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Protein

N-alpha-acetyltransferase 16, NatA auxiliary subunit

Gene

NAA16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Auxillary subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity.

GO - Molecular functioni

  • ribosome binding Source: UniProtKB

GO - Biological processi

  • negative regulation of apoptotic process Source: UniProtKB
  • N-terminal peptidyl-methionine acetylation Source: GO_Central
  • N-terminal protein amino acid acetylation Source: UniProtKB
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • protein stabilization Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
N-alpha-acetyltransferase 16, NatA auxiliary subunit
Alternative name(s):
NMDA receptor-regulated 1-like protein
Short name:
NARG1-like protein
Gene namesi
Name:NAA16
Synonyms:NARG1L, NAT2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:26164. NAA16.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • NatA complex Source: UniProtKB
  • nucleus Source: UniProtKB
  • transcription factor complex Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165505266.

Chemistry

ChEMBLiCHEMBL3430873.

Polymorphism and mutation databases

BioMutaiNAA16.
DMDMi57012940.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 864864N-alpha-acetyltransferase 16, NatA auxiliary subunitPRO_0000106297Add
BLAST

Proteomic databases

EPDiQ6N069.
MaxQBiQ6N069.
PaxDbiQ6N069.
PRIDEiQ6N069.

PTM databases

iPTMnetiQ6N069.
PhosphoSiteiQ6N069.

Expressioni

Gene expression databases

BgeeiQ6N069.
CleanExiHS_NARG1L.
HS_NAT2.
ExpressionAtlasiQ6N069. baseline and differential.
GenevisibleiQ6N069. HS.

Organism-specific databases

HPAiHPA039761.
HPA040157.

Interactioni

Subunit structurei

Component of the N-terminal acetyltransferase A (NatA) complex composed of NAA10 and NAA16.

Protein-protein interaction databases

BioGridi122746. 18 interactions.
IntActiQ6N069. 4 interactions.
STRINGi9606.ENSP00000368716.

Structurei

3D structure databases

ProteinModelPortaliQ6N069.
SMRiQ6N069. Positions 1-724.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati46 – 7934TPR 1Add
BLAST
Repeati80 – 11334TPR 2Add
BLAST
Repeati148 – 18437TPR 3Add
BLAST
Repeati224 – 25734TPR 4Add
BLAST
Repeati374 – 40734TPR 5Add
BLAST
Repeati409 – 44133TPR 6Add
BLAST
Repeati485 – 51834TPR 7Add
BLAST

Sequence similaritiesi

Contains 7 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG1156. Eukaryota.
ENOG410XR7D. LUCA.
GeneTreeiENSGT00390000007676.
HOGENOMiHOG000191711.
HOVERGENiHBG100627.
InParanoidiQ6N069.
OMAiFLISQHY.
OrthoDBiEOG747PKD.
PhylomeDBiQ6N069.
TreeFamiTF106301.

Family and domain databases

Gene3Di1.25.40.10. 4 hits.
InterProiIPR021183. NatA_aux_su.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR013105. TPR_2.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF12569. NARP1. 1 hit.
PF07719. TPR_2. 1 hit.
[Graphical view]
PIRSFiPIRSF000422. N-terminal-AcTrfase-A_aux_su. 1 hit.
SMARTiSM00028. TPR. 6 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 2 hits.
PROSITEiPS50005. TPR. 5 hits.
PS50293. TPR_REGION. 3 hits.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6N069-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPNVLLPPKE SNLFKRILKC YEQKQYKNGL KFCKMILSNP KFAEHGETLA
60 70 80 90 100
MKGLTLNCLG KKEEAYEFVR KGLRNDVKSH VCWHVYGLLQ RSDKKYDEAI
110 120 130 140 150
KCYRNALKLD KDNLQILRDL SLLQIQMRDL EGYRETRYQL LQLRPTQRAS
160 170 180 190 200
WIGYAIAYHL LKDYDMALKL LEEFRQTQQV PPNKIDYEYS ELILYQNQVM
210 220 230 240 250
READLLQESL EHIEMYEKQI CDKLLVEEIK GEILLKLGRL KEASEVFKNL
260 270 280 290 300
IDRNAENWCY YEGLEKALQI STLEERLQIY EEISKQHPKA ITPRRLPLTL
310 320 330 340 350
VPGERFRELM DKFLRVNFSK GCPPLFTTLK SLYYNTEKVS IIQELVTNYE
360 370 380 390 400
ASLKTCDFFS PYENGEKEPP TTLLWVQYFL AQHFDKLGQY SLALDYINAA
410 420 430 440 450
IASTPTLIEL FYMKAKIYKH IGNLKEAAKW MDEAQSLDTA DRFINSKCAK
460 470 480 490 500
YMLRANMIKE AEEMCSKFTR EGTSAMENLN EMQCMWFQTE CISAYQRLGR
510 520 530 540 550
YGDALKKCHE VERHFFEITD DQFDFHTYCM RKMTLRAYVD LLRLEDILRR
560 570 580 590 600
HAFYFKAARS AIEIYLKLYD NPLTNESKQQ EINSENLSAK ELKKMLSKQR
610 620 630 640 650
RAQKKAKLEE ERKHAERERQ QKNQKKKRDE EEEEASGLKE ELIPEKLERV
660 670 680 690 700
ENPLEEAVKF LIPLKNLVAD NIDTHLLAFE IYFRKGKFLL MLQSVKRAFA
710 720 730 740 750
INSNNPWLHE CLIRFSKSVS NHSNLPDIVS KVLSQEMQKI FVKKDLESFN
760 770 780 790 800
EDFLKRNATS LQHLLSGAKM MYFLDKSRQE KAIAIATRLD ETIKDKDVKT
810 820 830 840 850
LIKVSEALLD GSFGNCSSQY EEYRMACHNL LPFTSAFLPA VNEVDNPNVA
860
LNHTANYDVL ANEI
Length:864
Mass (Da):101,462
Last modified:January 4, 2005 - v2
Checksum:i510001EC0D9DD592
GO
Isoform 2 (identifier: Q6N069-2) [UniParc]FASTAAdd to basket

Also known as: Long

The sequence of this isoform differs from the canonical sequence as follows:
     515-530: FFEITDDQFDFHTYCM → SPSTWTTGGKEPQMHP
     531-864: Missing.

Note: No experimental confirmation available.
Show »
Length:530
Mass (Da):62,300
Checksum:i9550E897093E3A80
GO
Isoform 3 (identifier: Q6N069-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     514-516: HFF → VSC
     517-864: Missing.

Note: No experimental confirmation available.
Show »
Length:516
Mass (Da):60,729
Checksum:iF6E647FB31D5AD59
GO
Isoform 4 (identifier: Q6N069-4) [UniParc]FASTAAdd to basket

Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     420-429: HIGNLKEAAK → VKSESCFLSS
     430-864: Missing.

Note: No experimental confirmation available.
Show »
Length:429
Mass (Da):50,561
Checksum:i49887E7C291ECE13
GO
Isoform 5 (identifier: Q6N069-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     304-311: ERFRELMD → FYNPGTCY
     312-864: Missing.

Note: No experimental confirmation available.
Show »
Length:311
Mass (Da):36,854
Checksum:iD5B5BA001EFCCE74
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti344 – 3441E → G.
Corresponds to variant rs17062054 [ dbSNP | Ensembl ].
VAR_052618

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei304 – 3118ERFRELMD → FYNPGTCY in isoform 5. 1 PublicationVSP_012562
Alternative sequencei312 – 864553Missing in isoform 5. 1 PublicationVSP_012563Add
BLAST
Alternative sequencei420 – 42910HIGNLKEAAK → VKSESCFLSS in isoform 4. 1 PublicationVSP_012564
Alternative sequencei430 – 864435Missing in isoform 4. 1 PublicationVSP_012565Add
BLAST
Alternative sequencei514 – 5163HFF → VSC in isoform 3. 1 PublicationVSP_012566
Alternative sequencei515 – 53016FFEIT…HTYCM → SPSTWTTGGKEPQMHP in isoform 2. 1 PublicationVSP_012568Add
BLAST
Alternative sequencei517 – 864348Missing in isoform 3. 1 PublicationVSP_012567Add
BLAST
Alternative sequencei531 – 864334Missing in isoform 2. 1 PublicationVSP_012569Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590665, AL354696, AL731858 Genomic DNA. Translation: CAH71511.1.
AL731858, AL354696, AL590665 Genomic DNA. Translation: CAH73370.1.
AL354696, AL590665, AL731858 Genomic DNA. Translation: CAI16619.1.
AL354696, AL590665 Genomic DNA. Translation: CAQ06902.1.
AL590665, AL354696 Genomic DNA. Translation: CAQ09847.1.
AK097224 mRNA. No translation available.
BX640665 mRNA. Translation: CAE45801.1.
CH471075 Genomic DNA. Translation: EAX08654.1.
BC032318 mRNA. Translation: AAH32318.1.
BC064592 mRNA. Translation: AAH64592.1.
CCDSiCCDS45044.1. [Q6N069-4]
CCDS9379.1. [Q6N069-1]
RefSeqiNP_001104268.1. NM_001110798.1. [Q6N069-4]
NP_060997.2. NM_018527.3. [Q6N069-5]
NP_078837.3. NM_024561.4. [Q6N069-1]
XP_011533530.1. XM_011535228.1. [Q6N069-2]
UniGeneiHs.512914.

Genome annotation databases

EnsembliENST00000379406; ENSP00000368716; ENSG00000172766. [Q6N069-1]
ENST00000403412; ENSP00000386103; ENSG00000172766. [Q6N069-4]
ENST00000464857; ENSP00000432364; ENSG00000172766. [Q6N069-3]
GeneIDi79612.
KEGGihsa:79612.
UCSCiuc001uye.5. human. [Q6N069-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590665, AL354696, AL731858 Genomic DNA. Translation: CAH71511.1.
AL731858, AL354696, AL590665 Genomic DNA. Translation: CAH73370.1.
AL354696, AL590665, AL731858 Genomic DNA. Translation: CAI16619.1.
AL354696, AL590665 Genomic DNA. Translation: CAQ06902.1.
AL590665, AL354696 Genomic DNA. Translation: CAQ09847.1.
AK097224 mRNA. No translation available.
BX640665 mRNA. Translation: CAE45801.1.
CH471075 Genomic DNA. Translation: EAX08654.1.
BC032318 mRNA. Translation: AAH32318.1.
BC064592 mRNA. Translation: AAH64592.1.
CCDSiCCDS45044.1. [Q6N069-4]
CCDS9379.1. [Q6N069-1]
RefSeqiNP_001104268.1. NM_001110798.1. [Q6N069-4]
NP_060997.2. NM_018527.3. [Q6N069-5]
NP_078837.3. NM_024561.4. [Q6N069-1]
XP_011533530.1. XM_011535228.1. [Q6N069-2]
UniGeneiHs.512914.

3D structure databases

ProteinModelPortaliQ6N069.
SMRiQ6N069. Positions 1-724.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122746. 18 interactions.
IntActiQ6N069. 4 interactions.
STRINGi9606.ENSP00000368716.

Chemistry

ChEMBLiCHEMBL3430873.

PTM databases

iPTMnetiQ6N069.
PhosphoSiteiQ6N069.

Polymorphism and mutation databases

BioMutaiNAA16.
DMDMi57012940.

Proteomic databases

EPDiQ6N069.
MaxQBiQ6N069.
PaxDbiQ6N069.
PRIDEiQ6N069.

Protocols and materials databases

DNASUi79612.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000379406; ENSP00000368716; ENSG00000172766. [Q6N069-1]
ENST00000403412; ENSP00000386103; ENSG00000172766. [Q6N069-4]
ENST00000464857; ENSP00000432364; ENSG00000172766. [Q6N069-3]
GeneIDi79612.
KEGGihsa:79612.
UCSCiuc001uye.5. human. [Q6N069-1]

Organism-specific databases

CTDi79612.
GeneCardsiNAA16.
HGNCiHGNC:26164. NAA16.
HPAiHPA039761.
HPA040157.
neXtProtiNX_Q6N069.
PharmGKBiPA165505266.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1156. Eukaryota.
ENOG410XR7D. LUCA.
GeneTreeiENSGT00390000007676.
HOGENOMiHOG000191711.
HOVERGENiHBG100627.
InParanoidiQ6N069.
OMAiFLISQHY.
OrthoDBiEOG747PKD.
PhylomeDBiQ6N069.
TreeFamiTF106301.

Miscellaneous databases

GenomeRNAii79612.
PROiQ6N069.

Gene expression databases

BgeeiQ6N069.
CleanExiHS_NARG1L.
HS_NAT2.
ExpressionAtlasiQ6N069. baseline and differential.
GenevisibleiQ6N069. HS.

Family and domain databases

Gene3Di1.25.40.10. 4 hits.
InterProiIPR021183. NatA_aux_su.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR013105. TPR_2.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF12569. NARP1. 1 hit.
PF07719. TPR_2. 1 hit.
[Graphical view]
PIRSFiPIRSF000422. N-terminal-AcTrfase-A_aux_su. 1 hit.
SMARTiSM00028. TPR. 6 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 2 hits.
PROSITEiPS50005. TPR. 5 hits.
PS50293. TPR_REGION. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Spleen.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Colon endothelium.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 4 AND 5).
    Tissue: Colon and Pancreas.
  6. "A novel human NatA Nalpha-terminal acetyltransferase complex: hNaa16p-hNaa10p (hNat2-hArd1)."
    Arnesen T., Gromyko D., Kagabo D., Betts M.J., Starheim K.K., Varhaug J.E., Anderson D., Lillehaug J.R.
    BMC Biochem. 10:15-15(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH NAA10.
  7. "A synopsis of eukaryotic Nalpha-terminal acetyltransferases: nomenclature, subunits and substrates."
    Polevoda B., Arnesen T., Sherman F.
    BMC Proc. 3:S2-S2(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NOMENCLATURE.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiNAA16_HUMAN
AccessioniPrimary (citable) accession number: Q6N069
Secondary accession number(s): B0QZ59
, Q5VSP9, Q6P2D5, Q8N5J3, Q8N870
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: January 4, 2005
Last modified: June 8, 2016
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.