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Q6MSR0

- SYL_MYCMS

UniProt

Q6MSR0 - SYL_MYCMS

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Mycoplasma mycoides subsp. mycoides SC (strain PG1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 2 (01 Mar 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei583 – 5831ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMMYC272632:GI1G-696-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:MSC_0709
    OrganismiMycoplasma mycoides subsp. mycoides SC (strain PG1)
    Taxonomic identifieri272632 [NCBI]
    Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
    ProteomesiUP000001016: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 804804Leucine--tRNA ligasePRO_0000152047Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272632.MSC_0709.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6MSR0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi39 – 5012"HIGH" regionAdd
    BLAST
    Motifi580 – 5845"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200748.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 2 hits.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6MSR0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDFSHKAIEK KWQKYWKENN IYKTTNNSEK KAYILDMFPY PSGAGLHVGH    50
    IKGYTATDVY SRFKRMQGYD VLHPIGWDAF GLPAEQYALK TGNDPREFTL 100
    QNIENFKIQL NKMGFSYDYD KEINTADPNY YKTTQWIFKQ LYKKGLAENR 150
    DIDVNWCQEL GTVLANDEII EKDGLMVSER GEYPVVKKKM RQWVLKITDY 200
    ADKLLDGLDN LDWPNSVKEL QRNWIGKSEG CEINFKSNDI NIPVFTTRAD 250
    TIFGVTYIVL ASENELVLKL TAPEKLEEVK KYIELTANKS EIERKDESRT 300
    KTGVFIGSYA TNPLTKEQIQ IWISDYVLND YGSGAIMAVP AHDKRDWDFA 350
    AKFNLPIKFV IQTKDQSKAF VGEGIHINSE FLNDLDRIQA LQVIHDYVDK 400
    NNLGKRKINY KLRDWLFSRQ RFYGEPFPVL YDKDNNIVLI EDNNLPITLP 450
    ITDYIKPTNT GESPLANVKN WVNVKIGDKE YKRETNTMPQ SAASSWYFIA 500
    YILANSKNNL IDLTSDEAKK RLEKWLPVDL YIGGQEHAVG HLLYARFWTH 550
    FLYDLGLLPT NEPFKRLFNQ GMILGPDNRK MSKSWGNVIN PDDVIDTHGA 600
    DALRLYEMFM GPLDASLPWS FDGLDASLKW LNRCYRMINK IEFSNTNNHK 650
    LDYVYNDVVK KVTQMIQELK FNTAISQLMV LVNAIYKEEL NTVYKPYIEG 700
    FVKMLSLFAP HLSEELWEKL GNNSSVTLQT WPEFDETKII KNAVVIALQV 750
    NGKLRSTIEV EKGTDKETLI KLAQENENII RFIKDHKNLK YIAVVDRIVN 800
    IVIE 804
    Length:804
    Mass (Da):93,178
    Last modified:March 1, 2005 - v2
    Checksum:i8BD0473253647145
    GO

    Sequence cautioni

    The sequence CAE77328.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX293980 Genomic DNA. Translation: CAE77328.1. Different initiation.
    RefSeqiNP_975686.1. NC_005364.2.

    Genome annotation databases

    EnsemblBacteriaiCAE77328; CAE77328; MSC_0709.
    GeneIDi2744315.
    KEGGimmy:MSC_0709.
    PATRICi20018249. VBIMycMyc4973_0763.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX293980 Genomic DNA. Translation: CAE77328.1 . Different initiation.
    RefSeqi NP_975686.1. NC_005364.2.

    3D structure databases

    ProteinModelPortali Q6MSR0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272632.MSC_0709.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAE77328 ; CAE77328 ; MSC_0709 .
    GeneIDi 2744315.
    KEGGi mmy:MSC_0709.
    PATRICi 20018249. VBIMycMyc4973_0763.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200748.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci MMYC272632:GI1G-696-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 2 hits.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Mycoplasma mycoides subsp. mycoides SC type strain PG1T, the causative agent of contagious bovine pleuropneumonia (CBPP)."
      Westberg J., Persson A., Holmberg A., Goesmann A., Lundeberg J., Johansson K.-E., Pettersson B., Uhlen M.
      Genome Res. 14:221-227(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PG1.

    Entry informationi

    Entry nameiSYL_MYCMS
    AccessioniPrimary (citable) accession number: Q6MSR0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 2005
    Last sequence update: March 1, 2005
    Last modified: October 1, 2014
    This is version 76 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3