ID MFSD5_HUMAN Reviewed; 450 AA. AC Q6N075; G3V1N7; Q6NW04; Q8N7W8; Q8NCK0; Q96IA5; DT 23-JAN-2007, integrated into UniProtKB/Swiss-Prot. DT 23-JAN-2007, sequence version 2. DT 27-MAR-2024, entry version 144. DE RecName: Full=Molybdate-anion transporter; DE AltName: Full=Major facilitator superfamily domain-containing protein 5; DE AltName: Full=Molybdate transporter 2 homolog; DE Short=hsMOT2; GN Name=MFSD5; ORFNames=UNQ832/PRO1759; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RX PubMed=12975309; DOI=10.1101/gr.1293003; RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A., RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.; RT "The secreted protein discovery initiative (SPDI), a large-scale effort to RT identify novel human secreted and transmembrane proteins: a bioinformatics RT assessment."; RL Genome Res. 13:2265-2270(2003). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RC TISSUE=Colon endothelium; RX PubMed=17974005; DOI=10.1186/1471-2164-8-399; RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., RA Wiemann S., Schupp I.; RT "The full-ORF clone resource of the German cDNA consortium."; RL BMC Genomics 8:399-399(2007). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RC TISSUE=Testis; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RC TISSUE=Mammary gland; RX PubMed=16303743; DOI=10.1093/dnares/12.2.117; RA Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., RA Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., RA Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y., RA Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., RA Isogai T.; RT "Signal sequence and keyword trap in silico for selection of full-length RT human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA RT libraries."; RL DNA Res. 12:117-126(2005). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16541075; DOI=10.1038/nature04569; RA Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., RA Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., RA Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., RA Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., RA Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., RA Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., RA Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., RA Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., RA Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., RA Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., RA Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., RA Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., RA Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., RA Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., RA Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., RA Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., RA Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., RA David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., RA D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., RA Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., RA Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., RA Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., RA LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., RA Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., RA Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., RA Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., RA Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., RA Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., RA Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., RA Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., RA Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., RA Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., RA Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., RA Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., RA Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., RA Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., RA Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., RA Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., RA Gibbs R.A.; RT "The finished DNA sequence of human chromosome 12."; RL Nature 440:346-351(2006). RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., RA Hunkapiller M.W., Myers E.W., Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [7] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RC TISSUE=Brain, and Ovary; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [8] RP TISSUE SPECIFICITY. RX PubMed=21044875; DOI=10.1016/j.gene.2010.10.011; RA Sreedharan S., Stephansson O., Schioth H.B., Fredriksson R.; RT "Long evolutionary conservation and considerable tissue specificity of RT several atypical solute carrier transporters."; RL Gene 478:11-18(2011). RN [9] RP FUNCTION, AND BIOPHYSICOCHEMICAL PROPERTIES. RX PubMed=21464289; DOI=10.1073/pnas.1100700108; RA Tejada-Jimenez M., Galvan A., Fernandez E.; RT "Algae and humans share a molybdate transporter."; RL Proc. Natl. Acad. Sci. U.S.A. 108:6420-6425(2011). CC -!- FUNCTION: Mediates high-affinity intracellular uptake of the rare CC oligo-element molybdenum. {ECO:0000269|PubMed:21464289}. CC -!- BIOPHYSICOCHEMICAL PROPERTIES: CC Kinetic parameters: CC KM=546 nM for molybdate (when expressed in yeast) CC {ECO:0000269|PubMed:21464289}; CC -!- INTERACTION: CC Q6N075; Q9UHX3: ADGRE2; NbExp=3; IntAct=EBI-3920969, EBI-11277970; CC Q6N075; Q13520: AQP6; NbExp=3; IntAct=EBI-3920969, EBI-13059134; CC Q6N075; Q15041: ARL6IP1; NbExp=3; IntAct=EBI-3920969, EBI-714543; CC Q6N075; Q8NFU1: BEST2; NbExp=3; IntAct=EBI-3920969, EBI-19947314; CC Q6N075; P62952: BLCAP; NbExp=3; IntAct=EBI-3920969, EBI-3895726; CC Q6N075; Q6UXG8-3: BTNL9; NbExp=3; IntAct=EBI-3920969, EBI-17953245; CC Q6N075; O14523: C2CD2L; NbExp=3; IntAct=EBI-3920969, EBI-12822627; CC Q6N075; Q8N350-4: CBARP; NbExp=3; IntAct=EBI-3920969, EBI-19051169; CC Q6N075; Q8NHW4: CCL4L2; NbExp=3; IntAct=EBI-3920969, EBI-10271156; CC Q6N075; P25942: CD40; NbExp=3; IntAct=EBI-3920969, EBI-525714; CC Q6N075; P11912: CD79A; NbExp=3; IntAct=EBI-3920969, EBI-7797864; CC Q6N075; O95471: CLDN7; NbExp=3; IntAct=EBI-3920969, EBI-740744; CC Q6N075; P58418: CLRN1; NbExp=3; IntAct=EBI-3920969, EBI-17274839; CC Q6N075; Q96BA8: CREB3L1; NbExp=6; IntAct=EBI-3920969, EBI-6942903; CC Q6N075; O43169: CYB5B; NbExp=3; IntAct=EBI-3920969, EBI-1058710; CC Q6N075; O15552: FFAR2; NbExp=3; IntAct=EBI-3920969, EBI-2833872; CC Q6N075; Q14802-3: FXYD3; NbExp=3; IntAct=EBI-3920969, EBI-12175685; CC Q6N075; P36382: GJA5; NbExp=3; IntAct=EBI-3920969, EBI-750433; CC Q6N075; O14653: GOSR2; NbExp=3; IntAct=EBI-3920969, EBI-4401517; CC Q6N075; Q96P66: GPR101; NbExp=3; IntAct=EBI-3920969, EBI-17935713; CC Q6N075; Q8TDT2: GPR152; NbExp=3; IntAct=EBI-3920969, EBI-13345167; CC Q6N075; O00155: GPR25; NbExp=3; IntAct=EBI-3920969, EBI-10178951; CC Q6N075; O15529: GPR42; NbExp=3; IntAct=EBI-3920969, EBI-18076404; CC Q6N075; Q8TED1: GPX8; NbExp=3; IntAct=EBI-3920969, EBI-11721746; CC Q6N075; Q7Z5P4: HSD17B13; NbExp=3; IntAct=EBI-3920969, EBI-18053395; CC Q6N075; P24593: IGFBP5; NbExp=3; IntAct=EBI-3920969, EBI-720480; CC Q6N075; Q6UWB1: IL27RA; NbExp=3; IntAct=EBI-3920969, EBI-19045531; CC Q6N075; Q8N6L0: KASH5; NbExp=3; IntAct=EBI-3920969, EBI-749265; CC Q6N075; O43561-2: LAT; NbExp=3; IntAct=EBI-3920969, EBI-8070286; CC Q6N075; Q8TAF8: LHFPL5; NbExp=3; IntAct=EBI-3920969, EBI-2820517; CC Q6N075; Q8N4V1: MMGT1; NbExp=3; IntAct=EBI-3920969, EBI-6163737; CC Q6N075; P15941-11: MUC1; NbExp=3; IntAct=EBI-3920969, EBI-17263240; CC Q6N075; O15173: PGRMC2; NbExp=3; IntAct=EBI-3920969, EBI-1050125; CC Q6N075; Q99640-2: PKMYT1; NbExp=3; IntAct=EBI-3920969, EBI-12257782; CC Q6N075; P26678: PLN; NbExp=3; IntAct=EBI-3920969, EBI-692836; CC Q6N075; P50876: RNF144A; NbExp=3; IntAct=EBI-3920969, EBI-2340657; CC Q6N075; Q6ZMZ0: RNF19B; NbExp=3; IntAct=EBI-3920969, EBI-2466594; CC Q6N075; Q5QGT7: RTP2; NbExp=3; IntAct=EBI-3920969, EBI-10244780; CC Q6N075; Q9NY72: SCN3B; NbExp=3; IntAct=EBI-3920969, EBI-17247926; CC Q6N075; O75396: SEC22B; NbExp=3; IntAct=EBI-3920969, EBI-1058865; CC Q6N075; Q3SXP7: SHISAL1; NbExp=3; IntAct=EBI-3920969, EBI-18037857; CC Q6N075; Q3KNW5: SLC10A6; NbExp=3; IntAct=EBI-3920969, EBI-18159983; CC Q6N075; Q05940: SLC18A2; NbExp=3; IntAct=EBI-3920969, EBI-18036244; CC Q6N075; Q9NUM3: SLC39A9; NbExp=3; IntAct=EBI-3920969, EBI-2823239; CC Q6N075; Q8WWF3: SSMEM1; NbExp=3; IntAct=EBI-3920969, EBI-17280858; CC Q6N075; P02808: STATH; NbExp=3; IntAct=EBI-3920969, EBI-738687; CC Q6N075; Q0VAB0: TBXA2R; NbExp=3; IntAct=EBI-3920969, EBI-18271435; CC Q6N075; Q9NPL8: TIMMDC1; NbExp=3; IntAct=EBI-3920969, EBI-6268651; CC Q6N075; Q5BJH2-2: TMEM128; NbExp=3; IntAct=EBI-3920969, EBI-10694905; CC Q6N075; Q8N3G9: TMEM130; NbExp=3; IntAct=EBI-3920969, EBI-19763514; CC Q6N075; Q9NUH8: TMEM14B; NbExp=3; IntAct=EBI-3920969, EBI-8638294; CC Q6N075; Q7Z7N9: TMEM179B; NbExp=3; IntAct=EBI-3920969, EBI-11724423; CC Q6N075; Q969S6: TMEM203; NbExp=3; IntAct=EBI-3920969, EBI-12274070; CC Q6N075; Q96Q45-2: TMEM237; NbExp=3; IntAct=EBI-3920969, EBI-10982110; CC Q6N075; Q96EC8: YIPF6; NbExp=3; IntAct=EBI-3920969, EBI-751210; CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane CC protein {ECO:0000305}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=1; CC IsoId=Q6N075-1; Sequence=Displayed; CC Name=2; CC IsoId=Q6N075-2; Sequence=VSP_046647; CC -!- TISSUE SPECIFICITY: Expressed ubiquitously but at relatively higher CC levels in the olfactory bulb and the skeletal muscle. CC {ECO:0000269|PubMed:21044875}. CC -!- SIMILARITY: Belongs to the major facilitator superfamily. CC {ECO:0000305}. CC -!- SEQUENCE CAUTION: CC Sequence=BAC05108.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305}; CC Sequence=CAE45795.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY358604; AAQ88967.1; -; mRNA. DR EMBL; BX640649; CAE45795.1; ALT_INIT; mRNA. DR EMBL; AK097576; BAC05108.1; ALT_SEQ; mRNA. DR EMBL; AK074684; BAC11137.1; -; mRNA. DR EMBL; AC021072; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH471054; EAW96679.1; -; Genomic_DNA. DR EMBL; BC007703; AAH07703.1; -; mRNA. DR EMBL; BC067795; AAH67795.1; -; mRNA. DR CCDS; CCDS53796.1; -. [Q6N075-2] DR CCDS; CCDS8851.1; -. [Q6N075-1] DR RefSeq; NP_001164261.1; NM_001170790.1. [Q6N075-2] DR RefSeq; NP_116278.3; NM_032889.4. [Q6N075-1] DR RefSeq; XP_005269254.1; XM_005269197.1. [Q6N075-2] DR RefSeq; XP_005269255.1; XM_005269198.4. [Q6N075-1] DR AlphaFoldDB; Q6N075; -. DR SMR; Q6N075; -. DR BioGRID; 124404; 87. DR IntAct; Q6N075; 72. DR MINT; Q6N075; -. DR STRING; 9606.ENSP00000442688; -. DR TCDB; 2.A.1.40.2; the major facilitator superfamily (mfs). DR GlyGen; Q6N075; 2 sites, 1 O-linked glycan (2 sites). DR iPTMnet; Q6N075; -. DR PhosphoSitePlus; Q6N075; -. DR SwissPalm; Q6N075; -. DR BioMuta; MFSD5; -. DR DMDM; 124015161; -. DR EPD; Q6N075; -. DR jPOST; Q6N075; -. DR MassIVE; Q6N075; -. DR MaxQB; Q6N075; -. DR PaxDb; 9606-ENSP00000442688; -. DR PeptideAtlas; Q6N075; -. DR ProteomicsDB; 32391; -. DR ProteomicsDB; 66618; -. [Q6N075-1] DR ProteomicsDB; 66619; -. [Q6N075-2] DR Pumba; Q6N075; -. DR Antibodypedia; 48343; 101 antibodies from 14 providers. DR DNASU; 84975; -. DR Ensembl; ENST00000329548.5; ENSP00000332624.5; ENSG00000182544.9. [Q6N075-1] DR Ensembl; ENST00000534842.1; ENSP00000442688.1; ENSG00000182544.9. [Q6N075-2] DR GeneID; 84975; -. DR KEGG; hsa:84975; -. DR MANE-Select; ENST00000329548.5; ENSP00000332624.5; NM_032889.5; NP_116278.3. DR UCSC; uc001sch.3; human. [Q6N075-1] DR AGR; HGNC:28156; -. DR CTD; 84975; -. DR GeneCards; MFSD5; -. DR HGNC; HGNC:28156; MFSD5. DR HPA; ENSG00000182544; Low tissue specificity. DR MIM; 620345; gene. DR neXtProt; NX_Q6N075; -. DR OpenTargets; ENSG00000182544; -. DR PharmGKB; PA142671466; -. DR VEuPathDB; HostDB:ENSG00000182544; -. DR eggNOG; KOG4332; Eukaryota. DR GeneTree; ENSGT00390000012629; -. DR HOGENOM; CLU_034007_2_0_1; -. DR InParanoid; Q6N075; -. DR OrthoDB; 131892at2759; -. DR PhylomeDB; Q6N075; -. DR TreeFam; TF328562; -. DR PathwayCommons; Q6N075; -. DR SignaLink; Q6N075; -. DR BioGRID-ORCS; 84975; 15 hits in 1157 CRISPR screens. DR ChiTaRS; MFSD5; human. DR GenomeRNAi; 84975; -. DR Pharos; Q6N075; Tdark. DR PRO; PR:Q6N075; -. DR Proteomes; UP000005640; Chromosome 12. DR RNAct; Q6N075; Protein. DR Bgee; ENSG00000182544; Expressed in lower esophagus mucosa and 184 other cell types or tissues. DR ExpressionAtlas; Q6N075; baseline and differential. DR GO; GO:0016020; C:membrane; HDA:UniProtKB. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0015098; F:molybdate ion transmembrane transporter activity; IEA:InterPro. DR GO; GO:0006811; P:monoatomic ion transport; IEA:UniProtKB-KW. DR CDD; cd17487; MFS_MFSD5_like; 1. DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1. DR InterPro; IPR036259; MFS_trans_sf. DR InterPro; IPR008509; MOT2/MFSD5. DR PANTHER; PTHR23516:SF1; MOLYBDATE-ANION TRANSPORTER; 1. DR PANTHER; PTHR23516; SAM (S-ADENOSYL METHIONINE) TRANSPORTER; 1. DR Pfam; PF05631; MFS_5; 1. DR SUPFAM; SSF103473; MFS general substrate transporter; 1. DR Genevisible; Q6N075; HS. PE 1: Evidence at protein level; KW Alternative splicing; Cell membrane; Ion transport; Membrane; KW Reference proteome; Transmembrane; Transmembrane helix; Transport. FT CHAIN 1..450 FT /note="Molybdate-anion transporter" FT /id="PRO_0000273401" FT TRANSMEM 1..21 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 43..63 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 79..99 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 128..148 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 174..194 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 195..215 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 249..269 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 278..298 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 311..331 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 344..364 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 376..396 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 409..429 FT /note="Helical" FT /evidence="ECO:0000255" FT VAR_SEQ 1 FT /note="M -> MEVTAVGEEANQGDLLGFGQRCCSLGSSNPWLYRTAGIFPEHCTEEK FT KIGTYFRVAPQASKSQRSRCHGMAASEARPGEATAASYGRPFPTHPRRQEFRARVVRGP FT TM (in isoform 2)" FT /evidence="ECO:0000305" FT /id="VSP_046647" FT CONFLICT 130 FT /note="L -> M (in Ref. 5; AAH67795)" FT /evidence="ECO:0000305" FT CONFLICT 157 FT /note="V -> A (in Ref. 4; BAC11137)" FT /evidence="ECO:0000305" FT CONFLICT 425 FT /note="G -> E (in Ref. 2; CAE45795)" FT /evidence="ECO:0000305" SQ SEQUENCE 450 AA; 49765 MW; A15D005755941BA7 CRC64; MLVTAYLAFV GLLASCLGLE LSRCRAKPPG RACSNPSFLR FQLDFYQVYF LALAADWLQA PYLYKLYQHY YFLEGQIAIL YVCGLASTVL FGLVASSLVD WLGRKNSCVL FSLTYSLCCL TKLSQDYFVL LVGRALGGLS TALLFSAFEA WYIHEHVERH DFPAEWIPAT FARAAFWNHV LAVVAGVAAE AVASWIGLGP VAPFVAAIPL LALAGALALR NWGENYDRQR AFSRTCAGGL RCLLSDRRVL LLGTIQALFE SVIFIFVFLW TPVLDPHGAP LGIIFSSFMA ASLLGSSLYR IATSKRYHLQ PMHLLSLAVL IVVFSLFMLT FSTSPGQESP VESFIAFLLI ELACGLYFPS MSFLRRKVIP ETEQAGVLNW FRVPLHSLAC LGLLVLHDSD RKTGTRNMFS ICSAVMVMAL LAVVGLFTVV RHDAELRVPS PTEEPYAPEL //