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Protein

Follistatin-related protein 4

Gene

FSTL4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi187 – 19812PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Protein family/group databases

MEROPSiI01.977.

Names & Taxonomyi

Protein namesi
Recommended name:
Follistatin-related protein 4
Alternative name(s):
Follistatin-like protein 4
Gene namesi
Name:FSTL4
Synonyms:KIAA1061
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:21389. FSTL4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134969998.

Polymorphism and mutation databases

BioMutaiFSTL4.
DMDMi296439344.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Chaini23 – 842820Follistatin-related protein 4PRO_0000251925Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi270 ↔ 321By similarity
Glycosylationi318 – 3181N-linked (GlcNAc...)Sequence analysis
Disulfide bondi362 ↔ 413By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ6MZW2.
PaxDbiQ6MZW2.
PeptideAtlasiQ6MZW2.
PRIDEiQ6MZW2.

PTM databases

iPTMnetiQ6MZW2.
PhosphoSiteiQ6MZW2.

Expressioni

Gene expression databases

BgeeiQ6MZW2.
CleanExiHS_FSTL4.
ExpressionAtlasiQ6MZW2. baseline and differential.
GenevisibleiQ6MZW2. HS.

Organism-specific databases

HPAiHPA045920.

Interactioni

Protein-protein interaction databases

BioGridi116730. 3 interactions.
STRINGi9606.ENSP00000265342.

Structurei

3D structure databases

ProteinModelPortaliQ6MZW2.
SMRiQ6MZW2. Positions 64-133, 171-431.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini81 – 13555Kazal-likePROSITE-ProRule annotationAdd
BLAST
Domaini174 – 20936EF-handPROSITE-ProRule annotationAdd
BLAST
Domaini251 – 33888Ig-like 1Add
BLAST
Domaini341 – 42686Ig-like 2Add
BLAST

Sequence similaritiesi

Contains 1 EF-hand domain.PROSITE-ProRule annotation
Contains 1 Kazal-like domain.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IEEJ. Eukaryota.
ENOG410YBHC. LUCA.
GeneTreeiENSGT00530000063333.
HOGENOMiHOG000236319.
HOVERGENiHBG051667.
InParanoidiQ6MZW2.
OMAiHASGHEQ.
OrthoDBiEOG7V766P.
PhylomeDBiQ6MZW2.
TreeFamiTF350473.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
2.130.10.10. 1 hit.
2.60.40.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR002350. Kazal_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PfamiPF07648. Kazal_2. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
SM00280. KAZAL. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF48726. SSF48726. 2 hits.
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 1 hit.
PS50835. IG_LIKE. 3 hits.
PS51465. KAZAL_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6MZW2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKPGGFWLHL TLLGASLPAA LGWMDPGTSR GPDVGVGESQ AEEPRSFEVT
60 70 80 90 100
RREGLSSHNE LLASCGKKFC SRGSRCVLSR KTGEPECQCL EACRPSYVPV
110 120 130 140 150
CGSDGRFYEN HCKLHRAACL LGKRITVIHS KDCFLKGDTC TMAGYARLKN
160 170 180 190 200
VLLALQTRLQ PLQEGDSRQD PASQKRLLVE SLFRDLDADG NGHLSSSELA
210 220 230 240 250
QHVLKKQDLD EDLLGCSPGD LLRFDDYNSD SSLTLREFYM AFQVVQLSLA
260 270 280 290 300
PEDRVSVTTV TVGLSTVLTC AVHGDLRPPI IWKRNGLTLN FLDLEDINDF
310 320 330 340 350
GEDDSLYITK VTTIHMGNYT CHASGHEQLF QTHVLQVNVP PVIRVYPESQ
360 370 380 390 400
AQEPGVAASL RCHAEGIPMP RITWLKNGVD VSTQMSKQLS LLANGSELHI
410 420 430 440 450
SSVRYEDTGA YTCIAKNEVG VDEDISSLFI EDSARKTLAN ILWREEGLSV
460 470 480 490 500
GNMFYVFSDD GIIVIHPVDC EIQRHLKPTE KIFMSYEEIC PQREKNATQP
510 520 530 540 550
CQWVSAVNVR NRYIYVAQPA LSRVLVVDIQ AQKVLQSIGV DPLPAKLSYD
560 570 580 590 600
KSHDQVWVLS WGDVHKSRPS LQVITEASTG QSQHLIRTPF AGVDDFFIPP
610 620 630 640 650
TNLIINHIRF GFIFNKSDPA VHKVDLETMM PLKTIGLHHH GCVPQAMAHT
660 670 680 690 700
HLGGYFFIQC RQDSPASAAR QLLVDSVTDS VLGPNGDVTG TPHTSPDGRF
710 720 730 740 750
IVSAAADSPW LHVQEITVRG EIQTLYDLQI NSGISDLAFQ RSFTESNQYN
760 770 780 790 800
IYAALHTEPD LLFLELSTGK VGMLKNLKEP PAGPAQPWGG THRIMRDSGL
810 820 830 840
FGQYLLTPAR ESLFLINGRQ NTLRCEVSGI KGGTTVVWVG EV
Length:842
Mass (Da):93,096
Last modified:May 18, 2010 - v3
Checksum:i9EEE073CD3C99517
GO
Isoform 2 (identifier: Q6MZW2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     78-246: Missing.

Show »
Length:673
Mass (Da):74,158
Checksum:i2DDD63D9A07A2983
GO
Isoform 3 (identifier: Q6MZW2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     601-605: TNLII → INLEQ
     606-842: Missing.

Note: No experimental confirmation available.
Show »
Length:605
Mass (Da):67,196
Checksum:i96EBE5E3C84F9F71
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti60 – 601E → K in CAE45915 (PubMed:17974005).Curated
Sequence conflicti240 – 2401M → I in AAH24300 (PubMed:15489334).Curated
Sequence conflicti764 – 7641L → P in CAE45915 (PubMed:17974005).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti158 – 1581R → H.
Corresponds to variant rs17683306 [ dbSNP | Ensembl ].
VAR_027727
Natural varianti757 – 7571T → M.1 Publication
Corresponds to variant rs3749817 [ dbSNP | Ensembl ].
VAR_027728

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei78 – 246169Missing in isoform 2. 1 PublicationVSP_020800Add
BLAST
Alternative sequencei601 – 6055TNLII → INLEQ in isoform 3. 1 PublicationVSP_020801
Alternative sequencei606 – 842237Missing in isoform 3. 1 PublicationVSP_020802Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX640845 mRNA. Translation: CAE45915.1.
AC005195 Genomic DNA. No translation available.
AC010307 Genomic DNA. No translation available.
AC010608 Genomic DNA. No translation available.
AC012614 Genomic DNA. No translation available.
BC024300 mRNA. Translation: AAH24300.1.
AB028984 mRNA. Translation: BAA83013.1.
CCDSiCCDS34238.1. [Q6MZW2-1]
RefSeqiNP_055897.1. NM_015082.1. [Q6MZW2-1]
XP_011541585.1. XM_011543283.1. [Q6MZW2-1]
UniGeneiHs.483390.

Genome annotation databases

EnsembliENST00000265342; ENSP00000265342; ENSG00000053108. [Q6MZW2-1]
ENST00000621681; ENSP00000484273; ENSG00000053108. [Q6MZW2-2]
GeneIDi23105.
KEGGihsa:23105.
UCSCiuc003kyn.2. human. [Q6MZW2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX640845 mRNA. Translation: CAE45915.1.
AC005195 Genomic DNA. No translation available.
AC010307 Genomic DNA. No translation available.
AC010608 Genomic DNA. No translation available.
AC012614 Genomic DNA. No translation available.
BC024300 mRNA. Translation: AAH24300.1.
AB028984 mRNA. Translation: BAA83013.1.
CCDSiCCDS34238.1. [Q6MZW2-1]
RefSeqiNP_055897.1. NM_015082.1. [Q6MZW2-1]
XP_011541585.1. XM_011543283.1. [Q6MZW2-1]
UniGeneiHs.483390.

3D structure databases

ProteinModelPortaliQ6MZW2.
SMRiQ6MZW2. Positions 64-133, 171-431.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116730. 3 interactions.
STRINGi9606.ENSP00000265342.

Protein family/group databases

MEROPSiI01.977.

PTM databases

iPTMnetiQ6MZW2.
PhosphoSiteiQ6MZW2.

Polymorphism and mutation databases

BioMutaiFSTL4.
DMDMi296439344.

Proteomic databases

EPDiQ6MZW2.
PaxDbiQ6MZW2.
PeptideAtlasiQ6MZW2.
PRIDEiQ6MZW2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265342; ENSP00000265342; ENSG00000053108. [Q6MZW2-1]
ENST00000621681; ENSP00000484273; ENSG00000053108. [Q6MZW2-2]
GeneIDi23105.
KEGGihsa:23105.
UCSCiuc003kyn.2. human. [Q6MZW2-1]

Organism-specific databases

CTDi23105.
GeneCardsiFSTL4.
HGNCiHGNC:21389. FSTL4.
HPAiHPA045920.
neXtProtiNX_Q6MZW2.
PharmGKBiPA134969998.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEEJ. Eukaryota.
ENOG410YBHC. LUCA.
GeneTreeiENSGT00530000063333.
HOGENOMiHOG000236319.
HOVERGENiHBG051667.
InParanoidiQ6MZW2.
OMAiHASGHEQ.
OrthoDBiEOG7V766P.
PhylomeDBiQ6MZW2.
TreeFamiTF350473.

Miscellaneous databases

GenomeRNAii23105.
PROiQ6MZW2.

Gene expression databases

BgeeiQ6MZW2.
CleanExiHS_FSTL4.
ExpressionAtlasiQ6MZW2. baseline and differential.
GenevisibleiQ6MZW2. HS.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
2.130.10.10. 1 hit.
2.60.40.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR002350. Kazal_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PfamiPF07648. Kazal_2. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
SM00280. KAZAL. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF48726. SSF48726. 2 hits.
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 1 hit.
PS50835. IG_LIKE. 3 hits.
PS51465. KAZAL_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT MET-757.
    Tissue: Small intestine.
  2. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Lung.
  4. "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 150-842 (ISOFORM 1).
    Tissue: Brain.
  5. "An enigmatic fourth runt domain gene in the fugu genome: ancestral gene loss versus accelerated evolution."
    Glusman G., Kaur A., Hood L., Rowen L.
    BMC Evol. Biol. 4:43-43(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiFSTL4_HUMAN
AccessioniPrimary (citable) accession number: Q6MZW2
Secondary accession number(s): Q8TBU0, Q9UPU1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: May 18, 2010
Last modified: July 6, 2016
This is version 112 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.