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Protein

Guanylate kinase

Gene

gmk

Organism
Mycoplasma mycoides subsp. mycoides SC (strain PG1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Essential for recycling GMP and indirectly, cGMP.By similarity

Catalytic activityi

ATP + GMP = ADP + GDP.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi11 – 18ATPBy similarity8

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMMYC272632:G1G3L-235-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Guanylate kinase (EC:2.7.4.8)
Alternative name(s):
GMP kinase
Gene namesi
Name:gmk
Ordered Locus Names:MSC_0218
OrganismiMycoplasma mycoides subsp. mycoides SC (strain PG1)
Taxonomic identifieri272632 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
Proteomesi
  • UP000001016 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002663531 – 297Guanylate kinaseAdd BLAST297

Interactioni

Protein-protein interaction databases

STRINGi272632.MSC_0218

Structurei

3D structure databases

ProteinModelPortaliQ6MU25
SMRiQ6MU25
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 183Guanylate kinase-likeAdd BLAST180

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni204 – 297UnknownAdd BLAST94

Sequence similaritiesi

Belongs to the guanylate kinase family.Curated

Phylogenomic databases

eggNOGiENOG4108UHA Bacteria
COG0194 LUCA
HOGENOMiHOG000037639
KOiK00942
OMAiAGNYYGT

Family and domain databases

HAMAPiMF_00328 Guanylate_kinase, 1 hit
InterProiView protein in InterPro
IPR008145 GK/Ca_channel_bsu
IPR008144 Guanylate_kin-like_dom
IPR017665 Guanylate_kinase
IPR020590 Guanylate_kinase_CS
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00625 Guanylate_kin, 1 hit
SMARTiView protein in SMART
SM00072 GuKc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR03263 guanyl_kin, 1 hit
PROSITEiView protein in PROSITE
PS00856 GUANYLATE_KINASE_1, 1 hit
PS50052 GUANYLATE_KINASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q6MU25-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKGKMIIIS GPSGVGKGSV NGELLQNPDL HLRYSVSMTT RKPRNGEVDG
60 70 80 90 100
VNYFFVSNEE FAKAIVNDEL IEYAHFVGNS YGTPRKYVEQ ELKKGNNVIL
110 120 130 140 150
EIEVDGATQV LNKEPNVLSI FLMPPNPTEL ANRIRGRQTE DEEKIKARLD
160 170 180 190 200
KALLEIPLKH NYQYVIENDN VPNAVAKITD VLHLEGLTDI KTPTVYERLE
210 220 230 240 250
QIVEQIVKEK YMYFVNNWET NVKLLAKNEE EKNKAKNFDA ETYLIKLLTK
260 270 280 290
KVYHKVLGHG DFSKLLDKDF VDFKIQKLMF KINFFSVEQK HYNNDEF
Length:297
Mass (Da):34,274
Last modified:July 5, 2004 - v1
Checksum:i8163EA5A4A5CAE4B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX293980 Genomic DNA Translation: CAE76861.1
RefSeqiNP_975219.1, NC_005364.2
WP_011166418.1, NC_005364.2

Genome annotation databases

EnsemblBacteriaiCAE76861; CAE76861; MSC_0218
GeneIDi2744659
KEGGimmy:MSC_0218
PATRICifig|272632.4.peg.232

Similar proteinsi

Entry informationi

Entry nameiKGUA_MYCMS
AccessioniPrimary (citable) accession number: Q6MU25
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: July 5, 2004
Last modified: March 28, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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