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Protein

Homogentisate 1,2-dioxygenase

Gene

hmgA

Organism
Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the catabolism of homogentisate (2,5-dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate.UniRule annotation

Catalytic activityi

Homogentisate + O2 = 4-maleylacetoacetate.UniRule annotation

Cofactori

Fe cationUniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei303 – 3031Proton acceptorUniRule annotation
Metal bindingi346 – 3461IronUniRule annotation
Metal bindingi352 – 3521IronUniRule annotation
Binding sitei361 – 3611homogentisateUniRule annotation
Metal bindingi382 – 3821IronUniRule annotation
Binding sitei382 – 3821homogentisateUniRule annotation

GO - Molecular functioni

  1. homogentisate 1,2-dioxygenase activity Source: UniProtKB-HAMAP
  2. iron ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. L-phenylalanine catabolic process Source: UniProtKB-HAMAP
  2. tyrosine catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Dioxygenase, Oxidoreductase

Keywords - Biological processi

Phenylalanine catabolism, Tyrosine catabolism

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00139; UER00339.

Names & Taxonomyi

Protein namesi
Recommended name:
Homogentisate 1,2-dioxygenaseUniRule annotation (EC:1.13.11.5UniRule annotation)
Short name:
HGDOUniRule annotation
Alternative name(s):
Homogentisate oxygenaseUniRule annotation
Homogentisic acid oxidaseUniRule annotation
HomogentisicaseUniRule annotation
Gene namesi
Name:hmgAUniRule annotation
Ordered Locus Names:RPA4672
OrganismiRhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)
Taxonomic identifieri258594 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeRhodopseudomonas
ProteomesiUP000001426: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 448448Homogentisate 1,2-dioxygenasePRO_0000225795Add
BLAST

Interactioni

Subunit structurei

Hexamer; dimer of trimers.UniRule annotation

Protein-protein interaction databases

STRINGi258594.RPA4672.

Structurei

3D structure databases

ProteinModelPortaliQ6N0T9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the homogentisate dioxygenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG3508.
HOGENOMiHOG000139824.
KOiK00451.
OMAiRGYLCEN.
OrthoDBiEOG6D5FZK.
PhylomeDBiQ6N0T9.

Family and domain databases

Gene3Di2.60.120.10. 2 hits.
HAMAPiMF_00334. Homogentis_dioxygen.
InterProiIPR005708. Homogentis_dOase.
IPR022950. Homogentis_dOase_bac.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERiPTHR11056. PTHR11056. 1 hit.
PfamiPF04209. HgmA. 1 hit.
[Graphical view]
SUPFAMiSSF51182. SSF51182. 1 hit.
TIGRFAMsiTIGR01015. hmgA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6N0T9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNINAAPQIL GRSSQDITPG YMSGFGNSFE TEALPGALPV GRNSPQRCAY
60 70 80 90 100
GLYAEQLSGS PFTAPRGANE RSWLYRIRPS VKHSGRFAKT DMGLWRSAPC
110 120 130 140 150
FEHDLPIAQL RWDPPPMPQE ALTFLQGVRT MTTAGDVNTQ AGMATHLYLI
160 170 180 190 200
TQSMVDQHFY NADGEMMFVP QQGSLRLVTE FGIITIEPAE IAVIPRGVKF
210 220 230 240 250
RVELVDGPAR GYLCENYGGA FTLPERGPIG ANCLANSRDF LTPVAAYEDK
260 270 280 290 300
DTPTELYVKW GGSLYVTKLP HSPIDVVAWH GNYAPYKYDL RTYSPVGAIG
310 320 330 340 350
FDHPDPSIFT VLTSPSETPG TANIDFVIFP ERWMVADNTF RPPWYHMNIM
360 370 380 390 400
SEFMGLIYGV YDAKPQGFVP GGASLHNMML PHGPDREAFD HASNGELKPV
410 420 430 440
KLTGTMAFMF ETRYPQRVTE YAASSGLLQD DYADCWNGLE KRFDPNRP
Length:448
Mass (Da):49,761
Last modified:July 5, 2004 - v1
Checksum:i1E3C3C8BB33EE45D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX572608 Genomic DNA. Translation: CAE30112.1.
RefSeqiNP_950006.1. NC_005296.1.

Genome annotation databases

EnsemblBacteriaiCAE30112; CAE30112; RPA4672.
GeneIDi2692302.
KEGGirpa:RPA4672.
PATRICi23294017. VBIRhoPal84835_4909.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX572608 Genomic DNA. Translation: CAE30112.1.
RefSeqiNP_950006.1. NC_005296.1.

3D structure databases

ProteinModelPortaliQ6N0T9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi258594.RPA4672.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAE30112; CAE30112; RPA4672.
GeneIDi2692302.
KEGGirpa:RPA4672.
PATRICi23294017. VBIRhoPal84835_4909.

Phylogenomic databases

eggNOGiCOG3508.
HOGENOMiHOG000139824.
KOiK00451.
OMAiRGYLCEN.
OrthoDBiEOG6D5FZK.
PhylomeDBiQ6N0T9.

Enzyme and pathway databases

UniPathwayiUPA00139; UER00339.

Family and domain databases

Gene3Di2.60.120.10. 2 hits.
HAMAPiMF_00334. Homogentis_dioxygen.
InterProiIPR005708. Homogentis_dOase.
IPR022950. Homogentis_dOase_bac.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERiPTHR11056. PTHR11056. 1 hit.
PfamiPF04209. HgmA. 1 hit.
[Graphical view]
SUPFAMiSSF51182. SSF51182. 1 hit.
TIGRFAMsiTIGR01015. hmgA. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-98 / CGA009.

Entry informationi

Entry nameiHGD_RHOPA
AccessioniPrimary (citable) accession number: Q6N0T9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: July 5, 2004
Last modified: January 7, 2015
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.