Q6N069 (NAA16_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
N-alpha-acetyltransferase 16, NatA auxiliary subunit

Alternative name(s):
NMDA receptor-regulated 1-like protein
Short name=NARG1-like protein

Gene names

Name:	NAA16
Synonyms:	NARG1L, NAT2

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	864 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May belong to a complex displaying N-terminal acetyltransferase activity By similarity.
Sequence similarities	Contains 7 TPR repeats.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat TPR repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	N-terminal protein amino acid acetylation Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of transcription, DNA-dependent Inferred from sequence or structural similarity. Source: UniProtKB
Cellular component	cytoplasm Inferred from sequence or structural similarity. Source: UniProtKB transcription factor complex Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6N069-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6N069-2)

Also known as: Long;

The sequence of this isoform differs from the canonical sequence as follows:
     515-530: FFEITDDQFDFHTYCM → SPSTWTTGGKEPQMHP
     531-864: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q6N069-3)

The sequence of this isoform differs from the canonical sequence as follows:
     514-516: HFF → VSC
     517-864: Missing.

Note: No experimental confirmation available.

Isoform 4 (identifier: Q6N069-4)

Also known as: Short;

The sequence of this isoform differs from the canonical sequence as follows:
     420-429: HIGNLKEAAK → VKSESCFLSS
     430-864: Missing.

Note: No experimental confirmation available.

Isoform 5 (identifier: Q6N069-5)

The sequence of this isoform differs from the canonical sequence as follows:
     304-311: ERFRELMD → FYNPGTCY
     312-864: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 864	864	N-alpha-acetyltransferase 16, NatA auxiliary subunit		PRO_0000106297
Regions
	Repeat	46 – 79	34	TPR 1
	Repeat	80 – 113	34	TPR 2
	Repeat	148 – 184	37	TPR 3
	Repeat	224 – 257	34	TPR 4
	Repeat	374 – 407	34	TPR 5
	Repeat	409 – 441	33	TPR 6
	Repeat	485 – 518	34	TPR 7
Natural variations
	Alternative sequence	304 – 311	8	ERFRELMD → FYNPGTCY in isoform 5.		VSP_012562
	Alternative sequence	312 – 864	553	Missing in isoform 5.		VSP_012563
	Alternative sequence	420 – 429	10	HIGNLKEAAK → VKSESCFLSS in isoform 4.		VSP_012564
	Alternative sequence	430 – 864	435	Missing in isoform 4.		VSP_012565
	Alternative sequence	514 – 516	3	HFF → VSC in isoform 3.		VSP_012566
	Alternative sequence	515 – 530	16	FFEIT…HTYCM → SPSTWTTGGKEPQMHP in isoform 2.		VSP_012568
	Alternative sequence	517 – 864	348	Missing in isoform 3.		VSP_012567
	Alternative sequence	531 – 864	334	Missing in isoform 2.		VSP_012569
	Natural variant	344	1	E → G. Corresponds to variant rs17062054 [ dbSNP | Ensembl ].		VAR_052618

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified January 4, 2005. Version 2. Checksum: 510001EC0D9DD592	FASTA	864	101,462
	10 20 30 40 50 60 MPNVLLPPKE SNLFKRILKC YEQKQYKNGL KFCKMILSNP KFAEHGETLA MKGLTLNCLG 70 80 90 100 110 120 KKEEAYEFVR KGLRNDVKSH VCWHVYGLLQ RSDKKYDEAI KCYRNALKLD KDNLQILRDL 130 140 150 160 170 180 SLLQIQMRDL EGYRETRYQL LQLRPTQRAS WIGYAIAYHL LKDYDMALKL LEEFRQTQQV 190 200 210 220 230 240 PPNKIDYEYS ELILYQNQVM READLLQESL EHIEMYEKQI CDKLLVEEIK GEILLKLGRL 250 260 270 280 290 300 KEASEVFKNL IDRNAENWCY YEGLEKALQI STLEERLQIY EEISKQHPKA ITPRRLPLTL 310 320 330 340 350 360 VPGERFRELM DKFLRVNFSK GCPPLFTTLK SLYYNTEKVS IIQELVTNYE ASLKTCDFFS 370 380 390 400 410 420 PYENGEKEPP TTLLWVQYFL AQHFDKLGQY SLALDYINAA IASTPTLIEL FYMKAKIYKH 430 440 450 460 470 480 IGNLKEAAKW MDEAQSLDTA DRFINSKCAK YMLRANMIKE AEEMCSKFTR EGTSAMENLN 490 500 510 520 530 540 EMQCMWFQTE CISAYQRLGR YGDALKKCHE VERHFFEITD DQFDFHTYCM RKMTLRAYVD 550 560 570 580 590 600 LLRLEDILRR HAFYFKAARS AIEIYLKLYD NPLTNESKQQ EINSENLSAK ELKKMLSKQR 610 620 630 640 650 660 RAQKKAKLEE ERKHAERERQ QKNQKKKRDE EEEEASGLKE ELIPEKLERV ENPLEEAVKF 670 680 690 700 710 720 LIPLKNLVAD NIDTHLLAFE IYFRKGKFLL MLQSVKRAFA INSNNPWLHE CLIRFSKSVS 730 740 750 760 770 780 NHSNLPDIVS KVLSQEMQKI FVKKDLESFN EDFLKRNATS LQHLLSGAKM MYFLDKSRQE 790 800 810 820 830 840 KAIAIATRLD ETIKDKDVKT LIKVSEALLD GSFGNCSSQY EEYRMACHNL LPFTSAFLPA 850 860 VNEVDNPNVA LNHTANYDVL ANEI
	Isoform 2 (Long) [UniParc]. Checksum: 9550E897093E3A80	FASTA	530	62,300
	10 20 30 40 50 60 MPNVLLPPKE SNLFKRILKC YEQKQYKNGL KFCKMILSNP KFAEHGETLA MKGLTLNCLG 70 80 90 100 110 120 KKEEAYEFVR KGLRNDVKSH VCWHVYGLLQ RSDKKYDEAI KCYRNALKLD KDNLQILRDL 130 140 150 160 170 180 SLLQIQMRDL EGYRETRYQL LQLRPTQRAS WIGYAIAYHL LKDYDMALKL LEEFRQTQQV 190 200 210 220 230 240 PPNKIDYEYS ELILYQNQVM READLLQESL EHIEMYEKQI CDKLLVEEIK GEILLKLGRL 250 260 270 280 290 300 KEASEVFKNL IDRNAENWCY YEGLEKALQI STLEERLQIY EEISKQHPKA ITPRRLPLTL 310 320 330 340 350 360 VPGERFRELM DKFLRVNFSK GCPPLFTTLK SLYYNTEKVS IIQELVTNYE ASLKTCDFFS 370 380 390 400 410 420 PYENGEKEPP TTLLWVQYFL AQHFDKLGQY SLALDYINAA IASTPTLIEL FYMKAKIYKH 430 440 450 460 470 480 IGNLKEAAKW MDEAQSLDTA DRFINSKCAK YMLRANMIKE AEEMCSKFTR EGTSAMENLN 490 500 510 520 530 EMQCMWFQTE CISAYQRLGR YGDALKKCHE VERHSPSTWT TGGKEPQMHP
	Isoform 3 [UniParc]. Checksum: F6E647FB31D5AD59	FASTA	516	60,729
	10 20 30 40 50 60 MPNVLLPPKE SNLFKRILKC YEQKQYKNGL KFCKMILSNP KFAEHGETLA MKGLTLNCLG 70 80 90 100 110 120 KKEEAYEFVR KGLRNDVKSH VCWHVYGLLQ RSDKKYDEAI KCYRNALKLD KDNLQILRDL 130 140 150 160 170 180 SLLQIQMRDL EGYRETRYQL LQLRPTQRAS WIGYAIAYHL LKDYDMALKL LEEFRQTQQV 190 200 210 220 230 240 PPNKIDYEYS ELILYQNQVM READLLQESL EHIEMYEKQI CDKLLVEEIK GEILLKLGRL 250 260 270 280 290 300 KEASEVFKNL IDRNAENWCY YEGLEKALQI STLEERLQIY EEISKQHPKA ITPRRLPLTL 310 320 330 340 350 360 VPGERFRELM DKFLRVNFSK GCPPLFTTLK SLYYNTEKVS IIQELVTNYE ASLKTCDFFS 370 380 390 400 410 420 PYENGEKEPP TTLLWVQYFL AQHFDKLGQY SLALDYINAA IASTPTLIEL FYMKAKIYKH 430 440 450 460 470 480 IGNLKEAAKW MDEAQSLDTA DRFINSKCAK YMLRANMIKE AEEMCSKFTR EGTSAMENLN 490 500 510 EMQCMWFQTE CISAYQRLGR YGDALKKCHE VERVSC
	Isoform 4 (Short) [UniParc]. Checksum: 49887E7C291ECE13	FASTA	429	50,561
	10 20 30 40 50 60 MPNVLLPPKE SNLFKRILKC YEQKQYKNGL KFCKMILSNP KFAEHGETLA MKGLTLNCLG 70 80 90 100 110 120 KKEEAYEFVR KGLRNDVKSH VCWHVYGLLQ RSDKKYDEAI KCYRNALKLD KDNLQILRDL 130 140 150 160 170 180 SLLQIQMRDL EGYRETRYQL LQLRPTQRAS WIGYAIAYHL LKDYDMALKL LEEFRQTQQV 190 200 210 220 230 240 PPNKIDYEYS ELILYQNQVM READLLQESL EHIEMYEKQI CDKLLVEEIK GEILLKLGRL 250 260 270 280 290 300 KEASEVFKNL IDRNAENWCY YEGLEKALQI STLEERLQIY EEISKQHPKA ITPRRLPLTL 310 320 330 340 350 360 VPGERFRELM DKFLRVNFSK GCPPLFTTLK SLYYNTEKVS IIQELVTNYE ASLKTCDFFS 370 380 390 400 410 420 PYENGEKEPP TTLLWVQYFL AQHFDKLGQY SLALDYINAA IASTPTLIEL FYMKAKIYKV KSESCFLSS
	Isoform 5 [UniParc]. Checksum: D5B5BA001EFCCE74	FASTA	311	36,854
	10 20 30 40 50 60 MPNVLLPPKE SNLFKRILKC YEQKQYKNGL KFCKMILSNP KFAEHGETLA MKGLTLNCLG 70 80 90 100 110 120 KKEEAYEFVR KGLRNDVKSH VCWHVYGLLQ RSDKKYDEAI KCYRNALKLD KDNLQILRDL 130 140 150 160 170 180 SLLQIQMRDL EGYRETRYQL LQLRPTQRAS WIGYAIAYHL LKDYDMALKL LEEFRQTQQV 190 200 210 220 230 240 PPNKIDYEYS ELILYQNQVM READLLQESL EHIEMYEKQI CDKLLVEEIK GEILLKLGRL 250 260 270 280 290 300 KEASEVFKNL IDRNAENWCY YEGLEKALQI STLEERLQIY EEISKQHPKA ITPRRLPLTL 310 VPGFYNPGTC Y

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The DNA sequence and analysis of human chromosome 13." Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T. Nature 428:522-528(2004) [PubMed: 15057823] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Spleen.
[4]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Colon endothelium.
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 4 AND 5). Tissue: Colon and Pancreas.
[6]	"A synopsis of eukaryotic Nalpha-terminal acetyltransferases: nomenclature, subunits and substrates." Polevoda B., Arnesen T., Sherman F. BMC Proc. 3:S2-S2(2009) [PubMed: 19660095] [Abstract] Cited for: NOMENCLATURE.
[7]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL590665, AL354696, AL731858 Genomic DNA. Translation: CAH71511.1. AL731858, AL354696, AL590665 Genomic DNA. Translation: CAH73370.1. AL354696, AL590665, AL731858 Genomic DNA. Translation: CAI16619.1. AL354696, AL590665 Genomic DNA. Translation: CAQ06902.1. AL590665, AL354696 Genomic DNA. Translation: CAQ09847.1. AK097224 mRNA. No translation available. BX640665 mRNA. Translation: CAE45801.1. CH471075 Genomic DNA. Translation: EAX08654.1. BC032318 mRNA. Translation: AAH32318.1. BC064592 mRNA. Translation: AAH64592.1.
IPI	IPI00167368. IPI00413165. IPI00478058. IPI00513890. IPI00514816.
RefSeq	NP_001104268.1. NM_001110798.1. NP_060997.2. NM_018527.3. NP_078837.3. NM_024561.4.
UniGene	Hs.512914.
3D structure databases
ProteinModelPortal	Q6N069.
SMR	Q6N069. Positions 11-171, 224-288, 375-473.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q6N069. 1 interaction.
STRING	Q6N069.
PTM databases
PhosphoSite	Q6N069.
Polymorphism databases
DMDM	57012940.
Proteomic databases
PRIDE	Q6N069.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000379406; ENSP00000368716; ENSG00000172766.
GeneID	79612.
KEGG	hsa:79612.
UCSC	uc001uyd.2. human. uc001uye.2. human. uc001uyf.2. human.
Organism-specific databases
CTD	79612.
GeneCards	GC13P041885.
HGNC	HGNC:26164. NAA16.
HPA	HPA039761. HPA040157.
neXtProt	NX_Q6N069.
PharmGKB	PA134989177.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HBG736934.
HOVERGEN	HBG052576.
InParanoid	Q6N069.
OMA	YKHIGNL.
OrthoDB	EOG4001HM.
PhylomeDB	Q6N069.
Gene expression databases
ArrayExpress	Q6N069.
Bgee	Q6N069.
CleanEx	HS_NARG1L. HS_NAT2.
Genevestigator	Q6N069.
GermOnline	ENSG00000172766. Homo sapiens.
Family and domain databases
InterPro	IPR021183. Alpha-AcTfrase15_NatA. IPR001440. TPR-1. IPR013026. TPR-contain. IPR011990. TPR-like_helical. IPR019734. TPR_repeat. [Graphical view]
Gene3D	G3DSA:1.25.40.10. TPR-like_helical. 5 hits.
Pfam	PF12569. NARP1. 1 hit. PF00515. TPR_1. 1 hit. [Graphical view]
PIRSF	PIRSF000422. N-terminal-AcTrfase-A_aux_su. 1 hit.
SMART	SM00028. TPR. 5 hits. [Graphical view]
PROSITE	PS50005. TPR. 5 hits. PS50293. TPR_REGION. 3 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	68663.

Entry information

Entry name

NAA16_HUMAN

Accession

Primary (citable) accession number: Q6N069
Secondary accession number(s): B0QZ59 , Q5VSP9, Q6P2D5, Q8N5J3, Q8N870

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 4, 2005
Last sequence update:	January 4, 2005
Last modified:	January 25, 2012
This is version 82 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.