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Protein
Submitted name:

Putative uncharacterized protein DKFZp686O12165

Gene

DKFZp686O12165

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Submitted name:
Putative uncharacterized protein DKFZp686O12165Imported
Gene namesi
Name:DKFZp686O12165Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28194.

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PaxDbiQ6MZM7.
PRIDEiQ6MZM7.

Expressioni

Gene expression databases

GenevisibleiQ6MZM7. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000346839.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3T1WX-ray2.40A920-1286[»]
ProteinModelPortaliQ6MZM7.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ6MZM7.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini53 – 9240Fibronectin type-IInterPro annotationAdd
BLAST
Domaini102 – 15049Fibronectin type-IIInterPro annotationAdd
BLAST
Domaini162 – 21049Fibronectin type-IIInterPro annotationAdd
BLAST
Domaini215 – 25844Fibronectin type-IInterPro annotationAdd
BLAST
Domaini263 – 30543Fibronectin type-IInterPro annotationAdd
BLAST
Domaini306 – 34944Fibronectin type-IInterPro annotationAdd
BLAST
Domaini357 – 44993Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini469 – 55991Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini560 – 65192Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini656 – 74590Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini746 – 83590Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini836 – 92287Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini923 – 101795Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini1018 – 110689Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini1107 – 119993Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini1200 – 128788Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini1288 – 138194Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini1382 – 147392Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini1474 – 156188Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini1562 – 165594Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini1656 – 174287Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini1743 – 183391Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini1912 – 200493Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini2011 – 205545Fibronectin type-IInterPro annotationAdd
BLAST
Domaini2056 – 209843Fibronectin type-IInterPro annotationAdd
BLAST
Domaini2100 – 214041Fibronectin type-IInterPro annotationAdd
BLAST

Keywords - Domaini

RepeatSAAS annotation

Phylogenomic databases

eggNOGiENOG410IF4N. Eukaryota.
ENOG410Y2NH. LUCA.
HOGENOMiHOG000234344.
HOVERGENiHBG005731.

Family and domain databases

Gene3Di2.10.10.10. 2 hits.
2.60.40.10. 17 hits.
InterProiIPR000083. Fibronectin_type1.
IPR003961. FN3_dom.
IPR000562. FN_type2_col-bd.
IPR013783. Ig-like_fold.
IPR013806. Kringle-like.
[Graphical view]
PfamiPF00039. fn1. 7 hits.
PF00040. fn2. 2 hits.
PF00041. fn3. 17 hits.
[Graphical view]
SMARTiSM00058. FN1. 7 hits.
SM00059. FN2. 2 hits.
SM00060. FN3. 17 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 11 hits.
SSF57440. SSF57440. 2 hits.
PROSITEiPS01253. FN1_1. 7 hits.
PS51091. FN1_2. 7 hits.
PS00023. FN2_1. 2 hits.
PS51092. FN2_2. 2 hits.
PS50853. FN3. 17 hits.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q6MZM7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
ARAGCAAQGE EREPQARAGR GDLQPQLLWS SASLLSLHPS PSPPSGPQPP
60 70 80 90 100
PYGHCVTDSG VVYSVGMQWL KTQGNKQMLC TCLGNGVSCQ ETAVTQTYGG
110 120 130 140 150
NSNGEPCVLP FTYNGRTFYS CTTEGRQDGH LWCSTTSNYE QDQKYSFCTD
160 170 180 190 200
HTVLVQTRGG NSNGALCHFP FLYNNHNYTD CTSEGRRDNM KWCGTTQNYD
210 220 230 240 250
ADQKFGFCPM AAHEEICTTN EGVMYRIGDQ WDKQHDMGHM MRCTCVGNGR
260 270 280 290 300
GEWTCIAYSQ LRDQCIVDDI TYNVNDTFHK RHEEGHMLNC TCFGQGRGRW
310 320 330 340 350
KCDPVDQCQD SETGTFYQIG DSWEKYVHGV RYQCYCYGRG IGEWHCQPLQ
360 370 380 390 400
TYPSSSGPVE VFITETPSQP NSHPIQWNAP QPSHISKYIL RWRPKNSVGR
410 420 430 440 450
WKEATIPGHL NSYTIKGLKP GVVYEGQLIS IQQYGHQEVT RFDFTTTSTS
460 470 480 490 500
TPVTSNTVTG ETTPFSPLVA TSESVTEITA SSFVVSWVSA SDTVSGFRVE
510 520 530 540 550
YELSEEGDEP QYLDLPSTAT SVNIPDLLPG RKYIVNVYQI SEDGEQSLIL
560 570 580 590 600
STSQTTAPDA PPDPTVDQVD DTSIVVRWSR PQAPITGYRI VYSPSVEGSS
610 620 630 640 650
TELNLPETAN SVTLSDLQPG VQYNITIYAV EENQESTPVV IQQETTGTPR
660 670 680 690 700
SDTVPSPRDL QFVEVTDVKV TIMWTPPESA VTGYRVDVIP VNLPGEHGQR
710 720 730 740 750
LPISRNTFAE VTGLSPGVTY YFKVFAVSHG RESKPLTAQQ TTKLDAPTNL
760 770 780 790 800
QFVNETDSTV LVRWTPPRAQ ITGYRLTVGL TRRGQPRQYN VGPSVSKYPL
810 820 830 840 850
RNLQPASEYT VSLVAIKGNQ ESPKATGVFT TLQPGSSIPP YNTEVTETTI
860 870 880 890 900
VITWTPAPRI GFKLGVRPSQ GGEAPREVTS DSGSIVVSGL TPGVEYVYTI
910 920 930 940 950
QVLRDGQERD APIVNKVVTP LSPPTNLHLE ANPDTGVLTV SWERSTTPDI
960 970 980 990 1000
TGYRITTTPT NGQQGNSLEE VVHADQSSCT FDNLSPGLEY NVSVYTVKDD
1010 1020 1030 1040 1050
KESVPISDTI IPEVPQLTDL SFVDITDSSI GLRWTPLNSS TIIGYRITVV
1060 1070 1080 1090 1100
AAGEGIPIFE DFVDSSVGYY TVTGLEPGID YDISVITLIN GGESAPTTLT
1110 1120 1130 1140 1150
QQTAVPPPTD LRFTNIGPDT MRVTWAPPPS IDLTNFLVRY SPVKNEEDVA
1160 1170 1180 1190 1200
ELSISPSDNA VVLTNLLPGT EYVVSVSSVY EQHESTPLRG RQKTGLDSPT
1210 1220 1230 1240 1250
GIDFSDITAN SFTVHWIAPR ATITGYRIRH HPEHFSGRPR EDRVPHSRNS
1260 1270 1280 1290 1300
ITLTNLTPGT EYVVSIVALN GREESPLLIG QQSTVSDVPR DLEVVAATPT
1310 1320 1330 1340 1350
SLLISWDAPA VTVRYYRITY GETGGNSPVQ EFTVPGSKST ATISGLKPGV
1360 1370 1380 1390 1400
DYTITVHAVT GRGDSPASSK PISINYRTEI DKPSQMQVTD VQDNSISVKW
1410 1420 1430 1440 1450
LPSSSPVTGY RVTTTPKNGP GPTKTKTAGP DQTEMTIEGL QPTVEYVVSV
1460 1470 1480 1490 1500
YAQNPSGESQ PLVQTAVTNI DRPKGLAFTD VDVDSIKIAW ESPQGQVSRY
1510 1520 1530 1540 1550
RVTYSSPEDG IHELFPAPDG EEDTAELQGL RPGSEYTVSV VALHDDMESQ
1560 1570 1580 1590 1600
PLIGTQSTAI PAPTDLKFTQ VTPTSLSAQW TPPNVQLTGY RVRVTPKEKT
1610 1620 1630 1640 1650
GPMKEINLAP DSSSVVVSGL MVATKYEVSV YALKDTLTSR PAQGVVTTLE
1660 1670 1680 1690 1700
NVGPPRRARV TDATETTITI SWRTKTETIT GFQVDAVPAN GQTPIQRTIK
1710 1720 1730 1740 1750
PDVRSYTITG LQPGTDYKIY LYTLNDNARS SPVVIDASTA IDAPSNLRFL
1760 1770 1780 1790 1800
ATTPNSLLVS WQPPRARITG YIIKYEKPGS PPREVVPRPR PGVTEATITG
1810 1820 1830 1840 1850
LEPGTEYTIY VIALKNNQKS EPLIGRKKTD ELPQLVTLPH PNLHGPEILD
1860 1870 1880 1890 1900
VPSTVQKTPF VTHPGYDTGN GIQLPGTSGQ QPSVGQQMIF EEHGFRRTTP
1910 1920 1930 1940 1950
PTTATPIRHR PRPYPPNVGQ EALSQTTISW APFQDTSEYI ISCHPVGTDE
1960 1970 1980 1990 2000
EPLQFRVPGT STSATLTGLT RGATYNIIVE ALKDQQRHKV REEVVTVGNS
2010 2020 2030 2040 2050
VNEGLNQPTD DSCFDPYTVS HYAVGDEWER MSESGFKLLC QCLGFGSGHF
2060 2070 2080 2090 2100
RCDSSRWCHD NGVNYKIGEK WDRQGENGQM MSCTCLGNGK GEFKCDPHEA
2110 2120 2130 2140 2150
TCYDDGKTYH VGEQWQKEYL GAICSCTCFG GQRGWRCDNC RRPGGEPTPE
2160 2170 2180 2190
GTTGQSYNQY SQRYHQRTNT NVNCPIECFM PLDVQADRED SRE
Length:2,193
Mass (Da):240,642
Last modified:July 5, 2004 - v1
Checksum:iF876E93106540EF3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX640999 mRNA. Translation: CAE46002.1.
RefSeqiNP_001293060.1. NM_001306131.1.
NP_997647.1. NM_212482.2.
UniGeneiHs.203717.

Genome annotation databases

GeneIDi2335.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX640999 mRNA. Translation: CAE46002.1.
RefSeqiNP_001293060.1. NM_001306131.1.
NP_997647.1. NM_212482.2.
UniGeneiHs.203717.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3T1WX-ray2.40A920-1286[»]
ProteinModelPortaliQ6MZM7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000346839.

Proteomic databases

PaxDbiQ6MZM7.
PRIDEiQ6MZM7.

Protocols and materials databases

DNASUi2335.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2335.

Organism-specific databases

CTDi2335.
PharmGKBiPA28194.

Phylogenomic databases

eggNOGiENOG410IF4N. Eukaryota.
ENOG410Y2NH. LUCA.
HOGENOMiHOG000234344.
HOVERGENiHBG005731.

Miscellaneous databases

EvolutionaryTraceiQ6MZM7.
GenomeRNAii2335.
NextBioi9473.

Gene expression databases

GenevisibleiQ6MZM7. HS.

Family and domain databases

Gene3Di2.10.10.10. 2 hits.
2.60.40.10. 17 hits.
InterProiIPR000083. Fibronectin_type1.
IPR003961. FN3_dom.
IPR000562. FN_type2_col-bd.
IPR013783. Ig-like_fold.
IPR013806. Kringle-like.
[Graphical view]
PfamiPF00039. fn1. 7 hits.
PF00040. fn2. 2 hits.
PF00041. fn3. 17 hits.
[Graphical view]
SMARTiSM00058. FN1. 7 hits.
SM00059. FN2. 2 hits.
SM00060. FN3. 17 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 11 hits.
SSF57440. SSF57440. 2 hits.
PROSITEiPS01253. FN1_1. 7 hits.
PS51091. FN1_2. 7 hits.
PS00023. FN2_1. 2 hits.
PS51092. FN2_2. 2 hits.
PS50853. FN3. 17 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. The German Human cDNA Consortium
    Lauber J., Bahr A., Mewes H.W., Weil B., Amid C., Osanger A., Fobo G., Han M., Wiemann S.
    Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Human uterus endothel primary cell cultureImported.
  2. "Extra-domain B in oncofetal fibronectin structurally promotes fibrillar head-to-tail dimerization of extracellular matrix protein."
    Schiefner A., Gebauer M., Skerra A.
    J. Biol. Chem. 287:17578-17588(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS) OF 920-1286.

Entry informationi

Entry nameiQ6MZM7_HUMAN
AccessioniPrimary (citable) accession number: Q6MZM7
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: March 16, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.