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Q6MZZ7

- CAN13_HUMAN

UniProt

Q6MZZ7 - CAN13_HUMAN

Protein

Calpain-13

Gene

CAPN13

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 2 (31 Oct 2006)
      Previous versions | rss
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    Functioni

    Probable non-lysosomal thiol-protease.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei93 – 931PROSITE-ProRule annotation
    Active sitei249 – 2491PROSITE-ProRule annotation
    Active sitei273 – 2731PROSITE-ProRule annotation

    GO - Molecular functioni

    1. calcium-dependent cysteine-type endopeptidase activity Source: RefGenome
    2. calcium ion binding Source: InterPro

    GO - Biological processi

    1. proteolysis Source: RefGenome

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Protein family/group databases

    MEROPSiC02.020.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Calpain-13 (EC:3.4.22.-)
    Alternative name(s):
    Calcium-activated neutral proteinase 13
    Short name:
    CANP 13
    Gene namesi
    Name:CAPN13
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:16663. CAPN13.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: RefGenome

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134931170.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 669669Calpain-13PRO_0000259582Add
    BLAST

    Proteomic databases

    PaxDbiQ6MZZ7.
    PRIDEiQ6MZZ7.

    PTM databases

    PhosphoSiteiQ6MZZ7.

    Expressioni

    Tissue specificityi

    Weakly expressed in lung and testis. Weakly or not expressed in other tissues.1 Publication

    Gene expression databases

    ArrayExpressiQ6MZZ7.
    BgeeiQ6MZZ7.
    CleanExiHS_CAPN13.
    GenevestigatoriQ6MZZ7.

    Organism-specific databases

    HPAiHPA029497.
    HPA030034.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000295055.

    Structurei

    Secondary structure

    1
    669
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi518 – 52912
    Helixi540 – 55011
    Beta strandi555 – 5584
    Helixi560 – 58021
    Beta strandi586 – 5883
    Helixi589 – 5913
    Helixi592 – 5976
    Helixi600 – 6023
    Helixi609 – 61911
    Beta strandi624 – 6263
    Helixi628 – 64821
    Beta strandi650 – 6534
    Helixi659 – 6679

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2I7AX-ray1.80A515-669[»]
    ProteinModelPortaliQ6MZZ7.
    SMRiQ6MZZ7. Positions 14-669.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ6MZZ7.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini34 – 333300Calpain catalyticPROSITE-ProRule annotationAdd
    BLAST
    Domaini538 – 57336EF-hand 1Add
    BLAST
    Domaini636 – 66934EF-hand 2Add
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase C2 family.Curated
    Contains 1 calpain catalytic domain.PROSITE-ProRule annotation
    Contains 2 EF-hand domains.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG257157.
    HOGENOMiHOG000232035.
    HOVERGENiHBG012645.
    KOiK08581.
    OMAiRIFLKMP.
    OrthoDBiEOG7RV9FM.
    PhylomeDBiQ6MZZ7.
    TreeFamiTF314748.

    Family and domain databases

    Gene3Di1.10.238.10. 1 hit.
    InterProiIPR022684. Calpain_cysteine_protease.
    IPR022682. Calpain_domain_III.
    IPR029544. CANP13.
    IPR011992. EF-hand-dom_pair.
    IPR001300. Peptidase_C2_calpain_cat.
    [Graphical view]
    PANTHERiPTHR10183:SF37. PTHR10183:SF37. 1 hit.
    PfamiPF01067. Calpain_III. 1 hit.
    PF00648. Peptidase_C2. 1 hit.
    [Graphical view]
    PRINTSiPR00704. CALPAIN.
    SMARTiSM00230. CysPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF49758. SSF49758. 1 hit.
    PROSITEiPS50203. CALPAIN_CAT. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6MZZ7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAYYQEPSVE TSIIKFKDQD FTTLRDHCLS MGRTFKDETF PAADSSIGQK    50
    LLQEKRLSNV IWKRPQDLPG GPPHFILDDI SRFDIQQGGA ADCWFLAALG 100
    SLTQNPQYRQ KILMVQSFSH QYAGIFRFRF WQCGQWVEVV IDDRLPVQGD 150
    KCLFVRPRHQ NQEFWPCLLE KAYAKLLGSY SDLHYGFLED ALVDLTGGVI 200
    TNIHLHSSPV DLVKAVKTAT KAGSLITCAT PSGPTDTAQA MENGLVSLHA 250
    YTVTGAEQIQ YRRGWEEIIS LWNPWGWGEA EWRGRWSDGS QEWEETCDPR 300
    KSQLHKKRED GEFWMSCQDF QQKFIAMFIC SEIPITLDHG NTLHEGWSQI 350
    MFRKQVILGN TAGGPRNDAQ FNFSVQEPME GTNVVVCVTV AVTPSNLKAE 400
    DAKFPLDFQV ILAGSQRFRE KFPPVFFSSF RNTVQSSNNK FRRNFTMTYH 450
    LSPGNYVVVA QTRRKSAEFL LRIFLKMPDS DRHLSSHFNL RMKGSPSEHG 500
    SQQSIFNRYA QQRLDIDATQ LQGLLNQELL TGPPGDMFSL DECRSLVALM 550
    ELKVNGRLDQ EEFARLWKRL VHYQHVFQKV QTSPGVLLSS DLWKAIENTD 600
    FLRGIFISRE LLHLVTLRYS DSVGRVSFPS LVCFLMRLEA MAKTFRNLSK 650
    DGKGLYLTEM EWMSLVMYN 669
    Length:669
    Mass (Da):76,696
    Last modified:October 31, 2006 - v2
    Checksum:iBB24CF09D55CF790
    GO
    Isoform 2 (identifier: Q6MZZ7-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         417-423: RFREKFP → KHCPKLK
         424-669: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:423
    Mass (Da):48,002
    Checksum:i54122B6EFF505BCC
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti562 – 5621E → G in CAE45878. (PubMed:17974005)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti249 – 2491H → Y.
    Corresponds to variant rs17010210 [ dbSNP | Ensembl ].
    VAR_028964
    Natural varianti280 – 2801A → T.2 Publications
    Corresponds to variant rs508405 [ dbSNP | Ensembl ].
    VAR_028965
    Natural varianti596 – 5961I → T.
    Corresponds to variant rs2276568 [ dbSNP | Ensembl ].
    VAR_028966

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei417 – 4237RFREKFP → KHCPKLK in isoform 2. 1 PublicationVSP_021476
    Alternative sequencei424 – 669246Missing in isoform 2. 1 PublicationVSP_021477Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK074418 mRNA. Translation: BAB85075.1.
    BX640793 mRNA. Translation: CAE45878.1.
    AC092569 Genomic DNA. Translation: AAX82015.1.
    BC117347 mRNA. Translation: AAI17348.1.
    BC117345 mRNA. Translation: AAI17346.1.
    CCDSiCCDS46252.1. [Q6MZZ7-1]
    RefSeqiNP_653176.2. NM_144575.2. [Q6MZZ7-1]
    UniGeneiHs.660911.

    Genome annotation databases

    EnsembliENST00000295055; ENSP00000295055; ENSG00000162949. [Q6MZZ7-1]
    ENST00000458085; ENSP00000416191; ENSG00000162949. [Q6MZZ7-2]
    GeneIDi92291.
    KEGGihsa:92291.
    UCSCiuc002rnp.1. human. [Q6MZZ7-1]

    Polymorphism databases

    DMDMi117949375.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK074418 mRNA. Translation: BAB85075.1 .
    BX640793 mRNA. Translation: CAE45878.1 .
    AC092569 Genomic DNA. Translation: AAX82015.1 .
    BC117347 mRNA. Translation: AAI17348.1 .
    BC117345 mRNA. Translation: AAI17346.1 .
    CCDSi CCDS46252.1. [Q6MZZ7-1 ]
    RefSeqi NP_653176.2. NM_144575.2. [Q6MZZ7-1 ]
    UniGenei Hs.660911.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2I7A X-ray 1.80 A 515-669 [» ]
    ProteinModelPortali Q6MZZ7.
    SMRi Q6MZZ7. Positions 14-669.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000295055.

    Protein family/group databases

    MEROPSi C02.020.

    PTM databases

    PhosphoSitei Q6MZZ7.

    Polymorphism databases

    DMDMi 117949375.

    Proteomic databases

    PaxDbi Q6MZZ7.
    PRIDEi Q6MZZ7.

    Protocols and materials databases

    DNASUi 92291.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000295055 ; ENSP00000295055 ; ENSG00000162949 . [Q6MZZ7-1 ]
    ENST00000458085 ; ENSP00000416191 ; ENSG00000162949 . [Q6MZZ7-2 ]
    GeneIDi 92291.
    KEGGi hsa:92291.
    UCSCi uc002rnp.1. human. [Q6MZZ7-1 ]

    Organism-specific databases

    CTDi 92291.
    GeneCardsi GC02M030945.
    H-InvDB HIX0018641.
    HGNCi HGNC:16663. CAPN13.
    HPAi HPA029497.
    HPA030034.
    MIMi 610228. gene.
    neXtProti NX_Q6MZZ7.
    PharmGKBi PA134931170.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG257157.
    HOGENOMi HOG000232035.
    HOVERGENi HBG012645.
    KOi K08581.
    OMAi RIFLKMP.
    OrthoDBi EOG7RV9FM.
    PhylomeDBi Q6MZZ7.
    TreeFami TF314748.

    Miscellaneous databases

    ChiTaRSi CAPN13. human.
    EvolutionaryTracei Q6MZZ7.
    GenomeRNAii 92291.
    NextBioi 77670.
    PROi Q6MZZ7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q6MZZ7.
    Bgeei Q6MZZ7.
    CleanExi HS_CAPN13.
    Genevestigatori Q6MZZ7.

    Family and domain databases

    Gene3Di 1.10.238.10. 1 hit.
    InterProi IPR022684. Calpain_cysteine_protease.
    IPR022682. Calpain_domain_III.
    IPR029544. CANP13.
    IPR011992. EF-hand-dom_pair.
    IPR001300. Peptidase_C2_calpain_cat.
    [Graphical view ]
    PANTHERi PTHR10183:SF37. PTHR10183:SF37. 1 hit.
    Pfami PF01067. Calpain_III. 1 hit.
    PF00648. Peptidase_C2. 1 hit.
    [Graphical view ]
    PRINTSi PR00704. CALPAIN.
    SMARTi SM00230. CysPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49758. SSF49758. 1 hit.
    PROSITEi PS50203. CALPAIN_CAT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT THR-280.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Esophageal carcinoma.
    3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT THR-280.
      Tissue: Colon.
    5. "Identification and characterization of two novel calpain large subunit genes."
      Dear T.N., Boehm T.
      Gene 274:245-252(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    6. "Structure of human calpain 13."
      Structural genomics consortium (SGC)
      Submitted (FEB-2009) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 515-669.

    Entry informationi

    Entry nameiCAN13_HUMAN
    AccessioniPrimary (citable) accession number: Q6MZZ7
    Secondary accession number(s): Q17RF0, Q580X1, Q8TE80
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: October 31, 2006
    Last modified: October 1, 2014
    This is version 86 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. Peptidase families
      Classification of peptidase families and list of entries
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3