Q6MZ72 (Q6MZ72_MYCUA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Type I modular polyketide synthase EMBL CAE46843.1

Gene names

Name:	mlsB EMBL CAE46843.1
Ordered Locus Names:	MUP032c

Encoded on

Plasmid pMUM001 EMBL CAE46843.1

Organism

Mycobacterium ulcerans (strain Agy99) [Complete proteome] [HAMAP]

Taxonomic identifier

362242 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	14130 AA.
Sequence status	Complete.
Protein existence	Predicted

Ontologies

Keywords
Ligand	Phosphopantetheine RuleBase RU000721
Molecular function	Transferase RuleBase RU000693
Technical term	Complete proteome Plasmid EMBL CAE46843.1
Gene Ontology (GO)
Biological process	biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	acyl carrier activity Inferred from electronic annotation. Source: InterPro cofactor binding Inferred from electronic annotation. Source: InterPro nucleotide binding Inferred from electronic annotation. Source: InterPro phosphopantetheine binding Inferred from electronic annotation. Source: InterPro transferase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q6MZ72 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: A150D995F1815034	FASTA	14,130	1,497,639
	10 20 30 40 50 60 MIFGDAHQNC RGGRVLGDAV AVVGMSCRVP GASDPDALWA LLRDGISVVD EIPSARWNLD 70 80 90 100 110 120 GLVAHRLTDE QRSALRHGAF LDDVEGFDAA FFGINPSEAG SMDPQQRLML ELTWAALEDA 130 140 150 160 170 180 RIVPEHLSGS SSGVFTGAMS DDYTTAVTYR AAMTAHTFAG THRSLIANRV SYTLGLRGPS 190 200 210 220 230 240 LVIDTGQSSS LVAVHVAMES LRREETSLAI AGGIHLNLSL AAALSAAHFG ALSPDGRCYT 250 260 270 280 290 300 FDARANGYVR GEGGGVVVLK RLNDALADGN HIYCVIRGSS VNNDGATQDL TAPGVDGQRQ 310 320 330 340 350 360 ALLQAYERAE IDPSEVQYVE LHGTGTRLGD PTEAHSLHSV FGTSTVPRSP LLVGSIKTNI 370 380 390 400 410 420 GHLEGAAGIL GLIKTALAVH HRQLPPSLNY TVPNPKIPLE QLGLRVQTTL SEWPDLDKPL 430 440 450 460 470 480 TAGVSSFSMG GTNAHLILQQ PPTPDTTQTP NPTTGSDPAV GSDPAVGVLV WPLSARSAPG 490 500 510 520 530 540 LSAQAARLYQ HLSAHPDLDP IDVAHSLATT RSHHPHRATI TTSIEHHSEN NHDTTDALAA 550 560 570 580 590 600 LHALANNGTH PLLSRGLLTP QGPGKTVFVF PGQGSQYPGM GADLYRQFPV FAHALDEVAA 610 620 630 640 650 660 ALNPHLDVAL LEVMFSQQDT AMAQLLDQTF YAQPALFALG TALHRLFTHA GIHPDYLLGH 670 680 690 700 710 720 SIGELTAAYA AGVLSLQDAA TLVTSRGRLM QSCTPGGTML ALQASEAEVQ PLLEGLDHAV 730 740 750 760 770 780 SIAAINGATS IVLSGDHDSL EQIGEHFITQ DRRTTRLQVS HAFHSPHMDP ILEQFRQIAA 790 800 810 820 830 840 QLTFSAPTLP ILSNLTGQIA RHDQLASPDY WTQQLRNTVR FHDTVAALLG AGEQVFLELS 850 860 870 880 890 900 PHPVLTQAIT DTVEQAGGGG AAVPALRKDR PDAVAFAAAL GQLHCHGISP SWNVLYCQAR 910 920 930 940 950 960 PLTLPTYAFQ HQRYWLLPTA GDFSGANTHA MHPLLDTATE LAENRGWVFT GRISPRTQPW 970 980 990 1000 1010 1020 LNEHAVESAV LFPNTGFVEL ALHVADRAGY SSVNELIVHT PLLLAGHDTA DLQITVTDTD 1030 1040 1050 1060 1070 1080 DMGRQSLNIH SHPHIGHDNT TTGDEQPEWV LHASAVLTAQ TTDHNHLPLT PVPWPPPGTA 1090 1100 1110 1120 1130 1140 AIEVDDFYDD LAAQGYNYGP TFQGVQRIWR DHATPDVIYA EVELPEDTDI DGYGIHPALF 1150 1160 1170 1180 1190 1200 DAALHPLLAL TQPPTNDTDD TNTADTGDQV RLPYAFTGIS LHATHATRLR VRLTRTGADA 1210 1220 1230 1240 1250 1260 ITVHTSDTTG APVAIIDSLI TRPLTTATGS APATTAAGLL HLSWPPHPDT TTDTDTDTDA 1270 1280 1290 1300 1310 1320 LRYQVIAEPT QQLPRYLHDL HTSTDLHTST TEADVVVWPV PVPSNEELQA HQASDTAVSS 1330 1340 1350 1360 1370 1380 RIHTLTRQTL TVVQDWLTHP DTTGTRLVIV TRHGVSTSAH DPVPDLAHAA VWGLIRSAQN 1390 1400 1410 1420 1430 1440 EHPGRFTLLD TDDNTNSDTL TTALTLPTRE NQLAIRRDTI HIPRLTRHSS DGALTAPVVV 1450 1460 1470 1480 1490 1500 DPEGTVLITG GTGTLGALFA EHLVSAHGVR HLLLTSRRGP QAHGATDLQQ RLTDLGAHVT 1510 1520 1530 1540 1550 1560 ITACDISDPE ALAALVNSVP TQHRLTAVVH TAAVLADTPV TELTGDQLDQ VLAPKIDAAW 1570 1580 1590 1600 1610 1620 QLHQLTYEHN LSAFIMFSSM AGMIGSPGQG NYAAANTALD ALADYRHRLG LPATSLAWGY 1630 1640 1650 1660 1670 1680 WQTHTGLTAH LTDVDLARMT RLGLMPIATS HGLALFDAAL ATGQPVSIPA PINTHTLARH 1690 1700 1710 1720 1730 1740 ARDNTLAPIL SALITTPRRR AASAATDLAA RLNGLSPQQQ QQTLATLVAA ATATVLGHHT 1750 1760 1770 1780 1790 1800 PESISPATAF KDLGIDSLTA LELRNTLTHN TGLNLSSTLI FDHPTPHAVA EHLLEQIPGI 1810 1820 1830 1840 1850 1860 GALVPAPVVI AAGRTEEPVA VVGMACRFPG GVASADQLWD LVIAGRDVVG NFPADRGWDV 1870 1880 1890 1900 1910 1920 EGLFDPDPDA VGKTYTRYGA FLDDAAGFDA GFFGISPREA RAMDPQQRLL LEVCWEALET 1930 1940 1950 1960 1970 1980 AGIPAHTLAG TSTGVFVGAW AQSYGATNSD DAEGYAMTGG ATSVMSGRIA YTLGLEGPAI 1990 2000 2010 2020 2030 2040 TVDTACSSSL VAIHLACQSL RNNESQLALA GGVTVMSTPA VFTEFSRQRG LAPDGRCKAF 2050 2060 2070 2080 2090 2100 AATADGTGWG EGAAVLVLER LSEARRNNHP VLAIVAGSAI NQDGASNGLT APHGPSQQRV 2110 2120 2130 2140 2150 2160 INQALANAGL THDQVDAVEA HGTGTTLGDP IEASALHATY GHHHTPDQPL WLGSIKSNIG 2170 2180 2190 2200 2210 2220 HTQAAAGAAG VVKMIQAITH ATLPATLHVD QPSPHIDWSS GTVRLLTEPI QWPNTDHPRT 2230 2240 2250 2260 2270 2280 AAVSSFGISG TNAHLILQQP PTPNPTQTPE DCSPAQSPCA TITDAGTGLS FVPWVISAKS 2290 2300 2310 2320 2330 2340 AEALSAQASR LLTRLDDDPV VDAIDLGWSL IATRSMFEHR AVVVGADRHQ LQRGLAELAS 2350 2360 2370 2380 2390 2400 GNLGADVVVG RARAAGETVM VFPGQGSQRL GMGAQLYEQF PVFAAAFDDV VDALDQYLRL 2410 2420 2430 2440 2450 2460 PLRQVMWGDD EGLLNSTEFA QPSLFAVEVA LFALLRFWGV VPDYVIGHSV GELAAAQVAG 2470 2480 2490 2500 2510 2520 VLSLQDAAKL VSARGRLMQA LPAGGAMVAV AASQHEVEPL LVEGVDIAAL NAPGSVVISG 2530 2540 2550 2560 2570 2580 DQAAVRLIAN RLADRGYRAH ELAVSHAFHS SLMEPMLEEF ARLASEIVVE QPQIPLISNV 2590 2600 2610 2620 2630 2640 TGQLANADYG SAGYWVDHIR RPVRFADSVA SLEAMGASCF IEVGPASGLG AAIEQSLKSA 2650 2660 2670 2680 2690 2700 EPTVSVSALS TDKPESVAVL RAAARLSTSG IPVDWQSVFD GRSTQTVNLP TYAFQRQRFW 2710 2720 2730 2740 2750 2760 LDANRIGQGD PASQPQAQNV ESRFWEAVER EDVDGLADSI GVTASAMQTV LPALSSWRRA 2770 2780 2790 2800 2810 2820 ERTQSELDSW RYQVTWLSSP ATPSSITLSG IWLLIVPSEL AKTDPVIGCA AALEAHGALV 2830 2840 2850 2860 2870 2880 TIITIFEPDF NRSLMGASLK DIGSHISGVI SFLGIHGSEF SDSGAVKTLN LVQAMGDVHL 2890 2900 2910 2920 2930 2940 DVPLWCLTQG AVSISADDLI RCSSAALVWG LGRVVALEHP GSWGGLVDLP ESPDDAAWER 2950 2960 2970 2980 2990 3000 LCALLAQPTD EDQFAIRPSG VFLRRLIHAP ATTTSKSSTA WAPRGTVLIT GGTGALGAHV 3010 3020 3030 3040 3050 3060 ARWLAHKYES VDLLLTSRRG MAADGATELV DDLRTAGASV TVHACDVTDR TSVEAAIAGK 3070 3080 3090 3100 3110 3120 SLDAVFHLAG RHQPTLLTEL EDESFSDELA PKVHGAQVLS DITSNLTLSA FVMFSSVAGI 3130 3140 3150 3160 3170 3180 WGGKSQGAYA AANAFLDSLA EKRRTLGLPA TSVAWGLWAG GGMGDRPSAS GLNLIGLKSM 3190 3200 3210 3220 3230 3240 SADLAVQALS DAIDRPQATL TVASVNWDRF YPTFALARPR PFLHEITEVM AYRESMRSSS 3250 3260 3270 3280 3290 3300 ASTATLLTSK LAGLTATEQR AVTRKLVLDQ AASVLGYAST ESLDTHESFK DLGFDSLTAL 3310 3320 3330 3340 3350 3360 ELRDHLQTAT GLNLSSTLIF DHPTPHAVAE HLLEQIPGIG ALVPAPVVIA AGRTEEPVAV 3370 3380 3390 3400 3410 3420 VGMACRFPGG VASADQLWDL VIAGRDVVGN FPADRGWDVE GLFDPDPDAV GKTYTRYGAF 3430 3440 3450 3460 3470 3480 LDDAAGFDAG FFGISPREAR AMDPQQRLLL EVCWEALETA GIPAHTLAGT STGVFVGAWA 3490 3500 3510 3520 3530 3540 QSYGATNSDD AEGYAMTGGA TSVMSGRIAY TLGLEGPAIT VDTACSSSLV AIHLACQSLR 3550 3560 3570 3580 3590 3600 NNESQLALAG GVTVMSTPAV FTEFSRQRGL APDGRCKAFA ATADGTGWGE GAAVLVLERL 3610 3620 3630 3640 3650 3660 SEARRNNHPV LAIVAGSAIN QDGASNGLTA PHGPSQQRVI NQALANAGLT HDQVDAVEAH 3670 3680 3690 3700 3710 3720 GTGTTLGDPI EASALHATYG HHHTPDQPLW LGSIKSNIGH TQAAAGAAGV VKMIQAITHA 3730 3740 3750 3760 3770 3780 TLPATLHVDQ PSPHIDWSSG TVRLLTEPIQ WPNTDHPRTA AVSSFGISGT NAHLILQQPP 3790 3800 3810 3820 3830 3840 TPNPTQTPED CSPAQSPCAT ITDAGTGLSF VPWVISAKSA EALSAQASRL LTRLDDDPVV 3850 3860 3870 3880 3890 3900 DAIDLGWSLI ATRSMFEHRA VVVGADRHQL QRGLAELASG NLGADVVVGR ARAAGETVMV 3910 3920 3930 3940 3950 3960 FPGQGSQRLG MGAQLYEQFP VFAAAFDDVV DALDQYLRLP LRQVMWGDDE GLLNSTEFAQ 3970 3980 3990 4000 4010 4020 PSLFAVEVAL FALLRFWGVV PDYVIGHSVG ELAAAQVAGV LSLQDAAKLV SARGRLMQAL 4030 4040 4050 4060 4070 4080 PAGGAMVAVA ASQHEVEPLL VEGVDIAALN APGSVVISGD QAAVRLIANR LADRGYRAHE 4090 4100 4110 4120 4130 4140 LAVSHAFHSS LMEPMLEEFA RLASEIVVEQ PQIPLISNVT GQLANADYGS AGYWVDHIRR 4150 4160 4170 4180 4190 4200 PVRFADSVAS LEAMGASCFI EVGPASGLGA AIEQSLKSAE PTVSVSALST DKPESVAVLR 4210 4220 4230 4240 4250 4260 AAARLSTSGI PVDWQSVFDG RSTQTVNLPT YAFQRQRFWL DANRIGQGDP ASQPQAQNVE 4270 4280 4290 4300 4310 4320 SRFWEAVERE DVDGLADSIG VTASAMQTVL PALSSWRRAE RTQSELDSWR YQVTWLSSPA 4330 4340 4350 4360 4370 4380 TPSSITLSGI WLLIVPSELA KTDPVIGCAA ALEAHGALVT IITIFEPDFN RSLMGASLKD 4390 4400 4410 4420 4430 4440 IGSHISGVIS FLGIHGSEFS DSGAVKTLNL VQAMGDVHLD VPLWCLTQGA VSISADDLIR 4450 4460 4470 4480 4490 4500 CSSAALVWGL GRVVALEHPG SWGGLVDLPE SPDDAAWERL CALLAQPTDE DQFAIRPSGV 4510 4520 4530 4540 4550 4560 FLRRLIHAPA TTTSKSSTAW APRGTVLITG GTGALGAHVA RWLAHKYESV DLLLTSRRGM 4570 4580 4590 4600 4610 4620 AADGATELVD DLRTAGASVT VHACDVTDRT SVEAAIAGKS LDAVFHLAGR HQPTLLTELE 4630 4640 4650 4660 4670 4680 DESFSDELAP KVHGAQVLSD ITSNLTLSAF VMFSSVAGIW GGKSQGAYAA ANAFLDSLAE 4690 4700 4710 4720 4730 4740 KRRTLGLPAT SVAWGLWAGG GMGDRPSASG LNLIGLKSMS ADLAVQALSD AIDRPQATLT 4750 4760 4770 4780 4790 4800 VASVNWDRFY PTFALARPRP FLHEITEVMA YRESMRSSSA STATLLTSKL AGLTATEQRA 4810 4820 4830 4840 4850 4860 VTRKLVLDQA ASVLGYASTE SLDTHESFKD LGFDSLTALE LRDHLQTATG LNLSSTLIFD 4870 4880 4890 4900 4910 4920 HPTPHAVAEH LLEQIPGIGA LVPAPVVIAA GRTEEPVAVV GMACRFPGGV ASADQLWDLV 4930 4940 4950 4960 4970 4980 IAGRDVVGNF PADRGWDVEG LFDPDPDAVG KTYTRYGAFL DDAAGFDAGF FGISPREARA 4990 5000 5010 5020 5030 5040 MDPQQRLLLE VCWEALETAG IPAHTLAGTS TGVFVGAWAQ SYGATNSDDA EGYAMTGGAI 5050 5060 5070 5080 5090 5100 SVMSGRIAYT LGLEGPAITV DTACSSSLVA IHLACQSLRN NESQLALTGG VTVMSTPAIF 5110 5120 5130 5140 5150 5160 TEFSRQRGLA PDGRCKAFAA TADGTGWGEG AAVLVLERLS EARRNNHPVL AIVAGSAINQ 5170 5180 5190 5200 5210 5220 DGASNGLTAP HGPSQQRVIN QALANAGLTH DQVDAVEAHG TGTTLGDPIE ASALHATYGH 5230 5240 5250 5260 5270 5280 HHTPDQPLWL GSIKSNIGHT QAAAGAAGVV KMIQAITHAT LPATLHVDQP SPHIDWSSGT 5290 5300 5310 5320 5330 5340 VRLLTEPIQW PNTDHPRTAA VSSFGISGTN AHLILQQPPT PDTTQTPNTT TGSDPAVGSD 5350 5360 5370 5380 5390 5400 PAVGVLVWPL SARSAPGLSA QAARLYQHLS AHPDLDPIDV AHSLATTRSH HPHRATITTS 5410 5420 5430 5440 5450 5460 IEHHSENNHD TTDALAALHA LANNGTHPLL SRGLLTPQGP GKTVFVFPGQ GSQYPGMGAD 5470 5480 5490 5500 5510 5520 LYRQFPVFAH ALDACDAALQ PFTGWSVLAV LHDEPEAPSL ERVDVVQPVL FSVMVSLAAL 5530 5540 5550 5560 5570 5580 WRWAGITPDA VIGHSQGEIA AAHVAGALTL PEAAAVVALR SRVLTDLAGA GAMASVLSPE 5590 5600 5610 5620 5630 5640 EPLTQLLARW DGKITVAAVN GPASAVVSGD TTAITELLIT CEHENIDARA IPVDYPSHSP 5650 5660 5670 5680 5690 5700 YMEHIRHQFL DELPELTPRP STIAMYSTVD GEPHDTAYDT TTMTADYWYR NIRNTVRFHD 5710 5720 5730 5740 5750 5760 TVAALLGAGE QVFLELSPHP VLTQAITDTV EQAGGGGAAV PALRKDRPDA VAFAAALGQL 5770 5780 5790 5800 5810 5820 HCHGISPSWN VLYCQARPLT LPTYAFQHQR YWLLPTAGDF SGANTHAMHP LLDTATELAE 5830 5840 5850 5860 5870 5880 NRGWVFTGRI SPRTQPWLNE HAVESAVLFP GTGFVELALH VADRAGYSSV NELIVHTPLL 5890 5900 5910 5920 5930 5940 LAGHDTADLQ ITVTDTDDMG RQSLNIHSRP HIGHDNTTTG DEQPEWVLHA SAVLTAQTTD 5950 5960 5970 5980 5990 6000 HNHLPLTPVP WPPPGTAAIE VDDFYDDLAA QGYNYGPTFQ GVQRIWRDHA TPDVIYAEVE 6010 6020 6030 6040 6050 6060 LPEDTDIDGY GIHPALFDAA LHPLLALTQP PTNDTDDTNT ADTGDQVRLP YAFTGISLHA 6070 6080 6090 6100 6110 6120 THATRLRVRL TRTGADAITV HTSDTTGAPV AIIDSLITRP LTTATGSAPA TTAAGLLHLS 6130 6140 6150 6160 6170 6180 WPPHPDTTTD TDTDTDALRY QVIAEPTQQL PRYLHDLHTS TDLHTSTTEA DVVVWPVPVP 6190 6200 6210 6220 6230 6240 SNEELQAHQA SDTAVSSRIH TLTRQTLTVV QDWLTHPDTT GTRLVIVTRH GVSTSAHDPV 6250 6260 6270 6280 6290 6300 PDLAHAAVWG LIRSAQNEHP GRFTLLDTDD NTNSDTLTTA LTLPTRENQL AIRRDTIHIP 6310 6320 6330 6340 6350 6360 RLTRHSSDGA LTAPVVVDPE GTVLITGGTG TLGALFAEHL VSAHGVRHLL LTSRRGPQAH 6370 6380 6390 6400 6410 6420 GATDLQQRLT DLGAHVTITA CDISDPEALA ALVNSVPTQH RLTAVVHTAA VLADTPVTEL 6430 6440 6450 6460 6470 6480 TGDQLDQVLA PKIDAAWQLH QLTYEHNLSA FIMFSSMAGM IGSPGQGNYA AANTALDALA 6490 6500 6510 6520 6530 6540 DYRHRLGLPA TSLAWGYWQT HTGLTAHLTD VDLARMTRLG LMPIATSHGL ALFDAALATG 6550 6560 6570 6580 6590 6600 QPVSIPAPIN THTLARHARD NTLAPILSAL ITTPRRRAAS AATDLAARLN GLSPQQQQQT 6610 6620 6630 6640 6650 6660 LATLVAAATA TVLGHHTPES ISPATAFKDL GIDSLTALEL RNTLTHNTGL DLPPTLIFDH 6670 6680 6690 6700 6710 6720 PTPHAVAEHL LEQIPGIGAL VPAPVVIAAG RTEEPVAVVG MACRFPGGVA SADQLWDLVI 6730 6740 6750 6760 6770 6780 AGRDVVGNFP ADRGWDVEGL FDPDPDAVGK TYTRYGAFLD DAAGFDAGFF GISPREARAM 6790 6800 6810 6820 6830 6840 DPQQRLLLEV CWEALETAGI PAHTLAGTST GVFAGAWAQS YGATNSDDAE GYAMTGGSTS 6850 6860 6870 6880 6890 6900 VMSGRIAYTL GLEGPAITVD TACSSSLVAI HLACQSLRNN ESQLALAGGV TVMSTPAVFT 6910 6920 6930 6940 6950 6960 EFSRQRGLAP DGRCKAFAAT ADGTGFGEGA AVLVLERLSE ARRNNHPVLA IVAGSAINQD 6970 6980 6990 7000 7010 7020 GASNGLTAPH GPSQQRVINQ ALANAGLTHD QVDAVEAHGT GTTLGDPIEA SALHATYGHH 7030 7040 7050 7060 7070 7080 HTPDQPLWLG SIKSNIGHTQ AAAGAAGVVK MIQAITHATL PATLHVDQPS PHIDWSSGTV 7090 7100 7110 7120 7130 7140 RLLTEPIQWP NTDHPRTAAV SSFGISGTNA HLILQQPPTP DTTQTPNPTT GSDPAVGSDP 7150 7160 7170 7180 7190 7200 AVGVLVWPLS ARSAPGLSAQ AARLYQHLSA HPDLDPIDVA HSLATTRSHH PHRATITTSI 7210 7220 7230 7240 7250 7260 EHHSENNHDT TDALAALHAL ANNGTHPLLS RGLLTPQGPG KTVFVFPGQG SQYPGMGADL 7270 7280 7290 7300 7310 7320 YRQFPVFAHA LDEVAAALNP HLDVALLEVM FSQQDTAMAQ LLDQTFYAQP ALFALGTALH 7330 7340 7350 7360 7370 7380 RLFTHAGIHP DYLLGHSIGE LTAAYAAGVL SLQDAATLVT SRGRLMQSCT PGGTMLALQA 7390 7400 7410 7420 7430 7440 SEAEVQPLLE GLDHAVSIAA INGATSIVLS GDHDSLEQIG EHFITQDRRT TRLQVSHAFH 7450 7460 7470 7480 7490 7500 SPHMDPILEQ FRQIAAQLTF SAPTLPILSN LTGQIARHDQ LASPDYWTQQ LRNTVRFHDT 7510 7520 7530 7540 7550 7560 VAALLGAGEQ VFLELSPHPV LTQAITDTVE QAGGGGAAVP ALRKDRPDAV AFAAALGQLH 7570 7580 7590 7600 7610 7620 CHGISPSWNV LYCQARPLTL PTYAFQHQRY WLLPTAGDFS GANTHAMHPL LDTATELAEN 7630 7640 7650 7660 7670 7680 RGWVFTGRIS PRTQPWLNEH AVESAVLFPG TGFVELALHV ADRAGYSSVN ELIVHTPLLL 7690 7700 7710 7720 7730 7740 AGHDTADLQI TVTDTDDMGR QSLNIHSRPH IGHDNTTTGD EQPEWVLHAS AVLTAQTTDH 7750 7760 7770 7780 7790 7800 NHLPLTPVPW PPPGTAAIEV DDFYDDLAAQ GYNYGPTFQG VQRIWRDHAT PDVIYAEVEL 7810 7820 7830 7840 7850 7860 PEDTDIDGYG IHPALFDAAL HPLLALTQPP TNDTDDTNTA DTGDQVRLPY AFTGISLHAT 7870 7880 7890 7900 7910 7920 HATRLRVRLT RTGADAITVH TSDTTGAPVA IIDSLITRPL TTATGSAPAT TAAGLLHLSW 7930 7940 7950 7960 7970 7980 PPHPDTTTDT DTDTDALRYQ VIAEPTQQLP RYLHDLHTST DLHTSTTEAD VVVWPVPVPS 7990 8000 8010 8020 8030 8040 NEELQAHQAS DTAVSSRIHT LTRQTLTVVQ DWLTHPDTTG TRLVIVTRHG VSTSAHDPVP 8050 8060 8070 8080 8090 8100 DLAHAAVWGL IRSAQNEHPG RFTLLDTDDN TNSDTLTTAL TLPTRENQLA IRRDTIHIPR 8110 8120 8130 8140 8150 8160 LTRHSSDGAL TAPVVVDPEG TVLITGGTGT LGALFAEHLV SAHGVRHLLL TSRRGPQAHG 8170 8180 8190 8200 8210 8220 ATDLQQRLTD LGAHVTITAC DISDPEALAA LVNSVPTQHR LTAVVHTAAV LADTPVTELT 8230 8240 8250 8260 8270 8280 GDQLDQVLAP KIDAAWQLHQ LTYEHNLSAF IMFSSMAGMI GSPGQGNYAA ANTALDALAD 8290 8300 8310 8320 8330 8340 YRHRLGLPAT SLAWGYWQTH TGLTAHLTDV DLARMTRLGL MPIATSHGLA LFDAALATGQ 8350 8360 8370 8380 8390 8400 PVSIPAPINT HTLARHARDN TLAPILSALI TTPRRRAASA ATDLAARLNG LSPQQQQQTL 8410 8420 8430 8440 8450 8460 ATLVAAATAT VLGHHTPESI SPATAFKDLG IDSLTALELR NTLTHNTGLD LPPTLIFDHP 8470 8480 8490 8500 8510 8520 TPHAVAEHLL EQIPGIGALV PAPVVIAAGR TEEPVAVVGM ACRFPGGVAS ADQLWDLVIA 8530 8540 8550 8560 8570 8580 GRDVVGNFPA DRGWDVEGLF DPDPDAVGKT YTRYGAFLDD AAGFDAGFFG ISPREARAMD 8590 8600 8610 8620 8630 8640 PQQRLLLEVC WEALETAGIP AHTLAGTSTG VFAGAWAQSY GATNSDDAEG YAMTGGATSV 8650 8660 8670 8680 8690 8700 MSGRIAYTLG LEGPAITVDT ACSSSLVAIH LACQSLRNNE SQLALAGGVT VMSTPAVFTE 8710 8720 8730 8740 8750 8760 FSRQRGLAPD GRCKAFAATA DGTGFGEGAA VLVLERLSEA RRNNHPVLAI VAGSAINQDG 8770 8780 8790 8800 8810 8820 ASNGLTAPHG PSQQRVINQA LANAGLTHDQ VDAVEAHGTG TTLGDPIEAS ALHATYGHHH 8830 8840 8850 8860 8870 8880 TPDQPLWLGS IKSNIGHTQA AAGAAGVVKM IQAITHATLP ATLHVDQPSP HIDWSSGTVR 8890 8900 8910 8920 8930 8940 LLTEPIQWPN TDHPRTAAVS SFGISGTNAH LILQQPPTPD TTQTPNTTTG SDPAVGSDPA 8950 8960 8970 8980 8990 9000 VGVLVWPLSA RSAPGLSAQA ARLYQHLSAH PDLDPIDVAH SLATTRSHHP HRATITTSIE 9010 9020 9030 9040 9050 9060 HHSENNHDTT DALAALHALA NNGTHPLLSR GLLTPQGPGK TVFVFPGQGS QYPGMGADLY 9070 9080 9090 9100 9110 9120 RQFPVFAHAL DACDAALQPF TGWSVLAVLH DEPEAPSLER VDVVQPVLFS VMVSLAALWR 9130 9140 9150 9160 9170 9180 WAGITPDAVI GHSQGEIAAA HVAGALTLPE AAAVVALRSR VLTDLAGAGA MASVLSPEEP 9190 9200 9210 9220 9230 9240 LTQLLARWDG KITVAAVNGP ASAVVSGDTT AITELLITCE HENIDARAIP VDYPSHSPYM 9250 9260 9270 9280 9290 9300 EHIRHQFLDE LPELTPRPST IAMYSTVDGE PHDTAYDTTT MTADYWYRNI RNTVRFHDTV 9310 9320 9330 9340 9350 9360 AALLGAGEQV FLELSPHPVL TQAITDTVEQ AGGGGAAVPA LRKDRPDAVA FAAALGQLHC 9370 9380 9390 9400 9410 9420 HGISPSWNVL YCQARPLTLP TYAFQHQRYW LLPTAGDFSG ANTHAMHPLL DTATELAENR 9430 9440 9450 9460 9470 9480 GWVFTGRISP RTQPWLNEHA VESAVLFPGT GFVELALHVA DRAGYSSVNE LIVHTPLLLA 9490 9500 9510 9520 9530 9540 GHDTADLQIT VTDTDDMGRQ SLNIHSHPHI GHDNTTTGDE QPEWVLHASA VLTAQTTDHN 9550 9560 9570 9580 9590 9600 HLPLTPVPWP PPGTAAIEVD DFYDDLAAQG YNYGPTFQGV QRIWRDHATP DVIYAEVELP 9610 9620 9630 9640 9650 9660 EDTDIDGYGI HPALFDAALH PLLALTQPPT NDTDDTNTAD TGDQVRLPYA FTGISLHATH 9670 9680 9690 9700 9710 9720 ATRLRVRLTR TGADAITVHT SDTTGAPVAI IDSLITRPLT TATGSAPATT AAGLLHLSWP 9730 9740 9750 9760 9770 9780 PHPDTTTDTD TDTDALRYRV IAEPTQQLPR YLHDLHTSTD LHTSTTEADV VVWPVPVPSN 9790 9800 9810 9820 9830 9840 EELQAHQASD TAVSSRIHTL TRQTLTVVQD WLTHPDTTGT RLVIVTRHGV STSAHDPVPD 9850 9860 9870 9880 9890 9900 LAHAAVWGLI RSAQNEHPGR FTLLDTDDNT NSDTLTTALT LPTRENQLAI RRDTIHIPRL 9910 9920 9930 9940 9950 9960 TRHSSDGALT APVVVDPEGT VLITGGTGTL GALFAEHLVS AHGVRHLLLT SRRGPQAHGA 9970 9980 9990 10000 10010 10020 TDLQQRLTDL GAHVTITACD ISDPEALAAL VNSVPTQHRL TAVVHTAAVL ADTPVTELTG 10030 10040 10050 10060 10070 10080 DQLDQVLAPK IDAAWQLHQL TYEHNLSAFI MFSSMAGMIG SPGQGNYAAA NTALDALADY 10090 10100 10110 10120 10130 10140 RHRLGLPATS LAWGYWQTHT GLTAHLTDVD LARMTRLGLM PIATSHGLAL FDAALATGQP 10150 10160 10170 10180 10190 10200 VSIPAPINTH TLARHARDNT LAPILSALIT TPRRRAASAA TDLAARLNGL SPQQQQQTLA 10210 10220 10230 10240 10250 10260 TLVAAATATV LGHHTPESIS PATAFKDLGI DSLTALELRN TLTHNTGLDL PPTLIFDHPT 10270 10280 10290 10300 10310 10320 PHAVAEHLLE QIPGIGALVP APVVIAAGRT EEPVAVVGMA CRFPGGVASA DQLWDLVIAG 10330 10340 10350 10360 10370 10380 RDVVGNFPAD RGWDVEGLFD PDPDAVGKTY TRYGAFLDDA AGFDAGFFGI SPREARAMDP 10390 10400 10410 10420 10430 10440 QQRLLLEVCW EALETAGIPA HTLAGTSTGV FAGAWAQSYG ATNSDDAEGY AMTGGATSVM 10450 10460 10470 10480 10490 10500 SGRIAYTLGL EGPAITVDTA CSSSLVAIHL ACQSLRNNES QLALAGGVTV MSTPAVFTEF 10510 10520 10530 10540 10550 10560 SRQRGLAPDG RCKAFAATAD GTGFGEGAAV LVLERLSEAR RNNHPVLAIV AGSAINQDGA 10570 10580 10590 10600 10610 10620 SNGLTAPHGP SQQRVINQAL ANAGLTHDQV DAVEAHGTGT TLGDPIEASA LHATYGHHHT 10630 10640 10650 10660 10670 10680 PDQPLWLGSI KSNIGHTQAA AGAAGVVKMI QAITHATLPA TLHVDQPSPH IDWSSGTVRL 10690 10700 10710 10720 10730 10740 LTEPIQWPNT DHPRTAAVSS FGISGTNAHL ILQQPPTPDT TQTPNTTTGS DPAVGSDPAV 10750 10760 10770 10780 10790 10800 GVLVWPLSAR SAPGLSAQAA RLYQHLSAHP DLDPIDVAHS LATTRSHHPH RATITTSIEH 10810 10820 10830 10840 10850 10860 HSENNHDTTD ALAALHALAN NGTHPLLSRG LLTPQGPGKT VFVFPGQGSQ YPGMGADLYR 10870 10880 10890 10900 10910 10920 QFPVFAHALD ACDAALQPFT GWSVLAVLHD EPEAPSLERV DVVQPVLFSV MVSLAALWRW 10930 10940 10950 10960 10970 10980 AGITPDAVIG HSQGEIAAAH VAGALTLPEA AAVVALRSRV LTDLAGAGAM ASVLSPEEPL 10990 11000 11010 11020 11030 11040 TQLLARWDGK ITVAAVNGPA SAVVSGDTTA ITELLITCEH ENIDARAIPV DYPSHSPYME 11050 11060 11070 11080 11090 11100 HIRHQFLDEL PELTPRPSTI AMYSTVDGEP HDTAYDTTTM TADYWYRNIR NTVRFHDTVA 11110 11120 11130 11140 11150 11160 ALLGAGEQVF LELSPHPVLT QAITDTVEQA GGGGAAVPAL RKDRPDAVAF AAALGQLHCH 11170 11180 11190 11200 11210 11220 GISPSWNVLY CQARPLTLPT YAFQHQRYWL LPTAGDFSGA NTHAMHPLLD TATELAENRG 11230 11240 11250 11260 11270 11280 WVFTGRISPR TQPWLNEHAV ESAVLFPGTG FVELALHVAD RAGYSSVNEL IVHTPLLLAG 11290 11300 11310 11320 11330 11340 HDTADLQITV TDTDDMGRQS LNIHSRPHIG HDNTTTGDEQ PEWVLHASAV LTAQTTDHNH 11350 11360 11370 11380 11390 11400 LPLTPVPWPP PGTAAIEVDD FYDDLAAQGY NYGPTFQGVQ RIWRDHATPD VIYAEVELPE 11410 11420 11430 11440 11450 11460 DTDIDGYGIH PALFDAALHP LLALTQPPTN DTDDTNTADT GDQVRLPYAF TGISLHATHA 11470 11480 11490 11500 11510 11520 TRLRVRLTRT GADAITVHTS DTTGAPVAII DSLITRPLTT ATGSAPATTA AGLLHLSWPP 11530 11540 11550 11560 11570 11580 HPDTTTDTDT DTDALRYQVI AEPTQQLPRY LHDLHTSTDL HTSTTEADVV VWPVPVPSNE 11590 11600 11610 11620 11630 11640 ELQAHQASDT AVSSRIHTLT RQTLTVVQDW LTHPDTTGTR LVIVTRHGVS TSAHDPVPDL 11650 11660 11670 11680 11690 11700 AHAAVWGLIR SAQNEHPGRF TLLDTDDNTN SDTLTTALTL PTRENQLAIR RDTIHIPRLT 11710 11720 11730 11740 11750 11760 RHSSDGALTA PVVVDPEGTV LITGGTGTLG ALFAEHLVSA HGVRHLLLTS RRGPQAHGAT 11770 11780 11790 11800 11810 11820 DLQQRLTDLG AHVTITACDI SDPEALAALV NSVPTQHRLT AVVHTAAVLA DTPVTELTGD 11830 11840 11850 11860 11870 11880 QLDQVLAPKI DAAWQLHQLT YEHNLSAFIM FSSMAGMIGS PGQGNYAAAN TALDALADYR 11890 11900 11910 11920 11930 11940 HRLGLPATSL AWGYWQTHTG LTAHLTDVDL ARMTRLGLMP IATSHGLALF DAALATGQPV 11950 11960 11970 11980 11990 12000 SIPAPINTHT LARHARDNTL APILSALITT PRRRAASAAT DLAARLNGLS PQQQQQTLAT 12010 12020 12030 12040 12050 12060 LVAAATATVL GHHTPESISP ATAFKDLGID SLTALELRNT LTHNTGLDLP PTLIFDHPTP 12070 12080 12090 12100 12110 12120 HAVAEHLLEQ IPGIGALVPA PVVIAAGRTE EPVAVVGMAC RFPGGVASAD QLWDLVIAGR 12130 12140 12150 12160 12170 12180 DVVGNFPADR GWDVEGLFDP DPDAVGKTYT RYGAFLDDAA GFDAGFFGIS PREARAMDPQ 12190 12200 12210 12220 12230 12240 QRLLLEVCWE ALETAGIPAH TLAGTSTGVF AGAWAQSYGA TNSDDAEGYA MTGGATSVMS 12250 12260 12270 12280 12290 12300 GRIAYTLGLE GPAITVDTAC SSSLVAIHLA CQSLRNNESQ LALAGGVTVM STPAVFTEFS 12310 12320 12330 12340 12350 12360 RQRGLAPDGR CKAFAATADG TGFGEGAAVL VLERLSEARR NNHPVLAIVA GSAINQDGAS 12370 12380 12390 12400 12410 12420 NGLTAPHGPS QQRVINQALA NAGLTHDQVD AVEAHGTGTT LGDPIEASAL HATYGHHHTP 12430 12440 12450 12460 12470 12480 DQPLWLGSIK SNIGHTQAAA GAAGVVKMIQ AITHATLPAT LHVDQPSPHI DWSSGTVRLL 12490 12500 12510 12520 12530 12540 TEPIQWPNTD HPRTAAVSSF GISGTNAHLI LQQPPTPDTT QTPNTTTGSD PAVGSDPAVG 12550 12560 12570 12580 12590 12600 VLVWPLSARS APGLSAQAAR LYQHLSAHPD LDPIDVAHSL ATTRSHHPHR ATITTSIEHH 12610 12620 12630 12640 12650 12660 SENNHDTTDA LAALHALANN GTHPLLSRGL LTPQGPGKTV FVFPGQGSQY PGMGADLYRQ 12670 12680 12690 12700 12710 12720 FPVFAHALDE VAAALNPHLD VALLEVMFSQ QDTAMAQLLD QTFYAQPALF ALGTALHRLF 12730 12740 12750 12760 12770 12780 THAGIHPDYL LGHSIGELTA AYAAGVLSLQ DAATLVTSRG RLMQSCTPGG TMLALQASEA 12790 12800 12810 12820 12830 12840 EVQPLLEGLD HAVSIAAING ATSIVLSGDH DSLEQIGEHF ITQDRRTTRL QVSHAFHSPH 12850 12860 12870 12880 12890 12900 MDPILEQFRQ IAAQLTFSAP TLPILSNLTG QIARHDQLAS PDYWTQQLRN TVRFHDTVAA 12910 12920 12930 12940 12950 12960 LLGAGEQVFL ELSPHPVLTQ AITDTVEQAG GGGAAVPALR KDRPDAVAFA AALGQLHCHG 12970 12980 12990 13000 13010 13020 ISPSWNVLYC QARPLTLPTY AFQHQRYWLL PTAGDFSGAN THAMHPLLDT ATELAENRGW 13030 13040 13050 13060 13070 13080 VFTGRISPRT QPWLNEHAVE SAVLFPGTGF VELALHVADR AGYSSVNELI VHTPLLLAGH 13090 13100 13110 13120 13130 13140 DTADLQITVT DTDDMGRQSL NIHSRPHIGH DNTTTGDEQP EWVLHASAVL TAQTTDHNHL 13150 13160 13170 13180 13190 13200 PLTPVPWPPP GTAAIEVDDF YDDLAAQGYN YGPTFQGVQR IWRDHATPDV IYAEVELPED 13210 13220 13230 13240 13250 13260 TDIDGYGIHP ALFDAALHPL LALTQPPTND TDDTNTADTG DQVRLPYAFT GISLHATHAT 13270 13280 13290 13300 13310 13320 RLRVRLTRTG ADAITVHTSD TTGAPVAIID SLITRPLTTA TGSAPATTAA GLLHLSWPPH 13330 13340 13350 13360 13370 13380 PDTTTDTDTD TDALRYQVIA EPTQQLPRYL HDLHTSTDLH TSTTEADVVV WPVPVPSNEE 13390 13400 13410 13420 13430 13440 LQAHQASDTA VSSRIHTLTR QTLTVVQDWL THPDTTGTRL VIVTRHGVST SAHDPVPDLA 13450 13460 13470 13480 13490 13500 HAAVWGLIRS AQNEHPGRFT LLDTDDNTNS DTLTTALTLP TRENQLAIRR DTIHIPRLTR 13510 13520 13530 13540 13550 13560 HSSDGALTAP VVVDPEGTVL ITGGTGTLGA LFAEHLVSAH GVRHLLLTSR RGPQAHGATD 13570 13580 13590 13600 13610 13620 LQQRLTDLGA HVTITACDIS DPEALAALVN SVPTQHRLTA VVHTAAVLAD TPVTELTGDQ 13630 13640 13650 13660 13670 13680 LDQVLAPKID AAWQLHQLTY EHNLSAFIMF SSMAGMIGSP GQGNYAAANT ALDALADYRH 13690 13700 13710 13720 13730 13740 RLGLPATSLA WGYWQTHTGL TAHLTDVDLA RMTRLGLMPI ATSHGLALFD AALATGQPVS 13750 13760 13770 13780 13790 13800 IPAPINTHTL ARHARDNTLA PILSALITTP RRRAASAATD LAARLNGLSP QQQQQTLATL 13810 13820 13830 13840 13850 13860 VAAATATVLG HHTPESISPA TAFKDLGIDS LTALELRNTL THNTGLDLPP TLIFDHPTPH 13870 13880 13890 13900 13910 13920 ALTQHLHTRL TQSHTPVGPI ASLLSHAIDE GKFRAGADLL MAASNLNQSF SNMAELNQLP 13930 13940 13950 13960 13970 13980 AVTDIADASP DGLLTLICIS TSENEYARLA AANIHSLTFA EIAAPGFYDA QLPNSIETSA 13990 14000 14010 14020 14030 14040 EALATAITGA YANTSIVLVA HSIVCELAQA TMTRLQDADI DLVGLVLLDP LEGTNSTEDY 14050 14060 14070 14080 14090 14100 VETVLTRIEH INAPRVGVDG YLAALGRYLQ FHEDRRIPIP ETRHMTLHSD TKIDRAQTPM 14110 14120 14130 NLLQDEAALT ALKIGNWMND VGVALSVNLE

References

[1]

"Giant plasmid-encoded polyketide synthases produce the macrolide toxin of Mycobacterium ulcerans." Stinear T.P., Mve-Obiang A., Small P.L.C., Frigui W., Pryor M.J., Brosch R., Jenkin G.A., Johnson P.D.R., Davies J.K., Lee R.E., Adusumilli S., Garnier T., Haydock S.F., Leadlay P.F., Cole S.T. Proc. Natl. Acad. Sci. U.S.A. 101:1345-1349(2004) [PubMed: 14736915] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

[2]

"Functional analysis and annotation of the virulence plasmid pMUM001 from Mycobacterium ulcerans." Stinear T.P., Pryor M.J., Porter J.L., Cole S.T. Microbiology 151:683-692(2005) [PubMed: 15758215] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX649209 Genomic DNA. Translation: CAE46843.1.
RefSeq	YP_025554.1. NC_005916.1.
3D structure databases
ProteinModelPortal	Q6MZ72.
ModBase	Search...
Protein-protein interaction databases
STRING	Q6MZ72.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000077410; EBMYCP00000075364; EBMYCG00000077405.
GeneID	2846550.
GenomeReviews	Gene locus MUP032c in contig BX649209_GR.
KEGG	mul:MUP032c.
PATRIC	18166305. VBIMycUlc37413_0035.
Organism-specific databases
GenoList	MUP032c.
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000020090.
ProtClustDB	CLSK2395195.
Family and domain databases
InterPro	IPR001227. Ac_transferase_dom. IPR009081. Acyl_carrier_prot-like. IPR014043. Acyl_transferase. IPR016035. Acyl_Trfase/lysoPLipase. IPR000794. Beta-ketoacyl_synthase. IPR018201. Ketoacyl_synth_AS. IPR014031. Ketoacyl_synth_C. IPR014030. Ketoacyl_synth_N. IPR016036. Malonyl_transacylase_ACP-bd. IPR016040. NAD(P)-bd_dom. IPR006163. Phsphopanteth-bd. IPR020842. PKS/FAS_KR. IPR020801. PKS_acyl_transferase. IPR020841. PKS_Beta-ketoAc_synthase_dom. IPR020807. PKS_dehydratase. IPR013968. PKS_KR. IPR020806. PKS_PP-bd. IPR006162. PPantetheine_attach_site. IPR016039. Thiolase-like. IPR016038. Thiolase-like_subgr. [Graphical view]
Gene3D	G3DSA:3.40.366.10. Ac_transferase_reg. 16 hits. G3DSA:1.10.1200.10. ACP_like. 8 hits. G3DSA:3.40.50.720. NAD(P)-bd. 8 hits. G3DSA:3.40.47.10. Thiolase-like_subgr. 16 hits.
PANTHER	PTHR11712. Ketoacyl_synth. 1 hit.
Pfam	PF00698. Acyl_transf_1. 8 hits. PF00109. ketoacyl-synt. 8 hits. PF02801. Ketoacyl-synt_C. 8 hits. PF08659. KR. 8 hits. PF00550. PP-binding. 8 hits. [Graphical view]
SMART	SM00827. PKS_AT. 8 hits. SM00826. PKS_DH. 6 hits. SM00822. PKS_KR. 8 hits. SM00825. PKS_KS. 8 hits. SM00823. PKS_PP. 8 hits. [Graphical view]
SUPFAM	SSF47336. ACP_like. 8 hits. SSF52151. Acyl_Trfase/lysoPlipase. 8 hits. SSF55048. Malonyl_transacylase_ACP-bd. 8 hits. SSF53901. Thiolase-like. 8 hits.
PROSITE	PS50075. ACP_DOMAIN. 8 hits. PS00606. B_KETOACYL_SYNTHASE. 7 hits. PS00012. PHOSPHOPANTETHEINE. 8 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q6MZ72_MYCUA

Accession

Primary (citable) accession number: Q6MZ72

Entry history

Integrated into UniProtKB/TrEMBL:	July 5, 2004
Last sequence update:	July 5, 2004
Last modified:	December 14, 2011
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)