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Q6MT14 (SYR_MYCMS) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Arginine--tRNA ligase

EC=6.1.1.19
Alternative name(s):
Arginyl-tRNA synthetase
Short name=ArgRS
Gene names
Name:argS
Ordered Locus Names:MSC_0599
OrganismMycoplasma mycoides subsp. mycoides SC (strain PG1) [Reference proteome] [HAMAP]
Taxonomic identifier272632 [NCBI]
Taxonomic lineageBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma

Protein attributes

Sequence length554 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP-Rule MF_00123

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00123

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00123.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processarginyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

arginine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 554554Arginine--tRNA ligase HAMAP-Rule MF_00123
PRO_0000242051

Regions

Motif123 – 13311"HIGH" region HAMAP-Rule MF_00123

Sequences

Sequence LengthMass (Da)Tools
Q6MT14 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: BB3C5401357D35DD

FASTA55463,407
        10         20         30         40         50         60 
MSTTIIEMFY NDLKNICQKL NITKEPIIEI NKNNTPGLLS SSICLISSKQ VNKKPLELAE 

        70         80         90        100        110        120 
IFKQELLLTN SYLNIDIAAP GFLNVLVKPE ILSNVISNVL SLKSKYGNLE KQNKTINIEY 

       130        140        150        160        170        180 
VSANPTGYLH VGHARNAVIG SVLVNLFKKA GYNVQTEYYV NDAGNQINVL AVTVFVHYLQ 

       190        200        210        220        230        240 
ALNIDAKKPE NCYAGDMYDD LAKIIINKYN YQFKDIKYTD NKILDYNVHS LFKQISIDYF 

       250        260        270        280        290        300 
LKVIKQQLAD FNVKIKHWSS EQEVYDTHQI EKVLKLYESK DALYYKDDAL FLKTTQFGDD 

       310        320        330        340        350        360 
KDRVLVKSDK TYTYILPDLA THNLRIKRTK ADKLINVWGG DHHGYIKRMQ AGLALLGNDP 

       370        380        390        400        410        420 
DILEIQMVQM VRLIKDGSEY KMSKRKGTAV WLVDILELVG VDALRYMLAS KSSNSHMDLD 

       430        440        450        460        470        480 
LDLITLKNSS NPVYYAQYAT ARCHSILNQA RTKKITPLVK ETNLLNNPKE IELLLVLDNF 

       490        500        510        520        530        540 
KEVIKNSANN RSTQQICDYI QNICKIFHSY YAEIKIIDEN NLQLTKLRLG FIKAVLQVLE 

       550 
NAFFIIGIQP VLEM 

« Hide

References

[1]"The genome sequence of Mycoplasma mycoides subsp. mycoides SC type strain PG1T, the causative agent of contagious bovine pleuropneumonia (CBPP)."
Westberg J., Persson A., Holmberg A., Goesmann A., Lundeberg J., Johansson K.-E., Pettersson B., Uhlen M.
Genome Res. 14:221-227(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PG1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX293980 Genomic DNA. Translation: CAE77222.1.
RefSeqNP_975580.1. NC_005364.2.

3D structure databases

ProteinModelPortalQ6MT14.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272632.MSC_0599.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAE77222; CAE77222; MSC_0599.
GeneID2744697.
KEGGmmy:MSC_0599.
PATRIC20018003. VBIMycMyc4973_0644.

Phylogenomic databases

eggNOGCOG0018.
HOGENOMHOG000247214.
KOK01887.
OMAMEHMGFG.
OrthoDBEOG6JB13C.

Enzyme and pathway databases

BioCycMMYC272632:GI1G-587-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPMF_00123. Arg_tRNA_synth.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERPTHR11956. PTHR11956. 1 hit.
PfamPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSPR01038. TRNASYNTHARG.
SMARTSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsTIGR00456. argS. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYR_MYCMS
AccessionPrimary (citable) accession number: Q6MT14
Entry history
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: July 5, 2004
Last modified: May 14, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries