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Q6N022

- TEN4_HUMAN

UniProt

Q6N022 - TEN4_HUMAN

Protein

Teneurin-4

Gene

TENM4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 2 (31 Oct 2006)
      Previous versions | rss
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    Functioni

    Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Plays a role in the establishment of the anterior-posterior axis during gastrulation. Regulates the differentiation and cellular process formation of oligodendrocytes and myelination of small-diameter axons in the central nervous system (CNS). Promotes activation of focal adhesion kinase. May function as a cellular signal transducer By similarity.By similarity

    GO - Molecular functioni

    1. protein homodimerization activity Source: UniProtKB

    GO - Biological processi

    1. cardiac cell fate specification Source: Ensembl
    2. cardiac muscle cell proliferation Source: Ensembl
    3. central nervous system myelin formation Source: UniProtKB
    4. gastrulation with mouth forming second Source: Ensembl
    5. neuron development Source: InterPro
    6. positive regulation of gastrulation Source: UniProtKB
    7. positive regulation of myelination Source: UniProtKB
    8. positive regulation of oligodendrocyte differentiation Source: UniProtKB
    9. signal transduction Source: InterPro

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Differentiation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Teneurin-4
    Short name:
    Ten-4
    Alternative name(s):
    Protein Odd Oz/ten-m homolog 4
    Tenascin-M4
    Short name:
    Ten-m4
    Teneurin transmembrane protein 4
    Gene namesi
    Name:TENM4
    Synonyms:KIAA1302, ODZ4, TNM4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:29945. TENM4.

    Subcellular locationi

    Membrane Curated; Single-pass membrane protein Curated. Nucleus By similarity. Cytoplasm By similarity. Cell projection By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. integral component of plasma membrane Source: InterPro
    3. neuron projection Source: UniProtKB
    4. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Cell projection, Cytoplasm, Membrane, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134896466.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 27692769Teneurin-4PRO_0000259508Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi467 – 4671N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi566 ↔ 576PROSITE-ProRule annotation
    Disulfide bondi570 ↔ 581PROSITE-ProRule annotation
    Disulfide bondi583 ↔ 592PROSITE-ProRule annotation
    Disulfide bondi601 ↔ 612PROSITE-ProRule annotation
    Disulfide bondi614 ↔ 623PROSITE-ProRule annotation
    Disulfide bondi630 ↔ 641PROSITE-ProRule annotation
    Disulfide bondi635 ↔ 646PROSITE-ProRule annotation
    Disulfide bondi648 ↔ 657PROSITE-ProRule annotation
    Disulfide bondi662 ↔ 673PROSITE-ProRule annotation
    Disulfide bondi667 ↔ 678PROSITE-ProRule annotation
    Disulfide bondi680 ↔ 689PROSITE-ProRule annotation
    Disulfide bondi700 ↔ 713PROSITE-ProRule annotation
    Disulfide bondi715 ↔ 724PROSITE-ProRule annotation
    Disulfide bondi729 ↔ 739PROSITE-ProRule annotation
    Disulfide bondi733 ↔ 744PROSITE-ProRule annotation
    Disulfide bondi746 ↔ 755PROSITE-ProRule annotation
    Disulfide bondi760 ↔ 770PROSITE-ProRule annotation
    Disulfide bondi764 ↔ 775PROSITE-ProRule annotation
    Disulfide bondi777 ↔ 786PROSITE-ProRule annotation
    Disulfide bondi800 ↔ 810PROSITE-ProRule annotation
    Disulfide bondi804 ↔ 819PROSITE-ProRule annotation
    Disulfide bondi821 ↔ 830PROSITE-ProRule annotation
    Glycosylationi940 – 9401N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1259 – 12591N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1609 – 16091N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1705 – 17051N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1741 – 17411N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1799 – 17991N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1884 – 18841N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1985 – 19851N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2188 – 21881N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2328 – 23281N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2646 – 26461N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiQ6N022.
    PaxDbiQ6N022.
    PRIDEiQ6N022.

    PTM databases

    PhosphoSiteiQ6N022.

    Expressioni

    Gene expression databases

    ArrayExpressiQ6N022.
    BgeeiQ6N022.
    CleanExiHS_ODZ4.
    GenevestigatoriQ6N022.

    Interactioni

    Subunit structurei

    Homodimer; disulfide-linked Probable. May also form heterodimer with either TENM1 or TENM2 or TENM3 By similarity.By similarityCurated

    Protein-protein interaction databases

    BioGridi117484. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6N022.
    SMRiQ6N022. Positions 538-865, 1535-1564.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 345345CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini367 – 27692403ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei346 – 36621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 341341Teneurin N-terminalPROSITE-ProRule annotationAdd
    BLAST
    Domaini562 – 59332EGF-like 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini594 – 62431EGF-like 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini626 – 65833EGF-like 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini659 – 69032EGF-like 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini692 – 72534EGF-like 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini726 – 75732EGF-like 6PROSITE-ProRule annotationAdd
    BLAST
    Domaini758 – 78730EGF-like 7PROSITE-ProRule annotationAdd
    BLAST
    Domaini788 – 83144EGF-like 8PROSITE-ProRule annotationAdd
    BLAST
    Repeati1216 – 125944NHL 1Add
    BLAST
    Repeati1264 – 130845NHL 2Add
    BLAST
    Repeati1334 – 137845NHL 3Add
    BLAST
    Repeati1393 – 144452NHL 4Add
    BLAST
    Repeati1523 – 156644NHL 5Add
    BLAST
    Repeati1576 – 159520YD 1Add
    BLAST
    Repeati1612 – 163221YD 2Add
    BLAST
    Repeati1675 – 169420YD 3Add
    BLAST
    Repeati1695 – 171723YD 4Add
    BLAST
    Repeati1887 – 190620YD 5Add
    BLAST
    Repeati1928 – 194619YD 6Add
    BLAST
    Repeati1947 – 196721YD 7Add
    BLAST
    Repeati1974 – 199118YD 8Add
    BLAST
    Repeati1992 – 201322YD 9Add
    BLAST
    Repeati2014 – 203118YD 10Add
    BLAST
    Repeati2034 – 205421YD 11Add
    BLAST
    Repeati2057 – 207721YD 12Add
    BLAST
    Repeati2085 – 210420YD 13Add
    BLAST
    Repeati2110 – 212718YD 14Add
    BLAST
    Repeati2128 – 215427YD 15Add
    BLAST
    Repeati2156 – 216914YD 16Add
    BLAST
    Repeati2170 – 219324YD 17Add
    BLAST
    Repeati2196 – 221621YD 18Add
    BLAST
    Repeati2217 – 223721YD 19Add
    BLAST
    Repeati2239 – 225921YD 20Add
    BLAST
    Repeati2271 – 229121YD 21Add
    BLAST
    Repeati2293 – 231321YD 22Add
    BLAST
    Repeati2339 – 238042YD 23Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi179 – 1824Poly-Pro

    Domaini

    EGF-like domains 2 and 5 which have an odd number of cysteines might enable the formation of intermolecular disulfide bonds.
    Cytoplasmic proline-rich regions could serve as docking domains for intracellular SH3-containing proteins.

    Sequence similaritiesi

    Belongs to the tenascin family. Teneurin subfamily.Curated
    Contains 8 EGF-like domains.PROSITE-ProRule annotation
    Contains 5 NHL repeats.Curated
    Contains 1 teneurin N-terminal domain.PROSITE-ProRule annotation
    Contains 23 YD repeats.Curated

    Keywords - Domaini

    EGF-like domain, Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG323120.
    HOGENOMiHOG000231701.
    HOVERGENiHBG080306.
    InParanoidiQ6N022.
    OMAiNQFVSQQ.
    OrthoDBiEOG7H791C.
    PhylomeDBiQ6N022.
    TreeFamiTF316833.

    Family and domain databases

    Gene3Di2.120.10.30. 1 hit.
    InterProiIPR011042. 6-blade_b-propeller_TolB-like.
    IPR008969. CarboxyPept-like_regulatory.
    IPR000742. EG-like_dom.
    IPR013032. EGF-like_CS.
    IPR013111. EGF_extracell.
    IPR022385. Rhs_assc_core.
    IPR027691. Ten-4.
    IPR009471. Ten_N.
    IPR028916. Tox-GHH_dom.
    IPR006530. YD.
    [Graphical view]
    PANTHERiPTHR11219:SF9. PTHR11219:SF9. 1 hit.
    PfamiPF07974. EGF_2. 1 hit.
    PF12661. hEGF. 1 hit.
    PF05593. RHS_repeat. 1 hit.
    PF06484. Ten_N. 2 hits.
    PF15636. Tox-GHH. 1 hit.
    [Graphical view]
    SMARTiSM00181. EGF. 7 hits.
    [Graphical view]
    SUPFAMiSSF49464. SSF49464. 1 hit.
    TIGRFAMsiTIGR03696. Rhs_assc_core. 1 hit.
    TIGR01643. YD_repeat_2x. 2 hits.
    PROSITEiPS00022. EGF_1. 8 hits.
    PS01186. EGF_2. 7 hits.
    PS50026. EGF_3. 5 hits.
    PS51361. TENEURIN_N. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6N022-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDVKERKPYR SLTRRRDAER RYTSSSADSE EGKAPQKSYS SSETLKAYDQ     50
    DARLAYGSRV KDIVPQEAEE FCRTGANFTL RELGLEEVTP PHGTLYRTDI 100
    GLPHCGYSMG AGSDADMEAD TVLSPEHPVR LWGRSTRSGR SSCLSSRANS 150
    NLTLTDTEHE NTETDHPGGL QNHARLRTPP PPLSHAHTPN QHHAASINSL 200
    NRGNFTPRSN PSPAPTDHSL SGEPPAGGAQ EPAHAQENWL LNSNIPLETR 250
    NLGKQPFLGT LQDNLIEMDI LGASRHDGAY SDGHFLFKPG GTSPLFCTTS 300
    PGYPLTSSTV YSPPPRPLPR STFARPAFNL KKPSKYCNWK CAALSAIVIS 350
    ATLVILLAYF VAMHLFGLNW HLQPMEGQMY EITEDTASSW PVPTDVSLYP 400
    SGGTGLETPD RKGKGTTEGK PSSFFPEDSF IDSGEIDVGR RASQKIPPGT 450
    FWRSQVFIDH PVHLKFNVSL GKAALVGIYG RKGLPPSHTQ FDFVELLDGR 500
    RLLTQEARSL EGTPRQSRGT VPPSSHETGF IQYLDSGIWH LAFYNDGKES 550
    EVVSFLTTAI ESVDNCPSNC YGNGDCISGT CHCFLGFLGP DCGRASCPVL 600
    CSGNGQYMKG RCLCHSGWKG AECDVPTNQC IDVACSNHGT CITGTCICNP 650
    GYKGESCEEV DCMDPTCSGR GVCVRGECHC SVGWGGTNCE TPRATCLDQC 700
    SGHGTFLPDT GLCSCDPSWT GHDCSIEICA ADCGGHGVCV GGTCRCEDGW 750
    MGAACDQRAC HPRCAEHGTC RDGKCECSPG WNGEHCTIAH YLDRVVKEGC 800
    PGLCNGNGRC TLDLNGWHCV CQLGWRGAGC DTSMETACGD SKDNDGDGLV 850
    DCMDPDCCLQ PLCHINPLCL GSPNPLDIIQ ETQVPVSQQN LHSFYDRIKF 900
    LVGRDSTHII PGENPFDGGH ACVIRGQVMT SDGTPLVGVN ISFVNNPLFG 950
    YTISRQDGSF DLVTNGGISI ILRFERAPFI TQEHTLWLPW DRFFVMETII 1000
    MRHEENEIPS CDLSNFARPN PVVSPSPLTS FASSCAEKGP IVPEIQALQE 1050
    EISISGCKMR LSYLSSRTPG YKSVLRISLT HPTIPFNLMK VHLMVAVEGR 1100
    LFRKWFAAAP DLSYYFIWDK TDVYNQKVFG LSEAFVSVGY EYESCPDLIL 1150
    WEKRTTVLQG YEIDASKLGG WSLDKHHALN IQSGILHKGN GENQFVSQQP 1200
    PVIGSIMGNG RRRSISCPSC NGLADGNKLL APVALTCGSD GSLYVGDFNY 1250
    IRRIFPSGNV TNILELRNKD FRHSHSPAHK YYLATDPMSG AVFLSDSNSR 1300
    RVFKIKSTVV VKDLVKNSEV VAGTGDQCLP FDDTRCGDGG KATEATLTNP 1350
    RGITVDKFGL IYFVDGTMIR RIDQNGIIST LLGSNDLTSA RPLSCDSVMD 1400
    ISQVHLEWPT DLAINPMDNS LYVLDNNVVL QISENHQVRI VAGRPMHCQV 1450
    PGIDHFLLSK VAIHATLESA TALAVSHNGV LYIAETDEKK INRIRQVTTS 1500
    GEISLVAGAP SGCDCKNDAN CDCFSGDDGY AKDAKLNTPS SLAVCADGEL 1550
    YVADLGNIRI RFIRKNKPFL NTQNMYELSS PIDQELYLFD TTGKHLYTQS 1600
    LPTGDYLYNF TYTGDGDITL ITDNNGNMVN VRRDSTGMPL WLVVPDGQVY 1650
    WVTMGTNSAL KSVTTQGHEL AMMTYHGNSG LLATKSNENG WTTFYEYDSF 1700
    GRLTNVTFPT GQVSSFRSDT DSSVHVQVET SSKDDVTITT NLSASGAFYT 1750
    LLQDQVRNSY YIGADGSLRL LLANGMEVAL QTEPHLLAGT VNPTVGKRNV 1800
    TLPIDNGLNL VEWRQRKEQA RGQVTVFGRR LRVHNRNLLS LDFDRVTRTE 1850
    KIYDDHRKFT LRILYDQAGR PSLWSPSSRL NGVNVTYSPG GYIAGIQRGI 1900
    MSERMEYDQA GRITSRIFAD GKTWSYTYLE KSMVLLLHSQ RQYIFEFDKN 1950
    DRLSSVTMPN VARQTLETIR SVGYYRNIYQ PPEGNASVIQ DFTEDGHLLH 2000
    TFYLGTGRRV IYKYGKLSKL AETLYDTTKV SFTYDETAGM LKTINLQNEG 2050
    FTCTIRYRQI GPLIDRQIFR FTEEGMVNAR FDYNYDNSFR VTSMQAVINE 2100
    TPLPIDLYRY DDVSGKTEQF GKFGVIYYDI NQIITTAVMT HTKHFDAYGR 2150
    MKEVQYEIFR SLMYWMTVQY DNMGRVVKKE LKVGPYANTT RYSYEYDADG 2200
    QLQTVSINDK PLWRYSYDLN GNLHLLSPGN SARLTPLRYD IRDRITRLGD 2250
    VQYKMDEDGF LRQRGGDIFE YNSAGLLIKA YNRAGSWSVR YRYDGLGRRV 2300
    SSKSSHSHHL QFFYADLTNP TKVTHLYNHS SSEITSLYYD LQGHLFAMEL 2350
    SSGDEFYIAC DNIGTPLAVF SGTGLMIKQI LYTAYGEIYM DTNPNFQIII 2400
    GYHGGLYDPL TKLVHMGRRD YDVLAGRWTS PDHELWKHLS SSNVMPFNLY 2450
    MFKNNNPISN SQDIKCFMTD VNSWLLTFGF QLHNVIPGYP KPDMDAMEPS 2500
    YELIHTQMKT QEWDNSKSIL GVQCEVQKQL KAFVTLERFD QLYGSTITSC 2550
    QQAPKTKKFA SSGSVFGKGV KFALKDGRVT TDIISVANED GRRVAAILNH 2600
    AHYLENLHFT IDGVDTHYFV KPGPSEGDLA ILGLSGGRRT LENGVNVTVS 2650
    QINTVLNGRT RRYTDIQLQY GALCLNTRYG TTLDEEKARV LELARQRAVR 2700
    QAWAREQQRL REGEEGLRAW TEGEKQQVLS TGRVQGYDGF FVISVEQYPE 2750
    LSDSANNIHF MRQSEMGRR 2769
    Length:2,769
    Mass (Da):307,957
    Last modified:October 31, 2006 - v2
    Checksum:i280D87D43FBE88A1
    GO

    Sequence cautioni

    The sequence BAB71206.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti1471 – 14711T → I in CAE45850. (PubMed:17974005)Curated
    Sequence conflicti1842 – 18421D → G in CAD97943. (PubMed:17974005)Curated
    Sequence conflicti2024 – 20241L → F in CAD97943. (PubMed:17974005)Curated
    Sequence conflicti2393 – 23931N → D in CAE45850. (PubMed:17974005)Curated
    Sequence conflicti2551 – 25511Q → L in BAB71206. (PubMed:14702039)Curated
    Sequence conflicti2586 – 25861V → G in CAB45719. (PubMed:17974005)Curated
    Sequence conflicti2599 – 25991N → D in CAB45719. (PubMed:17974005)Curated
    Sequence conflicti2657 – 26571N → S in BAB71206. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti14 – 141R → Q.
    Corresponds to variant rs58537389 [ dbSNP | Ensembl ].
    VAR_062167
    Natural varianti396 – 3961V → I.
    Corresponds to variant rs3812723 [ dbSNP | Ensembl ].
    VAR_060130
    Natural varianti506 – 5061E → Q.
    Corresponds to variant rs17137261 [ dbSNP | Ensembl ].
    VAR_060131

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP002515 Genomic DNA. No translation available.
    AP002768 Genomic DNA. No translation available.
    AP002958 Genomic DNA. No translation available.
    AP002957 Genomic DNA. No translation available.
    AB037723 mRNA. Translation: BAA92540.3.
    BX640737 mRNA. Translation: CAE45850.1.
    AL080120 mRNA. Translation: CAB45719.1.
    BX537983 mRNA. Translation: CAD97943.1.
    AK056531 mRNA. Translation: BAB71206.1. Different initiation.
    CCDSiCCDS44688.1.
    PIRiT12457.
    RefSeqiNP_001092286.2. NM_001098816.2.
    UniGeneiHs.213087.

    Genome annotation databases

    EnsembliENST00000278550; ENSP00000278550; ENSG00000149256.
    GeneIDi26011.
    KEGGihsa:26011.
    UCSCiuc001ozl.4. human.

    Polymorphism databases

    DMDMi117949795.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP002515 Genomic DNA. No translation available.
    AP002768 Genomic DNA. No translation available.
    AP002958 Genomic DNA. No translation available.
    AP002957 Genomic DNA. No translation available.
    AB037723 mRNA. Translation: BAA92540.3 .
    BX640737 mRNA. Translation: CAE45850.1 .
    AL080120 mRNA. Translation: CAB45719.1 .
    BX537983 mRNA. Translation: CAD97943.1 .
    AK056531 mRNA. Translation: BAB71206.1 . Different initiation.
    CCDSi CCDS44688.1.
    PIRi T12457.
    RefSeqi NP_001092286.2. NM_001098816.2.
    UniGenei Hs.213087.

    3D structure databases

    ProteinModelPortali Q6N022.
    SMRi Q6N022. Positions 538-865, 1535-1564.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117484. 1 interaction.

    PTM databases

    PhosphoSitei Q6N022.

    Polymorphism databases

    DMDMi 117949795.

    Proteomic databases

    MaxQBi Q6N022.
    PaxDbi Q6N022.
    PRIDEi Q6N022.

    Protocols and materials databases

    DNASUi 26011.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000278550 ; ENSP00000278550 ; ENSG00000149256 .
    GeneIDi 26011.
    KEGGi hsa:26011.
    UCSCi uc001ozl.4. human.

    Organism-specific databases

    CTDi 26011.
    GeneCardsi GC11M078363.
    H-InvDB HIX0009980.
    HGNCi HGNC:29945. TENM4.
    MIMi 610084. gene.
    neXtProti NX_Q6N022.
    PharmGKBi PA134896466.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG323120.
    HOGENOMi HOG000231701.
    HOVERGENi HBG080306.
    InParanoidi Q6N022.
    OMAi NQFVSQQ.
    OrthoDBi EOG7H791C.
    PhylomeDBi Q6N022.
    TreeFami TF316833.

    Miscellaneous databases

    ChiTaRSi ODZ4. human.
    GeneWikii ODZ4.
    GenomeRNAii 26011.
    NextBioi 47758.
    PROi Q6N022.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q6N022.
    Bgeei Q6N022.
    CleanExi HS_ODZ4.
    Genevestigatori Q6N022.

    Family and domain databases

    Gene3Di 2.120.10.30. 1 hit.
    InterProi IPR011042. 6-blade_b-propeller_TolB-like.
    IPR008969. CarboxyPept-like_regulatory.
    IPR000742. EG-like_dom.
    IPR013032. EGF-like_CS.
    IPR013111. EGF_extracell.
    IPR022385. Rhs_assc_core.
    IPR027691. Ten-4.
    IPR009471. Ten_N.
    IPR028916. Tox-GHH_dom.
    IPR006530. YD.
    [Graphical view ]
    PANTHERi PTHR11219:SF9. PTHR11219:SF9. 1 hit.
    Pfami PF07974. EGF_2. 1 hit.
    PF12661. hEGF. 1 hit.
    PF05593. RHS_repeat. 1 hit.
    PF06484. Ten_N. 2 hits.
    PF15636. Tox-GHH. 1 hit.
    [Graphical view ]
    SMARTi SM00181. EGF. 7 hits.
    [Graphical view ]
    SUPFAMi SSF49464. SSF49464. 1 hit.
    TIGRFAMsi TIGR03696. Rhs_assc_core. 1 hit.
    TIGR01643. YD_repeat_2x. 2 hits.
    PROSITEi PS00022. EGF_1. 8 hits.
    PS01186. EGF_2. 7 hits.
    PS50026. EGF_3. 5 hits.
    PS51361. TENEURIN_N. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
      DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 754-2769.
      Tissue: Brain.
    3. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
      Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
      DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: SEQUENCE REVISION.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1371-2769.
      Tissue: Brain, Cervix and Fetal kidney.
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2040-2715.
    6. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.

    Entry informationi

    Entry nameiTEN4_HUMAN
    AccessioniPrimary (citable) accession number: Q6N022
    Secondary accession number(s): A6ND26
    , Q7Z3C7, Q96MS6, Q9P2P4, Q9Y4S2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: October 31, 2006
    Last modified: October 1, 2014
    This is version 97 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3