Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Teneurin-4

Gene

TENM4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Plays a role in the establishment of the anterior-posterior axis during gastrulation. Regulates the differentiation and cellular process formation of oligodendrocytes and myelination of small-diameter axons in the central nervous system (CNS) (PubMed:26188006). Promotes activation of focal adhesion kinase. May function as a cellular signal transducer (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation

Names & Taxonomyi

Protein namesi
Recommended name:
Teneurin-4
Short name:
Ten-4
Alternative name(s):
Protein Odd Oz/ten-m homolog 4
Tenascin-M4
Short name:
Ten-m4
Teneurin transmembrane protein 4
Gene namesi
Name:TENM4
Synonyms:KIAA1302, ODZ4, TNM4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:29945. TENM4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 345CytoplasmicSequence analysisAdd BLAST345
Transmembranei346 – 366HelicalSequence analysisAdd BLAST21
Topological domaini367 – 2769ExtracellularSequence analysisAdd BLAST2403

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • integral component of plasma membrane Source: GO_Central
  • neuron projection Source: UniProtKB
  • nucleus Source: UniProtKB
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Involvement in diseasei

Tremor, hereditary essential 5 (ETM5)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA common movement disorder mainly characterized by postural tremor of the arms. Head, legs, trunk, voice, jaw, and facial muscles also may be involved. The condition can be aggravated by emotions, hunger, fatigue and temperature extremes, and may cause a functional disability or even incapacitation. Inheritance is autosomal dominant.
See also OMIM:616736
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07665453R → P in ETM5; unknown pathological significance. 1 PublicationCorresponds to variant rs760852624dbSNPEnsembl.1
Natural variantiVAR_076655474A → D in ETM5; unknown pathological significance. 1 Publication1
Natural variantiVAR_076656518R → Q in ETM5; unknown pathological significance. 1 PublicationCorresponds to variant rs201191369dbSNPEnsembl.1
Natural variantiVAR_0766571128V → M in ETM5; unknown pathological significance. 1 Publication1
Natural variantiVAR_0765211138V → M in ETM5; dominant negative effect on central nervous myelination and axon guidance; changed localization to the plasma membrane; clustered plasma membrane localization. 1 PublicationCorresponds to variant rs538881762dbSNPEnsembl.1
Natural variantiVAR_0765221367T → N in ETM5; dominant negative effect on central nervous myelination and axon guidance; changed localization to the plasma membrane; clustered plasma membrane localization. 1 Publication1
Natural variantiVAR_0765231442A → T in ETM5; dominant negative effect on central nervous myelination and axon guidance; changed localization to the plasma membrane; clustered plasma membrane localization. 1 PublicationCorresponds to variant rs375681722dbSNPEnsembl.1
Natural variantiVAR_0766581535K → Q in ETM5; unknown pathological significance. 1 PublicationCorresponds to variant rs770111861dbSNPEnsembl.1
Natural variantiVAR_0766591632R → H in ETM5; unknown pathological significance. 1 PublicationCorresponds to variant rs199687168dbSNPEnsembl.1
Natural variantiVAR_0766601763G → R in ETM5; unknown pathological significance. 1 PublicationCorresponds to variant rs201995608dbSNPEnsembl.1
Natural variantiVAR_0766612451M → I in ETM5; unknown pathological significance. 1 PublicationCorresponds to variant rs201769315dbSNPEnsembl.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi26011.
MIMi616736. phenotype.
OpenTargetsiENSG00000149256.
PharmGKBiPA134896466.

Polymorphism and mutation databases

BioMutaiTENM4.
DMDMi117949795.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002595081 – 2769Teneurin-4Add BLAST2769

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei124PhosphoserineBy similarity1
Modified residuei178PhosphothreonineBy similarity1
Glycosylationi467N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi566 ↔ 576PROSITE-ProRule annotation
Disulfide bondi570 ↔ 581PROSITE-ProRule annotation
Disulfide bondi583 ↔ 592PROSITE-ProRule annotation
Disulfide bondi601 ↔ 612PROSITE-ProRule annotation
Disulfide bondi614 ↔ 623PROSITE-ProRule annotation
Disulfide bondi630 ↔ 641PROSITE-ProRule annotation
Disulfide bondi635 ↔ 646PROSITE-ProRule annotation
Disulfide bondi648 ↔ 657PROSITE-ProRule annotation
Disulfide bondi662 ↔ 673PROSITE-ProRule annotation
Disulfide bondi667 ↔ 678PROSITE-ProRule annotation
Disulfide bondi680 ↔ 689PROSITE-ProRule annotation
Disulfide bondi700 ↔ 713PROSITE-ProRule annotation
Disulfide bondi715 ↔ 724PROSITE-ProRule annotation
Disulfide bondi729 ↔ 739PROSITE-ProRule annotation
Disulfide bondi733 ↔ 744PROSITE-ProRule annotation
Disulfide bondi746 ↔ 755PROSITE-ProRule annotation
Disulfide bondi760 ↔ 770PROSITE-ProRule annotation
Disulfide bondi764 ↔ 775PROSITE-ProRule annotation
Disulfide bondi777 ↔ 786PROSITE-ProRule annotation
Disulfide bondi800 ↔ 810PROSITE-ProRule annotation
Disulfide bondi804 ↔ 819PROSITE-ProRule annotation
Disulfide bondi821 ↔ 830PROSITE-ProRule annotation
Glycosylationi940N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1259N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1609N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1705N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1741N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1799N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1884N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1985N-linked (GlcNAc...)Sequence analysis1
Glycosylationi2188N-linked (GlcNAc...)Sequence analysis1
Glycosylationi2328N-linked (GlcNAc...)Sequence analysis1
Glycosylationi2646N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ6N022.
MaxQBiQ6N022.
PaxDbiQ6N022.
PeptideAtlasiQ6N022.
PRIDEiQ6N022.

PTM databases

iPTMnetiQ6N022.
PhosphoSitePlusiQ6N022.

Expressioni

Gene expression databases

BgeeiENSG00000149256.
CleanExiHS_ODZ4.
ExpressionAtlasiQ6N022. baseline and differential.
GenevisibleiQ6N022. HS.

Interactioni

Subunit structurei

Homodimer; disulfide-linked (Probable). May also form heterodimer with either TENM1 or TENM2 or TENM3 (By similarity).By similarityCurated

GO - Molecular functioni

Protein-protein interaction databases

BioGridi117484. 1 interactor.
STRINGi9606.ENSP00000278550.

Structurei

3D structure databases

ProteinModelPortaliQ6N022.
SMRiQ6N022.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 341Teneurin N-terminalPROSITE-ProRule annotationAdd BLAST341
Domaini562 – 593EGF-like 1PROSITE-ProRule annotationAdd BLAST32
Domaini594 – 624EGF-like 2PROSITE-ProRule annotationAdd BLAST31
Domaini626 – 658EGF-like 3PROSITE-ProRule annotationAdd BLAST33
Domaini659 – 690EGF-like 4PROSITE-ProRule annotationAdd BLAST32
Domaini692 – 725EGF-like 5PROSITE-ProRule annotationAdd BLAST34
Domaini726 – 757EGF-like 6PROSITE-ProRule annotationAdd BLAST32
Domaini758 – 787EGF-like 7PROSITE-ProRule annotationAdd BLAST30
Domaini788 – 831EGF-like 8PROSITE-ProRule annotationAdd BLAST44
Repeati1216 – 1259NHL 1Add BLAST44
Repeati1264 – 1308NHL 2Add BLAST45
Repeati1334 – 1378NHL 3Add BLAST45
Repeati1393 – 1444NHL 4Add BLAST52
Repeati1523 – 1566NHL 5Add BLAST44
Repeati1576 – 1595YD 1Add BLAST20
Repeati1612 – 1632YD 2Add BLAST21
Repeati1675 – 1694YD 3Add BLAST20
Repeati1695 – 1717YD 4Add BLAST23
Repeati1887 – 1906YD 5Add BLAST20
Repeati1928 – 1946YD 6Add BLAST19
Repeati1947 – 1967YD 7Add BLAST21
Repeati1974 – 1991YD 8Add BLAST18
Repeati1992 – 2013YD 9Add BLAST22
Repeati2014 – 2031YD 10Add BLAST18
Repeati2034 – 2054YD 11Add BLAST21
Repeati2057 – 2077YD 12Add BLAST21
Repeati2085 – 2104YD 13Add BLAST20
Repeati2110 – 2127YD 14Add BLAST18
Repeati2128 – 2154YD 15Add BLAST27
Repeati2156 – 2169YD 16Add BLAST14
Repeati2170 – 2193YD 17Add BLAST24
Repeati2196 – 2216YD 18Add BLAST21
Repeati2217 – 2237YD 19Add BLAST21
Repeati2239 – 2259YD 20Add BLAST21
Repeati2271 – 2291YD 21Add BLAST21
Repeati2293 – 2313YD 22Add BLAST21
Repeati2339 – 2380YD 23Add BLAST42

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi179 – 182Poly-Pro4

Domaini

EGF-like domains 2 and 5 which have an odd number of cysteines might enable the formation of intermolecular disulfide bonds.
Cytoplasmic proline-rich regions could serve as docking domains for intracellular SH3-containing proteins.

Sequence similaritiesi

Belongs to the tenascin family. Teneurin subfamily.Curated
Contains 8 EGF-like domains.PROSITE-ProRule annotation
Contains 5 NHL repeats.Curated
Contains 1 teneurin N-terminal domain.PROSITE-ProRule annotation
Contains 23 YD repeats.Curated

Keywords - Domaini

EGF-like domain, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IT6V. Eukaryota.
ENOG410Z5H4. LUCA.
GeneTreeiENSGT00760000119131.
HOGENOMiHOG000231701.
HOVERGENiHBG080306.
InParanoidiQ6N022.
OMAiYEVSSPI.
OrthoDBiEOG091G02H3.
PhylomeDBiQ6N022.
TreeFamiTF316833.

Family and domain databases

Gene3Di2.120.10.30. 1 hit.
InterProiIPR011042. 6-blade_b-propeller_TolB-like.
IPR008969. CarboxyPept-like_regulatory.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR013111. EGF_extracell.
IPR022385. Rhs_assc_core.
IPR027691. Ten-4.
IPR009471. Ten_N.
IPR028916. Tox-GHH_dom.
IPR006530. YD.
[Graphical view]
PANTHERiPTHR11219:SF9. PTHR11219:SF9. 2 hits.
PfamiPF07974. EGF_2. 2 hits.
PF06484. Ten_N. 2 hits.
PF15636. Tox-GHH. 1 hit.
[Graphical view]
SMARTiSM00181. EGF. 8 hits.
[Graphical view]
SUPFAMiSSF49464. SSF49464. 1 hit.
TIGRFAMsiTIGR03696. Rhs_assc_core. 1 hit.
TIGR01643. YD_repeat_2x. 2 hits.
PROSITEiPS00022. EGF_1. 8 hits.
PS01186. EGF_2. 7 hits.
PS50026. EGF_3. 5 hits.
PS51361. TENEURIN_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6N022-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVKERKPYR SLTRRRDAER RYTSSSADSE EGKAPQKSYS SSETLKAYDQ
60 70 80 90 100
DARLAYGSRV KDIVPQEAEE FCRTGANFTL RELGLEEVTP PHGTLYRTDI
110 120 130 140 150
GLPHCGYSMG AGSDADMEAD TVLSPEHPVR LWGRSTRSGR SSCLSSRANS
160 170 180 190 200
NLTLTDTEHE NTETDHPGGL QNHARLRTPP PPLSHAHTPN QHHAASINSL
210 220 230 240 250
NRGNFTPRSN PSPAPTDHSL SGEPPAGGAQ EPAHAQENWL LNSNIPLETR
260 270 280 290 300
NLGKQPFLGT LQDNLIEMDI LGASRHDGAY SDGHFLFKPG GTSPLFCTTS
310 320 330 340 350
PGYPLTSSTV YSPPPRPLPR STFARPAFNL KKPSKYCNWK CAALSAIVIS
360 370 380 390 400
ATLVILLAYF VAMHLFGLNW HLQPMEGQMY EITEDTASSW PVPTDVSLYP
410 420 430 440 450
SGGTGLETPD RKGKGTTEGK PSSFFPEDSF IDSGEIDVGR RASQKIPPGT
460 470 480 490 500
FWRSQVFIDH PVHLKFNVSL GKAALVGIYG RKGLPPSHTQ FDFVELLDGR
510 520 530 540 550
RLLTQEARSL EGTPRQSRGT VPPSSHETGF IQYLDSGIWH LAFYNDGKES
560 570 580 590 600
EVVSFLTTAI ESVDNCPSNC YGNGDCISGT CHCFLGFLGP DCGRASCPVL
610 620 630 640 650
CSGNGQYMKG RCLCHSGWKG AECDVPTNQC IDVACSNHGT CITGTCICNP
660 670 680 690 700
GYKGESCEEV DCMDPTCSGR GVCVRGECHC SVGWGGTNCE TPRATCLDQC
710 720 730 740 750
SGHGTFLPDT GLCSCDPSWT GHDCSIEICA ADCGGHGVCV GGTCRCEDGW
760 770 780 790 800
MGAACDQRAC HPRCAEHGTC RDGKCECSPG WNGEHCTIAH YLDRVVKEGC
810 820 830 840 850
PGLCNGNGRC TLDLNGWHCV CQLGWRGAGC DTSMETACGD SKDNDGDGLV
860 870 880 890 900
DCMDPDCCLQ PLCHINPLCL GSPNPLDIIQ ETQVPVSQQN LHSFYDRIKF
910 920 930 940 950
LVGRDSTHII PGENPFDGGH ACVIRGQVMT SDGTPLVGVN ISFVNNPLFG
960 970 980 990 1000
YTISRQDGSF DLVTNGGISI ILRFERAPFI TQEHTLWLPW DRFFVMETII
1010 1020 1030 1040 1050
MRHEENEIPS CDLSNFARPN PVVSPSPLTS FASSCAEKGP IVPEIQALQE
1060 1070 1080 1090 1100
EISISGCKMR LSYLSSRTPG YKSVLRISLT HPTIPFNLMK VHLMVAVEGR
1110 1120 1130 1140 1150
LFRKWFAAAP DLSYYFIWDK TDVYNQKVFG LSEAFVSVGY EYESCPDLIL
1160 1170 1180 1190 1200
WEKRTTVLQG YEIDASKLGG WSLDKHHALN IQSGILHKGN GENQFVSQQP
1210 1220 1230 1240 1250
PVIGSIMGNG RRRSISCPSC NGLADGNKLL APVALTCGSD GSLYVGDFNY
1260 1270 1280 1290 1300
IRRIFPSGNV TNILELRNKD FRHSHSPAHK YYLATDPMSG AVFLSDSNSR
1310 1320 1330 1340 1350
RVFKIKSTVV VKDLVKNSEV VAGTGDQCLP FDDTRCGDGG KATEATLTNP
1360 1370 1380 1390 1400
RGITVDKFGL IYFVDGTMIR RIDQNGIIST LLGSNDLTSA RPLSCDSVMD
1410 1420 1430 1440 1450
ISQVHLEWPT DLAINPMDNS LYVLDNNVVL QISENHQVRI VAGRPMHCQV
1460 1470 1480 1490 1500
PGIDHFLLSK VAIHATLESA TALAVSHNGV LYIAETDEKK INRIRQVTTS
1510 1520 1530 1540 1550
GEISLVAGAP SGCDCKNDAN CDCFSGDDGY AKDAKLNTPS SLAVCADGEL
1560 1570 1580 1590 1600
YVADLGNIRI RFIRKNKPFL NTQNMYELSS PIDQELYLFD TTGKHLYTQS
1610 1620 1630 1640 1650
LPTGDYLYNF TYTGDGDITL ITDNNGNMVN VRRDSTGMPL WLVVPDGQVY
1660 1670 1680 1690 1700
WVTMGTNSAL KSVTTQGHEL AMMTYHGNSG LLATKSNENG WTTFYEYDSF
1710 1720 1730 1740 1750
GRLTNVTFPT GQVSSFRSDT DSSVHVQVET SSKDDVTITT NLSASGAFYT
1760 1770 1780 1790 1800
LLQDQVRNSY YIGADGSLRL LLANGMEVAL QTEPHLLAGT VNPTVGKRNV
1810 1820 1830 1840 1850
TLPIDNGLNL VEWRQRKEQA RGQVTVFGRR LRVHNRNLLS LDFDRVTRTE
1860 1870 1880 1890 1900
KIYDDHRKFT LRILYDQAGR PSLWSPSSRL NGVNVTYSPG GYIAGIQRGI
1910 1920 1930 1940 1950
MSERMEYDQA GRITSRIFAD GKTWSYTYLE KSMVLLLHSQ RQYIFEFDKN
1960 1970 1980 1990 2000
DRLSSVTMPN VARQTLETIR SVGYYRNIYQ PPEGNASVIQ DFTEDGHLLH
2010 2020 2030 2040 2050
TFYLGTGRRV IYKYGKLSKL AETLYDTTKV SFTYDETAGM LKTINLQNEG
2060 2070 2080 2090 2100
FTCTIRYRQI GPLIDRQIFR FTEEGMVNAR FDYNYDNSFR VTSMQAVINE
2110 2120 2130 2140 2150
TPLPIDLYRY DDVSGKTEQF GKFGVIYYDI NQIITTAVMT HTKHFDAYGR
2160 2170 2180 2190 2200
MKEVQYEIFR SLMYWMTVQY DNMGRVVKKE LKVGPYANTT RYSYEYDADG
2210 2220 2230 2240 2250
QLQTVSINDK PLWRYSYDLN GNLHLLSPGN SARLTPLRYD IRDRITRLGD
2260 2270 2280 2290 2300
VQYKMDEDGF LRQRGGDIFE YNSAGLLIKA YNRAGSWSVR YRYDGLGRRV
2310 2320 2330 2340 2350
SSKSSHSHHL QFFYADLTNP TKVTHLYNHS SSEITSLYYD LQGHLFAMEL
2360 2370 2380 2390 2400
SSGDEFYIAC DNIGTPLAVF SGTGLMIKQI LYTAYGEIYM DTNPNFQIII
2410 2420 2430 2440 2450
GYHGGLYDPL TKLVHMGRRD YDVLAGRWTS PDHELWKHLS SSNVMPFNLY
2460 2470 2480 2490 2500
MFKNNNPISN SQDIKCFMTD VNSWLLTFGF QLHNVIPGYP KPDMDAMEPS
2510 2520 2530 2540 2550
YELIHTQMKT QEWDNSKSIL GVQCEVQKQL KAFVTLERFD QLYGSTITSC
2560 2570 2580 2590 2600
QQAPKTKKFA SSGSVFGKGV KFALKDGRVT TDIISVANED GRRVAAILNH
2610 2620 2630 2640 2650
AHYLENLHFT IDGVDTHYFV KPGPSEGDLA ILGLSGGRRT LENGVNVTVS
2660 2670 2680 2690 2700
QINTVLNGRT RRYTDIQLQY GALCLNTRYG TTLDEEKARV LELARQRAVR
2710 2720 2730 2740 2750
QAWAREQQRL REGEEGLRAW TEGEKQQVLS TGRVQGYDGF FVISVEQYPE
2760
LSDSANNIHF MRQSEMGRR
Length:2,769
Mass (Da):307,957
Last modified:October 31, 2006 - v2
Checksum:i280D87D43FBE88A1
GO

Sequence cautioni

The sequence BAB71206 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1471T → I in CAE45850 (PubMed:17974005).Curated1
Sequence conflicti1842D → G in CAD97943 (PubMed:17974005).Curated1
Sequence conflicti2024L → F in CAD97943 (PubMed:17974005).Curated1
Sequence conflicti2393N → D in CAE45850 (PubMed:17974005).Curated1
Sequence conflicti2551Q → L in BAB71206 (PubMed:14702039).Curated1
Sequence conflicti2586V → G in CAB45719 (PubMed:17974005).Curated1
Sequence conflicti2599N → D in CAB45719 (PubMed:17974005).Curated1
Sequence conflicti2657N → S in BAB71206 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06216714R → Q.Corresponds to variant rs58537389dbSNPEnsembl.1
Natural variantiVAR_07665453R → P in ETM5; unknown pathological significance. 1 PublicationCorresponds to variant rs760852624dbSNPEnsembl.1
Natural variantiVAR_060130396V → I.Corresponds to variant rs3812723dbSNPEnsembl.1
Natural variantiVAR_076655474A → D in ETM5; unknown pathological significance. 1 Publication1
Natural variantiVAR_060131506E → Q.Corresponds to variant rs17137261dbSNPEnsembl.1
Natural variantiVAR_076656518R → Q in ETM5; unknown pathological significance. 1 PublicationCorresponds to variant rs201191369dbSNPEnsembl.1
Natural variantiVAR_0766571128V → M in ETM5; unknown pathological significance. 1 Publication1
Natural variantiVAR_0765211138V → M in ETM5; dominant negative effect on central nervous myelination and axon guidance; changed localization to the plasma membrane; clustered plasma membrane localization. 1 PublicationCorresponds to variant rs538881762dbSNPEnsembl.1
Natural variantiVAR_0765221367T → N in ETM5; dominant negative effect on central nervous myelination and axon guidance; changed localization to the plasma membrane; clustered plasma membrane localization. 1 Publication1
Natural variantiVAR_0765231442A → T in ETM5; dominant negative effect on central nervous myelination and axon guidance; changed localization to the plasma membrane; clustered plasma membrane localization. 1 PublicationCorresponds to variant rs375681722dbSNPEnsembl.1
Natural variantiVAR_0766581535K → Q in ETM5; unknown pathological significance. 1 PublicationCorresponds to variant rs770111861dbSNPEnsembl.1
Natural variantiVAR_0766591632R → H in ETM5; unknown pathological significance. 1 PublicationCorresponds to variant rs199687168dbSNPEnsembl.1
Natural variantiVAR_0766601763G → R in ETM5; unknown pathological significance. 1 PublicationCorresponds to variant rs201995608dbSNPEnsembl.1
Natural variantiVAR_0766612451M → I in ETM5; unknown pathological significance. 1 PublicationCorresponds to variant rs201769315dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP002515 Genomic DNA. No translation available.
AP002768 Genomic DNA. No translation available.
AP002958 Genomic DNA. No translation available.
AP002957 Genomic DNA. No translation available.
AB037723 mRNA. Translation: BAA92540.3.
BX640737 mRNA. Translation: CAE45850.1.
AL080120 mRNA. Translation: CAB45719.1.
BX537983 mRNA. Translation: CAD97943.1.
AK056531 mRNA. Translation: BAB71206.1. Different initiation.
CCDSiCCDS44688.1.
PIRiT12457.
RefSeqiNP_001092286.2. NM_001098816.2.
XP_016873015.1. XM_017017526.1.
UniGeneiHs.213087.

Genome annotation databases

EnsembliENST00000278550; ENSP00000278550; ENSG00000149256.
GeneIDi26011.
KEGGihsa:26011.
UCSCiuc001ozl.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP002515 Genomic DNA. No translation available.
AP002768 Genomic DNA. No translation available.
AP002958 Genomic DNA. No translation available.
AP002957 Genomic DNA. No translation available.
AB037723 mRNA. Translation: BAA92540.3.
BX640737 mRNA. Translation: CAE45850.1.
AL080120 mRNA. Translation: CAB45719.1.
BX537983 mRNA. Translation: CAD97943.1.
AK056531 mRNA. Translation: BAB71206.1. Different initiation.
CCDSiCCDS44688.1.
PIRiT12457.
RefSeqiNP_001092286.2. NM_001098816.2.
XP_016873015.1. XM_017017526.1.
UniGeneiHs.213087.

3D structure databases

ProteinModelPortaliQ6N022.
SMRiQ6N022.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117484. 1 interactor.
STRINGi9606.ENSP00000278550.

PTM databases

iPTMnetiQ6N022.
PhosphoSitePlusiQ6N022.

Polymorphism and mutation databases

BioMutaiTENM4.
DMDMi117949795.

Proteomic databases

EPDiQ6N022.
MaxQBiQ6N022.
PaxDbiQ6N022.
PeptideAtlasiQ6N022.
PRIDEiQ6N022.

Protocols and materials databases

DNASUi26011.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000278550; ENSP00000278550; ENSG00000149256.
GeneIDi26011.
KEGGihsa:26011.
UCSCiuc001ozl.5. human.

Organism-specific databases

CTDi26011.
DisGeNETi26011.
GeneCardsiTENM4.
H-InvDBHIX0009980.
HGNCiHGNC:29945. TENM4.
MIMi610084. gene.
616736. phenotype.
neXtProtiNX_Q6N022.
OpenTargetsiENSG00000149256.
PharmGKBiPA134896466.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IT6V. Eukaryota.
ENOG410Z5H4. LUCA.
GeneTreeiENSGT00760000119131.
HOGENOMiHOG000231701.
HOVERGENiHBG080306.
InParanoidiQ6N022.
OMAiYEVSSPI.
OrthoDBiEOG091G02H3.
PhylomeDBiQ6N022.
TreeFamiTF316833.

Miscellaneous databases

ChiTaRSiTENM4. human.
GeneWikiiODZ4.
GenomeRNAii26011.
PROiQ6N022.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000149256.
CleanExiHS_ODZ4.
ExpressionAtlasiQ6N022. baseline and differential.
GenevisibleiQ6N022. HS.

Family and domain databases

Gene3Di2.120.10.30. 1 hit.
InterProiIPR011042. 6-blade_b-propeller_TolB-like.
IPR008969. CarboxyPept-like_regulatory.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR013111. EGF_extracell.
IPR022385. Rhs_assc_core.
IPR027691. Ten-4.
IPR009471. Ten_N.
IPR028916. Tox-GHH_dom.
IPR006530. YD.
[Graphical view]
PANTHERiPTHR11219:SF9. PTHR11219:SF9. 2 hits.
PfamiPF07974. EGF_2. 2 hits.
PF06484. Ten_N. 2 hits.
PF15636. Tox-GHH. 1 hit.
[Graphical view]
SMARTiSM00181. EGF. 8 hits.
[Graphical view]
SUPFAMiSSF49464. SSF49464. 1 hit.
TIGRFAMsiTIGR03696. Rhs_assc_core. 1 hit.
TIGR01643. YD_repeat_2x. 2 hits.
PROSITEiPS00022. EGF_1. 8 hits.
PS01186. EGF_2. 7 hits.
PS50026. EGF_3. 5 hits.
PS51361. TENEURIN_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTEN4_HUMAN
AccessioniPrimary (citable) accession number: Q6N022
Secondary accession number(s): A6ND26
, Q7Z3C7, Q96MS6, Q9P2P4, Q9Y4S2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 31, 2006
Last modified: November 2, 2016
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.