Q6MZH4 (Q6MZH4_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Putative uncharacterized protein DKFZp686A22123 EMBL CAE46059.1

Gene names

Name:

DKFZp686A22123 EMBL CAE46059.1

Organism

Homo sapiens (Human) EMBL CAE46059.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	819 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Cofactor

Cobalamin By similarity. PIRSR PIRSR000381-2

Ontologies

Keywords
Ligand	Cobalamin PIRSR PIRSR000381-2 Cobalt Metal-binding PIRSR PIRSR000381-1 S-adenosyl-L-methionine PIRSR PIRSR000381-2
Gene Ontology (GO)
Biological_process	pteridine-containing compound metabolic process Inferred from electronic annotation. Source: InterPro
Cellular_component	intracellular Inferred from electronic annotation. Source: InterPro
Molecular_function	cobalamin binding Inferred from electronic annotation. Source: UniProtKB-KW methionine synthase activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Region	414 – 415	2	Cobalamin-binding By similarity PIRSR PIRSR000381-2
	Region	781 – 782	2	S-adenosyl-L-methionine binding By similarity PIRSR PIRSR000381-2
Sites
	Metal binding	339	1	Cobalt (cobalamin axial ligand) By similarity PIRSR PIRSR000381-1
	Binding site	528	1	S-adenosyl-L-methionine By similarity PIRSR PIRSR000381-2
	Binding site	726	1	S-adenosyl-L-methionine; via carbonyl oxygen By similarity PIRSR PIRSR000381-2
	Binding site	730	1	Cobalamin; via carbonyl oxygen By similarity PIRSR PIRSR000381-2
Experimental info
	Non-terminal residue	1	1	EMBL CAE46059.1

Sequences

	Sequence		Length	Mass (Da)
	Q6MZH4 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: F7E740BE2F828B8C	FASTA	819	91,731
	10 20 30 40 50 60 GMLDGPSAMT RFCNLIASEP DIAKVPLCID SSNFAVIEAG LKCCQGKCIV NSISLKEGQA 70 80 90 100 110 120 TETDTKIRVC TRAYHLLVKK LGFNPNDIIF DPNILTIGTG MEEHNLYAIN FIHATKVIKE 130 140 150 160 170 180 TLPGARISGG LSNLSFSFRG MEAIREAMHG VFLYHAIKSG MDMGIVNAGN LPVYDDIHKE 190 200 210 220 230 240 LLQLCEDLIW NKDPEATEKL LRYAQTQGTG GKKVIQTDEW RNGPVEERLE YALVKGIEKH 250 260 270 280 290 300 IIEDTEEARL NQKKYPRPLN IIEGPLMNGM KIVGDLFGAG KMFLPQVIKS ARVMKKAVGH 310 320 330 340 350 360 LIPFMEKERE ETRVLNGTVE EEDPYQGTIV LATVKGDVHD IGKNIVGVVL GCNNFRVIDL 370 380 390 400 410 420 GVMTPCDKIL KAALDHKADI IGLSGLITPS LDEMIFVAKE MERLAIRIPL LIGGATTSKT 430 440 450 460 470 480 HTAVKIAPRY SAPVIHVLDA SKSVVVCSQL LDENLKDEYF EEIMEEYEDI RQGHYESLKE 490 500 510 520 530 540 RRYLPLSQAR KSGFQMDWLP EPHPVKPTFI GTQVFEDYDL QKLVDYIDWK PFFDVWQLRG 550 560 570 580 590 600 KYPNRGFPKI FNDKTVGGEA RKVYDDAHNM LNTLISQKKL RARGVVGFWP AQSIQDDIHL 610 620 630 640 650 660 YAEAAVPQAA EPIATFYGLR QQAEKDSAST EPYYCLSDFI APLHSGIRDY LGLFAVACFG 670 680 690 700 710 720 VEELSKAYED DGDDYSSIMV KALGDRLAEA FAEELHERVR RELWAYCGSE QLDVADLRRL 730 740 750 760 770 780 RYKGIRPAPG YPSQPDHTEK LTMWRLADIE QSTGIRLTES LAMAPASAVS GLYFSNLKSK 790 800 810 YFAVGKISKD QVEDYALRKN ISVAEVEKWL GPILGYDTD

References

[1]	The German Human cDNA Consortium Lauber J., Bahr A., Mewes H.W., Weil B., Amid C., Osanger A., Fobo G., Han M., Wiemann S. Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Human uterus EMBL CAE46059.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX641132 mRNA. Translation: CAE46059.1.
IPI	IPI00644782.
UniGene	Hs.498187.
3D structure databases
HSSP	HSSP built from PDB template 1K7Y based on UniProtKB P13009.
ProteinModelPortal	Q6MZH4.
ModBase	Search...
Protein-protein interaction databases
STRING	Q6MZH4.
Proteomic databases
PRIDE	Q6MZH4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG006347.
Gene expression databases
ArrayExpress	Q6MZH4.
Family and domain databases
Gene3D	1.10.1240.10. 1 hit. 3.10.196.10. 1 hit. 3.20.20.20. 2 hits. 3.40.50.280. 1 hit.
InterPro	IPR003759. Cbl-bd_cap. IPR006158. Cobalamin-bd. IPR011005. Dihydropteroate_synth-like. IPR011822. MetH. IPR000489. Pterin-binding. IPR004223. VitB12-dep_Met_synth_activ_dom. [Graphical view]
PANTHER	PTHR21091:SF9. PTHR21091:SF9. 1 hit.
Pfam	PF02310. B12-binding. 1 hit. PF02607. B12-binding_2. 1 hit. PF02965. Met_synt_B12. 1 hit. PF00809. Pterin_bind. 1 hit. [Graphical view]
PIRSF	PIRSF000381. MetH. 1 hit.
SMART	SM01018. B12-binding_2. 1 hit. [Graphical view]
SUPFAM	SSF52242. Cbl-bd. 1 hit. SSF51717. DHP_synth_like. 1 hit. SSF56507. Met_synth_B12. 1 hit. SSF47644. Met_synth_Cbl-bd. 1 hit.
TIGRFAMs	TIGR02082. metH. 1 hit.
PROSITE	PS50974. ADOMET_ACTIVATION. 1 hit. PS51332. B12_BINDING. 1 hit. PS51337. B12_BINDING_NTER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q6MZH4_HUMAN

Accession

Primary (citable) accession number: Q6MZH4

Entry history

Integrated into UniProtKB/TrEMBL:	July 5, 2004
Last sequence update:	July 5, 2004
Last modified:	April 3, 2013
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.