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Q6MQU3

- SYL_BDEBA

UniProt

Q6MQU3 - SYL_BDEBA

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Bdellovibrio bacteriovorus (strain ATCC 15356 / DSM 50701 / NCIB 9529 / HD100)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei572 – 5721ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Bd0365
    OrganismiBdellovibrio bacteriovorus (strain ATCC 15356 / DSM 50701 / NCIB 9529 / HD100)
    Taxonomic identifieri264462 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaBdellovibrionalesBdellovibrionaceaeBdellovibrio
    ProteomesiUP000008080: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 796796Leucine--tRNA ligasePRO_0000151977Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi264462.Bd0365.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6MQU3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi40 – 5112"HIGH" regionAdd
    BLAST
    Motifi569 – 5735"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200748.
    KOiK01869.
    OMAiDKPKYYA.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q6MQU3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSLNFTEYEA KWQKKWADAK AFQAETTSSK PKYYALDMFP YPSASGLHVG    50
    HMASYTPGDI ISRYKRVNGF NVLHPMGYDA FGLPAEQYAI QTGVHPAITT 100
    KKAIDSFRKT LQTFGFSFDW SREISTCEPD YYKWTQFIFL KLYERGLAYQ 150
    KEVPVNWCPA LKTVLANDEV VDGKSERGGH PVIRVPMKQW MLKITDYAER 200
    LLNDLDKLDW PERTKEGQRN WIGKSEGARI TFKVHGEKDT FEVFTTRPDT 250
    LFGVTFMVMA PEHPLVKKIT SQPQYTAVEN YIADTAKKSE VDRKASTEKT 300
    GVFTGAHATH PITGDKIEIW ISDYVLMDYG TGAIMAVPGH DARDFEFATK 350
    FNIPIKSVLE SDMLPFEGDS IMINSEFLDG LNKTEAISKM LKHLEENKLG 400
    VREVQYKLRD WLFSRQRYWG EPFPIVHFAD GSKGVPVNEL PVILPEVADY 450
    EPADTGEAPL ARNADWVKYM DGDKEGRRET DTMPGAAGSS WYFLRYIDPK 500
    NTEAPFSPEA EKYWMPVDLY VGGPEHTVGH LLYARFWTKV LFDCGLVTHD 550
    EPFQKLAHQG MILGPDGEKM SKSRGNVISP EDIARSHGAD ALRTFISFMG 600
    PVDKDKPWAP TGIDGVKRFL DRITRLVVND DGQLVATSEA LTPEIEKLVH 650
    KTIKKVTEDI ESMSFNTAIS AMMILVNELY RAECRSVLAV KPLVQILAPF 700
    APHLAEELWE KMNGEGLCAL APWPKYDNTL CADDTVTIGV QVNGKMRGTI 750
    EIGVAASEQE AVAAAKAVQQ VAAVLGDKNP DKVIYKAGKI LNLIVK 796
    Length:796
    Mass (Da):89,437
    Last modified:July 5, 2004 - v1
    Checksum:i01B10754DBB8D8A5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX842646 Genomic DNA. Translation: CAE78015.1.
    RefSeqiNP_967361.1. NC_005363.1.

    Genome annotation databases

    EnsemblBacteriaiCAE78015; CAE78015; Bd0365.
    GeneIDi2734277.
    KEGGibba:Bd0365.
    PATRICi21075494. VBIBdeBac73187_0336.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX842646 Genomic DNA. Translation: CAE78015.1 .
    RefSeqi NP_967361.1. NC_005363.1.

    3D structure databases

    ProteinModelPortali Q6MQU3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 264462.Bd0365.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAE78015 ; CAE78015 ; Bd0365 .
    GeneIDi 2734277.
    KEGGi bba:Bd0365.
    PATRICi 21075494. VBIBdeBac73187_0336.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200748.
    KOi K01869.
    OMAi DKPKYYA.
    OrthoDBi EOG63Z74X.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "A predator unmasked: life cycle of Bdellovibrio bacteriovorus from a genomic perspective."
      Rendulic S., Jagtap P., Rosinus A., Eppinger M., Baar C., Lanz C., Keller H., Lambert C., Evans K.J., Goesmann A., Meyer F., Sockett R.E., Schuster S.C.
      Science 303:689-692(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 15356 / DSM 50701 / NCIB 9529 / HD100.

    Entry informationi

    Entry nameiSYL_BDEBA
    AccessioniPrimary (citable) accession number: Q6MQU3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 2005
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3