hmgA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q6N0T9-1 [UniParc]FASTAAdd to Basket

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    MNINAAPQIL GRSSQDITPG YMSGFGNSFE TEALPGALPV GRNSPQRCAY    50
    GLYAEQLSGS PFTAPRGANE RSWLYRIRPS VKHSGRFAKT DMGLWRSAPC 100
    FEHDLPIAQL RWDPPPMPQE ALTFLQGVRT MTTAGDVNTQ AGMATHLYLI 150
    TQSMVDQHFY NADGEMMFVP QQGSLRLVTE FGIITIEPAE IAVIPRGVKF 200
    RVELVDGPAR GYLCENYGGA FTLPERGPIG ANCLANSRDF LTPVAAYEDK 250
    DTPTELYVKW GGSLYVTKLP HSPIDVVAWH GNYAPYKYDL RTYSPVGAIG 300
    FDHPDPSIFT VLTSPSETPG TANIDFVIFP ERWMVADNTF RPPWYHMNIM 350
    SEFMGLIYGV YDAKPQGFVP GGASLHNMML PHGPDREAFD HASNGELKPV 400
    KLTGTMAFMF ETRYPQRVTE YAASSGLLQD DYADCWNGLE KRFDPNRP 448
    Length:448
    Mass (Da):49,761
    Last modified:July 5, 2004 - v1
    Checksum:i1E3C3C8BB33EE45D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX572608 Genomic DNA. Translation: CAE30112.1.
    RefSeqiNP_950006.1. NC_005296.1.

    Genome annotation databases

    EnsemblBacteriaiCAE30112; CAE30112; RPA4672.
    GeneIDi2692302.
    KEGGirpa:RPA4672.
    PATRICi23294017. VBIRhoPal84835_4909.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX572608 Genomic DNA. Translation: CAE30112.1 .
    RefSeqi NP_950006.1. NC_005296.1.

    3D structure databases

    ProteinModelPortali Q6N0T9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 258594.RPA4672.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAE30112 ; CAE30112 ; RPA4672 .
    GeneIDi 2692302.
    KEGGi rpa:RPA4672.
    PATRICi 23294017. VBIRhoPal84835_4909.

    Phylogenomic databases

    eggNOGi COG3508.
    HOGENOMi HOG000139824.
    KOi K00451.
    OMAi FQSPVAC.
    OrthoDBi EOG6D5FZK.
    PhylomeDBi Q6N0T9.

    Enzyme and pathway databases

    UniPathwayi UPA00139 ; UER00339 .

    Family and domain databases

    Gene3Di 2.60.120.10. 2 hits.
    HAMAPi MF_00334. Homogentis_dioxygen.
    InterProi IPR005708. Homogentis_dOase.
    IPR022950. Homogentis_dOase_bac.
    IPR014710. RmlC-like_jellyroll.
    IPR011051. RmlC_Cupin.
    [Graphical view ]
    PANTHERi PTHR11056. PTHR11056. 1 hit.
    Pfami PF04209. HgmA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51182. SSF51182. 1 hit.
    TIGRFAMsi TIGR01015. hmgA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-98 / CGA009.

    Entry informationi

    Entry nameiHGD_RHOPA
    AccessioniPrimary (citable) accession number: Q6N0T9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 7, 2006
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3