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Protein

Cell division protein FtsZ

Gene

ftsZ

Organism
Mycoplasma mycoides subsp. mycoides SC (strain PG1)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei136 – 1361GTPUniRule annotation
Binding sitei140 – 1401GTPUniRule annotation
Binding sitei183 – 1831GTPUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi18 – 225GTPUniRule annotation
Nucleotide bindingi105 – 1073GTPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, SeptationUniRule annotation

Keywords - Ligandi

GTP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciMMYC272632:GI1G-573-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division protein FtsZUniRule annotation
Gene namesi
Name:ftsZUniRule annotationImported
Ordered Locus Names:MSC_0588Imported
OrganismiMycoplasma mycoides subsp. mycoides SC (strain PG1)Imported
Taxonomic identifieri272632 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
Proteomesi
  • UP000001016 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi272632.MSC_0588.

Structurei

3D structure databases

ProteinModelPortaliQ6MT25.
SMRiQ6MT25. Positions 9-314.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini10 – 201192TubulinInterPro annotationAdd
BLAST
Domaini203 – 323121Tubulin_CInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the FtsZ family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CDK. Bacteria.
COG0206. LUCA.
HOGENOMiHOG000049094.
KOiK03531.
OMAiGMAMMGI.
OrthoDBiEOG6S7XZG.

Family and domain databases

Gene3Di3.30.1330.20. 1 hit.
3.40.50.1440. 1 hit.
HAMAPiMF_00909. FtsZ.
InterProiIPR000158. Cell_div_FtsZ.
IPR020805. Cell_div_FtsZ_CS.
IPR024757. FtsZ_C.
IPR008280. Tub_FtsZ_C.
IPR018316. Tubulin/FtsZ_2-layer-sand-dom.
IPR003008. Tubulin_FtsZ_GTPase.
[Graphical view]
PfamiPF12327. FtsZ_C. 1 hit.
PF00091. Tubulin. 1 hit.
[Graphical view]
PRINTSiPR00423. CELLDVISFTSZ.
SMARTiSM00864. Tubulin. 1 hit.
SM00865. Tubulin_C. 1 hit.
[Graphical view]
SUPFAMiSSF52490. SSF52490. 1 hit.
SSF55307. SSF55307. 1 hit.
TIGRFAMsiTIGR00065. ftsZ. 1 hit.
PROSITEiPS01134. FTSZ_1. 1 hit.
PS01135. FTSZ_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6MT25-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNEFKQIAR IKVLGVGGAG NNAIRRMFEE NVQGVEFYII NTDAQILESS
60 70 80 90 100
PVPNKIILGE KTTKGLGAGG NPEVGKAAAI ESEEELRKVV EGADLIFIAA
110 120 130 140 150
GMGGGTGTGA APVIAKIAQE SGALVIGIVT KPFIFEGRHR NVNAKEGLEE
160 170 180 190 200
LRKYVDSVIV VSNDKLLEYI GSIPIVESFK EADTILKQGV QTITDLIAVP
210 220 230 240 250
ATINLDFADV KSVMSKKGNA LFGIGVASGK DKAVEAAKEA INSKLLEASI
260 270 280 290 300
EGAKDIIVNI TGGRTVSLND AYDAVGVISQ AVNNKELNIV FGMAINDDLT
310 320 330 340 350
DDDEIIVTVI ATGFENKNLQ NQESNIIKTP RVEPVVQQAQ PSKPIQQEQE
360 370 380
EEQHEEVDEF DDEMSLTTTD DTEEDFNDDD FPTFLK
Length:386
Mass (Da):41,493
Last modified:July 5, 2004 - v1
Checksum:iB7AC68D048B79227
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX293980 Genomic DNA. Translation: CAE77211.1.
RefSeqiNP_975569.1. NC_005364.2.
WP_011166766.1. NC_005364.2.

Genome annotation databases

EnsemblBacteriaiCAE77211; CAE77211; MSC_0588.
GeneIDi2744434.
KEGGimmy:MSC_0588.
PATRICi20017975. VBIMycMyc4973_0633.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX293980 Genomic DNA. Translation: CAE77211.1.
RefSeqiNP_975569.1. NC_005364.2.
WP_011166766.1. NC_005364.2.

3D structure databases

ProteinModelPortaliQ6MT25.
SMRiQ6MT25. Positions 9-314.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272632.MSC_0588.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAE77211; CAE77211; MSC_0588.
GeneIDi2744434.
KEGGimmy:MSC_0588.
PATRICi20017975. VBIMycMyc4973_0633.

Phylogenomic databases

eggNOGiENOG4105CDK. Bacteria.
COG0206. LUCA.
HOGENOMiHOG000049094.
KOiK03531.
OMAiGMAMMGI.
OrthoDBiEOG6S7XZG.

Enzyme and pathway databases

BioCyciMMYC272632:GI1G-573-MONOMER.

Family and domain databases

Gene3Di3.30.1330.20. 1 hit.
3.40.50.1440. 1 hit.
HAMAPiMF_00909. FtsZ.
InterProiIPR000158. Cell_div_FtsZ.
IPR020805. Cell_div_FtsZ_CS.
IPR024757. FtsZ_C.
IPR008280. Tub_FtsZ_C.
IPR018316. Tubulin/FtsZ_2-layer-sand-dom.
IPR003008. Tubulin_FtsZ_GTPase.
[Graphical view]
PfamiPF12327. FtsZ_C. 1 hit.
PF00091. Tubulin. 1 hit.
[Graphical view]
PRINTSiPR00423. CELLDVISFTSZ.
SMARTiSM00864. Tubulin. 1 hit.
SM00865. Tubulin_C. 1 hit.
[Graphical view]
SUPFAMiSSF52490. SSF52490. 1 hit.
SSF55307. SSF55307. 1 hit.
TIGRFAMsiTIGR00065. ftsZ. 1 hit.
PROSITEiPS01134. FTSZ_1. 1 hit.
PS01135. FTSZ_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Mycoplasma mycoides subsp. mycoides SC type strain PG1T, the causative agent of contagious bovine pleuropneumonia (CBPP)."
    Westberg J., Persson A., Holmberg A., Goesmann A., Lundeberg J., Johansson K.-E., Pettersson B., Uhlen M.
    Genome Res. 14:221-227(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PG1Imported.

Entry informationi

Entry nameiQ6MT25_MYCMS
AccessioniPrimary (citable) accession number: Q6MT25
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: July 6, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.