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Q6MZZ7

- CAN13_HUMAN

UniProt

Q6MZZ7 - CAN13_HUMAN

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Protein

Calpain-13

Gene
CAPN13
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Probable non-lysosomal thiol-protease By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei93 – 931 By similarity
Active sitei249 – 2491 By similarity
Active sitei273 – 2731 By similarity

GO - Molecular functioni

  1. calcium-dependent cysteine-type endopeptidase activity Source: RefGenome
  2. calcium ion binding Source: InterPro

GO - Biological processi

  1. proteolysis Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Protein family/group databases

MEROPSiC02.020.

Names & Taxonomyi

Protein namesi
Recommended name:
Calpain-13 (EC:3.4.22.-)
Alternative name(s):
Calcium-activated neutral proteinase 13
Short name:
CANP 13
Gene namesi
Name:CAPN13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:16663. CAPN13.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: RefGenome
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134931170.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 669669Calpain-13PRO_0000259582Add
BLAST

Proteomic databases

PaxDbiQ6MZZ7.
PRIDEiQ6MZZ7.

PTM databases

PhosphoSiteiQ6MZZ7.

Expressioni

Tissue specificityi

Weakly expressed in lung and testis. Weakly or not expressed in other tissues.1 Publication

Gene expression databases

ArrayExpressiQ6MZZ7.
BgeeiQ6MZZ7.
CleanExiHS_CAPN13.
GenevestigatoriQ6MZZ7.

Organism-specific databases

HPAiHPA029497.
HPA030034.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000295055.

Structurei

Secondary structure

1
669
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi518 – 52912
Helixi540 – 55011
Beta strandi555 – 5584
Helixi560 – 58021
Beta strandi586 – 5883
Helixi589 – 5913
Helixi592 – 5976
Helixi600 – 6023
Helixi609 – 61911
Beta strandi624 – 6263
Helixi628 – 64821
Beta strandi650 – 6534
Helixi659 – 6679

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2I7AX-ray1.80A515-669[»]
ProteinModelPortaliQ6MZZ7.
SMRiQ6MZZ7. Positions 14-669.

Miscellaneous databases

EvolutionaryTraceiQ6MZZ7.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini34 – 333300Calpain catalyticAdd
BLAST
Domaini538 – 57336EF-hand 1Add
BLAST
Domaini636 – 66934EF-hand 2Add
BLAST

Sequence similaritiesi

Belongs to the peptidase C2 family.
Contains 2 EF-hand domains.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG257157.
HOGENOMiHOG000232035.
HOVERGENiHBG012645.
KOiK08581.
OMAiRIFLKMP.
OrthoDBiEOG7RV9FM.
PhylomeDBiQ6MZZ7.
TreeFamiTF314748.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR022684. Calpain_cysteine_protease.
IPR022682. Calpain_domain_III.
IPR029544. CANP13.
IPR011992. EF-hand-dom_pair.
IPR001300. Peptidase_C2_calpain_cat.
[Graphical view]
PANTHERiPTHR10183:SF37. PTHR10183:SF37. 1 hit.
PfamiPF01067. Calpain_III. 1 hit.
PF00648. Peptidase_C2. 1 hit.
[Graphical view]
PRINTSiPR00704. CALPAIN.
SMARTiSM00230. CysPc. 1 hit.
[Graphical view]
SUPFAMiSSF49758. SSF49758. 1 hit.
PROSITEiPS50203. CALPAIN_CAT. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6MZZ7-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAYYQEPSVE TSIIKFKDQD FTTLRDHCLS MGRTFKDETF PAADSSIGQK    50
LLQEKRLSNV IWKRPQDLPG GPPHFILDDI SRFDIQQGGA ADCWFLAALG 100
SLTQNPQYRQ KILMVQSFSH QYAGIFRFRF WQCGQWVEVV IDDRLPVQGD 150
KCLFVRPRHQ NQEFWPCLLE KAYAKLLGSY SDLHYGFLED ALVDLTGGVI 200
TNIHLHSSPV DLVKAVKTAT KAGSLITCAT PSGPTDTAQA MENGLVSLHA 250
YTVTGAEQIQ YRRGWEEIIS LWNPWGWGEA EWRGRWSDGS QEWEETCDPR 300
KSQLHKKRED GEFWMSCQDF QQKFIAMFIC SEIPITLDHG NTLHEGWSQI 350
MFRKQVILGN TAGGPRNDAQ FNFSVQEPME GTNVVVCVTV AVTPSNLKAE 400
DAKFPLDFQV ILAGSQRFRE KFPPVFFSSF RNTVQSSNNK FRRNFTMTYH 450
LSPGNYVVVA QTRRKSAEFL LRIFLKMPDS DRHLSSHFNL RMKGSPSEHG 500
SQQSIFNRYA QQRLDIDATQ LQGLLNQELL TGPPGDMFSL DECRSLVALM 550
ELKVNGRLDQ EEFARLWKRL VHYQHVFQKV QTSPGVLLSS DLWKAIENTD 600
FLRGIFISRE LLHLVTLRYS DSVGRVSFPS LVCFLMRLEA MAKTFRNLSK 650
DGKGLYLTEM EWMSLVMYN 669
Length:669
Mass (Da):76,696
Last modified:October 31, 2006 - v2
Checksum:iBB24CF09D55CF790
GO
Isoform 2 (identifier: Q6MZZ7-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     417-423: RFREKFP → KHCPKLK
     424-669: Missing.

Note: No experimental confirmation available.

Show »
Length:423
Mass (Da):48,002
Checksum:i54122B6EFF505BCC
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti249 – 2491H → Y.
Corresponds to variant rs17010210 [ dbSNP | Ensembl ].
VAR_028964
Natural varianti280 – 2801A → T.2 Publications
Corresponds to variant rs508405 [ dbSNP | Ensembl ].
VAR_028965
Natural varianti596 – 5961I → T.
Corresponds to variant rs2276568 [ dbSNP | Ensembl ].
VAR_028966

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei417 – 4237RFREKFP → KHCPKLK in isoform 2. VSP_021476
Alternative sequencei424 – 669246Missing in isoform 2. VSP_021477Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti562 – 5621E → G in CAE45878. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK074418 mRNA. Translation: BAB85075.1.
BX640793 mRNA. Translation: CAE45878.1.
AC092569 Genomic DNA. Translation: AAX82015.1.
BC117347 mRNA. Translation: AAI17348.1.
BC117345 mRNA. Translation: AAI17346.1.
CCDSiCCDS46252.1. [Q6MZZ7-1]
RefSeqiNP_653176.2. NM_144575.2. [Q6MZZ7-1]
UniGeneiHs.660911.

Genome annotation databases

EnsembliENST00000295055; ENSP00000295055; ENSG00000162949. [Q6MZZ7-1]
ENST00000458085; ENSP00000416191; ENSG00000162949. [Q6MZZ7-2]
GeneIDi92291.
KEGGihsa:92291.
UCSCiuc002rnp.1. human. [Q6MZZ7-1]

Polymorphism databases

DMDMi117949375.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK074418 mRNA. Translation: BAB85075.1 .
BX640793 mRNA. Translation: CAE45878.1 .
AC092569 Genomic DNA. Translation: AAX82015.1 .
BC117347 mRNA. Translation: AAI17348.1 .
BC117345 mRNA. Translation: AAI17346.1 .
CCDSi CCDS46252.1. [Q6MZZ7-1 ]
RefSeqi NP_653176.2. NM_144575.2. [Q6MZZ7-1 ]
UniGenei Hs.660911.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2I7A X-ray 1.80 A 515-669 [» ]
ProteinModelPortali Q6MZZ7.
SMRi Q6MZZ7. Positions 14-669.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000295055.

Protein family/group databases

MEROPSi C02.020.

PTM databases

PhosphoSitei Q6MZZ7.

Polymorphism databases

DMDMi 117949375.

Proteomic databases

PaxDbi Q6MZZ7.
PRIDEi Q6MZZ7.

Protocols and materials databases

DNASUi 92291.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000295055 ; ENSP00000295055 ; ENSG00000162949 . [Q6MZZ7-1 ]
ENST00000458085 ; ENSP00000416191 ; ENSG00000162949 . [Q6MZZ7-2 ]
GeneIDi 92291.
KEGGi hsa:92291.
UCSCi uc002rnp.1. human. [Q6MZZ7-1 ]

Organism-specific databases

CTDi 92291.
GeneCardsi GC02M030945.
H-InvDB HIX0018641.
HGNCi HGNC:16663. CAPN13.
HPAi HPA029497.
HPA030034.
MIMi 610228. gene.
neXtProti NX_Q6MZZ7.
PharmGKBi PA134931170.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG257157.
HOGENOMi HOG000232035.
HOVERGENi HBG012645.
KOi K08581.
OMAi RIFLKMP.
OrthoDBi EOG7RV9FM.
PhylomeDBi Q6MZZ7.
TreeFami TF314748.

Miscellaneous databases

ChiTaRSi CAPN13. human.
EvolutionaryTracei Q6MZZ7.
GenomeRNAii 92291.
NextBioi 77670.
PROi Q6MZZ7.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q6MZZ7.
Bgeei Q6MZZ7.
CleanExi HS_CAPN13.
Genevestigatori Q6MZZ7.

Family and domain databases

Gene3Di 1.10.238.10. 1 hit.
InterProi IPR022684. Calpain_cysteine_protease.
IPR022682. Calpain_domain_III.
IPR029544. CANP13.
IPR011992. EF-hand-dom_pair.
IPR001300. Peptidase_C2_calpain_cat.
[Graphical view ]
PANTHERi PTHR10183:SF37. PTHR10183:SF37. 1 hit.
Pfami PF01067. Calpain_III. 1 hit.
PF00648. Peptidase_C2. 1 hit.
[Graphical view ]
PRINTSi PR00704. CALPAIN.
SMARTi SM00230. CysPc. 1 hit.
[Graphical view ]
SUPFAMi SSF49758. SSF49758. 1 hit.
PROSITEi PS50203. CALPAIN_CAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT THR-280.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Esophageal carcinoma.
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT THR-280.
    Tissue: Colon.
  5. "Identification and characterization of two novel calpain large subunit genes."
    Dear T.N., Boehm T.
    Gene 274:245-252(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  6. "Structure of human calpain 13."
    Structural genomics consortium (SGC)
    Submitted (FEB-2009) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 515-669.

Entry informationi

Entry nameiCAN13_HUMAN
AccessioniPrimary (citable) accession number: Q6MZZ7
Secondary accession number(s): Q17RF0, Q580X1, Q8TE80
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 31, 2006
Last modified: September 3, 2014
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Peptidase families
    Classification of peptidase families and list of entries
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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