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Q6N075

- MFSD5_HUMAN

UniProt

Q6N075 - MFSD5_HUMAN

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Protein

Molybdate-anion transporter

Gene

MFSD5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Mediates high-affinity intracellular uptake of the rare oligo-element molybdenum.1 Publication

Kineticsi

  1. KM=546 nM for molybdate (when expressed in yeast)1 Publication

GO - Biological processi

  1. ion transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Molybdate-anion transporter
Alternative name(s):
Major facilitator superfamily domain-containing protein 5
Molybdate transporter 2 homolog
Short name:
hsMOT2
Gene namesi
Name:MFSD5
ORF Names:UNQ832/PRO1759
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:28156. MFSD5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1 – 2121HelicalSequence AnalysisAdd
BLAST
Transmembranei43 – 6321HelicalSequence AnalysisAdd
BLAST
Transmembranei79 – 9921HelicalSequence AnalysisAdd
BLAST
Transmembranei128 – 14821HelicalSequence AnalysisAdd
BLAST
Transmembranei174 – 19421HelicalSequence AnalysisAdd
BLAST
Transmembranei195 – 21521HelicalSequence AnalysisAdd
BLAST
Transmembranei249 – 26921HelicalSequence AnalysisAdd
BLAST
Transmembranei278 – 29821HelicalSequence AnalysisAdd
BLAST
Transmembranei311 – 33121HelicalSequence AnalysisAdd
BLAST
Transmembranei344 – 36421HelicalSequence AnalysisAdd
BLAST
Transmembranei376 – 39621HelicalSequence AnalysisAdd
BLAST
Transmembranei409 – 42921HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. membrane Source: UniProtKB
  3. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671466.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 450450Molybdate-anion transporterPRO_0000273401Add
BLAST

Proteomic databases

MaxQBiQ6N075.
PaxDbiQ6N075.
PRIDEiQ6N075.

PTM databases

PhosphoSiteiQ6N075.

Expressioni

Tissue specificityi

Expressed ubiquitously but at relatively higher levels in the olfactory bulb and the skeletal muscle.1 Publication

Gene expression databases

BgeeiQ6N075.
CleanExiHS_MFSD5.
ExpressionAtlasiQ6N075. baseline and differential.
GenevestigatoriQ6N075.

Organism-specific databases

HPAiHPA039773.

Interactioni

Protein-protein interaction databases

BioGridi124404. 5 interactions.
IntActiQ6N075. 3 interactions.
MINTiMINT-4724121.
STRINGi9606.ENSP00000332624.

Structurei

3D structure databases

ProteinModelPortaliQ6N075.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the major facilitator superfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG309381.
GeneTreeiENSGT00390000012629.
HOGENOMiHOG000239662.
HOVERGENiHBG081970.
InParanoidiQ6N075.
OMAiFPKEWIP.
OrthoDBiEOG71ZP22.
PhylomeDBiQ6N075.
TreeFamiTF328562.

Family and domain databases

InterProiIPR008509. DUF791.
IPR016196. MFS_dom_general_subst_transpt.
[Graphical view]
PfamiPF05631. DUF791. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6N075-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLVTAYLAFV GLLASCLGLE LSRCRAKPPG RACSNPSFLR FQLDFYQVYF
60 70 80 90 100
LALAADWLQA PYLYKLYQHY YFLEGQIAIL YVCGLASTVL FGLVASSLVD
110 120 130 140 150
WLGRKNSCVL FSLTYSLCCL TKLSQDYFVL LVGRALGGLS TALLFSAFEA
160 170 180 190 200
WYIHEHVERH DFPAEWIPAT FARAAFWNHV LAVVAGVAAE AVASWIGLGP
210 220 230 240 250
VAPFVAAIPL LALAGALALR NWGENYDRQR AFSRTCAGGL RCLLSDRRVL
260 270 280 290 300
LLGTIQALFE SVIFIFVFLW TPVLDPHGAP LGIIFSSFMA ASLLGSSLYR
310 320 330 340 350
IATSKRYHLQ PMHLLSLAVL IVVFSLFMLT FSTSPGQESP VESFIAFLLI
360 370 380 390 400
ELACGLYFPS MSFLRRKVIP ETEQAGVLNW FRVPLHSLAC LGLLVLHDSD
410 420 430 440 450
RKTGTRNMFS ICSAVMVMAL LAVVGLFTVV RHDAELRVPS PTEEPYAPEL
Length:450
Mass (Da):49,765
Last modified:January 23, 2007 - v2
Checksum:iA15D005755941BA7
GO
Isoform 2 (identifier: Q6N075-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MEVTAVGEEA...RARVVRGPTM

Note: No experimental confirmation available.

Show »
Length:557
Mass (Da):61,504
Checksum:i85CD96E4BF023226
GO

Sequence cautioni

The sequence BAC05108.1 differs from that shown. Reason: Probable cloning artifact.Curated
The sequence CAE45795.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti130 – 1301L → M in AAH67795. (PubMed:16541075)Curated
Sequence conflicti157 – 1571V → A in BAC11137. (PubMed:16303743)Curated
Sequence conflicti425 – 4251G → E in CAE45795. (PubMed:17974005)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 11M → MEVTAVGEEANQGDLLGFGQ RCCSLGSSNPWLYRTAGIFP EHCTEEKKIGTYFRVAPQAS KSQRSRCHGMAASEARPGEA TAASYGRPFPTHPRRQEFRA RVVRGPTM in isoform 2. CuratedVSP_046647

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358604 mRNA. Translation: AAQ88967.1.
BX640649 mRNA. Translation: CAE45795.1. Different initiation.
AK097576 mRNA. Translation: BAC05108.1. Sequence problems.
AK074684 mRNA. Translation: BAC11137.1.
AC021072 Genomic DNA. No translation available.
CH471054 Genomic DNA. Translation: EAW96679.1.
BC007703 mRNA. Translation: AAH07703.1.
BC067795 mRNA. Translation: AAH67795.1.
CCDSiCCDS53796.1. [Q6N075-2]
CCDS8851.1. [Q6N075-1]
RefSeqiNP_001164261.1. NM_001170790.1. [Q6N075-2]
NP_116278.3. NM_032889.4. [Q6N075-1]
XP_005269254.1. XM_005269197.1. [Q6N075-2]
XP_005269255.1. XM_005269198.2. [Q6N075-1]
UniGeneiHs.654660.

Genome annotation databases

EnsembliENST00000329548; ENSP00000332624; ENSG00000182544. [Q6N075-1]
ENST00000534842; ENSP00000442688; ENSG00000182544. [Q6N075-2]
GeneIDi84975.
KEGGihsa:84975.
UCSCiuc001sch.2. human.
uc001sci.2. human. [Q6N075-1]

Polymorphism databases

DMDMi124015161.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358604 mRNA. Translation: AAQ88967.1 .
BX640649 mRNA. Translation: CAE45795.1 . Different initiation.
AK097576 mRNA. Translation: BAC05108.1 . Sequence problems.
AK074684 mRNA. Translation: BAC11137.1 .
AC021072 Genomic DNA. No translation available.
CH471054 Genomic DNA. Translation: EAW96679.1 .
BC007703 mRNA. Translation: AAH07703.1 .
BC067795 mRNA. Translation: AAH67795.1 .
CCDSi CCDS53796.1. [Q6N075-2 ]
CCDS8851.1. [Q6N075-1 ]
RefSeqi NP_001164261.1. NM_001170790.1. [Q6N075-2 ]
NP_116278.3. NM_032889.4. [Q6N075-1 ]
XP_005269254.1. XM_005269197.1. [Q6N075-2 ]
XP_005269255.1. XM_005269198.2. [Q6N075-1 ]
UniGenei Hs.654660.

3D structure databases

ProteinModelPortali Q6N075.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 124404. 5 interactions.
IntActi Q6N075. 3 interactions.
MINTi MINT-4724121.
STRINGi 9606.ENSP00000332624.

PTM databases

PhosphoSitei Q6N075.

Polymorphism databases

DMDMi 124015161.

Proteomic databases

MaxQBi Q6N075.
PaxDbi Q6N075.
PRIDEi Q6N075.

Protocols and materials databases

DNASUi 84975.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000329548 ; ENSP00000332624 ; ENSG00000182544 . [Q6N075-1 ]
ENST00000534842 ; ENSP00000442688 ; ENSG00000182544 . [Q6N075-2 ]
GeneIDi 84975.
KEGGi hsa:84975.
UCSCi uc001sch.2. human.
uc001sci.2. human. [Q6N075-1 ]

Organism-specific databases

CTDi 84975.
GeneCardsi GC12P053645.
HGNCi HGNC:28156. MFSD5.
HPAi HPA039773.
neXtProti NX_Q6N075.
PharmGKBi PA142671466.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG309381.
GeneTreei ENSGT00390000012629.
HOGENOMi HOG000239662.
HOVERGENi HBG081970.
InParanoidi Q6N075.
OMAi FPKEWIP.
OrthoDBi EOG71ZP22.
PhylomeDBi Q6N075.
TreeFami TF328562.

Miscellaneous databases

GenomeRNAii 84975.
NextBioi 75529.
PROi Q6N075.

Gene expression databases

Bgeei Q6N075.
CleanExi HS_MFSD5.
ExpressionAtlasi Q6N075. baseline and differential.
Genevestigatori Q6N075.

Family and domain databases

InterProi IPR008509. DUF791.
IPR016196. MFS_dom_general_subst_transpt.
[Graphical view ]
Pfami PF05631. DUF791. 1 hit.
[Graphical view ]
SUPFAMi SSF103473. SSF103473. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Colon endothelium.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.
  4. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
    Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
    , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
    DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Mammary gland.
  5. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain and Ovary.
  8. "Long evolutionary conservation and considerable tissue specificity of several atypical solute carrier transporters."
    Sreedharan S., Stephansson O., Schioth H.B., Fredriksson R.
    Gene 478:11-18(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  9. Cited for: FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES.

Entry informationi

Entry nameiMFSD5_HUMAN
AccessioniPrimary (citable) accession number: Q6N075
Secondary accession number(s): G3V1N7
, Q6NW04, Q8N7W8, Q8NCK0, Q96IA5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3