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Q6MUI1 (GUAC_MYCMS) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
GMP reductase
EC=1.7.1.7
Alternative name(s):
Guanosine 5'-monophosphate oxidoreductase
Short name=Guanosine monophosphate reductase
Gene names
Name:guaC
Ordered Locus Names:MSC_0050
OrganismMycoplasma mycoides subsp. mycoides SC (strain PG1)
Taxonomic identifier272632 [NCBI]
Taxonomic lineageBacteria › Tenericutes › Mollicutes › Mycoplasmataceae › Mycoplasma

Protein attributes

Sequence length320 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides By similarity. HAMAP MF_01511

Catalytic activity

Inosine 5'-phosphate + NH3 + NADP+ = guanosine 5'-phosphate + NADPH. HAMAP MF_01511

Sequence similarities

Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily.

Ontologies

Keywords
   LigandNADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processpurine nucleotide metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular functionGMP reductase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 320320GMP reductase HAMAP MF_01511
PRO_0000294278

Regions

Nucleotide binding203 – 22624NADP Potential

Sites

Active site1741Thioimidate intermediate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6MUI1 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 3C96F2F3EDA24979

FASTA32035,962
        10         20         30         40         50         60 
MKIFDYDDVQ LIPEMCIVNS RKECETTATL GKHTFKLPVV PANMATIINE ELAEKLARND 

        70         80         90        100        110        120 
YFYIMHRFNV DQLKFIKNMK DKNLITSISL GVKPDEYKLV DQMVQQNLIP DYITIDIAHG 

       130        140        150        160        170        180 
HALSVKNMIS YIREKMKDQV FIIAGNVTTP KAVRDLELWG ADATKIEIGP GKVCITKLKT 

       190        200        210        220        230        240 
GFGTGGWQLS ALKYCAKTAS KPIIADGGLR VHGDIAKSIR MGASFCMIVS LFAAHLESPG 

       250        260        270        280        290        300 
KEVEINNCIY KEYYGSASEY NKSEKRYVEG KKELIKIRGS IFDTLKEMTE DLQSSISYAG 

       310        320 
GKDLQAIKRV DYVLLGDYKD

« Hide

References

[1]"The genome sequence of Mycoplasma mycoides subsp. mycoides SC type strain PG1T, the causative agent of contagious bovine pleuropneumonia (CBPP)."
Westberg J., Persson A., Holmberg A., Goesmann A., Lundeberg J., Johansson K.-E., Pettersson B., Uhlen M.
Genome Res. 14:221-227(2004) [PubMed: 14762060] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PG1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX293980 Genomic DNA. Translation: CAE76703.1.
RefSeqNP_975061.1. NC_005364.2.

3D structure databases

HSSPHSSP built from PDB template 1YPF based on UniProtKB Q81JJ9.
ProteinModelPortalQ6MUI1.
SMRQ6MUI1. Positions 3-315.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2745129.
GenomeReviewsGene locus MSC_0050 in contig BX293980_GR.
KEGGmmy:MSC_0050.
PATRIC20016776. VBIMycMyc4973_0050.

Phylogenomic databases

HOGENOMHBG298985.
OMAPDYITID.
ProtClustDBPRK05458.

Enzyme and pathway databases

BioCycMMYC272632:MSC_0050-MONOMER.

Family and domain databases

HAMAPMF_01511. GMP_reduct_type2.
[Tree]
InterProIPR013785. Aldolase_TIM.
IPR005994. GMP_reduct2.
IPR001093. IMP_DH_GMPRt.
[Graphical view]
Gene3DG3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KOK00364.
PANTHERPTHR11911:SF30. PTHR11911:SF30. 1 hit.
PfamPF00478. IMPDH. 1 hit.
[Graphical view]
PIRSFPIRSF036500. GMP_red_Firmic. 1 hit.
TIGRFAMsTIGR01306. GMP_reduct_2. 1 hit.
PROSITEPS00487. IMP_DH_GMP_RED. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGUAC_MYCMS
AccessionPrimary (citable) accession number: Q6MUI1
Entry history
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 5, 2004
Last modified: January 25, 2012
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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