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Q6N022 (TEN4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Teneurin-4

Short name=Ten-4
Alternative name(s):
Protein Odd Oz/ten-m homolog 4
Tenascin-M4
Short name=Ten-m4
Teneurin transmembrane protein 4
Gene names
Name:TENM4
Synonyms:KIAA1302, ODZ4, TNM4
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length2769 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Plays a role in the establishment of the anterior-posterior axis during gastrulation. Regulates the differentiation and cellular process formation of oligodendrocytes and myelination of small-diameter axons in the central nervous system (CNS). Promotes activation of focal adhesion kinase. May function as a cellular signal transducer By similarity.

Subunit structure

Homodimer; disulfide-linked Probable. May also form heterodimer with either TENM1 or TENM2 or TENM3 By similarity.

Subcellular location

Membrane; Single-pass membrane protein Probable. Nucleus By similarity. Cytoplasm By similarity. Cell projection By similarity.

Domain

EGF-like domains 2 and 5 which have an odd number of cysteines might enable the formation of intermolecular disulfide bonds.

Cytoplasmic proline-rich regions could serve as docking domains for intracellular SH3-containing proteins.

Sequence similarities

Belongs to the tenascin family. Teneurin subfamily.

Contains 8 EGF-like domains.

Contains 5 NHL repeats.

Contains 1 teneurin N-terminal domain.

Contains 23 YD repeats.

Sequence caution

The sequence BAB71206.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
   Biological processDifferentiation
   Cellular componentCell projection
Cytoplasm
Membrane
Nucleus
   Coding sequence diversityPolymorphism
   DomainEGF-like domain
Repeat
Transmembrane
Transmembrane helix
   Molecular functionDevelopmental protein
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcardiac cell fate specification

Inferred from electronic annotation. Source: Ensembl

cardiac muscle cell proliferation

Inferred from electronic annotation. Source: Ensembl

central nervous system myelin formation

Inferred from sequence or structural similarity. Source: UniProtKB

gastrulation with mouth forming second

Inferred from electronic annotation. Source: Ensembl

neuron development

Inferred from electronic annotation. Source: InterPro

positive regulation of gastrulation

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of myelination

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of oligodendrocyte differentiation

Inferred from sequence or structural similarity. Source: UniProtKB

signal transduction

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from sequence or structural similarity. Source: UniProtKB

integral component of plasma membrane

Inferred from electronic annotation. Source: InterPro

neuron projection

Inferred from sequence or structural similarity. Source: UniProtKB

nucleus

Inferred from sequence or structural similarity. Source: UniProtKB

   Molecular_functionprotein homodimerization activity

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 27692769Teneurin-4
PRO_0000259508

Regions

Topological domain1 – 345345Cytoplasmic Potential
Transmembrane346 – 36621Helical; Potential
Topological domain367 – 27692403Extracellular Potential
Domain1 – 341341Teneurin N-terminal
Domain562 – 59332EGF-like 1
Domain594 – 62431EGF-like 2
Domain626 – 65833EGF-like 3
Domain659 – 69032EGF-like 4
Domain692 – 72534EGF-like 5
Domain726 – 75732EGF-like 6
Domain758 – 78730EGF-like 7
Domain788 – 83144EGF-like 8
Repeat1216 – 125944NHL 1
Repeat1264 – 130845NHL 2
Repeat1334 – 137845NHL 3
Repeat1393 – 144452NHL 4
Repeat1523 – 156644NHL 5
Repeat1576 – 159520YD 1
Repeat1612 – 163221YD 2
Repeat1675 – 169420YD 3
Repeat1695 – 171723YD 4
Repeat1887 – 190620YD 5
Repeat1928 – 194619YD 6
Repeat1947 – 196721YD 7
Repeat1974 – 199118YD 8
Repeat1992 – 201322YD 9
Repeat2014 – 203118YD 10
Repeat2034 – 205421YD 11
Repeat2057 – 207721YD 12
Repeat2085 – 210420YD 13
Repeat2110 – 212718YD 14
Repeat2128 – 215427YD 15
Repeat2156 – 216914YD 16
Repeat2170 – 219324YD 17
Repeat2196 – 221621YD 18
Repeat2217 – 223721YD 19
Repeat2239 – 225921YD 20
Repeat2271 – 229121YD 21
Repeat2293 – 231321YD 22
Repeat2339 – 238042YD 23
Compositional bias179 – 1824Poly-Pro

Amino acid modifications

Glycosylation4671N-linked (GlcNAc...) Potential
Glycosylation9401N-linked (GlcNAc...) Potential
Glycosylation12591N-linked (GlcNAc...) Potential
Glycosylation16091N-linked (GlcNAc...) Potential
Glycosylation17051N-linked (GlcNAc...) Potential
Glycosylation17411N-linked (GlcNAc...) Potential
Glycosylation17991N-linked (GlcNAc...) Potential
Glycosylation18841N-linked (GlcNAc...) Potential
Glycosylation19851N-linked (GlcNAc...) Potential
Glycosylation21881N-linked (GlcNAc...) Potential
Glycosylation23281N-linked (GlcNAc...) Potential
Glycosylation26461N-linked (GlcNAc...) Potential
Disulfide bond566 ↔ 576 By similarity
Disulfide bond570 ↔ 581 By similarity
Disulfide bond583 ↔ 592 By similarity
Disulfide bond601 ↔ 612 By similarity
Disulfide bond614 ↔ 623 By similarity
Disulfide bond630 ↔ 641 By similarity
Disulfide bond635 ↔ 646 By similarity
Disulfide bond648 ↔ 657 By similarity
Disulfide bond662 ↔ 673 By similarity
Disulfide bond667 ↔ 678 By similarity
Disulfide bond680 ↔ 689 By similarity
Disulfide bond700 ↔ 713 By similarity
Disulfide bond715 ↔ 724 By similarity
Disulfide bond729 ↔ 739 By similarity
Disulfide bond733 ↔ 744 By similarity
Disulfide bond746 ↔ 755 By similarity
Disulfide bond760 ↔ 770 By similarity
Disulfide bond764 ↔ 775 By similarity
Disulfide bond777 ↔ 786 By similarity
Disulfide bond800 ↔ 810 By similarity
Disulfide bond804 ↔ 819 By similarity
Disulfide bond821 ↔ 830 By similarity

Natural variations

Natural variant141R → Q.
Corresponds to variant rs58537389 [ dbSNP | Ensembl ].
VAR_062167
Natural variant3961V → I.
Corresponds to variant rs3812723 [ dbSNP | Ensembl ].
VAR_060130
Natural variant5061E → Q.
Corresponds to variant rs17137261 [ dbSNP | Ensembl ].
VAR_060131

Experimental info

Sequence conflict14711T → I in CAE45850. Ref.4
Sequence conflict18421D → G in CAD97943. Ref.4
Sequence conflict20241L → F in CAD97943. Ref.4
Sequence conflict23931N → D in CAE45850. Ref.4
Sequence conflict25511Q → L in BAB71206. Ref.5
Sequence conflict25861V → G in CAB45719. Ref.4
Sequence conflict25991N → D in CAB45719. Ref.4
Sequence conflict26571N → S in BAB71206. Ref.5

Sequences

Sequence LengthMass (Da)Tools
Q6N022 [UniParc].

Last modified October 31, 2006. Version 2.
Checksum: 280D87D43FBE88A1

FASTA2,769307,957
        10         20         30         40         50         60 
MDVKERKPYR SLTRRRDAER RYTSSSADSE EGKAPQKSYS SSETLKAYDQ DARLAYGSRV 

        70         80         90        100        110        120 
KDIVPQEAEE FCRTGANFTL RELGLEEVTP PHGTLYRTDI GLPHCGYSMG AGSDADMEAD 

       130        140        150        160        170        180 
TVLSPEHPVR LWGRSTRSGR SSCLSSRANS NLTLTDTEHE NTETDHPGGL QNHARLRTPP 

       190        200        210        220        230        240 
PPLSHAHTPN QHHAASINSL NRGNFTPRSN PSPAPTDHSL SGEPPAGGAQ EPAHAQENWL 

       250        260        270        280        290        300 
LNSNIPLETR NLGKQPFLGT LQDNLIEMDI LGASRHDGAY SDGHFLFKPG GTSPLFCTTS 

       310        320        330        340        350        360 
PGYPLTSSTV YSPPPRPLPR STFARPAFNL KKPSKYCNWK CAALSAIVIS ATLVILLAYF 

       370        380        390        400        410        420 
VAMHLFGLNW HLQPMEGQMY EITEDTASSW PVPTDVSLYP SGGTGLETPD RKGKGTTEGK 

       430        440        450        460        470        480 
PSSFFPEDSF IDSGEIDVGR RASQKIPPGT FWRSQVFIDH PVHLKFNVSL GKAALVGIYG 

       490        500        510        520        530        540 
RKGLPPSHTQ FDFVELLDGR RLLTQEARSL EGTPRQSRGT VPPSSHETGF IQYLDSGIWH 

       550        560        570        580        590        600 
LAFYNDGKES EVVSFLTTAI ESVDNCPSNC YGNGDCISGT CHCFLGFLGP DCGRASCPVL 

       610        620        630        640        650        660 
CSGNGQYMKG RCLCHSGWKG AECDVPTNQC IDVACSNHGT CITGTCICNP GYKGESCEEV 

       670        680        690        700        710        720 
DCMDPTCSGR GVCVRGECHC SVGWGGTNCE TPRATCLDQC SGHGTFLPDT GLCSCDPSWT 

       730        740        750        760        770        780 
GHDCSIEICA ADCGGHGVCV GGTCRCEDGW MGAACDQRAC HPRCAEHGTC RDGKCECSPG 

       790        800        810        820        830        840 
WNGEHCTIAH YLDRVVKEGC PGLCNGNGRC TLDLNGWHCV CQLGWRGAGC DTSMETACGD 

       850        860        870        880        890        900 
SKDNDGDGLV DCMDPDCCLQ PLCHINPLCL GSPNPLDIIQ ETQVPVSQQN LHSFYDRIKF 

       910        920        930        940        950        960 
LVGRDSTHII PGENPFDGGH ACVIRGQVMT SDGTPLVGVN ISFVNNPLFG YTISRQDGSF 

       970        980        990       1000       1010       1020 
DLVTNGGISI ILRFERAPFI TQEHTLWLPW DRFFVMETII MRHEENEIPS CDLSNFARPN 

      1030       1040       1050       1060       1070       1080 
PVVSPSPLTS FASSCAEKGP IVPEIQALQE EISISGCKMR LSYLSSRTPG YKSVLRISLT 

      1090       1100       1110       1120       1130       1140 
HPTIPFNLMK VHLMVAVEGR LFRKWFAAAP DLSYYFIWDK TDVYNQKVFG LSEAFVSVGY 

      1150       1160       1170       1180       1190       1200 
EYESCPDLIL WEKRTTVLQG YEIDASKLGG WSLDKHHALN IQSGILHKGN GENQFVSQQP 

      1210       1220       1230       1240       1250       1260 
PVIGSIMGNG RRRSISCPSC NGLADGNKLL APVALTCGSD GSLYVGDFNY IRRIFPSGNV 

      1270       1280       1290       1300       1310       1320 
TNILELRNKD FRHSHSPAHK YYLATDPMSG AVFLSDSNSR RVFKIKSTVV VKDLVKNSEV 

      1330       1340       1350       1360       1370       1380 
VAGTGDQCLP FDDTRCGDGG KATEATLTNP RGITVDKFGL IYFVDGTMIR RIDQNGIIST 

      1390       1400       1410       1420       1430       1440 
LLGSNDLTSA RPLSCDSVMD ISQVHLEWPT DLAINPMDNS LYVLDNNVVL QISENHQVRI 

      1450       1460       1470       1480       1490       1500 
VAGRPMHCQV PGIDHFLLSK VAIHATLESA TALAVSHNGV LYIAETDEKK INRIRQVTTS 

      1510       1520       1530       1540       1550       1560 
GEISLVAGAP SGCDCKNDAN CDCFSGDDGY AKDAKLNTPS SLAVCADGEL YVADLGNIRI 

      1570       1580       1590       1600       1610       1620 
RFIRKNKPFL NTQNMYELSS PIDQELYLFD TTGKHLYTQS LPTGDYLYNF TYTGDGDITL 

      1630       1640       1650       1660       1670       1680 
ITDNNGNMVN VRRDSTGMPL WLVVPDGQVY WVTMGTNSAL KSVTTQGHEL AMMTYHGNSG 

      1690       1700       1710       1720       1730       1740 
LLATKSNENG WTTFYEYDSF GRLTNVTFPT GQVSSFRSDT DSSVHVQVET SSKDDVTITT 

      1750       1760       1770       1780       1790       1800 
NLSASGAFYT LLQDQVRNSY YIGADGSLRL LLANGMEVAL QTEPHLLAGT VNPTVGKRNV 

      1810       1820       1830       1840       1850       1860 
TLPIDNGLNL VEWRQRKEQA RGQVTVFGRR LRVHNRNLLS LDFDRVTRTE KIYDDHRKFT 

      1870       1880       1890       1900       1910       1920 
LRILYDQAGR PSLWSPSSRL NGVNVTYSPG GYIAGIQRGI MSERMEYDQA GRITSRIFAD 

      1930       1940       1950       1960       1970       1980 
GKTWSYTYLE KSMVLLLHSQ RQYIFEFDKN DRLSSVTMPN VARQTLETIR SVGYYRNIYQ 

      1990       2000       2010       2020       2030       2040 
PPEGNASVIQ DFTEDGHLLH TFYLGTGRRV IYKYGKLSKL AETLYDTTKV SFTYDETAGM 

      2050       2060       2070       2080       2090       2100 
LKTINLQNEG FTCTIRYRQI GPLIDRQIFR FTEEGMVNAR FDYNYDNSFR VTSMQAVINE 

      2110       2120       2130       2140       2150       2160 
TPLPIDLYRY DDVSGKTEQF GKFGVIYYDI NQIITTAVMT HTKHFDAYGR MKEVQYEIFR 

      2170       2180       2190       2200       2210       2220 
SLMYWMTVQY DNMGRVVKKE LKVGPYANTT RYSYEYDADG QLQTVSINDK PLWRYSYDLN 

      2230       2240       2250       2260       2270       2280 
GNLHLLSPGN SARLTPLRYD IRDRITRLGD VQYKMDEDGF LRQRGGDIFE YNSAGLLIKA 

      2290       2300       2310       2320       2330       2340 
YNRAGSWSVR YRYDGLGRRV SSKSSHSHHL QFFYADLTNP TKVTHLYNHS SSEITSLYYD 

      2350       2360       2370       2380       2390       2400 
LQGHLFAMEL SSGDEFYIAC DNIGTPLAVF SGTGLMIKQI LYTAYGEIYM DTNPNFQIII 

      2410       2420       2430       2440       2450       2460 
GYHGGLYDPL TKLVHMGRRD YDVLAGRWTS PDHELWKHLS SSNVMPFNLY MFKNNNPISN 

      2470       2480       2490       2500       2510       2520 
SQDIKCFMTD VNSWLLTFGF QLHNVIPGYP KPDMDAMEPS YELIHTQMKT QEWDNSKSIL 

      2530       2540       2550       2560       2570       2580 
GVQCEVQKQL KAFVTLERFD QLYGSTITSC QQAPKTKKFA SSGSVFGKGV KFALKDGRVT 

      2590       2600       2610       2620       2630       2640 
TDIISVANED GRRVAAILNH AHYLENLHFT IDGVDTHYFV KPGPSEGDLA ILGLSGGRRT 

      2650       2660       2670       2680       2690       2700 
LENGVNVTVS QINTVLNGRT RRYTDIQLQY GALCLNTRYG TTLDEEKARV LELARQRAVR 

      2710       2720       2730       2740       2750       2760 
QAWAREQQRL REGEEGLRAW TEGEKQQVLS TGRVQGYDGF FVISVEQYPE LSDSANNIHF 


MRQSEMGRR 

« Hide

References

« Hide 'large scale' references
[1]"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. expand/collapse author list , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y.
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 754-2769.
Tissue: Brain.
[3]"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: SEQUENCE REVISION.
[4]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1371-2769.
Tissue: Brain, Cervix and Fetal kidney.
[5]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2040-2715.
[6]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP002515 Genomic DNA. No translation available.
AP002768 Genomic DNA. No translation available.
AP002958 Genomic DNA. No translation available.
AP002957 Genomic DNA. No translation available.
AB037723 mRNA. Translation: BAA92540.3.
BX640737 mRNA. Translation: CAE45850.1.
AL080120 mRNA. Translation: CAB45719.1.
BX537983 mRNA. Translation: CAD97943.1.
AK056531 mRNA. Translation: BAB71206.1. Different initiation.
CCDSCCDS44688.1.
PIRT12457.
RefSeqNP_001092286.2. NM_001098816.2.
UniGeneHs.213087.

3D structure databases

ProteinModelPortalQ6N022.
SMRQ6N022. Positions 538-865, 1535-1564.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid117484. 1 interaction.

PTM databases

PhosphoSiteQ6N022.

Polymorphism databases

DMDM117949795.

Proteomic databases

MaxQBQ6N022.
PaxDbQ6N022.
PRIDEQ6N022.

Protocols and materials databases

DNASU26011.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000278550; ENSP00000278550; ENSG00000149256.
GeneID26011.
KEGGhsa:26011.
UCSCuc001ozl.4. human.

Organism-specific databases

CTD26011.
GeneCardsGC11M078363.
H-InvDBHIX0009980.
HGNCHGNC:29945. TENM4.
MIM610084. gene.
neXtProtNX_Q6N022.
PharmGKBPA134896466.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG323120.
HOGENOMHOG000231701.
HOVERGENHBG080306.
InParanoidQ6N022.
OMANQFVSQQ.
OrthoDBEOG7H791C.
PhylomeDBQ6N022.
TreeFamTF316833.

Gene expression databases

ArrayExpressQ6N022.
BgeeQ6N022.
CleanExHS_ODZ4.
GenevestigatorQ6N022.

Family and domain databases

Gene3D2.120.10.30. 1 hit.
InterProIPR011042. 6-blade_b-propeller_TolB-like.
IPR008969. CarboxyPept-like_regulatory.
IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR013111. EGF_extracell.
IPR022385. Rhs_assc_core.
IPR027691. Ten-4.
IPR009471. Ten_N.
IPR028916. Tox-GHH_dom.
IPR006530. YD.
[Graphical view]
PANTHERPTHR11219:SF9. PTHR11219:SF9. 1 hit.
PfamPF07974. EGF_2. 1 hit.
PF12661. hEGF. 1 hit.
PF05593. RHS_repeat. 1 hit.
PF06484. Ten_N. 2 hits.
PF15636. Tox-GHH. 1 hit.
[Graphical view]
SMARTSM00181. EGF. 7 hits.
[Graphical view]
SUPFAMSSF49464. SSF49464. 1 hit.
TIGRFAMsTIGR03696. Rhs_assc_core. 1 hit.
TIGR01643. YD_repeat_2x. 2 hits.
PROSITEPS00022. EGF_1. 8 hits.
PS01186. EGF_2. 7 hits.
PS50026. EGF_3. 5 hits.
PS51361. TENEURIN_N. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSODZ4. human.
GeneWikiODZ4.
GenomeRNAi26011.
NextBio47758.
PROQ6N022.
SOURCESearch...

Entry information

Entry nameTEN4_HUMAN
AccessionPrimary (citable) accession number: Q6N022
Secondary accession number(s): A6ND26 expand/collapse secondary AC list , Q7Z3C7, Q96MS6, Q9P2P4, Q9Y4S2
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 31, 2006
Last modified: July 9, 2014
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM