ID Q6N089_HUMAN Unreviewed; 472 AA. AC Q6N089; DT 05-JUL-2004, integrated into UniProtKB/TrEMBL. DT 05-JUL-2004, sequence version 1. DT 27-MAR-2024, entry version 132. DE RecName: Full=Ig-like domain-containing protein {ECO:0000259|PROSITE:PS50835}; GN Name=DKFZp686P15220 {ECO:0000313|EMBL:CAE45781.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:CAE45781.1}; RN [1] {ECO:0007829|PDB:1U6A} RP X-RAY CRYSTALLOGRAPHY (2.81 ANGSTROMS) OF 20-243, AND DISULFIDE BONDS. RX PubMed=16189008; DOI=10.1128/JVI.79.20.13060-13069.2005; RA Wilkinson R.A., Piscitelli C., Teintze M., Cavacini L.A., Posner M.R., RA Lawrence C.M.; RT "Structure of the Fab fragment of F105, a broadly reactive anti-human RT immunodeficiency virus (HIV) antibody that recognizes the CD4 binding site RT of HIV type 1 gp120."; RL J. Virol. 79:13060-13069(2005). RN [2] {ECO:0000313|EMBL:CAE45781.1} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Rectum tumor {ECO:0000313|EMBL:CAE45781.1}; RG The German cDNA Consortium; RA Bahr A., Lauber J., Mewes H.W., Weil B., Amid C., Osanger A., Fobo G., RA Han M., Wiemann S.; RL Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0007829|PDB:2OQJ} RP X-RAY CRYSTALLOGRAPHY (2.80 ANGSTROMS) OF 20-243, AND DISULFIDE BONDS. RX PubMed=18198210; DOI=10.1096/fj.07-8983com; RA Menendez A., Calarese D.A., Stanfield R.L., Chow K.C., Scanlan C.N., RA Kunert R., Katinger H., Burton D.R., Wilson I.A., Scott J.K.; RT "A peptide inhibitor of HIV-1 neutralizing antibody 2G12 is not a RT structural mimic of the natural carbohydrate epitope on gp120."; RL FASEB J. 22:1380-1392(2008). RN [4] {ECO:0007829|PDB:3CFJ, ECO:0007829|PDB:3CFK} RP X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS) OF 20-246, AND DISULFIDE BONDS. RX PubMed=18417480; DOI=10.1074/jbc.M710256200; RA Debler E.W., Muller R., Hilvert D., Wilson I.A.; RT "Conformational isomerism can limit antibody catalysis."; RL J. Biol. Chem. 283:16554-16560(2008). RN [5] {ECO:0007829|PDB:3MNV} RP X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS) OF 20-247, AND DISULFIDE BONDS. RX PubMed=21076400; DOI=10.1038/nsmb.1944; RA Nicely N.I., Dennison S.M., Spicer L., Scearce R.M., Kelsoe G., Ueda Y., RA Chen H., Liao H.X., Alam S.M., Haynes B.F.; RT "Crystal structure of a non-neutralizing antibody to the HIV-1 gp41 RT membrane-proximal external region."; RL Nat. Struct. Mol. Biol. 17:1492-1494(2010). RN [6] {ECO:0007829|PDB:3QCT, ECO:0007829|PDB:3QCU} RP X-RAY CRYSTALLOGRAPHY (1.98 ANGSTROMS) OF 20-243, AND DISULFIDE BONDS. RX PubMed=21392506; DOI=10.1016/j.jmb.2011.02.061; RA Fleming J.K., Wojciak J.M., Campbell M.A., Huxford T.; RT "Biochemical and structural characterization of lysophosphatidic Acid RT binding by a humanized monoclonal antibody."; RL J. Mol. Biol. 408:462-476(2011). RN [7] {ECO:0007829|PDB:4HPY} RP X-RAY CRYSTALLOGRAPHY (1.50 ANGSTROMS) OF 20-247, AND DISULFIDE BONDS. RX PubMed=23313589; DOI=10.1016/j.immuni.2012.11.011; RA Liao H.X., Bonsignori M., Alam S.M., McLellan J.S., Tomaras G.D., RA Moody M.A., Kozink D.M., Hwang K.K., Chen X., Tsao C.Y., Liu P., Lu X., RA Parks R.J., Montefiori D.C., Ferrari G., Pollara J., Rao M., Peachman K.K., RA Santra S., Letvin N.L., Karasavvas N., Yang Z.Y., Dai K., Pancera M., RA Gorman J., Wiehe K., Nicely N.I., Rerks-Ngarm S., Nitayaphan S., RA Kaewkungwal J., Pitisuttithum P., Tartaglia J., Sinangil F., Kim J.H., RA Michael N.L., Kepler T.B., Kwong P.D., Mascola J.R., Nabel G.J., Pinter A., RA Zolla-Pazner S., Haynes B.F.; RT "Vaccine induction of antibodies against a structurally heterogeneous site RT of immune pressure within HIV-1 envelope protein variable regions 1 and RT 2."; RL Immunity 38:176-186(2013). RN [8] {ECO:0007829|PDB:4NUJ} RP X-RAY CRYSTALLOGRAPHY (1.83 ANGSTROMS) OF 20-247, AND DISULFIDE BONDS. RX PubMed=24768348; DOI=10.1016/j.immuni.2014.04.008; RA Blattner C., Lee J.H., Sliepen K., Derking R., Falkowska E., RA de la Pena A.T., Cupo A., Julien J.P., van Gils M., Lee P.S., Peng W., RA Paulson J.C., Poignard P., Burton D.R., Moore J.P., Sanders R.W., RA Wilson I.A., Ward A.B.; RT "Structural delineation of a quaternary, cleavage-dependent epitope at the RT gp41-gp120 interface on intact HIV-1 Env trimers."; RL Immunity 40:669-680(2014). RN [9] {ECO:0007829|PDB:5WKO} RP X-RAY CRYSTALLOGRAPHY (3.49 ANGSTROMS) OF 20-244, AND DISULFIDE BONDS. RX PubMed=28930686; DOI=10.1016/j.celrep.2017.08.084; RA Lang S., Xie J., Zhu X., Wu N.C., Lerner R.A., Wilson I.A.; RT "Antibody 27F3 Broadly Targets Influenza A Group 1 and 2 Hemagglutinins RT through a Further Variation in VH1-69 Antibody Orientation on RT the HA Stem."; RL Cell Rep. 20:2935-2943(2017). RN [10] {ECO:0007829|PDB:5EWI} RP X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS) OF 20-247, AND DISULFIDE BONDS. RX PubMed=28514685; DOI=10.1016/j.immuni.2017.04.011; RA Cale E.M., Gorman J., Radakovich N.A., Crooks E.T., Osawa K., Tong T., RA Li J., Nagarajan R., Ozorowski G., Ambrozak D.R., Asokan M., Bailer R.T., RA Bennici A.K., Chen X., Doria-Rose N.A., Druz A., Feng Y., Joyce M.G., RA Louder M.K., O'Dell S., Oliver C., Pancera M., Connors M., Hope T.J., RA Kepler T.B., Wyatt R.T., Ward A.B., Georgiev I.S., Kwong P.D., RA Mascola J.R., Binley J.M.; RT "Virus-like Particles Identify an HIV V1V2 Apex-Binding Neutralizing RT Antibody that Lacks a Protruding Loop."; RL Immunity 46:777-791.e10(2017). RN [11] {ECO:0007829|PDB:5UG0} RP X-RAY CRYSTALLOGRAPHY (3.40 ANGSTROMS) OF 20-247, AND DISULFIDE BONDS. RX PubMed=28506635; DOI=10.1016/j.jmb.2017.05.011; RA Liu Y., Pan J., Jenni S., Raymond D.D., Caradonna T., Do K.T., RA Schmidt A.G., Harrison S.C., Grigorieff N.; RT "CryoEM Structure of an Influenza Virus Receptor-Binding Site Antibody- RT Antigen Interface."; RL J. Mol. Biol. 429:1829-1839(2017). RN [12] {ECO:0007829|PDB:5VKK} RP X-RAY CRYSTALLOGRAPHY (2.01 ANGSTROMS) OF 20-245, AND DISULFIDE BONDS. RX PubMed=28970495; DOI=10.1038/s41467-017-00836-6; RA Ereno-Orbea J., Sicard T., Cui H., Mazhab-Jafari M.T., Benlekbir S., RA Guarne A., Rubinstein J.L., Julien J.P.; RT "Molecular basis of human CD22 function and therapeutic targeting."; RL Nat. Commun. 8:764-764(2017). RN [13] {ECO:0007829|PDB:5W1M} RP X-RAY CRYSTALLOGRAPHY (3.91 ANGSTROMS) OF 21-245, AND DISULFIDE BONDS. RX PubMed=29760382; DOI=10.1038/s41467-018-04271-z; RA Clark L.E., Mahmutovic S., Raymond D.D., Dilanyan T., Koma T., RA Manning J.T., Shankar S., Levis S.C., Briggiler A.M., Enria D.A., RA Wucherpfennig K.W., Paessler S., Abraham J.; RT "Vaccine-elicited receptor-binding site antibodies neutralize two New World RT hemorrhagic fever arenaviruses."; RL Nat. Commun. 9:1884-1884(2018). RN [14] {ECO:0007829|PDB:5W42, ECO:0007829|PDB:5XRQ} RP X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS) OF 20-245, AND DISULFIDE BONDS. RX PubMed=29991715; DOI=10.1038/s41467-018-04704-9; RA Bangaru S., Zhang H., Gilchuk I.M., Voss T.G., Irving R.P., Gilchuk P., RA Matta P., Zhu X., Lang S., Nieusma T., Richt J.A., Albrecht R.A., RA Vanderven H.A., Bombardi R., Kent S.J., Ward A.B., Wilson I.A., Crowe J.E.; RT "A multifunctional human monoclonal neutralizing antibody that targets a RT unique conserved epitope on influenza HA."; RL Nat. Commun. 9:2669-2669(2018). RN [15] {ECO:0007829|PDB:6DC3} RP X-RAY CRYSTALLOGRAPHY (3.50 ANGSTROMS) OF 20-245, AND DISULFIDE BONDS. RX PubMed=31306469; DOI=10.1371/journal.ppat.1007944; RA Jones H.G., Battles M.B., Lin C.C., Bianchi S., Corti D., McLellan J.S.; RT "Alternative conformations of a major antigenic site on RSV F."; RL PLoS Pathog. 15:e1007944-e1007944(2019). RN [16] {ECO:0007829|PDB:6V8Z} RP STRUCTURE BY ELECTRON MICROSCOPY (2.90 ANGSTROMS) OF 20-245, AND DISULFIDE RP BONDS. RX PubMed=31980614; DOI=10.1038/s41467-019-14196-w; RA Henderson R., Lu M., Zhou Y., Mu Z., Parks R., Han Q., Hsu A.L., Carter E., RA Blanchard S.C., Edwards R.J., Wiehe K., Saunders K.O., Borgnia M.J., RA Bartesaghi A., Mothes W., Haynes B.F., Acharya P., Munir Alam S.; RT "Disruption of the HIV-1 Envelope allosteric network blocks CD4-induced RT rearrangements."; RL Nat. Commun. 11:520-520(2020). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BX640627; CAE45781.1; -; mRNA. DR PDB; 1U6A; X-ray; 2.81 A; H=20-243. DR PDB; 2OQJ; X-ray; 2.80 A; B/E/H/K=20-243. DR PDB; 3CFJ; X-ray; 2.60 A; B/D/F/H=20-246. DR PDB; 3CFK; X-ray; 2.60 A; B/D/F/H/I/K/N/P=20-246. DR PDB; 3MNV; X-ray; 2.40 A; B/D=20-247. DR PDB; 3QCT; X-ray; 2.15 A; H=20-243. DR PDB; 3QCU; X-ray; 1.98 A; H/I=20-243. DR PDB; 3QCV; X-ray; 2.51 A; H/I=20-243. DR PDB; 4HPY; X-ray; 1.50 A; H=20-247. DR PDB; 4NUJ; X-ray; 1.83 A; B=20-247. DR PDB; 5EWI; X-ray; 1.60 A; H=20-247. DR PDB; 5UG0; X-ray; 3.40 A; D=20-247. DR PDB; 5VKK; X-ray; 2.01 A; A/H=20-245. DR PDB; 5W1M; X-ray; 3.91 A; B/D/F/H=21-245. DR PDB; 5W42; X-ray; 3.57 A; H=20-245. DR PDB; 5WKO; X-ray; 3.49 A; A/C/E/G/I/K=20-244. DR PDB; 5XRQ; X-ray; 2.60 A; A/H=20-245. DR PDB; 6DC3; X-ray; 3.50 A; H=20-245. DR PDB; 6V8Z; EM; 2.90 A; D/J/P=20-245. DR PDBsum; 1U6A; -. DR PDBsum; 3CFJ; -. DR PDBsum; 3CFK; -. DR PDBsum; 4HPY; -. DR PDBsum; 5W1M; -. DR PDBsum; 6V8Z; -. DR AlphaFoldDB; Q6N089; -. DR SMR; Q6N089; -. DR IntAct; Q6N089; 2. DR MINT; Q6N089; -. DR MaxQB; Q6N089; -. DR EvolutionaryTrace; Q6N089; -. DR GO; GO:0019814; C:immunoglobulin complex; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW. DR CDD; cd21817; IgC1_CH1_IgEG; 1. DR CDD; cd07696; IgC1_CH3_IgAEM_CH2_IgG; 1. DR CDD; cd05768; IgC1_CH3_IgAGD_CH4_IgAEM; 1. DR CDD; cd04981; IgV_H; 1. DR Gene3D; 2.60.40.10; Immunoglobulins; 4. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR013106; Ig_V-set. DR PANTHER; PTHR23411:SF39; IMMUNOGLOBULIN HEAVY CONSTANT GAMMA 1-RELATED; 1. DR PANTHER; PTHR23411; TAPASIN; 1. DR Pfam; PF07654; C1-set; 3. DR Pfam; PF07686; V-set; 1. DR SMART; SM00409; IG; 2. DR SMART; SM00407; IGc1; 3. DR SMART; SM00406; IGv; 1. DR SUPFAM; SSF48726; Immunoglobulin; 4. DR PROSITE; PS50835; IG_LIKE; 4. DR PROSITE; PS00290; IG_MHC; 2. PE 1: Evidence at protein level; KW 3D-structure {ECO:0007829|PDB:1U6A, ECO:0007829|PDB:2OQJ}; KW Adaptive immunity {ECO:0000256|ARBA:ARBA00023130}; KW Cell membrane {ECO:0000256|ARBA:ARBA00022475}; KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157}; KW Immunity {ECO:0000256|ARBA:ARBA00043265}; KW Immunoglobulin {ECO:0000256|ARBA:ARBA00043265}; KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319}; KW Membrane {ECO:0000256|ARBA:ARBA00022475}; Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1..19 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 20..472 FT /note="Ig-like domain-containing protein" FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5004278679" FT DOMAIN 31..115 FT /note="Ig-like" FT /evidence="ECO:0000259|PROSITE:PS50835" FT DOMAIN 148..241 FT /note="Ig-like" FT /evidence="ECO:0000259|PROSITE:PS50835" FT DOMAIN 263..362 FT /note="Ig-like" FT /evidence="ECO:0000259|PROSITE:PS50835" FT DOMAIN 371..467 FT /note="Ig-like" FT /evidence="ECO:0000259|PROSITE:PS50835" FT DISULFID 41..115 FT /evidence="ECO:0007829|PDB:1U6A, ECO:0007829|PDB:2OQJ" FT DISULFID 169..225 FT /evidence="ECO:0007829|PDB:1U6A, ECO:0007829|PDB:2OQJ" SQ SEQUENCE 472 AA; 51725 MW; 26CB340D0046D279 CRC64; MELGLTWIFL LAILKGVQCE VQLVESGGGL VQPGRSLRLS CAASGFTFDD YAMHWVRQAP GKGLEWVSGI SWNSGSIAYA DSVKGRFTIS RDNGKNSLYL QMNSLRAEDT ALYYCAKEIG AHNFYYYGMD VWGQGTTVTV SSASTKGPSV FPLAPSSKST SGGTAALGCL VKDYFPEPVT VSWNSGALTS GVHTFPAVLQ SSGLYSLSSV VTVPSSSLGT QTYICNVNHK PSNTKVDKRV EPKSCDKTHT CPPCPAPELL GGPSVFLFPP KPKDTLMISR TPEVTCVVVD VSHEDPEVKF NWYVDGVEVH NAKTKPREEQ YNSTYRVVSV LTVLHQDWLN GKEYKCKVSN KALPAPIEKT ISKAKGQPRE PQVYTLPPSR DELTKNQVSL TCLVKGFYPS DIAVEWESNG QPENNYKTTP PVLDSDGSFF LYSKLTVDKS RWQQGNVFSC SVMHEALHNH YTQKSLSLSP GK //