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Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Mycoplasma mycoides subsp. mycoides SC (strain PG1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (pgi)
  3. ATP-dependent 6-phosphofructokinase (pfk)
  4. no protein annotated in this organism
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei277Proton donorUniRule annotation1
Active sitei298UniRule annotation1
Active sitei414UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processGluconeogenesis, Glycolysis

Enzyme and pathway databases

BioCyciMMYC272632:G1G3L-537-MONOMER
UniPathwayiUPA00109; UER00181

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomeraseUniRule annotation (EC:5.3.1.9UniRule annotation)
Short name:
GPIUniRule annotation
Alternative name(s):
Phosphoglucose isomeraseUniRule annotation
Short name:
PGIUniRule annotation
Phosphohexose isomeraseUniRule annotation
Short name:
PHIUniRule annotation
Gene namesi
Name:pgiUniRule annotation
Ordered Locus Names:MSC_0505
OrganismiMycoplasma mycoides subsp. mycoides SC (strain PG1)
Taxonomic identifieri272632 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
Proteomesi
  • UP000001016 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001806841 – 427Glucose-6-phosphate isomeraseAdd BLAST427

Interactioni

Protein-protein interaction databases

STRINGi272632.MSC_0505

Structurei

3D structure databases

ProteinModelPortaliQ6MTA3
SMRiQ6MTA3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QYV Bacteria
COG0166 LUCA
HOGENOMiHOG000100403
KOiK01810
OMAiSFIIPDD

Family and domain databases

CDDicd05015 SIS_PGI_1, 1 hit
cd05016 SIS_PGI_2, 1 hit
HAMAPiMF_00473 G6P_isomerase, 1 hit
InterProiView protein in InterPro
IPR001672 G6P_Isomerase
IPR018189 Phosphoglucose_isomerase_CS
IPR035476 SIS_PGI_1
IPR035482 SIS_PGI_2
PANTHERiPTHR11469 PTHR11469, 1 hit
PfamiView protein in Pfam
PF00342 PGI, 1 hit
PRINTSiPR00662 G6PISOMERASE
PROSITEiView protein in PROSITE
PS00765 P_GLUCOSE_ISOMERASE_1, 1 hit
PS00174 P_GLUCOSE_ISOMERASE_2, 1 hit
PS51463 P_GLUCOSE_ISOMERASE_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q6MTA3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIKVNLDHTN IDINKVVDLN KVKQIHQMII NKTGKGNDYL GWLNWPNDYN
60 70 80 90 100
KTEYEQMKQV ANKLRSEIEV LVVIGIGGSY LGCRAADEMI RGLYHQDKVE
110 120 130 140 150
LIYAGNTMSS TYIYQLVEYL KNKNFGICVI SKSGTTTEPG ISFRVFEKLL
160 170 180 190 200
VDKVGLNKAK DLIVAITDKN KGALKQLADK KGYQTFVIPN DIGGRFSVLT
210 220 230 240 250
PVGIFPLLVS GINTDNIFNG ALKAKNELIN DDLSNQAYKY AVIRNYLYNQ
260 270 280 290 300
GYKTDALISY ELQLQMLTEW WKQLFGESEG KDNKGLLPSS MIFSTDLHSL
310 320 330 340 350
GQWVQEGPRN VMFETIIKIE KPNYDLNVPI DEDNYDGLNY LTKNSFHQIN
360 370 380 390 400
QTALKGAIQA HSVTGNMPNI VLEFEKMDDE QFGYLVYFFE LALTMSAYLL
410 420
DVNPFNQPGV EVYKYNMFKL LNKPGIK
Length:427
Mass (Da):48,539
Last modified:July 5, 2004 - v1
Checksum:iAF14C1026A04A111
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX293980 Genomic DNA Translation: CAE77133.1
RefSeqiNP_975491.1, NC_005364.2
WP_011166689.1, NC_005364.2

Genome annotation databases

EnsemblBacteriaiCAE77133; CAE77133; MSC_0505
GeneIDi2744799
KEGGimmy:MSC_0505
PATRICifig|272632.4.peg.545

Similar proteinsi

Entry informationi

Entry nameiG6PI_MYCMS
AccessioniPrimary (citable) accession number: Q6MTA3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: July 5, 2004
Last modified: February 28, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome