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Q6N022

- TEN4_HUMAN

UniProt

Q6N022 - TEN4_HUMAN

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Protein

Teneurin-4

Gene

TENM4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Plays a role in the establishment of the anterior-posterior axis during gastrulation. Regulates the differentiation and cellular process formation of oligodendrocytes and myelination of small-diameter axons in the central nervous system (CNS). Promotes activation of focal adhesion kinase. May function as a cellular signal transducer (By similarity).By similarity

GO - Molecular functioni

  1. protein homodimerization activity Source: UniProtKB

GO - Biological processi

  1. cardiac cell fate specification Source: Ensembl
  2. cardiac muscle cell proliferation Source: Ensembl
  3. central nervous system myelin formation Source: UniProtKB
  4. gastrulation with mouth forming second Source: Ensembl
  5. neuron development Source: InterPro
  6. positive regulation of gastrulation Source: UniProtKB
  7. positive regulation of myelination Source: UniProtKB
  8. positive regulation of oligodendrocyte differentiation Source: UniProtKB
  9. self proteolysis Source: InterPro
  10. signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation

Names & Taxonomyi

Protein namesi
Recommended name:
Teneurin-4
Short name:
Ten-4
Alternative name(s):
Protein Odd Oz/ten-m homolog 4
Tenascin-M4
Short name:
Ten-m4
Teneurin transmembrane protein 4
Gene namesi
Name:TENM4
Synonyms:KIAA1302, ODZ4, TNM4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:29945. TENM4.

Subcellular locationi

Membrane Curated; Single-pass membrane protein Curated. Nucleus By similarity. Cytoplasm By similarity. Cell projection By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 345345CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei346 – 36621HelicalSequence AnalysisAdd
BLAST
Topological domaini367 – 27692403ExtracellularSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. integral component of plasma membrane Source: InterPro
  3. neuron projection Source: UniProtKB
  4. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134896466.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 27692769Teneurin-4PRO_0000259508Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi467 – 4671N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi566 ↔ 576PROSITE-ProRule annotation
Disulfide bondi570 ↔ 581PROSITE-ProRule annotation
Disulfide bondi583 ↔ 592PROSITE-ProRule annotation
Disulfide bondi601 ↔ 612PROSITE-ProRule annotation
Disulfide bondi614 ↔ 623PROSITE-ProRule annotation
Disulfide bondi630 ↔ 641PROSITE-ProRule annotation
Disulfide bondi635 ↔ 646PROSITE-ProRule annotation
Disulfide bondi648 ↔ 657PROSITE-ProRule annotation
Disulfide bondi662 ↔ 673PROSITE-ProRule annotation
Disulfide bondi667 ↔ 678PROSITE-ProRule annotation
Disulfide bondi680 ↔ 689PROSITE-ProRule annotation
Disulfide bondi700 ↔ 713PROSITE-ProRule annotation
Disulfide bondi715 ↔ 724PROSITE-ProRule annotation
Disulfide bondi729 ↔ 739PROSITE-ProRule annotation
Disulfide bondi733 ↔ 744PROSITE-ProRule annotation
Disulfide bondi746 ↔ 755PROSITE-ProRule annotation
Disulfide bondi760 ↔ 770PROSITE-ProRule annotation
Disulfide bondi764 ↔ 775PROSITE-ProRule annotation
Disulfide bondi777 ↔ 786PROSITE-ProRule annotation
Disulfide bondi800 ↔ 810PROSITE-ProRule annotation
Disulfide bondi804 ↔ 819PROSITE-ProRule annotation
Disulfide bondi821 ↔ 830PROSITE-ProRule annotation
Glycosylationi940 – 9401N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1259 – 12591N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1609 – 16091N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1705 – 17051N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1741 – 17411N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1799 – 17991N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1884 – 18841N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1985 – 19851N-linked (GlcNAc...)Sequence Analysis
Glycosylationi2188 – 21881N-linked (GlcNAc...)Sequence Analysis
Glycosylationi2328 – 23281N-linked (GlcNAc...)Sequence Analysis
Glycosylationi2646 – 26461N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ6N022.
PaxDbiQ6N022.
PRIDEiQ6N022.

PTM databases

PhosphoSiteiQ6N022.

Expressioni

Gene expression databases

BgeeiQ6N022.
CleanExiHS_ODZ4.
ExpressionAtlasiQ6N022. baseline and differential.
GenevestigatoriQ6N022.

Interactioni

Subunit structurei

Homodimer; disulfide-linked (Probable). May also form heterodimer with either TENM1 or TENM2 or TENM3 (By similarity).By similarityCurated

Protein-protein interaction databases

BioGridi117484. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ6N022.
SMRiQ6N022. Positions 566-865, 1535-1564.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 341341Teneurin N-terminalPROSITE-ProRule annotationAdd
BLAST
Domaini562 – 59332EGF-like 1PROSITE-ProRule annotationAdd
BLAST
Domaini594 – 62431EGF-like 2PROSITE-ProRule annotationAdd
BLAST
Domaini626 – 65833EGF-like 3PROSITE-ProRule annotationAdd
BLAST
Domaini659 – 69032EGF-like 4PROSITE-ProRule annotationAdd
BLAST
Domaini692 – 72534EGF-like 5PROSITE-ProRule annotationAdd
BLAST
Domaini726 – 75732EGF-like 6PROSITE-ProRule annotationAdd
BLAST
Domaini758 – 78730EGF-like 7PROSITE-ProRule annotationAdd
BLAST
Domaini788 – 83144EGF-like 8PROSITE-ProRule annotationAdd
BLAST
Repeati1216 – 125944NHL 1Add
BLAST
Repeati1264 – 130845NHL 2Add
BLAST
Repeati1334 – 137845NHL 3Add
BLAST
Repeati1393 – 144452NHL 4Add
BLAST
Repeati1523 – 156644NHL 5Add
BLAST
Repeati1576 – 159520YD 1Add
BLAST
Repeati1612 – 163221YD 2Add
BLAST
Repeati1675 – 169420YD 3Add
BLAST
Repeati1695 – 171723YD 4Add
BLAST
Repeati1887 – 190620YD 5Add
BLAST
Repeati1928 – 194619YD 6Add
BLAST
Repeati1947 – 196721YD 7Add
BLAST
Repeati1974 – 199118YD 8Add
BLAST
Repeati1992 – 201322YD 9Add
BLAST
Repeati2014 – 203118YD 10Add
BLAST
Repeati2034 – 205421YD 11Add
BLAST
Repeati2057 – 207721YD 12Add
BLAST
Repeati2085 – 210420YD 13Add
BLAST
Repeati2110 – 212718YD 14Add
BLAST
Repeati2128 – 215427YD 15Add
BLAST
Repeati2156 – 216914YD 16Add
BLAST
Repeati2170 – 219324YD 17Add
BLAST
Repeati2196 – 221621YD 18Add
BLAST
Repeati2217 – 223721YD 19Add
BLAST
Repeati2239 – 225921YD 20Add
BLAST
Repeati2271 – 229121YD 21Add
BLAST
Repeati2293 – 231321YD 22Add
BLAST
Repeati2339 – 238042YD 23Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi179 – 1824Poly-Pro

Domaini

EGF-like domains 2 and 5 which have an odd number of cysteines might enable the formation of intermolecular disulfide bonds.
Cytoplasmic proline-rich regions could serve as docking domains for intracellular SH3-containing proteins.

Sequence similaritiesi

Belongs to the tenascin family. Teneurin subfamily.Curated
Contains 8 EGF-like domains.PROSITE-ProRule annotation
Contains 5 NHL repeats.Curated
Contains 1 teneurin N-terminal domain.PROSITE-ProRule annotation
Contains 23 YD repeats.Curated

Keywords - Domaini

EGF-like domain, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG323120.
GeneTreeiENSGT00760000119131.
HOGENOMiHOG000231701.
HOVERGENiHBG080306.
InParanoidiQ6N022.
OMAiNQFVSQQ.
OrthoDBiEOG7H791C.
PhylomeDBiQ6N022.
TreeFamiTF316833.

Family and domain databases

Gene3Di2.120.10.30. 1 hit.
InterProiIPR011042. 6-blade_b-propeller_TolB-like.
IPR008969. CarboxyPept-like_regulatory.
IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR013111. EGF_extracell.
IPR022385. Rhs_assc_core.
IPR027691. Ten-4.
IPR009471. Ten_N.
IPR028916. Tox-GHH_dom.
IPR006530. YD.
[Graphical view]
PANTHERiPTHR11219:SF9. PTHR11219:SF9. 1 hit.
PfamiPF07974. EGF_2. 1 hit.
PF12661. hEGF. 1 hit.
PF05593. RHS_repeat. 1 hit.
PF06484. Ten_N. 2 hits.
PF15636. Tox-GHH. 1 hit.
[Graphical view]
SMARTiSM00181. EGF. 7 hits.
[Graphical view]
SUPFAMiSSF49464. SSF49464. 1 hit.
TIGRFAMsiTIGR03696. Rhs_assc_core. 1 hit.
TIGR01643. YD_repeat_2x. 2 hits.
PROSITEiPS00022. EGF_1. 8 hits.
PS01186. EGF_2. 7 hits.
PS50026. EGF_3. 5 hits.
PS51361. TENEURIN_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6N022-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDVKERKPYR SLTRRRDAER RYTSSSADSE EGKAPQKSYS SSETLKAYDQ
60 70 80 90 100
DARLAYGSRV KDIVPQEAEE FCRTGANFTL RELGLEEVTP PHGTLYRTDI
110 120 130 140 150
GLPHCGYSMG AGSDADMEAD TVLSPEHPVR LWGRSTRSGR SSCLSSRANS
160 170 180 190 200
NLTLTDTEHE NTETDHPGGL QNHARLRTPP PPLSHAHTPN QHHAASINSL
210 220 230 240 250
NRGNFTPRSN PSPAPTDHSL SGEPPAGGAQ EPAHAQENWL LNSNIPLETR
260 270 280 290 300
NLGKQPFLGT LQDNLIEMDI LGASRHDGAY SDGHFLFKPG GTSPLFCTTS
310 320 330 340 350
PGYPLTSSTV YSPPPRPLPR STFARPAFNL KKPSKYCNWK CAALSAIVIS
360 370 380 390 400
ATLVILLAYF VAMHLFGLNW HLQPMEGQMY EITEDTASSW PVPTDVSLYP
410 420 430 440 450
SGGTGLETPD RKGKGTTEGK PSSFFPEDSF IDSGEIDVGR RASQKIPPGT
460 470 480 490 500
FWRSQVFIDH PVHLKFNVSL GKAALVGIYG RKGLPPSHTQ FDFVELLDGR
510 520 530 540 550
RLLTQEARSL EGTPRQSRGT VPPSSHETGF IQYLDSGIWH LAFYNDGKES
560 570 580 590 600
EVVSFLTTAI ESVDNCPSNC YGNGDCISGT CHCFLGFLGP DCGRASCPVL
610 620 630 640 650
CSGNGQYMKG RCLCHSGWKG AECDVPTNQC IDVACSNHGT CITGTCICNP
660 670 680 690 700
GYKGESCEEV DCMDPTCSGR GVCVRGECHC SVGWGGTNCE TPRATCLDQC
710 720 730 740 750
SGHGTFLPDT GLCSCDPSWT GHDCSIEICA ADCGGHGVCV GGTCRCEDGW
760 770 780 790 800
MGAACDQRAC HPRCAEHGTC RDGKCECSPG WNGEHCTIAH YLDRVVKEGC
810 820 830 840 850
PGLCNGNGRC TLDLNGWHCV CQLGWRGAGC DTSMETACGD SKDNDGDGLV
860 870 880 890 900
DCMDPDCCLQ PLCHINPLCL GSPNPLDIIQ ETQVPVSQQN LHSFYDRIKF
910 920 930 940 950
LVGRDSTHII PGENPFDGGH ACVIRGQVMT SDGTPLVGVN ISFVNNPLFG
960 970 980 990 1000
YTISRQDGSF DLVTNGGISI ILRFERAPFI TQEHTLWLPW DRFFVMETII
1010 1020 1030 1040 1050
MRHEENEIPS CDLSNFARPN PVVSPSPLTS FASSCAEKGP IVPEIQALQE
1060 1070 1080 1090 1100
EISISGCKMR LSYLSSRTPG YKSVLRISLT HPTIPFNLMK VHLMVAVEGR
1110 1120 1130 1140 1150
LFRKWFAAAP DLSYYFIWDK TDVYNQKVFG LSEAFVSVGY EYESCPDLIL
1160 1170 1180 1190 1200
WEKRTTVLQG YEIDASKLGG WSLDKHHALN IQSGILHKGN GENQFVSQQP
1210 1220 1230 1240 1250
PVIGSIMGNG RRRSISCPSC NGLADGNKLL APVALTCGSD GSLYVGDFNY
1260 1270 1280 1290 1300
IRRIFPSGNV TNILELRNKD FRHSHSPAHK YYLATDPMSG AVFLSDSNSR
1310 1320 1330 1340 1350
RVFKIKSTVV VKDLVKNSEV VAGTGDQCLP FDDTRCGDGG KATEATLTNP
1360 1370 1380 1390 1400
RGITVDKFGL IYFVDGTMIR RIDQNGIIST LLGSNDLTSA RPLSCDSVMD
1410 1420 1430 1440 1450
ISQVHLEWPT DLAINPMDNS LYVLDNNVVL QISENHQVRI VAGRPMHCQV
1460 1470 1480 1490 1500
PGIDHFLLSK VAIHATLESA TALAVSHNGV LYIAETDEKK INRIRQVTTS
1510 1520 1530 1540 1550
GEISLVAGAP SGCDCKNDAN CDCFSGDDGY AKDAKLNTPS SLAVCADGEL
1560 1570 1580 1590 1600
YVADLGNIRI RFIRKNKPFL NTQNMYELSS PIDQELYLFD TTGKHLYTQS
1610 1620 1630 1640 1650
LPTGDYLYNF TYTGDGDITL ITDNNGNMVN VRRDSTGMPL WLVVPDGQVY
1660 1670 1680 1690 1700
WVTMGTNSAL KSVTTQGHEL AMMTYHGNSG LLATKSNENG WTTFYEYDSF
1710 1720 1730 1740 1750
GRLTNVTFPT GQVSSFRSDT DSSVHVQVET SSKDDVTITT NLSASGAFYT
1760 1770 1780 1790 1800
LLQDQVRNSY YIGADGSLRL LLANGMEVAL QTEPHLLAGT VNPTVGKRNV
1810 1820 1830 1840 1850
TLPIDNGLNL VEWRQRKEQA RGQVTVFGRR LRVHNRNLLS LDFDRVTRTE
1860 1870 1880 1890 1900
KIYDDHRKFT LRILYDQAGR PSLWSPSSRL NGVNVTYSPG GYIAGIQRGI
1910 1920 1930 1940 1950
MSERMEYDQA GRITSRIFAD GKTWSYTYLE KSMVLLLHSQ RQYIFEFDKN
1960 1970 1980 1990 2000
DRLSSVTMPN VARQTLETIR SVGYYRNIYQ PPEGNASVIQ DFTEDGHLLH
2010 2020 2030 2040 2050
TFYLGTGRRV IYKYGKLSKL AETLYDTTKV SFTYDETAGM LKTINLQNEG
2060 2070 2080 2090 2100
FTCTIRYRQI GPLIDRQIFR FTEEGMVNAR FDYNYDNSFR VTSMQAVINE
2110 2120 2130 2140 2150
TPLPIDLYRY DDVSGKTEQF GKFGVIYYDI NQIITTAVMT HTKHFDAYGR
2160 2170 2180 2190 2200
MKEVQYEIFR SLMYWMTVQY DNMGRVVKKE LKVGPYANTT RYSYEYDADG
2210 2220 2230 2240 2250
QLQTVSINDK PLWRYSYDLN GNLHLLSPGN SARLTPLRYD IRDRITRLGD
2260 2270 2280 2290 2300
VQYKMDEDGF LRQRGGDIFE YNSAGLLIKA YNRAGSWSVR YRYDGLGRRV
2310 2320 2330 2340 2350
SSKSSHSHHL QFFYADLTNP TKVTHLYNHS SSEITSLYYD LQGHLFAMEL
2360 2370 2380 2390 2400
SSGDEFYIAC DNIGTPLAVF SGTGLMIKQI LYTAYGEIYM DTNPNFQIII
2410 2420 2430 2440 2450
GYHGGLYDPL TKLVHMGRRD YDVLAGRWTS PDHELWKHLS SSNVMPFNLY
2460 2470 2480 2490 2500
MFKNNNPISN SQDIKCFMTD VNSWLLTFGF QLHNVIPGYP KPDMDAMEPS
2510 2520 2530 2540 2550
YELIHTQMKT QEWDNSKSIL GVQCEVQKQL KAFVTLERFD QLYGSTITSC
2560 2570 2580 2590 2600
QQAPKTKKFA SSGSVFGKGV KFALKDGRVT TDIISVANED GRRVAAILNH
2610 2620 2630 2640 2650
AHYLENLHFT IDGVDTHYFV KPGPSEGDLA ILGLSGGRRT LENGVNVTVS
2660 2670 2680 2690 2700
QINTVLNGRT RRYTDIQLQY GALCLNTRYG TTLDEEKARV LELARQRAVR
2710 2720 2730 2740 2750
QAWAREQQRL REGEEGLRAW TEGEKQQVLS TGRVQGYDGF FVISVEQYPE
2760
LSDSANNIHF MRQSEMGRR
Length:2,769
Mass (Da):307,957
Last modified:October 31, 2006 - v2
Checksum:i280D87D43FBE88A1
GO

Sequence cautioni

The sequence BAB71206.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1471 – 14711T → I in CAE45850. (PubMed:17974005)Curated
Sequence conflicti1842 – 18421D → G in CAD97943. (PubMed:17974005)Curated
Sequence conflicti2024 – 20241L → F in CAD97943. (PubMed:17974005)Curated
Sequence conflicti2393 – 23931N → D in CAE45850. (PubMed:17974005)Curated
Sequence conflicti2551 – 25511Q → L in BAB71206. (PubMed:14702039)Curated
Sequence conflicti2586 – 25861V → G in CAB45719. (PubMed:17974005)Curated
Sequence conflicti2599 – 25991N → D in CAB45719. (PubMed:17974005)Curated
Sequence conflicti2657 – 26571N → S in BAB71206. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti14 – 141R → Q.
Corresponds to variant rs58537389 [ dbSNP | Ensembl ].
VAR_062167
Natural varianti396 – 3961V → I.
Corresponds to variant rs3812723 [ dbSNP | Ensembl ].
VAR_060130
Natural varianti506 – 5061E → Q.
Corresponds to variant rs17137261 [ dbSNP | Ensembl ].
VAR_060131

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP002515 Genomic DNA. No translation available.
AP002768 Genomic DNA. No translation available.
AP002958 Genomic DNA. No translation available.
AP002957 Genomic DNA. No translation available.
AB037723 mRNA. Translation: BAA92540.3.
BX640737 mRNA. Translation: CAE45850.1.
AL080120 mRNA. Translation: CAB45719.1.
BX537983 mRNA. Translation: CAD97943.1.
AK056531 mRNA. Translation: BAB71206.1. Different initiation.
CCDSiCCDS44688.1.
PIRiT12457.
RefSeqiNP_001092286.2. NM_001098816.2.
UniGeneiHs.213087.

Genome annotation databases

EnsembliENST00000278550; ENSP00000278550; ENSG00000149256.
ENST00000612046; ENSP00000483150; ENSG00000149256.
GeneIDi26011.
KEGGihsa:26011.
UCSCiuc001ozl.4. human.

Polymorphism databases

DMDMi117949795.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP002515 Genomic DNA. No translation available.
AP002768 Genomic DNA. No translation available.
AP002958 Genomic DNA. No translation available.
AP002957 Genomic DNA. No translation available.
AB037723 mRNA. Translation: BAA92540.3 .
BX640737 mRNA. Translation: CAE45850.1 .
AL080120 mRNA. Translation: CAB45719.1 .
BX537983 mRNA. Translation: CAD97943.1 .
AK056531 mRNA. Translation: BAB71206.1 . Different initiation.
CCDSi CCDS44688.1.
PIRi T12457.
RefSeqi NP_001092286.2. NM_001098816.2.
UniGenei Hs.213087.

3D structure databases

ProteinModelPortali Q6N022.
SMRi Q6N022. Positions 566-865, 1535-1564.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117484. 1 interaction.

PTM databases

PhosphoSitei Q6N022.

Polymorphism databases

DMDMi 117949795.

Proteomic databases

MaxQBi Q6N022.
PaxDbi Q6N022.
PRIDEi Q6N022.

Protocols and materials databases

DNASUi 26011.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000278550 ; ENSP00000278550 ; ENSG00000149256 .
ENST00000612046 ; ENSP00000483150 ; ENSG00000149256 .
GeneIDi 26011.
KEGGi hsa:26011.
UCSCi uc001ozl.4. human.

Organism-specific databases

CTDi 26011.
GeneCardsi GC11M078363.
H-InvDB HIX0009980.
HGNCi HGNC:29945. TENM4.
MIMi 610084. gene.
neXtProti NX_Q6N022.
PharmGKBi PA134896466.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG323120.
GeneTreei ENSGT00760000119131.
HOGENOMi HOG000231701.
HOVERGENi HBG080306.
InParanoidi Q6N022.
OMAi NQFVSQQ.
OrthoDBi EOG7H791C.
PhylomeDBi Q6N022.
TreeFami TF316833.

Miscellaneous databases

ChiTaRSi TENM4. human.
GeneWikii ODZ4.
GenomeRNAii 26011.
NextBioi 47758.
PROi Q6N022.
SOURCEi Search...

Gene expression databases

Bgeei Q6N022.
CleanExi HS_ODZ4.
ExpressionAtlasi Q6N022. baseline and differential.
Genevestigatori Q6N022.

Family and domain databases

Gene3Di 2.120.10.30. 1 hit.
InterProi IPR011042. 6-blade_b-propeller_TolB-like.
IPR008969. CarboxyPept-like_regulatory.
IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR013111. EGF_extracell.
IPR022385. Rhs_assc_core.
IPR027691. Ten-4.
IPR009471. Ten_N.
IPR028916. Tox-GHH_dom.
IPR006530. YD.
[Graphical view ]
PANTHERi PTHR11219:SF9. PTHR11219:SF9. 1 hit.
Pfami PF07974. EGF_2. 1 hit.
PF12661. hEGF. 1 hit.
PF05593. RHS_repeat. 1 hit.
PF06484. Ten_N. 2 hits.
PF15636. Tox-GHH. 1 hit.
[Graphical view ]
SMARTi SM00181. EGF. 7 hits.
[Graphical view ]
SUPFAMi SSF49464. SSF49464. 1 hit.
TIGRFAMsi TIGR03696. Rhs_assc_core. 1 hit.
TIGR01643. YD_repeat_2x. 2 hits.
PROSITEi PS00022. EGF_1. 8 hits.
PS01186. EGF_2. 7 hits.
PS50026. EGF_3. 5 hits.
PS51361. TENEURIN_N. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
    DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 754-2769.
    Tissue: Brain.
  3. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
    Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
    DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1371-2769.
    Tissue: Brain, Cervix and Fetal kidney.
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2040-2715.
  6. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.

Entry informationi

Entry nameiTEN4_HUMAN
AccessioniPrimary (citable) accession number: Q6N022
Secondary accession number(s): A6ND26
, Q7Z3C7, Q96MS6, Q9P2P4, Q9Y4S2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 31, 2006
Last modified: November 26, 2014
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3