Q6N075 (MFSD5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Major facilitator superfamily domain-containing protein 5

Gene names

Name:	MFSD5
ORF Names:	UNQ832/PRO1759

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	450 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the major facilitator superfamily.
Sequence caution	The sequence BAC05108.1 differs from that shown. Reason: Probable cloning artifact. The sequence CAE45795.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Biological process	Transport
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 450	450	Major facilitator superfamily domain-containing protein 5		PRO_0000273401
Regions
	Transmembrane	1 – 21	21	Helical; Potential
	Transmembrane	43 – 63	21	Helical; Potential
	Transmembrane	79 – 99	21	Helical; Potential
	Transmembrane	128 – 148	21	Helical; Potential
	Transmembrane	174 – 194	21	Helical; Potential
	Transmembrane	195 – 215	21	Helical; Potential
	Transmembrane	249 – 269	21	Helical; Potential
	Transmembrane	278 – 298	21	Helical; Potential
	Transmembrane	311 – 331	21	Helical; Potential
	Transmembrane	344 – 364	21	Helical; Potential
	Transmembrane	376 – 396	21	Helical; Potential
	Transmembrane	409 – 429	21	Helical; Potential
Experimental info
	Sequence conflict	130	1	L → M in AAH67795. Ref.5
	Sequence conflict	157	1	V → A in BAC11137. Ref.4
	Sequence conflict	425	1	G → E in CAE45795. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q6N075 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: A15D005755941BA7	FASTA	450	49,765
	10 20 30 40 50 60 MLVTAYLAFV GLLASCLGLE LSRCRAKPPG RACSNPSFLR FQLDFYQVYF LALAADWLQA 70 80 90 100 110 120 PYLYKLYQHY YFLEGQIAIL YVCGLASTVL FGLVASSLVD WLGRKNSCVL FSLTYSLCCL 130 140 150 160 170 180 TKLSQDYFVL LVGRALGGLS TALLFSAFEA WYIHEHVERH DFPAEWIPAT FARAAFWNHV 190 200 210 220 230 240 LAVVAGVAAE AVASWIGLGP VAPFVAAIPL LALAGALALR NWGENYDRQR AFSRTCAGGL 250 260 270 280 290 300 RCLLSDRRVL LLGTIQALFE SVIFIFVFLW TPVLDPHGAP LGIIFSSFMA ASLLGSSLYR 310 320 330 340 350 360 IATSKRYHLQ PMHLLSLAVL IVVFSLFMLT FSTSPGQESP VESFIAFLLI ELACGLYFPS 370 380 390 400 410 420 MSFLRRKVIP ETEQAGVLNW FRVPLHSLAC LGLLVLHDSD RKTGTRNMFS ICSAVMVMAL 430 440 450 LAVVGLFTVV RHDAELRVPS PTEEPYAPEL

References

[1]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Colon endothelium.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[4]	"Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries." Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y. , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T. DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Mammary gland.
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain and Ovary.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY358604 mRNA. Translation: AAQ88967.1. BX640649 mRNA. Translation: CAE45795.1. Different initiation. AK097576 mRNA. Translation: BAC05108.1. Sequence problems. AK074684 mRNA. Translation: BAC11137.1. BC007703 mRNA. Translation: AAH07703.1. BC067795 mRNA. Translation: AAH67795.1.
IPI	IPI00301554. IPI01014088.
RefSeq	NP_001164261.1. NM_001170790.1. NP_116278.3. NM_032889.4.
UniGene	Hs.654660.
3D structure databases
ProteinModelPortal	Q6N075.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q6N075. 1 interaction.
STRING	9606.ENSP00000332624.
PTM databases
PhosphoSite	Q6N075.
Polymorphism databases
DMDM	124015161.
Proteomic databases
PaxDb	Q6N075.
PRIDE	Q6N075.
Protocols and materials databases
DNASU	84975.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000329548; ENSP00000332624; ENSG00000182544.
GeneID	84975.
KEGG	hsa:84975.
UCSC	uc001sch.2. human.
Organism-specific databases
CTD	84975.
GeneCards	GC12P053645.
HGNC	HGNC:28156. MFSD5.
HPA	HPA039773.
neXtProt	NX_Q6N075.
PharmGKB	PA142671466.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG309381.
HOGENOM	HOG000239662.
HOVERGEN	HBG081970.
InParanoid	Q6N075.
PhylomeDB	Q6N075.
Gene expression databases
ArrayExpress	Q6N075.
Bgee	Q6N075.
CleanEx	HS_MFSD5.
Genevestigator	Q6N075.
Family and domain databases
InterPro	IPR008509. DUF791. IPR016196. MFS_dom_general_subst_transpt. [Graphical view]
Pfam	PF05631. DUF791. 1 hit. [Graphical view]
SUPFAM	SSF103473. MFS_gen_substrate_transporter. 1 hit.
PROSITE	PS50850. MFS. False negative. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	84975.
NextBio	75529.

Entry information

Entry name

MFSD5_HUMAN

Accession

Primary (citable) accession number: Q6N075
Secondary accession number(s): Q6NW04 , Q8N7W8, Q8NCK0, Q96IA5

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2007
Last sequence update:	January 23, 2007
Last modified:	April 3, 2013
This is version 68 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.