ID   Q6N030_HUMAN            Unreviewed;       518 AA.
AC   Q6N030;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   27-MAR-2024, entry version 114.
DE   RecName: Full=Ig-like domain-containing protein {ECO:0000259|PROSITE:PS50835};
GN   Name=DKFZp686I15212 {ECO:0000313|EMBL:CAE45841.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:CAE45841.1};
RN   [1] {ECO:0000313|EMBL:CAE45841.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Rectum tumor {ECO:0000313|EMBL:CAE45841.1};
RG   The German cDNA Consortium;
RA   Bahr A., Lauber J., Mewes H.W., Weil B., Amid C., Osanger A., Fobo G.,
RA   Han M., Wiemann S.;
RL   Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0007829|PDB:2NY1, ECO:0007829|PDB:2NY3}
RP   X-RAY CRYSTALLOGRAPHY (1.99 ANGSTROMS) OF 21-240, AND DISULFIDE BONDS.
RX   PubMed=17301785; DOI=10.1038/nature05580;
RA   Zhou T., Xu L., Dey B., Hessell A.J., Van Ryk D., Xiang S.H., Yang X.,
RA   Zhang M.Y., Zwick M.B., Arthos J., Burton D.R., Dimitrov D.S., Sodroski J.,
RA   Wyatt R., Nabel G.J., Kwong P.D.;
RT   "Structural definition of a conserved neutralization epitope on HIV-1
RT   gp120.";
RL   Nature 445:732-737(2007).
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DR   EMBL; BX640724; CAE45841.1; -; mRNA.
DR   PDB; 2NY1; X-ray; 1.99 A; D=20-242.
DR   PDB; 2NY3; X-ray; 2.00 A; D=20-242.
DR   PDB; 2NY6; X-ray; 2.80 A; D=20-242.
DR   PDBsum; 2NY1; -.
DR   PDBsum; 2NY3; -.
DR   PDBsum; 2NY6; -.
DR   AlphaFoldDB; Q6N030; -.
DR   SMR; Q6N030; -.
DR   IntAct; Q6N030; 1.
DR   EvolutionaryTrace; Q6N030; -.
DR   GO; GO:0019814; C:immunoglobulin complex; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   CDD; cd21817; IgC1_CH1_IgEG; 1.
DR   CDD; cd05768; IgC1_CH3_IgAGD_CH4_IgAEM; 1.
DR   CDD; cd04981; IgV_H; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 4.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003006; Ig/MHC_CS.
DR   InterPro; IPR003597; Ig_C1-set.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR013106; Ig_V-set.
DR   PANTHER; PTHR23411:SF39; IMMUNOGLOBULIN HEAVY CONSTANT GAMMA 1-RELATED; 1.
DR   PANTHER; PTHR23411; TAPASIN; 1.
DR   Pfam; PF07654; C1-set; 3.
DR   Pfam; PF07686; V-set; 1.
DR   SMART; SM00409; IG; 3.
DR   SMART; SM00407; IGc1; 3.
DR   SMART; SM00406; IGv; 1.
DR   SUPFAM; SSF48726; Immunoglobulin; 4.
DR   PROSITE; PS50835; IG_LIKE; 4.
DR   PROSITE; PS00290; IG_MHC; 2.
PE   1: Evidence at protein level;
KW   3D-structure {ECO:0007829|PDB:2NY1, ECO:0007829|PDB:2NY3};
KW   Adaptive immunity {ECO:0000256|ARBA:ARBA00023130};
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Immunity {ECO:0000256|ARBA:ARBA00043265};
KW   Immunoglobulin {ECO:0000256|ARBA:ARBA00043265};
KW   Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW   Membrane {ECO:0000256|ARBA:ARBA00022475}; Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           20..518
FT                   /note="Ig-like domain-containing protein"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5004278081"
FT   DOMAIN          19..115
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          147..240
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          309..408
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          417..513
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DISULFID        41..115
FT                   /evidence="ECO:0007829|PDB:2NY1, ECO:0007829|PDB:2NY3"
FT   DISULFID        168..224
FT                   /evidence="ECO:0007829|PDB:2NY1, ECO:0007829|PDB:2NY3"
SQ   SEQUENCE   518 AA;  57020 MW;  93B5F98613BF6382 CRC64;
     MDWTWRILFL VTAATGAHSQ VHLVQSGAEV KKPGASVKVS CTASGYPFTN HFINWVRQAP
     GQSLEWMGWI NTGNGNTKYS QKFQGRVTIT RDTWTTTAYM DLSSLRSEDT AVYWCARDAP
     QGVTTTYFDY WGQGTLVTVS SASTKGPSVF PLAPCSRSTS GGTAALGCLV KDYFPEPVTV
     SWNSGALTSG VHTFPAVLQS SGLYSLSSVV TVPSSSLGTQ TYTCNVNHKP SNTKVDKRVE
     LKTPLGDTTH TCPRCPEPKP CDTPPPCPRC PEPKSCDTPP PCPRCPEPKS CDTPPPCPRC
     PAPELLGGPS VFLFPPKPKD TLMISRTPEV TCVVVDVSHE DPEVQFKWYV DGVEVHNAKT
     KPREEQYNST FRVVSVLTVL HQDWLNGKEY KCKVSNKALP APIEKTISKT KGQPREPQVY
     TLPPSREEMT KNQVSLTCLV KGFYPSDIAV EWESSGQPEN NYNTTPPMLD SDGSFFLYSK
     LTVDKSRWQQ GNIFSCSVMH EALHNRFTQK SLSLSPGK
//