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Protein

Zinc finger protein 280D

Gene

ZNF280D

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May function as a transcription factor.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri321 – 343C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri358 – 381C2H2-type 2PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri388 – 412C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST25
Zinc fingeri418 – 441C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri449 – 469C2H2-type 5PROSITE-ProRule annotationAdd BLAST21

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 280D
Alternative name(s):
Suppressor of hairy wing homolog 4
Zinc finger protein 634
Gene namesi
Name:ZNF280D
Synonyms:KIAA1584, SUHW4, ZNF634
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:25953. ZNF280D.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000137871.
PharmGKBiPA162410004.

Polymorphism and mutation databases

BioMutaiZNF280D.
DMDMi223634726.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002279771 – 979Zinc finger protein 280DAdd BLAST979

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki34Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki74Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei104PhosphoserineCombined sources1
Cross-linki126Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki210Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki292Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei545PhosphoserineCombined sources1
Cross-linki740Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei908PhosphoserineBy similarity1
Modified residuei911PhosphoserineBy similarity1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ6N043.
MaxQBiQ6N043.
PaxDbiQ6N043.
PeptideAtlasiQ6N043.
PRIDEiQ6N043.

PTM databases

iPTMnetiQ6N043.
PhosphoSitePlusiQ6N043.

Expressioni

Gene expression databases

BgeeiENSG00000137871.
CleanExiHS_ZNF280D.
ExpressionAtlasiQ6N043. baseline and differential.
GenevisibleiQ6N043. HS.

Organism-specific databases

HPAiHPA030233.

Interactioni

Protein-protein interaction databases

BioGridi120173. 4 interactors.
IntActiQ6N043. 3 interactors.
MINTiMINT-4716449.
STRINGi9606.ENSP00000267807.

Structurei

3D structure databases

ProteinModelPortaliQ6N043.
SMRiQ6N043.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi20 – 27Poly-Glu8
Compositional biasi38 – 42Poly-Asp5

Sequence similaritiesi

Contains 5 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri321 – 343C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri358 – 381C2H2-type 2PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri388 – 412C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST25
Zinc fingeri418 – 441C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri449 – 469C2H2-type 5PROSITE-ProRule annotationAdd BLAST21

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000063300.
HOVERGENiHBG060885.
InParanoidiQ6N043.
OMAiKDFTNHF.
OrthoDBiEOG091G01UE.
PhylomeDBiQ6N043.
TreeFamiTF331707.

Family and domain databases

InterProiIPR025243. DUF4195.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
PfamiPF13836. DUF4195. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 9 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6N043-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGDNPFQPKS NSKMAELFME CEEEELEPWQ KKVKEVEDDD DDEPIFVGEI
60 70 80 90 100
SSSKPAISNI LNRVNPSSYS RGLKNGALSR GITAAFKPTS QHYTNPTSNP
110 120 130 140 150
VPASPINFHP ESRSSDSSVI VQPFSKPGYI TNSSRVVSNK SSELLFDLTQ
160 170 180 190 200
DTGLSHYQGG PTLSMAGMSE SSFLSKRPST SEVNNVNPKK PKPSESVSGA
210 220 230 240 250
NSSAVLPSVK SPSVTSSQAM LAKGTNTSSN QSKNGTPFPR ACPKCNIHFN
260 270 280 290 300
LLDPLKNHMK YCCPDMINNF LGLAKTEFSS TVNKNTTIDS EKGKLIMLVN
310 320 330 340 350
DFYYGKHEGD VQEEQKTHTT FKCFSCLKIL KNNIRFMNHM KHHLELEKQS
360 370 380 390 400
SESWENHTTC QHCYRQFPTP FQLQCHIEST HTPHEFSTIC KICELSFETE
410 420 430 440 450
HVLLQHMKDN HKPGEMPYVC QVCNYRSSSF SDVETHFRTS HENTKNLLCP
460 470 480 490 500
FCLKVIKIAT PYMHHYMKHQ KKGIHRCTKC RLQFLTCKEK MDHKTQHHRT
510 520 530 540 550
FIKPKQLEGL PPGTKVTIRA SVGPLQSGAS PTPSISASAS TLQLSPPRTK
560 570 580 590 600
NITAKNPAKS NTSKPNTVKS NASKPNTSKP NGSKSKYKPK ISNMQKKQST
610 620 630 640 650
LASSNKKSKV NTALRNLRYR RGIHKCIECC SEIKDFANHF PTYVHCSFCR
660 670 680 690 700
YNTSCSKAYV NHMMSFHSNR PSKRFCIFKK HSENLRGITL VCLNCDFLSD
710 720 730 740 750
VSGLDNMATH LSQHKTHTCQ VVMQKVSVCI PTSEHLSELK KEAPAKEQEP
760 770 780 790 800
VSKEIARPNM AERETETSNS ESKQDKAASS KEKNGCNANS FEGSSTTKSE
810 820 830 840 850
ESITVSDKEN ETCLADQETG SKNIVSCDSN IGADKVEKKK QIQHVCQEME
860 870 880 890 900
LKMCQSSENI ILSDQIKDHN SSEARFSSKN IKDLRLASDN VSIDQFLRKR
910 920 930 940 950
HEPESVSSDV SEQGSIHLEP LTPSEVLEYE ATEILQKGSG DPSAKTDEVV
960 970
SDQTDDIPGG NNPSTTEATV DLEDEKERS
Length:979
Mass (Da):109,285
Last modified:February 10, 2009 - v3
Checksum:i9B11A04F21298503
GO
Isoform 2 (identifier: Q6N043-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: Missing.

Show »
Length:966
Mass (Da):107,853
Checksum:iBD9D30A70160AD5D
GO
Isoform 3 (identifier: Q6N043-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     579-592: KPNGSKSKYKPKIS → IVGAFTNALSVVPK
     593-979: Missing.

Note: No experimental confirmation available.
Show »
Length:592
Mass (Da):65,943
Checksum:i72225464735559EE
GO
Isoform 4 (identifier: Q6N043-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-296: Missing.
     687-717: GITLVCLNCDFLSDVSGLDNMATHLSQHKTH → CVGGQIECDLPKLHKLVVEPRLTLGLLTPNF
     718-979: Missing.

Note: No experimental confirmation available.
Show »
Length:421
Mass (Da):48,513
Checksum:i88871CD7BBC6D00D
GO
Isoform 5 (identifier: Q6N043-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-759: Missing.

Note: No experimental confirmation available.
Show »
Length:220
Mass (Da):24,109
Checksum:i541C05BE7DD020D7
GO
Isoform 6 (identifier: Q6N043-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     128-158: GYITNSSRVVSNKSSELLFDLTQDTGLSHYQ → VSVSKTIRPAQGSIGCCLSISTVPSYNSGLS
     159-979: Missing.

Show »
Length:158
Mass (Da):17,134
Checksum:i19B2BFFFC789BA92
GO

Sequence cautioni

The sequence BAB13410 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAE46003 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti229S → P in CAE46003 (PubMed:17974005).Curated1
Sequence conflicti252L → W in CAE45785 (PubMed:17974005).Curated1
Sequence conflicti274A → T in CAE45785 (PubMed:17974005).Curated1
Sequence conflicti544L → P in BAA90940 (PubMed:14702039).Curated1
Sequence conflicti742E → R in CAE45827 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_054314568V → I.4 PublicationsCorresponds to variant rs28620278dbSNPEnsembl.1
Natural variantiVAR_054315778A → V.Corresponds to variant rs12900993dbSNPEnsembl.1
Natural variantiVAR_054316781K → I.Corresponds to variant rs12901843dbSNPEnsembl.1
Natural variantiVAR_054317785G → A.Corresponds to variant rs12900729dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0176221 – 759Missing in isoform 5. 1 PublicationAdd BLAST759
Alternative sequenceiVSP_0176231 – 296Missing in isoform 4. 1 PublicationAdd BLAST296
Alternative sequenceiVSP_0176241 – 13Missing in isoform 2. 2 PublicationsAdd BLAST13
Alternative sequenceiVSP_054317128 – 158GYITN…LSHYQ → VSVSKTIRPAQGSIGCCLSI STVPSYNSGLS in isoform 6. 1 PublicationAdd BLAST31
Alternative sequenceiVSP_054318159 – 979Missing in isoform 6. 1 PublicationAdd BLAST821
Alternative sequenceiVSP_017625579 – 592KPNGS…KPKIS → IVGAFTNALSVVPK in isoform 3. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_017626593 – 979Missing in isoform 3. 1 PublicationAdd BLAST387
Alternative sequenceiVSP_017627687 – 717GITLV…QHKTH → CVGGQIECDLPKLHKLVVEP RLTLGLLTPNF in isoform 4. 1 PublicationAdd BLAST31
Alternative sequenceiVSP_017628718 – 979Missing in isoform 4. 1 PublicationAdd BLAST262

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB046804 mRNA. Translation: BAB13410.1. Different initiation.
AK000093 mRNA. Translation: BAA90940.1.
AL136634 mRNA. Translation: CAB66569.1.
BX640637 mRNA. Translation: CAE45785.1.
BX640707 mRNA. Translation: CAE45827.1.
BX641000 mRNA. Translation: CAE46003.1. Different initiation.
AC010999 Genomic DNA. No translation available.
AC090517 Genomic DNA. No translation available.
AC090518 Genomic DNA. No translation available.
BC015382 mRNA. Translation: AAH15382.2.
BC053649 mRNA. Translation: AAH53649.2.
BC064359 mRNA. Translation: AAH64359.1.
BC130451 mRNA. Translation: AAI30452.1.
BC136412 mRNA. Translation: AAI36413.1.
CCDSiCCDS32245.1. [Q6N043-1]
CCDS42041.1. [Q6N043-2]
CCDS58364.1. [Q6N043-6]
RefSeqiNP_001002843.1. NM_001002843.2. [Q6N043-2]
NP_001002844.1. NM_001002844.2. [Q6N043-6]
NP_001275517.1. NM_001288588.1. [Q6N043-1]
NP_001275518.1. NM_001288589.1. [Q6N043-6]
NP_060131.2. NM_017661.3. [Q6N043-1]
XP_011520004.1. XM_011521702.1. [Q6N043-1]
XP_016877833.1. XM_017022344.1. [Q6N043-1]
XP_016877834.1. XM_017022345.1. [Q6N043-1]
UniGeneiHs.511477.

Genome annotation databases

EnsembliENST00000267807; ENSP00000267807; ENSG00000137871. [Q6N043-1]
ENST00000558067; ENSP00000454173; ENSG00000137871. [Q6N043-4]
ENST00000558320; ENSP00000453706; ENSG00000137871. [Q6N043-6]
ENST00000559237; ENSP00000454111; ENSG00000137871. [Q6N043-2]
ENST00000560002; ENSP00000453636; ENSG00000137871. [Q6N043-3]
GeneIDi54816.
KEGGihsa:54816.
UCSCiuc002adu.5. human. [Q6N043-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB046804 mRNA. Translation: BAB13410.1. Different initiation.
AK000093 mRNA. Translation: BAA90940.1.
AL136634 mRNA. Translation: CAB66569.1.
BX640637 mRNA. Translation: CAE45785.1.
BX640707 mRNA. Translation: CAE45827.1.
BX641000 mRNA. Translation: CAE46003.1. Different initiation.
AC010999 Genomic DNA. No translation available.
AC090517 Genomic DNA. No translation available.
AC090518 Genomic DNA. No translation available.
BC015382 mRNA. Translation: AAH15382.2.
BC053649 mRNA. Translation: AAH53649.2.
BC064359 mRNA. Translation: AAH64359.1.
BC130451 mRNA. Translation: AAI30452.1.
BC136412 mRNA. Translation: AAI36413.1.
CCDSiCCDS32245.1. [Q6N043-1]
CCDS42041.1. [Q6N043-2]
CCDS58364.1. [Q6N043-6]
RefSeqiNP_001002843.1. NM_001002843.2. [Q6N043-2]
NP_001002844.1. NM_001002844.2. [Q6N043-6]
NP_001275517.1. NM_001288588.1. [Q6N043-1]
NP_001275518.1. NM_001288589.1. [Q6N043-6]
NP_060131.2. NM_017661.3. [Q6N043-1]
XP_011520004.1. XM_011521702.1. [Q6N043-1]
XP_016877833.1. XM_017022344.1. [Q6N043-1]
XP_016877834.1. XM_017022345.1. [Q6N043-1]
UniGeneiHs.511477.

3D structure databases

ProteinModelPortaliQ6N043.
SMRiQ6N043.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120173. 4 interactors.
IntActiQ6N043. 3 interactors.
MINTiMINT-4716449.
STRINGi9606.ENSP00000267807.

PTM databases

iPTMnetiQ6N043.
PhosphoSitePlusiQ6N043.

Polymorphism and mutation databases

BioMutaiZNF280D.
DMDMi223634726.

Proteomic databases

EPDiQ6N043.
MaxQBiQ6N043.
PaxDbiQ6N043.
PeptideAtlasiQ6N043.
PRIDEiQ6N043.

Protocols and materials databases

DNASUi54816.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000267807; ENSP00000267807; ENSG00000137871. [Q6N043-1]
ENST00000558067; ENSP00000454173; ENSG00000137871. [Q6N043-4]
ENST00000558320; ENSP00000453706; ENSG00000137871. [Q6N043-6]
ENST00000559237; ENSP00000454111; ENSG00000137871. [Q6N043-2]
ENST00000560002; ENSP00000453636; ENSG00000137871. [Q6N043-3]
GeneIDi54816.
KEGGihsa:54816.
UCSCiuc002adu.5. human. [Q6N043-1]

Organism-specific databases

CTDi54816.
GeneCardsiZNF280D.
HGNCiHGNC:25953. ZNF280D.
HPAiHPA030233.
neXtProtiNX_Q6N043.
OpenTargetsiENSG00000137871.
PharmGKBiPA162410004.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000063300.
HOVERGENiHBG060885.
InParanoidiQ6N043.
OMAiKDFTNHF.
OrthoDBiEOG091G01UE.
PhylomeDBiQ6N043.
TreeFamiTF331707.

Miscellaneous databases

ChiTaRSiZNF280D. human.
GeneWikiiSUHW4.
GenomeRNAii54816.
PROiQ6N043.

Gene expression databases

BgeeiENSG00000137871.
CleanExiHS_ZNF280D.
ExpressionAtlasiQ6N043. baseline and differential.
GenevisibleiQ6N043. HS.

Family and domain databases

InterProiIPR025243. DUF4195.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
PfamiPF13836. DUF4195. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 9 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZ280D_HUMAN
AccessioniPrimary (citable) accession number: Q6N043
Secondary accession number(s): A1L495
, B2RMT6, Q6MZM6, Q6N085, Q6P2R6, Q7Z6J5, Q9H0U5, Q9HCI8, Q9NXS0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: February 10, 2009
Last modified: November 30, 2016
This is version 123 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.