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Q6MSR0

- SYL_MYCMS

UniProt

Q6MSR0 - SYL_MYCMS

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Protein
Leucine--tRNA ligase
Gene
leuS, MSC_0709
Organism
Mycoplasma mycoides subsp. mycoides SC (strain PG1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei583 – 5831ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMMYC272632:GI1G-696-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:MSC_0709
OrganismiMycoplasma mycoides subsp. mycoides SC (strain PG1)
Taxonomic identifieri272632 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
ProteomesiUP000001016: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 804804Leucine--tRNA ligaseUniRule annotation
PRO_0000152047Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272632.MSC_0709.

Structurei

3D structure databases

ProteinModelPortaliQ6MSR0.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi39 – 5012"HIGH" regionUniRule annotation
Add
BLAST
Motifi580 – 5845"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 2 hits.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6MSR0-1 [UniParc]FASTAAdd to Basket

« Hide

MDFSHKAIEK KWQKYWKENN IYKTTNNSEK KAYILDMFPY PSGAGLHVGH    50
IKGYTATDVY SRFKRMQGYD VLHPIGWDAF GLPAEQYALK TGNDPREFTL 100
QNIENFKIQL NKMGFSYDYD KEINTADPNY YKTTQWIFKQ LYKKGLAENR 150
DIDVNWCQEL GTVLANDEII EKDGLMVSER GEYPVVKKKM RQWVLKITDY 200
ADKLLDGLDN LDWPNSVKEL QRNWIGKSEG CEINFKSNDI NIPVFTTRAD 250
TIFGVTYIVL ASENELVLKL TAPEKLEEVK KYIELTANKS EIERKDESRT 300
KTGVFIGSYA TNPLTKEQIQ IWISDYVLND YGSGAIMAVP AHDKRDWDFA 350
AKFNLPIKFV IQTKDQSKAF VGEGIHINSE FLNDLDRIQA LQVIHDYVDK 400
NNLGKRKINY KLRDWLFSRQ RFYGEPFPVL YDKDNNIVLI EDNNLPITLP 450
ITDYIKPTNT GESPLANVKN WVNVKIGDKE YKRETNTMPQ SAASSWYFIA 500
YILANSKNNL IDLTSDEAKK RLEKWLPVDL YIGGQEHAVG HLLYARFWTH 550
FLYDLGLLPT NEPFKRLFNQ GMILGPDNRK MSKSWGNVIN PDDVIDTHGA 600
DALRLYEMFM GPLDASLPWS FDGLDASLKW LNRCYRMINK IEFSNTNNHK 650
LDYVYNDVVK KVTQMIQELK FNTAISQLMV LVNAIYKEEL NTVYKPYIEG 700
FVKMLSLFAP HLSEELWEKL GNNSSVTLQT WPEFDETKII KNAVVIALQV 750
NGKLRSTIEV EKGTDKETLI KLAQENENII RFIKDHKNLK YIAVVDRIVN 800
IVIE 804
Length:804
Mass (Da):93,178
Last modified:March 1, 2005 - v2
Checksum:i8BD0473253647145
GO

Sequence cautioni

The sequence CAE77328.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX293980 Genomic DNA. Translation: CAE77328.1. Different initiation.
RefSeqiNP_975686.1. NC_005364.2.

Genome annotation databases

EnsemblBacteriaiCAE77328; CAE77328; MSC_0709.
GeneIDi2744315.
KEGGimmy:MSC_0709.
PATRICi20018249. VBIMycMyc4973_0763.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX293980 Genomic DNA. Translation: CAE77328.1 . Different initiation.
RefSeqi NP_975686.1. NC_005364.2.

3D structure databases

ProteinModelPortali Q6MSR0.
ModBasei Search...

Protein-protein interaction databases

STRINGi 272632.MSC_0709.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAE77328 ; CAE77328 ; MSC_0709 .
GeneIDi 2744315.
KEGGi mmy:MSC_0709.
PATRICi 20018249. VBIMycMyc4973_0763.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci MMYC272632:GI1G-696-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 2 hits.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Mycoplasma mycoides subsp. mycoides SC type strain PG1T, the causative agent of contagious bovine pleuropneumonia (CBPP)."
    Westberg J., Persson A., Holmberg A., Goesmann A., Lundeberg J., Johansson K.-E., Pettersson B., Uhlen M.
    Genome Res. 14:221-227(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PG1.

Entry informationi

Entry nameiSYL_MYCMS
AccessioniPrimary (citable) accession number: Q6MSR0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: March 1, 2005
Last modified: June 11, 2014
This is version 75 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi