Reviewed, UniProtKB/Swiss-Prot Q6MRM8 (DAPB_BDEBA)

Names and origin

Protein names

Recommended name:
    Dihydrodipicolinate reductase
      Short name=DHPR
    EC=1.3.1.26

Gene names

Name:	dapB
Ordered Locus Names:	Bd0047

Organism

Bdellovibrio bacteriovorus [Complete proteome] [HAMAP]

Taxonomic identifier

959 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Deltaproteobacteria › Bdellovibrionales › Bdellovibrionaceae › Bdellovibrio

Protein attributes

Sequence length	229 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	2,3,4,5-tetrahydrodipicolinate + NAD(P)+ = 2,3-dihydrodipicolinate + NAD(P)H. HAMAP MF_00102
Pathway	Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 4/4. HAMAP MF_00102
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the dihydrodipicolinate reductase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Diaminopimelate biosynthesis Lysine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	diaminopimelate biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	binding Inferred from electronic annotation. Source: InterPro dihydrodipicolinate reductase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 229	229	Dihydrodipicolinate reductase HAMAP MF_00102		PRO_0000228328

Sequences

	Sequence		Length	Mass (Da)
	Q6MRM8-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: A70F6574A1FF1A91	FASTA	229	25,371
	10 20 30 40 50 60 MKKIKIGLMG SAGRMGQEIA GVIEANPRCE LVYAPLRGEK WDSKKAQAVD VWIDFTSPEA 70 80 90 100 110 120 LKDILKKASE TKTPVVCGTT GFSKKEKELL KTYSKKIPVL WSSNMSLGVA VLNEALKAFS 130 140 150 160 170 180 AISHFDFQIE EIHHNRKKDR PSGTAITLQE NLEKAVDKKL PEALAIRGGG VFGVHKIFAM 190 200 210 220 SDEEVLTFEH TALNRTVFAK GSVQAAEWLV KQKPGLYQIR DVLFGKSKK

References

[1]

"A predator unmasked: life cycle of Bdellovibrio bacteriovorus from a genomic perspective." Rendulic S., Jagtap P., Rosinus A., Eppinger M., Baar C., Lanz C., Keller H., Lambert C., Evans K.J., Goesmann A., Meyer F., Sockett R.E., Schuster S.C. Science 303:689-692(2004) [PubMed: 14752164] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 15356 / HD100 / DSM 50701 / NCIB 9529.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BX842646 Genomic DNA. Translation: CAE77729.1.
RefSeq	NP_967075.1.
3D structure databases
HSSP	HSSP built from PDB template 1ARZ based on UniProtKB P04036.
ModBase	Search...
Genome annotation databases
GeneID	2733554.
GenomeReviews	Gene locus Bd0047 in contig BX842601_GR.
KEGG	bba:Bd0047.
NMPDR	fig|264462.1.peg.45.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q6MRM8.
OMA	RSKESIG.
Enzyme and pathway databases
BioCyc	BBAC264462:BD0047-MON.
BRENDA	1.3.1.26. 3459.
Family and domain databases
HAMAP	MF_00102. [Tree]
InterPro	IPR000846. DapB. IPR011770. Dihydrodipicolinate_Rdtase. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR20836. DapB_bac/pln. 1 hit.
Pfam	PF05173. DapB_C. 1 hit. PF01113. DapB_N. 1 hit. [Graphical view]
ProDom	PD004105. DapB. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00036. dapB. 1 hit.
PROSITE	PS01298. DAPB. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DAPB_BDEBA

Accession

Primary (citable) accession number: Q6MRM8

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 21, 2006
Last sequence update:	July 5, 2004
Last modified:	November 3, 2009
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)