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Q6MU75

- TRMB_MYCMS

UniProt

Q6MU75 - TRMB_MYCMS

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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene
trmB, MSC_0166
Organism
Mycoplasma mycoides subsp. mycoides SC (strain PG1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei43 – 431S-adenosyl-L-methionine By similarity
Binding sitei68 – 681S-adenosyl-L-methionine By similarity
Active sitei123 – 1231 By similarity
Binding sitei123 – 1231S-adenosyl-L-methionine By similarity
Binding sitei127 – 1271Substrate By similarity
Binding sitei159 – 1591Substrate By similarity

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciMMYC272632:GI1G-164-MONOMER.
UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferase (EC:2.1.1.33)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferase
tRNA(m7G46)-methyltransferase
Gene namesi
Name:trmB
Ordered Locus Names:MSC_0166
OrganismiMycoplasma mycoides subsp. mycoides SC (strain PG1)
Taxonomic identifieri272632 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
ProteomesiUP000001016: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 221221tRNA (guanine-N(7)-)-methyltransferaseUniRule annotationPRO_0000171356Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272632.MSC_0166.

Structurei

3D structure databases

ProteinModelPortaliQ6MU75.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni199 – 2024Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0220.
HOGENOMiHOG000251689.
KOiK03439.
OMAiINYLEAT.
OrthoDBiEOG6K6VBC.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01057. tRNA_methyltr_TrmB.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6MU75-1 [UniParc]FASTAAdd to Basket

« Hide

MRLRKKNWTD DFLNQHSFYL INYNNKKIDL KQIFLNNNPT CLEIGSGKGQ    50
FITTLALKNL NTNYIGMEKS STITGVALKK SLKEFENQLK DMTNLKYFNN 100
FAEDLSQMFS SDSFNKIYLN FSDPWPKTRH YKKRLTYVKF LDIYSDILIK 150
NGYLEFKTDN DSLYNFTIEQ LNLTNKWEIV INATDLYNNT EFLKDNIPTE 200
YETKFHLANK NIYKIVIKNL K 221
Length:221
Mass (Da):26,250
Last modified:July 5, 2004 - v1
Checksum:iD5F997239233E2D1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX293980 Genomic DNA. Translation: CAE76811.1.
RefSeqiNP_975169.1. NC_005364.2.

Genome annotation databases

EnsemblBacteriaiCAE76811; CAE76811; MSC_0166.
GeneIDi2744317.
KEGGimmy:MSC_0166.
PATRICi20017040. VBIMycMyc4973_0176.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX293980 Genomic DNA. Translation: CAE76811.1 .
RefSeqi NP_975169.1. NC_005364.2.

3D structure databases

ProteinModelPortali Q6MU75.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272632.MSC_0166.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAE76811 ; CAE76811 ; MSC_0166 .
GeneIDi 2744317.
KEGGi mmy:MSC_0166.
PATRICi 20017040. VBIMycMyc4973_0176.

Phylogenomic databases

eggNOGi COG0220.
HOGENOMi HOG000251689.
KOi K03439.
OMAi INYLEAT.
OrthoDBi EOG6K6VBC.

Enzyme and pathway databases

UniPathwayi UPA00989 .
BioCyci MMYC272632:GI1G-164-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_01057. tRNA_methyltr_TrmB.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Mycoplasma mycoides subsp. mycoides SC type strain PG1T, the causative agent of contagious bovine pleuropneumonia (CBPP)."
    Westberg J., Persson A., Holmberg A., Goesmann A., Lundeberg J., Johansson K.-E., Pettersson B., Uhlen M.
    Genome Res. 14:221-227(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PG1.

Entry informationi

Entry nameiTRMB_MYCMS
AccessioniPrimary (citable) accession number: Q6MU75
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 5, 2004
Last modified: June 11, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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