Reviewed, UniProtKB/Swiss-Prot Q6MUI1 (GUAC_MYCMS)

Names and origin

Protein names

Recommended name:
    GMP reductase
    EC=1.7.1.7
Alternative name(s):
    Guanosine 5'-monophosphate oxidoreductase
      Short name=Guanosine monophosphate reductase

Gene names

Name:	guaC
Ordered Locus Names:	MSC_0050

Organism

Mycoplasma mycoides subsp. mycoides SC [Complete proteome] [HAMAP]

Taxonomic identifier

44101 [NCBI]

Taxonomic lineage

Bacteria › Tenericutes › Mollicutes › Mycoplasmataceae › Mycoplasma

Protein attributes

Sequence length	320 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides By similarity.
Catalytic activity	Inosine 5'-phosphate + NH3 + NADP+ = guanosine 5'-phosphate + NADPH. HAMAP MF_01511
Sequence similarities	Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily.

Ontologies

Keywords
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW purine nucleotide metabolic process Inferred from electronic annotation. Source: HAMAP
Molecular function	GMP reductase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 320	320	GMP reductase HAMAP MF_01511		PRO_0000294278
Regions
	Nucleotide binding	203 – 226	24	NADP Potential
Sites
	Active site	174	1	Thioimidate intermediate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6MUI1-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 3C96F2F3EDA24979	FASTA	320	35,962
	10 20 30 40 50 60 MKIFDYDDVQ LIPEMCIVNS RKECETTATL GKHTFKLPVV PANMATIINE ELAEKLARND 70 80 90 100 110 120 YFYIMHRFNV DQLKFIKNMK DKNLITSISL GVKPDEYKLV DQMVQQNLIP DYITIDIAHG 130 140 150 160 170 180 HALSVKNMIS YIREKMKDQV FIIAGNVTTP KAVRDLELWG ADATKIEIGP GKVCITKLKT 190 200 210 220 230 240 GFGTGGWQLS ALKYCAKTAS KPIIADGGLR VHGDIAKSIR MGASFCMIVS LFAAHLESPG 250 260 270 280 290 300 KEVEINNCIY KEYYGSASEY NKSEKRYVEG KKELIKIRGS IFDTLKEMTE DLQSSISYAG 310 320 GKDLQAIKRV DYVLLGDYKD

References

[1]

"The genome sequence of Mycoplasma mycoides subsp. mycoides SC type strain PG1T, the causative agent of contagious bovine pleuropneumonia (CBPP)." Westberg J., Persson A., Holmberg A., Goesmann A., Lundeberg J., Johansson K.-E., Pettersson B., Uhlen M. Genome Res. 14:221-227(2004) [PubMed: 14762060] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PG1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BX293980 Genomic DNA. Translation: CAE76703.1.
RefSeq	NP_975061.1.
3D structure databases
HSSP	HSSP built from PDB template 1B3O based on UniProtKB P12268.
ModBase	Search...
Genome annotation databases
GeneID	2745129.
GenomeReviews	Gene locus MSC_0050 in contig BX293980_GR.
KEGG	mmy:MSC_0050.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q6MUI1.
OMA	Q6MUI1. NSRSECD.
Enzyme and pathway databases
BioCyc	MMYC272632:MSC_0050-MON.
BRENDA	1.7.1.7. 292844.
Family and domain databases
HAMAP	MF_01511. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR005994. GMP_reduct2. IPR015875. IMP_DH/GMP_Rdtase_CS. IPR001093. IMP_DH_GMPRt. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
Pfam	PF00478. IMPDH. 1 hit. [Graphical view]
PIRSF	PIRSF036500. GMP_red_Firmic. 1 hit.
TIGRFAMs	TIGR01306. GMP_reduct_2. 1 hit.
PROSITE	PS00487. IMP_DH_GMP_RED. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GUAC_MYCMS

Accession

Primary (citable) accession number: Q6MUI1

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 10, 2007
Last sequence update:	July 5, 2004
Last modified:	June 16, 2009
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)