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Protein

Regulator of G-protein signaling 7-binding protein

Gene

RGS7BP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Regulator of G protein-coupled receptor (GPCR) signaling. Regulatory subunit of the R7-Gbeta5 complexes that acts by controlling the subcellular location of the R7-Gbeta5 complexes. When palmitoylated, it targets the R7-Gbeta5 complexes to the plasma membrane, leading to inhibit G protein alpha subunits. When it is unpalmitoylated, the R7-Gbeta5 complexes undergo a nuclear/cypolasmic shuttling. May also act by controlling the proteolytic stability of R7 proteins, probably by protecting them from degradation.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Signal transduction inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of G-protein signaling 7-binding protein
Alternative name(s):
R7 family-binding protein
Gene namesi
Name:RGS7BP
Synonyms:R7BP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:23271. RGS7BP.

Subcellular locationi

  • Nucleus By similarity
  • Cytoplasm By similarity
  • Cell membrane By similarity; Lipid-anchor By similarity

  • Note: Shuttling between the plasma membrane, the cytoplasm and the nucleus is regulated by palmitoylation.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162401279.

Polymorphism and mutation databases

DMDMi296452985.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 257257Regulator of G-protein signaling 7-binding proteinPRO_0000287595Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi252 – 2521S-palmitoyl cysteineBy similarity
Lipidationi253 – 2531S-palmitoyl cysteineBy similarity

Post-translational modificationi

Palmitoylation regulates the cell membrane and nuclear shuttling and the regulation of GPCR signaling. Upon depalmitoylation, it is targeted into the nucleus.By similarity

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ6MZT1.
PeptideAtlasiQ6MZT1.
PRIDEiQ6MZT1.
TopDownProteomicsiQ6MZT1.

PTM databases

PhosphoSiteiQ6MZT1.

Expressioni

Gene expression databases

BgeeiENSG00000186479.
CleanExiHS_RGS7BP.
GenevisibleiQ6MZT1. HS.

Organism-specific databases

HPAiHPA039600.

Interactioni

Subunit structurei

Interacts with 'R7' family proteins RGS6, RGS7, RGS9 and RGS11. Component of some R7-Gbeta5 complex composed of some R7 protein (RGS6, RGS7, RGS9 or RGS11), Gbeta5 (GNB5) and RGS7BP.By similarity

Protein-protein interaction databases

BioGridi134967. 3 interactions.
STRINGi9606.ENSP00000334851.

Structurei

3D structure databases

ProteinModelPortaliQ6MZT1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi242 – 2476Nuclear localization signalBy similarity

Domaini

The nuclear localization signal is both required for nuclear localization and palmitoylation.By similarity

Sequence similaritiesi

Belongs to the RGS7BP/RGS9BP family.Curated

Phylogenomic databases

eggNOGiENOG410IH1X. Eukaryota.
ENOG410YXJD. LUCA.
GeneTreeiENSGT00390000006968.
HOGENOMiHOG000154060.
HOVERGENiHBG104928.
InParanoidiQ6MZT1.
OMAiGSLQLHR.
OrthoDBiEOG091G0GG3.
PhylomeDBiQ6MZT1.
TreeFamiTF330985.

Family and domain databases

InterProiIPR026512. RGS7BP/RGS9BP.
[Graphical view]
PANTHERiPTHR21029. PTHR21029. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6MZT1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSAPNGRKK RPSRSTRSSI FQISKPPLQS GDWERRGSGS ESAHKTQRAL
60 70 80 90 100
DDCKMLVQEF NTQVALYREL VISIGDVSVS CPSLRAEMHK TRTKGCEMAR
110 120 130 140 150
QAHQKLAAIS GPEDGEIHPE ICRLYIQLQC CLEMYTTEML KSICLLGSLQ
160 170 180 190 200
FHRKGKEPGG GTKSLDCKIE ESAETPALED SSSSPVDSQQ HSWQVSTDIE
210 220 230 240 250
NTERDMREMK NLLSKLRETM PLPLKNQDDS SLLNLTPYPL VRRRKRRFFG

LCCLISS
Length:257
Mass (Da):28,962
Last modified:May 18, 2010 - v3
Checksum:i889F690C6DCC40F5
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti255 – 2551I → V.3 Publications
Corresponds to variant rs889248 [ dbSNP | Ensembl ].
VAR_032334

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK296443 mRNA. Translation: BAH12357.1.
AC091862 Genomic DNA. No translation available.
AC035143 Genomic DNA. No translation available.
AC008854 Genomic DNA. No translation available.
CH471137 Genomic DNA. Translation: EAW51372.1.
BC140707 mRNA. Translation: AAI40708.1.
BX640900 mRNA. Translation: CAE45947.1.
CCDSiCCDS34170.1.
RefSeqiNP_001025046.1. NM_001029875.2.
NP_001258819.1. NM_001271890.1.
NP_001258820.1. NM_001271891.1.
UniGeneiHs.657133.

Genome annotation databases

EnsembliENST00000334025; ENSP00000334851; ENSG00000186479.
GeneIDi401190.
KEGGihsa:401190.
UCSCiuc003jtj.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK296443 mRNA. Translation: BAH12357.1.
AC091862 Genomic DNA. No translation available.
AC035143 Genomic DNA. No translation available.
AC008854 Genomic DNA. No translation available.
CH471137 Genomic DNA. Translation: EAW51372.1.
BC140707 mRNA. Translation: AAI40708.1.
BX640900 mRNA. Translation: CAE45947.1.
CCDSiCCDS34170.1.
RefSeqiNP_001025046.1. NM_001029875.2.
NP_001258819.1. NM_001271890.1.
NP_001258820.1. NM_001271891.1.
UniGeneiHs.657133.

3D structure databases

ProteinModelPortaliQ6MZT1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi134967. 3 interactions.
STRINGi9606.ENSP00000334851.

PTM databases

PhosphoSiteiQ6MZT1.

Polymorphism and mutation databases

DMDMi296452985.

Proteomic databases

PaxDbiQ6MZT1.
PeptideAtlasiQ6MZT1.
PRIDEiQ6MZT1.
TopDownProteomicsiQ6MZT1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334025; ENSP00000334851; ENSG00000186479.
GeneIDi401190.
KEGGihsa:401190.
UCSCiuc003jtj.5. human.

Organism-specific databases

CTDi401190.
GeneCardsiRGS7BP.
H-InvDBHIX0024981.
HGNCiHGNC:23271. RGS7BP.
HPAiHPA039600.
MIMi610890. gene.
neXtProtiNX_Q6MZT1.
PharmGKBiPA162401279.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IH1X. Eukaryota.
ENOG410YXJD. LUCA.
GeneTreeiENSGT00390000006968.
HOGENOMiHOG000154060.
HOVERGENiHBG104928.
InParanoidiQ6MZT1.
OMAiGSLQLHR.
OrthoDBiEOG091G0GG3.
PhylomeDBiQ6MZT1.
TreeFamiTF330985.

Miscellaneous databases

GenomeRNAii401190.
PROiQ6MZT1.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000186479.
CleanExiHS_RGS7BP.
GenevisibleiQ6MZT1. HS.

Family and domain databases

InterProiIPR026512. RGS7BP/RGS9BP.
[Graphical view]
PANTHERiPTHR21029. PTHR21029. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiR7BP_HUMAN
AccessioniPrimary (citable) accession number: Q6MZT1
Secondary accession number(s): B7Z3X1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 18, 2010
Last modified: September 7, 2016
This is version 84 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.