ID OGFD2_HUMAN Reviewed; 350 AA. AC Q6N063; B3KT24; Q4KN13; Q6N023; Q9H8K6; DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot. DT 29-MAY-2007, sequence version 2. DT 24-JAN-2024, entry version 136. DE RecName: Full=2-oxoglutarate and iron-dependent oxygenase domain-containing protein 2; DE EC=1.14.11.-; GN Name=OGFOD2; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). RC TISSUE=Brain, and Placenta; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.; RT "Cloning of human full open reading frames in Gateway(TM) system entry RT vector (pDONR201)."; RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3). RC TISSUE=Colon endothelium, and Fetal liver; RX PubMed=17974005; DOI=10.1186/1471-2164-8-399; RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., RA Wiemann S., Schupp I.; RT "The full-ORF clone resource of the German cDNA consortium."; RL BMC Genomics 8:399-399(2007). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., RA Hunkapiller M.W., Myers E.W., Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4). RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- COFACTOR: CC Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence={ECO:0000255|PROSITE- CC ProRule:PRU00805}; CC Note=Binds 1 Fe(2+) ion per subunit. {ECO:0000255|PROSITE- CC ProRule:PRU00805}; CC -!- COFACTOR: CC Name=L-ascorbate; Xref=ChEBI:CHEBI:38290; Evidence={ECO:0000250}; CC -!- INTERACTION: CC Q6N063-2; P55212: CASP6; NbExp=3; IntAct=EBI-22006224, EBI-718729; CC Q6N063-2; Q8NI60: COQ8A; NbExp=3; IntAct=EBI-22006224, EBI-745535; CC Q6N063-2; O00291: HIP1; NbExp=3; IntAct=EBI-22006224, EBI-473886; CC Q6N063-2; P13473-2: LAMP2; NbExp=3; IntAct=EBI-22006224, EBI-21591415; CC Q6N063-2; O75400-2: PRPF40A; NbExp=3; IntAct=EBI-22006224, EBI-5280197; CC Q6N063-2; P62826: RAN; NbExp=3; IntAct=EBI-22006224, EBI-286642; CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=4; CC Name=1; CC IsoId=Q6N063-1; Sequence=Displayed; CC Name=2; CC IsoId=Q6N063-2; Sequence=VSP_025856, VSP_025857; CC Name=3; CC IsoId=Q6N063-3; Sequence=VSP_025858, VSP_025859; CC Name=4; CC IsoId=Q6N063-4; Sequence=VSP_025855; CC -!- SIMILARITY: Belongs to the OGFOD2 family. {ECO:0000305}. CC -!- SEQUENCE CAUTION: CC Sequence=CAE45849.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305}; CC Sequence=CAE45849.1; Type=Frameshift; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK023553; BAB14610.1; -; mRNA. DR EMBL; AK094820; BAG52936.1; -; mRNA. DR EMBL; CR457316; CAG33597.1; -; mRNA. DR EMBL; BX640675; CAE45807.1; -; mRNA. DR EMBL; BX640734; CAE45849.1; ALT_SEQ; mRNA. DR EMBL; CH471054; EAW98364.1; -; Genomic_DNA. DR EMBL; BC098119; AAH98119.1; -; mRNA. DR EMBL; BC098293; AAH98293.1; -; mRNA. DR EMBL; BC101940; AAI01941.1; -; mRNA. DR EMBL; BC105637; AAI05638.1; -; mRNA. DR CCDS; CCDS41855.1; -. [Q6N063-2] DR CCDS; CCDS76617.1; -. [Q6N063-1] DR CCDS; CCDS76618.1; -. [Q6N063-4] DR RefSeq; NP_001291762.1; NM_001304833.1. [Q6N063-1] DR RefSeq; NP_001291763.1; NM_001304834.1. [Q6N063-4] DR RefSeq; NP_001291764.1; NM_001304835.1. [Q6N063-4] DR RefSeq; NP_001291765.1; NM_001304836.1. [Q6N063-4] DR RefSeq; NP_001291766.1; NM_001304837.1. [Q6N063-4] DR RefSeq; NP_001291767.1; NM_001304838.1. [Q6N063-4] DR RefSeq; NP_078899.1; NM_024623.2. [Q6N063-2] DR AlphaFoldDB; Q6N063; -. DR SMR; Q6N063; -. DR BioGRID; 122801; 7. DR IntAct; Q6N063; 9. DR STRING; 9606.ENSP00000228922; -. DR DrugBank; DB00126; Ascorbic acid. DR iPTMnet; Q6N063; -. DR PhosphoSitePlus; Q6N063; -. DR BioMuta; OGFOD2; -. DR DMDM; 156633666; -. DR EPD; Q6N063; -. DR jPOST; Q6N063; -. DR MassIVE; Q6N063; -. DR MaxQB; Q6N063; -. DR PaxDb; 9606-ENSP00000380544; -. DR PeptideAtlas; Q6N063; -. DR ProteomicsDB; 66608; -. [Q6N063-1] DR ProteomicsDB; 66609; -. [Q6N063-2] DR ProteomicsDB; 66610; -. [Q6N063-3] DR ProteomicsDB; 66611; -. [Q6N063-4] DR Pumba; Q6N063; -. DR Antibodypedia; 31731; 149 antibodies from 26 providers. DR DNASU; 79676; -. DR Ensembl; ENST00000228922.12; ENSP00000228922.7; ENSG00000111325.16. [Q6N063-1] DR Ensembl; ENST00000397389.6; ENSP00000380544.2; ENSG00000111325.16. [Q6N063-2] DR Ensembl; ENST00000454694.6; ENSP00000394175.2; ENSG00000111325.16. [Q6N063-4] DR Ensembl; ENST00000536150.5; ENSP00000438327.1; ENSG00000111325.16. [Q6N063-4] DR Ensembl; ENST00000538628.5; ENSP00000444608.1; ENSG00000111325.16. [Q6N063-4] DR Ensembl; ENST00000538755.5; ENSP00000442817.1; ENSG00000111325.16. [Q6N063-4] DR Ensembl; ENST00000540324.5; ENSP00000439667.1; ENSG00000111325.16. [Q6N063-3] DR Ensembl; ENST00000545317.5; ENSP00000438192.1; ENSG00000111325.16. [Q6N063-4] DR Ensembl; ENST00000545612.5; ENSP00000444436.1; ENSG00000111325.16. [Q6N063-4] DR GeneID; 79676; -. DR KEGG; hsa:79676; -. DR MANE-Select; ENST00000228922.12; ENSP00000228922.7; NM_001304833.2; NP_001291762.1. DR UCSC; uc001uds.2; human. [Q6N063-1] DR AGR; HGNC:25823; -. DR CTD; 79676; -. DR GeneCards; OGFOD2; -. DR HGNC; HGNC:25823; OGFOD2. DR HPA; ENSG00000111325; Low tissue specificity. DR neXtProt; NX_Q6N063; -. DR OpenTargets; ENSG00000111325; -. DR PharmGKB; PA143485569; -. DR VEuPathDB; HostDB:ENSG00000111325; -. DR eggNOG; KOG1971; Eukaryota. DR GeneTree; ENSGT00940000153974; -. DR HOGENOM; CLU_045835_1_0_1; -. DR InParanoid; Q6N063; -. DR OMA; CQAFVDE; -. DR OrthoDB; 5491612at2759; -. DR PhylomeDB; Q6N063; -. DR TreeFam; TF329650; -. DR PathwayCommons; Q6N063; -. DR SignaLink; Q6N063; -. DR BioGRID-ORCS; 79676; 11 hits in 1156 CRISPR screens. DR ChiTaRS; OGFOD2; human. DR GenomeRNAi; 79676; -. DR Pharos; Q6N063; Tdark. DR PRO; PR:Q6N063; -. DR Proteomes; UP000005640; Chromosome 12. DR RNAct; Q6N063; Protein. DR Bgee; ENSG00000111325; Expressed in right uterine tube and 99 other cell types or tissues. DR ExpressionAtlas; Q6N063; baseline and differential. DR GO; GO:0051213; F:dioxygenase activity; IEA:UniProtKB-KW. DR GO; GO:0005506; F:iron ion binding; IEA:InterPro. DR GO; GO:0031418; F:L-ascorbic acid binding; IEA:UniProtKB-KW. DR GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro. DR Gene3D; 2.60.120.620; q2cbj1_9rhob like domain; 1. DR InterPro; IPR005123; Oxoglu/Fe-dep_dioxygenase. DR InterPro; IPR006620; Pro_4_hyd_alph. DR PANTHER; PTHR24014; 2-OXOGLUTARATE AND IRON-DEPENDENT OXYGENASE DOMAIN-CONTAINING PROTEIN 2; 1. DR PANTHER; PTHR24014:SF4; 2-OXOGLUTARATE AND IRON-DEPENDENT OXYGENASE DOMAIN-CONTAINING PROTEIN 2; 1. DR SMART; SM00702; P4Hc; 1. DR PROSITE; PS51471; FE2OG_OXY; 1. DR Genevisible; Q6N063; HS. PE 1: Evidence at protein level; KW Alternative splicing; Dioxygenase; Iron; Metal-binding; Oxidoreductase; KW Reference proteome; Vitamin C. FT CHAIN 1..350 FT /note="2-oxoglutarate and iron-dependent oxygenase domain- FT containing protein 2" FT /id="PRO_0000288978" FT DOMAIN 215..309 FT /note="Fe2OG dioxygenase" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00805" FT BINDING 235 FT /ligand="Fe cation" FT /ligand_id="ChEBI:CHEBI:24875" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00805" FT BINDING 237 FT /ligand="Fe cation" FT /ligand_id="ChEBI:CHEBI:24875" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00805" FT BINDING 290 FT /ligand="Fe cation" FT /ligand_id="ChEBI:CHEBI:24875" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00805" FT BINDING 300 FT /ligand="2-oxoglutarate" FT /ligand_id="ChEBI:CHEBI:16810" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00805" FT VAR_SEQ 1..164 FT /note="Missing (in isoform 4)" FT /evidence="ECO:0000303|PubMed:15489334" FT /id="VSP_025855" FT VAR_SEQ 1..60 FT /note="Missing (in isoform 2)" FT /evidence="ECO:0000303|PubMed:14702039, ECO:0000303|Ref.2" FT /id="VSP_025856" FT VAR_SEQ 61..62 FT /note="LA -> MV (in isoform 2)" FT /evidence="ECO:0000303|PubMed:14702039, ECO:0000303|Ref.2" FT /id="VSP_025857" FT VAR_SEQ 64 FT /note="L -> WPQEDGRPHLVTTLCHPSLSRRWSGGSGWGRSQQLGKPSSRVPTTRH FT GLRSTTHCRMQLWPPSSWP (in isoform 3)" FT /evidence="ECO:0000303|PubMed:17974005" FT /id="VSP_025858" FT VAR_SEQ 65..350 FT /note="Missing (in isoform 3)" FT /evidence="ECO:0000303|PubMed:17974005" FT /id="VSP_025859" FT CONFLICT 244 FT /note="N -> S (in Ref. 2; CAE45807)" FT /evidence="ECO:0000305" FT CONFLICT 311 FT /note="A -> T (in Ref. 5; AAH98119/AAI01941)" FT /evidence="ECO:0000305" SQ SEQUENCE 350 AA; 38996 MW; 651D0F07A32EBB66 CRC64; MATVGAPRHF CRCACFCTDN LYVARYGLHV RFRGEQQLRR DYGPILRSRG CVSAKDFQQL LAELEQEVER RQRLGQESAA RKALIASSYH PARPEVYDSL QDAALAPEFL AVTEYSVSPD ADLKGLLQRL ETVSEEKRIY RVPVFTAPFC QALLEELEHF EQSDMPKGRP NTMNNYGVLL HELGLDEPLM TPLRERFLQP LMALLYPDCG GGRLDSHRAF VVKYAPGQDL ELGCHYDNAE LTLNVALGKV FTGGALYFGG LFQAPTALTE PLEVEHVVGQ GVLHRGGQLH GARPLGTGER WNLVVWLRAS AVRNSLCPMC CREPDLVDDE GFGDGFTREE PATVDVCALT //