Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Probable uroporphyrin-III C-methyltransferase HemD (Uroporphyrinogen III methylase) (Urogen III methylase) (SUMT) (Urogen III methylase) (UROM)

Gene

hemD

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • growth Source: MTBBASE
  • siroheme biosynthetic process Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

MethyltransferaseImported, Transferase

Enzyme and pathway databases

BioCyciMTBH37RV:G185E-4643-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Probable uroporphyrin-III C-methyltransferase HemD (Uroporphyrinogen III methylase) (Urogen III methylase) (SUMT) (Urogen III methylase) (UROM)Imported
Submitted name:
Uroporphyrin-III methyltransferaseImported
Gene namesi
Name:hemDImported
Ordered Locus Names:Rv0511Imported
ORF Names:LH57_02740Imported
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)Imported
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome
  • UP000031768 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

  • plasma membrane Source: MTBBASE
Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi83332.Rv0511.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 245TP_methylaseInterPro annotationAdd BLAST235
Domaini309 – 539HEM4InterPro annotationAdd BLAST231

Phylogenomic databases

eggNOGiENOG4107TEK. Bacteria.
COG0007. LUCA.
COG1587. LUCA.
HOGENOMiHOG000290967.
KOiK13542.
OMAiGVKIACI.

Family and domain databases

CDDicd06578. HemD. 1 hit.
Gene3Di3.30.950.10. 1 hit.
3.40.1010.10. 2 hits.
InterProiIPR000878. 4pyrrol_Mease.
IPR003754. 4pyrrol_synth_uPrphyn_synth.
IPR014777. 4pyrrole_Mease_sub1.
IPR014776. 4pyrrole_Mease_sub2.
[Graphical view]
PfamiPF02602. HEM4. 1 hit.
PF00590. TP_methylase. 1 hit.
[Graphical view]
SUPFAMiSSF53790. SSF53790. 2 hits.
SSF69618. SSF69618. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6MX34-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRGRKPRPG RIVFVGSGPG DPGLLTTRAA AVLANAALVF TDPDVPEPVV
60 70 80 90 100
ALIGTDLPPV SGPAPAEPVA GNGDAAGGGS AQEHGRAASA VVSGGPDIRP
110 120 130 140 150
ALGDPADVAK TLTAEARSGV DVVRLVAGDP LTVDAVISEV NAVARTHLHI
160 170 180 190 200
EIVPGLAASS AVPTYAGLPL GSSHTVADVR IDPENTDWDA LAAAPGPLIL
210 220 230 240 250
QATASHLAES ARSLIDHQLA ESTPCVVTAH GTTCQQRSVE TTLQGLTDPA
260 270 280 290 300
VLGATDPACS ANGRDSQAGP LIVTIGKTVT SRAKLNWWES RALYGWTVLV
310 320 330 340 350
PRTKDQAGEM SERLTSYGAL PVEVPTIAVE PPRSPAQMER AVKGLVDGRF
360 370 380 390 400
QWIVFTSTNA VRAVWEKFGE FGLDARAFSG VKIACVGEST ADRVRAFGIS
410 420 430 440 450
PELVPSGEQS SLGLLDDFPP YDSVFDPVNR VLLPRADIAT ETLAEGLRER
460 470 480 490 500
GWEIEDVTAY RTVRAAPPPA TTREMIKTGG FDAVCFTSSS TVRNLVGIAG
510 520 530 540 550
KPHARTIIAC IGPKTAETAA EFGLRVDVQP DTAAIGPLVD ALAEHAARLR
560
AEGALPPPRK KSRRR
Length:565
Mass (Da):58,836
Last modified:July 5, 2004 - v1
Checksum:iBA1C3CF881713D9F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP009480 Genomic DNA. Translation: AIR13237.1.
AL123456 Genomic DNA. Translation: CCP43248.1.
RefSeqiWP_003900163.1. NZ_KK339370.1.
YP_177733.1. NC_000962.3.

Genome annotation databases

EnsemblBacteriaiAIR13237; AIR13237; LH57_02740.
CCP43248; CCP43248; Rv0511.
GeneIDi887280.
KEGGimtu:Rv0511.
mtv:RVBD_0511.
PATRICi18149630. VBIMycTub87468_0567.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP009480 Genomic DNA. Translation: AIR13237.1.
AL123456 Genomic DNA. Translation: CCP43248.1.
RefSeqiWP_003900163.1. NZ_KK339370.1.
YP_177733.1. NC_000962.3.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi83332.Rv0511.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAIR13237; AIR13237; LH57_02740.
CCP43248; CCP43248; Rv0511.
GeneIDi887280.
KEGGimtu:Rv0511.
mtv:RVBD_0511.
PATRICi18149630. VBIMycTub87468_0567.

Phylogenomic databases

eggNOGiENOG4107TEK. Bacteria.
COG0007. LUCA.
COG1587. LUCA.
HOGENOMiHOG000290967.
KOiK13542.
OMAiGVKIACI.

Enzyme and pathway databases

BioCyciMTBH37RV:G185E-4643-MONOMER.

Family and domain databases

CDDicd06578. HemD. 1 hit.
Gene3Di3.30.950.10. 1 hit.
3.40.1010.10. 2 hits.
InterProiIPR000878. 4pyrrol_Mease.
IPR003754. 4pyrrol_synth_uPrphyn_synth.
IPR014777. 4pyrrole_Mease_sub1.
IPR014776. 4pyrrole_Mease_sub2.
[Graphical view]
PfamiPF02602. HEM4. 1 hit.
PF00590. TP_methylase. 1 hit.
[Graphical view]
SUPFAMiSSF53790. SSF53790. 2 hits.
SSF69618. SSF69618. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ6MX34_MYCTU
AccessioniPrimary (citable) accession number: Q6MX34
Secondary accession number(s): F2GNC6, I6XVG9, L0T6Q2
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.