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Protein

HLA class I histocompatibility antigen protein P5

Gene

HCP5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  • defense response Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
HLA class I histocompatibility antigen protein P5
Alternative name(s):
HLA complex protein P5
Protein P5-1
Gene namesi
Name:HCP5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:21659. HCP5.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134951826.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 132132HLA class I histocompatibility antigen protein P5PRO_0000329059Add
BLAST

Proteomic databases

PRIDEiQ6MZN7.

Expressioni

Tissue specificityi

Expressed in lymphoid tissues; Detected in spleen as well as in B-cell lines, NK cell lines and activated lymphocytes.1 Publication

Gene expression databases

CleanExiHS_HCP5.

Sequencei

Sequence statusi: Complete.

Q6MZN7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLRMSEHRN EALGNYLEMR LKSSFLRGLG SWKSNPLRLG GWTILLTLTM
60 70 80 90 100
GQGEPGGPQG DPWVPHELLL PSLCDSSHAS SWGSGSITCA WRGGDSSSHP
110 120 130
LVSGHILSNS PVAAVMCSSM GTHLSPFKGT LL
Length:132
Mass (Da):14,098
Last modified:July 5, 2004 - v1
Checksum:i33BFBD82E613F773
GO

Sequence cautioni

The sequence AAA59986.1 differs from that shown. Reason: Frameshift at positions 58 and 125. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti59 – 602QG → K in AAA59986 (PubMed:8462994).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti32 – 321W → R.
Corresponds to variant rs17206855 [ dbSNP | Ensembl ].
VAR_042638
Natural varianti82 – 821W → C.
Corresponds to variant rs2255221 [ dbSNP | Ensembl ].
VAR_042639
Natural varianti93 – 931G → E.
Corresponds to variant rs2255223 [ dbSNP | Ensembl ].
VAR_042640
Natural varianti112 – 1121V → G Associated with low viral load in HIV patients. 2 Publications
Corresponds to variant rs2395029 [ dbSNP | Ensembl ].
VAR_042641
Natural varianti123 – 1231H → R.
Corresponds to variant rs3130907 [ dbSNP | Ensembl ].
VAR_042642

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L06175 mRNA. Translation: AAA59986.1. Frameshift.
AK290875 mRNA. Translation: BAF83564.1.
BX640979 mRNA. Translation: CAE45991.1.
CH471081 Genomic DNA. Translation: EAX03398.1.
BC106759 mRNA. Translation: AAI06760.1.
UniGeneiHs.691948.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L06175 mRNA. Translation: AAA59986.1. Frameshift.
AK290875 mRNA. Translation: BAF83564.1.
BX640979 mRNA. Translation: CAE45991.1.
CH471081 Genomic DNA. Translation: EAX03398.1.
BC106759 mRNA. Translation: AAI06760.1.
UniGeneiHs.691948.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ6MZN7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

GeneCardsiHCP5.
H-InvDBHIX0166405.
HIX0166921.
HGNCiHGNC:21659. HCP5.
MIMi604676. gene.
neXtProtiNX_Q6MZN7.
PharmGKBiPA134951826.
GenAtlasiSearch...

Miscellaneous databases

NextBioi13629757.
PROiQ6MZN7.
SOURCEiSearch...

Gene expression databases

CleanExiHS_HCP5.

Family and domain databases

ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A novel coding sequence belonging to a new multicopy gene family mapping within the human MHC class I region."
    Vernet C., Ribouchon M.-T., Chimini G., Jouanolle A.-M., Sidibe I., Pontarotti P.
    Immunogenetics 38:47-53(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Spleen.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Rectum tumor.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. "The P5 multicopy gene family in the MHC is related in sequence to human endogenous retroviruses HERV-L and HERV-16."
    Kulski J.K., Dawkins R.L.
    Immunogenetics 49:404-412(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  7. Cited for: VARIANT GLY-112.
  8. "The role of protective HCP5 and HLA-C associated polymorphisms in the control of HIV-1 replication in a subset of elite suppressors."
    Han Y., Lai J., Barditch-Crovo P., Gallant J.E., Williams T.M., Siliciano R.F., Blankson J.N.
    AIDS 22:541-544(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT GLY-112.

Entry informationi

Entry nameiHCP5_HUMAN
AccessioniPrimary (citable) accession number: Q6MZN7
Secondary accession number(s): Q04490
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: July 5, 2004
Last modified: October 14, 2015
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Variation Gly-112 is associated with low viral loads in untreated HIV patients. The level of circulating virus in the plasma of HIV patients (viral set point) varies among individuals during the nonsymptomatic phase preceding the progression to AIDS. This polymorphism explains 9.6% of the total variation in set point and is associated with the HLA-B*5701 allele, which has the strongest described protective impact on HIV disease progression. However, it is possible that HPC5 polymorphism, and not HLA-B*5701 allele, plays a direct role in the control in viremia in HIV patients.
HCP5 is localized within the MHC class I region, but is not structurally related to MHC class I genes. HCP5 is related in sequence to human endogenous retroviruses HERV-L and HERV-16. It has sequence homology with retroviral Pol genes in HERV retroviral element; thus, it is itself a good candidate to interact with HIV-1, possibly through an antisense mechanism against retroviral transcript.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.