Q6MZA5 (Q6MZA5_MYCUA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Type I modular polyketide synthase EMBL CAE46850.1

Gene names

Name:	mlsA2 EMBL CAE46850.1
Ordered Locus Names:	MUP039c

Encoded on

Plasmid pMUM001 EMBL CAE46850.1

Organism

Mycobacterium ulcerans (strain Agy99) [Complete proteome] [HAMAP]

Taxonomic identifier

362242 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	2410 AA.
Sequence status	Complete.
Protein existence	Predicted

Ontologies

Keywords
Ligand	Phosphopantetheine RuleBase RU000721
Molecular function	Transferase RuleBase RU000693
Technical term	Complete proteome Plasmid EMBL CAE46850.1
Gene Ontology (GO)
Biological process	biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	acyl carrier activity Inferred from electronic annotation. Source: InterPro cofactor binding Inferred from electronic annotation. Source: InterPro nucleotide binding Inferred from electronic annotation. Source: InterPro oxidoreductase activity Inferred from electronic annotation. Source: InterPro phosphopantetheine binding Inferred from electronic annotation. Source: InterPro transferase activity, transferring acyl groups other than amino-acyl groups Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q6MZA5 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 809EE15E0C6BFF14	FASTA	2,410	256,284
	10 20 30 40 50 60 MVSTEENLRV YLKQVITDLH QMQARLRKIE KQRSERVAVV GMACRFPGGV ASADQLWDLV 70 80 90 100 110 120 IAGRDVVGNF PADRGWDVEG LFDPDPDAVG KTYTRYGAFL DDAAGFDAGF FGISPREARA 130 140 150 160 170 180 MDPQQRLLLE VCWEALETAG IPAHTLAGTS TGVFVGAWAQ SYGATNSDGA EGYAMTGGST 190 200 210 220 230 240 SVMSGRIAYT LGLEGPAITV DTACSSSLVA IHLACQSLRN NESQLALAGG VTVMSTPAVF 250 260 270 280 290 300 TEFSRQRGLA PDGRCKAFAA TADGTGWGEG AAVLVLERLS EARRNNHPVL AIVAGSAINQ 310 320 330 340 350 360 DGASNGLTAP HGPSQQRVIN QALANAGLTH DQVDAVEAHG TGTTLGDPIE ASALHATYGH 370 380 390 400 410 420 HHTPDQPLWL GSIKSNIGHT QAAAGAAGVV KMIQAITHAT LPATLHVDQP SPHIDWSSGT 430 440 450 460 470 480 VRLLTEPIQW PNTDHPRTAA VSSFGISGTN AHLILQQPPT PDTTQTPNTT TGSDPAVGSD 490 500 510 520 530 540 SAVGSDPAVG VLVWPLSARS APGLSAQAAR LYQHLSAHPD LDPIDVAHSL ATTRSHHPHR 550 560 570 580 590 600 ATITTSIEHH SENNHDTTDA LAALHALANN GTHPLLSRGL LTPQGPGKTV FVFPGQGSQY 610 620 630 640 650 660 PGMGADLYRQ FPVFAHALDE VAAALNPHLD VALLEVMFSQ QDTAMAQLLD QTFYAQPALF 670 680 690 700 710 720 ALGTALHRLF THAGIHPDYL LGHSIGELTA AYAAGVLSLQ DAATLVTSRG RLMQSCTPGG 730 740 750 760 770 780 TMLALQASEA EVQPLLEGLD HAVSIAAING ATSIVLSGDH DSLEQIGEHF ITQDRRTTRL 790 800 810 820 830 840 QVSHAFHSPH MDPILEQFRQ IAAQLTFSAP TLPILSNLTG QIARHDQLAS PDYWTQQLRN 850 860 870 880 890 900 TVRFHDTVAA LLGAGEQVFL ELSPHPVLTQ AITDTVEQAG GGGAAVPALR KDRPDAVAFA 910 920 930 940 950 960 AALGQLHCHG ISPSWNVLYC QARPLTLPTY AFQHQRYWLL PTAGDFSGAN THAMHPLLDT 970 980 990 1000 1010 1020 ATELAENRGW VFTGRISPRT QPWLNEHAVE SAVLFPGTGF VELALHVADR AGYSSVNELI 1030 1040 1050 1060 1070 1080 VHTPLLLAGH DTADLQITVT DTDDMGRQSL NIHSHPHIGH DNTTTGDEQP EWVLHASAVL 1090 1100 1110 1120 1130 1140 TAQTTDHNHL PLTPVPWPPP GTAAIEVDDF YDDLAAQGYN YGPTFQGVQR IWRDHATPDV 1150 1160 1170 1180 1190 1200 IYAEVELPED TDIDGYGIHP ALFDAALHPL LALTQPPTND TDDTNTADTG DQVRLPYAFT 1210 1220 1230 1240 1250 1260 GISLHATHAT RLRVRLTRTG ADAITVHTSD TTGAPVAIID SLITRPLTTA TGSAPATTAA 1270 1280 1290 1300 1310 1320 GLLHLSWPPH PDTTTDTDTD TDALRYQVIA EPTQQLPRYL HDLHTSTDLH TSTTEADVVV 1330 1340 1350 1360 1370 1380 WPVPVPSNEE LQAHQASDTA VSSRIHTLTR QTLTVVQDWL THPDTTGTRL VIVTRHGVST 1390 1400 1410 1420 1430 1440 SAHDPVPDLA HAAVWGLIRS AQNEHPGRFT LLDTDDNTNS DTLTTALTLP TRENQLAIRR 1450 1460 1470 1480 1490 1500 DTIHIPRLTR TAVLTPPDSG PWRLDTTGKG DLANLALLPT AHTALASGQI RIDVRAAGLN 1510 1520 1530 1540 1550 1560 FHDVVVALGL IPDDGFGGEA AGVISEIGPD VYGFAVGDAV TGMTVSGAFA PSTVADHRMV 1570 1580 1590 1600 1610 1620 MTIPARWSFP QAASIPVVFL TAYIALAEIS GLSRGQRVLI HAGTGGVGMA AIQLAHHLGA 1630 1640 1650 1660 1670 1680 EVFATASAAK WSTLEALGVP RDHIASSRTL DFSNAFLDAT NGAGVDVVLN CLSGEFVEAS 1690 1700 1710 1720 1730 1740 LALLPRGGHF VEIGKTDIRD TEVIAATHPG VIYRALDLLS VSPDHIQRTL AQLSPLFATD 1750 1760 1770 1780 1790 1800 TLKPLPTTNY SIYQAISALR DMSQARHTGK IVLTAPVVVD PEGTVLITGG TGTLGALFAE 1810 1820 1830 1840 1850 1860 HLVSAHGVRH LLLTSRRGPQ AHGATDLQQR LTDLGAHVTI TACDISDPEA LAALVNSVPT 1870 1880 1890 1900 1910 1920 QHRLTAVVHT AAVLADTPVT ELTGDQLDQV LAPKIDAAWQ LHQLTYEHNL SAFIMFSSMA 1930 1940 1950 1960 1970 1980 GMIGSPGQGN YAAANTALDA LADYRHRLGL PATSLAWGYW QTRTGVTAHL TDVDLARMTR 1990 2000 2010 2020 2030 2040 LGLMPIATSH GLALFDAALA TGQPVSIPAP INTHTLARHA RDNTLTPILS ALITTPRRRA 2050 2060 2070 2080 2090 2100 ASAATDLAAR LNGLSPQQQQ QTLATLVAAA TATVLGHHTP ESISPATAFK DLGIDSLTAL 2110 2120 2130 2140 2150 2160 ELRNTLTHNT GLDLPPTLIF DHPTPHALTQ HLHTRLTQSH TPVGPIASLL SHAIDEGKFR 2170 2180 2190 2200 2210 2220 AGADLLMAAS NLNQSFSNMA ELNQLPAVTD IADASPDGLL TLICISTSEN EYARLAAANI 2230 2240 2250 2260 2270 2280 HSLTFAEIAA PGFYDAQLPN SIETSAEALA TAITGAYANT SIVLVAHSIV CELAQATMTR 2290 2300 2310 2320 2330 2340 LQDADIDLVG LVLLDPLEGT NSTEDYVETV LTRIEHINAP RVGVDGYLAA LGRYLQFHED 2350 2360 2370 2380 2390 2400 RRIPIPETRH MTLHSDTKID RAQTPMNLLQ DEAALTALKI GNWMNDTGSI AVTLRDGPVF 2410 LGRARSVNMR

References

[1]

"Functional analysis and annotation of the virulence plasmid pMUM001 from Mycobacterium ulcerans." Stinear T.P., Pryor M.J., Porter J.L., Cole S.T. Microbiology 151:683-692(2005) [PubMed: 15758215] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

[2]

"Giant plasmid-encoded polyketide synthases produce the macrolide toxin of Mycobacterium ulcerans." Stinear T.P., Mve-Obiang A., Small P.L.C., Frigui W., Pryor M.J., Brosch R., Jenkin G.A., Johnson P.D.R., Davies J.K., Lee R.E., Adusumilli S., Garnier T., Haydock S.F., Leadlay P.F., Cole S.T. Proc. Natl. Acad. Sci. U.S.A. 101:1345-1349(2004) [PubMed: 14736915] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX649209 Genomic DNA. Translation: CAE46850.1.
RefSeq	YP_025561.1. NC_005916.1.
3D structure databases
ProteinModelPortal	Q6MZA5.
ModBase	Search...
Protein-protein interaction databases
STRING	Q6MZA5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000077378; EBMYCP00000075332; EBMYCG00000077373.
GeneID	2846549.
GenomeReviews	Gene locus MUP039c in contig BX649209_GR.
KEGG	mul:MUP039c.
PATRIC	18166323. VBIMycUlc37413_0044.
Organism-specific databases
GenoList	MUP039c.
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000020090.
HOGENOM	HBG669988.
OMA	WALLHSA.
ProtClustDB	CLSK2395196.
Family and domain databases
InterPro	IPR001227. Ac_transferase_dom. IPR009081. Acyl_carrier_prot-like. IPR014043. Acyl_transferase. IPR016035. Acyl_Trfase/lysoPLipase. IPR013149. ADH_C. IPR013154. ADH_GroES-like. IPR000794. Beta-ketoacyl_synthase. IPR011032. GroES-like. IPR018201. Ketoacyl_synth_AS. IPR014031. Ketoacyl_synth_C. IPR014030. Ketoacyl_synth_N. IPR016036. Malonyl_transacylase_ACP-bd. IPR016040. NAD(P)-bd_dom. IPR006163. Phsphopanteth-bd. IPR020842. PKS/FAS_KR. IPR020801. PKS_acyl_transferase. IPR020841. PKS_Beta-ketoAc_synthase_dom. IPR020807. PKS_dehydratase. IPR020843. PKS_ER. IPR013968. PKS_KR. IPR020806. PKS_PP-bd. IPR015083. Polyketide_synth_docking. IPR006162. PPantetheine_attach_site. IPR016039. Thiolase-like. IPR016038. Thiolase-like_subgr. [Graphical view]
Gene3D	G3DSA:3.40.366.10. Ac_transferase_reg. 2 hits. G3DSA:1.10.1200.10. ACP_like. 1 hit. G3DSA:3.40.50.720. NAD(P)-bd. 2 hits. G3DSA:3.40.47.10. Thiolase-like_subgr. 2 hits.
PANTHER	PTHR11712. Ketoacyl_synth. 1 hit.
Pfam	PF00698. Acyl_transf_1. 1 hit. PF08240. ADH_N. 1 hit. PF00107. ADH_zinc_N. 1 hit. PF08990. Docking. 1 hit. PF00109. ketoacyl-synt. 1 hit. PF02801. Ketoacyl-synt_C. 1 hit. PF08659. KR. 1 hit. PF00550. PP-binding. 1 hit. [Graphical view]
SMART	SM00827. PKS_AT. 1 hit. SM00826. PKS_DH. 1 hit. SM00829. PKS_ER. 1 hit. SM00822. PKS_KR. 1 hit. SM00825. PKS_KS. 1 hit. SM00823. PKS_PP. 1 hit. [Graphical view]
SUPFAM	SSF47336. ACP_like. 1 hit. SSF52151. Acyl_Trfase/lysoPlipase. 1 hit. SSF50129. GroES_like. 1 hit. SSF55048. Malonyl_transacylase_ACP-bd. 1 hit. SSF101173. Polyketide_synth_docking. 1 hit. SSF53901. Thiolase-like. 1 hit.
PROSITE	PS50075. ACP_DOMAIN. 1 hit. PS00606. B_KETOACYL_SYNTHASE. 1 hit. PS00012. PHOSPHOPANTETHEINE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q6MZA5_MYCUA

Accession

Primary (citable) accession number: Q6MZA5

Entry history

Integrated into UniProtKB/TrEMBL:	July 5, 2004
Last sequence update:	July 5, 2004
Last modified:	December 14, 2011
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)