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Q6MU75

- TRMB_MYCMS

UniProt

Q6MU75 - TRMB_MYCMS

Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Mycoplasma mycoides subsp. mycoides SC (strain PG1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

    Catalytic activityi

    S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei43 – 431S-adenosyl-L-methionineUniRule annotation
    Binding sitei68 – 681S-adenosyl-L-methionineUniRule annotation
    Active sitei123 – 1231By similarity
    Binding sitei123 – 1231S-adenosyl-L-methionineUniRule annotation
    Binding sitei127 – 1271SubstrateUniRule annotation
    Binding sitei159 – 1591SubstrateUniRule annotation

    GO - Molecular functioni

    1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciMMYC272632:GI1G-164-MONOMER.
    UniPathwayiUPA00989.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
    Alternative name(s):
    tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
    tRNA(m7G46)-methyltransferaseUniRule annotation
    Gene namesi
    Name:trmBUniRule annotation
    Ordered Locus Names:MSC_0166
    OrganismiMycoplasma mycoides subsp. mycoides SC (strain PG1)
    Taxonomic identifieri272632 [NCBI]
    Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
    ProteomesiUP000001016: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 221221tRNA (guanine-N(7)-)-methyltransferasePRO_0000171356Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272632.MSC_0166.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6MU75.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni199 – 2024Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0220.
    HOGENOMiHOG000251689.
    KOiK03439.
    OMAiINYLEAT.
    OrthoDBiEOG6K6VBC.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    HAMAPiMF_01057. tRNA_methyltr_TrmB.
    InterProiIPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view]
    PfamiPF02390. Methyltransf_4. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
    PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6MU75-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRLRKKNWTD DFLNQHSFYL INYNNKKIDL KQIFLNNNPT CLEIGSGKGQ    50
    FITTLALKNL NTNYIGMEKS STITGVALKK SLKEFENQLK DMTNLKYFNN 100
    FAEDLSQMFS SDSFNKIYLN FSDPWPKTRH YKKRLTYVKF LDIYSDILIK 150
    NGYLEFKTDN DSLYNFTIEQ LNLTNKWEIV INATDLYNNT EFLKDNIPTE 200
    YETKFHLANK NIYKIVIKNL K 221
    Length:221
    Mass (Da):26,250
    Last modified:July 5, 2004 - v1
    Checksum:iD5F997239233E2D1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX293980 Genomic DNA. Translation: CAE76811.1.
    RefSeqiNP_975169.1. NC_005364.2.

    Genome annotation databases

    EnsemblBacteriaiCAE76811; CAE76811; MSC_0166.
    GeneIDi2744317.
    KEGGimmy:MSC_0166.
    PATRICi20017040. VBIMycMyc4973_0176.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX293980 Genomic DNA. Translation: CAE76811.1 .
    RefSeqi NP_975169.1. NC_005364.2.

    3D structure databases

    ProteinModelPortali Q6MU75.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272632.MSC_0166.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAE76811 ; CAE76811 ; MSC_0166 .
    GeneIDi 2744317.
    KEGGi mmy:MSC_0166.
    PATRICi 20017040. VBIMycMyc4973_0176.

    Phylogenomic databases

    eggNOGi COG0220.
    HOGENOMi HOG000251689.
    KOi K03439.
    OMAi INYLEAT.
    OrthoDBi EOG6K6VBC.

    Enzyme and pathway databases

    UniPathwayi UPA00989 .
    BioCyci MMYC272632:GI1G-164-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    HAMAPi MF_01057. tRNA_methyltr_TrmB.
    InterProi IPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view ]
    Pfami PF02390. Methyltransf_4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
    PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Mycoplasma mycoides subsp. mycoides SC type strain PG1T, the causative agent of contagious bovine pleuropneumonia (CBPP)."
      Westberg J., Persson A., Holmberg A., Goesmann A., Lundeberg J., Johansson K.-E., Pettersson B., Uhlen M.
      Genome Res. 14:221-227(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PG1.

    Entry informationi

    Entry nameiTRMB_MYCMS
    AccessioniPrimary (citable) accession number: Q6MU75
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2004
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3