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Q6MQU3

- SYL_BDEBA

UniProt

Q6MQU3 - SYL_BDEBA

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Protein
Leucine--tRNA ligase
Gene
leuS, Bd0365
Organism
Bdellovibrio bacteriovorus (strain ATCC 15356 / DSM 50701 / NCIB 9529 / HD100)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei572 – 5721ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:Bd0365
OrganismiBdellovibrio bacteriovorus (strain ATCC 15356 / DSM 50701 / NCIB 9529 / HD100)
Taxonomic identifieri264462 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaBdellovibrionalesBdellovibrionaceaeBdellovibrio
ProteomesiUP000008080: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 796796Leucine--tRNA ligaseUniRule annotation
PRO_0000151977Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi264462.Bd0365.

Structurei

3D structure databases

ProteinModelPortaliQ6MQU3.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi40 – 5112"HIGH" regionUniRule annotation
Add
BLAST
Motifi569 – 5735"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiDKPKYYA.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6MQU3-1 [UniParc]FASTAAdd to Basket

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MSLNFTEYEA KWQKKWADAK AFQAETTSSK PKYYALDMFP YPSASGLHVG    50
HMASYTPGDI ISRYKRVNGF NVLHPMGYDA FGLPAEQYAI QTGVHPAITT 100
KKAIDSFRKT LQTFGFSFDW SREISTCEPD YYKWTQFIFL KLYERGLAYQ 150
KEVPVNWCPA LKTVLANDEV VDGKSERGGH PVIRVPMKQW MLKITDYAER 200
LLNDLDKLDW PERTKEGQRN WIGKSEGARI TFKVHGEKDT FEVFTTRPDT 250
LFGVTFMVMA PEHPLVKKIT SQPQYTAVEN YIADTAKKSE VDRKASTEKT 300
GVFTGAHATH PITGDKIEIW ISDYVLMDYG TGAIMAVPGH DARDFEFATK 350
FNIPIKSVLE SDMLPFEGDS IMINSEFLDG LNKTEAISKM LKHLEENKLG 400
VREVQYKLRD WLFSRQRYWG EPFPIVHFAD GSKGVPVNEL PVILPEVADY 450
EPADTGEAPL ARNADWVKYM DGDKEGRRET DTMPGAAGSS WYFLRYIDPK 500
NTEAPFSPEA EKYWMPVDLY VGGPEHTVGH LLYARFWTKV LFDCGLVTHD 550
EPFQKLAHQG MILGPDGEKM SKSRGNVISP EDIARSHGAD ALRTFISFMG 600
PVDKDKPWAP TGIDGVKRFL DRITRLVVND DGQLVATSEA LTPEIEKLVH 650
KTIKKVTEDI ESMSFNTAIS AMMILVNELY RAECRSVLAV KPLVQILAPF 700
APHLAEELWE KMNGEGLCAL APWPKYDNTL CADDTVTIGV QVNGKMRGTI 750
EIGVAASEQE AVAAAKAVQQ VAAVLGDKNP DKVIYKAGKI LNLIVK 796
Length:796
Mass (Da):89,437
Last modified:July 5, 2004 - v1
Checksum:i01B10754DBB8D8A5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX842646 Genomic DNA. Translation: CAE78015.1.
RefSeqiNP_967361.1. NC_005363.1.

Genome annotation databases

EnsemblBacteriaiCAE78015; CAE78015; Bd0365.
GeneIDi2734277.
KEGGibba:Bd0365.
PATRICi21075494. VBIBdeBac73187_0336.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX842646 Genomic DNA. Translation: CAE78015.1 .
RefSeqi NP_967361.1. NC_005363.1.

3D structure databases

ProteinModelPortali Q6MQU3.
ModBasei Search...

Protein-protein interaction databases

STRINGi 264462.Bd0365.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAE78015 ; CAE78015 ; Bd0365 .
GeneIDi 2734277.
KEGGi bba:Bd0365.
PATRICi 21075494. VBIBdeBac73187_0336.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi DKPKYYA.
OrthoDBi EOG63Z74X.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "A predator unmasked: life cycle of Bdellovibrio bacteriovorus from a genomic perspective."
    Rendulic S., Jagtap P., Rosinus A., Eppinger M., Baar C., Lanz C., Keller H., Lambert C., Evans K.J., Goesmann A., Meyer F., Sockett R.E., Schuster S.C.
    Science 303:689-692(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15356 / DSM 50701 / NCIB 9529 / HD100.

Entry informationi

Entry nameiSYL_BDEBA
AccessioniPrimary (citable) accession number: Q6MQU3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: July 5, 2004
Last modified: June 11, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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