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Q6MQU0

- TRMB_BDEBA

UniProt

Q6MQU0 - TRMB_BDEBA

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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Bdellovibrio bacteriovorus (strain ATCC 15356 / DSM 50701 / NCIB 9529 / HD100)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei40 – 401S-adenosyl-L-methionineUniRule annotation
Binding sitei65 – 651S-adenosyl-L-methionineUniRule annotation
Active sitei114 – 1141By similarity
Binding sitei114 – 1141S-adenosyl-L-methionineUniRule annotation
Binding sitei150 – 1501SubstrateUniRule annotation

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
tRNA(m7G46)-methyltransferaseUniRule annotation
Gene namesi
Name:trmBUniRule annotation
Ordered Locus Names:Bd0370
OrganismiBdellovibrio bacteriovorus (strain ATCC 15356 / DSM 50701 / NCIB 9529 / HD100)
Taxonomic identifieri264462 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaBdellovibrionalesBdellovibrionaceaeBdellovibrio
ProteomesiUP000008080: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 209209tRNA (guanine-N(7)-)-methyltransferasePRO_0000171299Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi264462.Bd0370.

Structurei

3D structure databases

ProteinModelPortaliQ6MQU0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni188 – 1914Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0220.
KOiK03439.
OMAiDNVMTEY.
OrthoDBiEOG6K6VBC.

Family and domain databases

HAMAPiMF_01057. tRNA_methyltr_TrmB.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6MQU0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MALNGEYAHV AFDELRAPLN KGKWRSDVFK ADAAMPLDVE VGTGNGTYFA
60 70 80 90 100
HHAKTHSDRL LVGLELKYKP LIQSIRRAVN AGCKNAAITR FHAFNIDHLF
110 120 130 140 150
AEGEIDNVYI HFPDPWTSPK KPKNRFVCKE NLELLFRLQK PGSFINFKTD
160 170 180 190 200
SLVYFLWAMD EIRQSPYKII FETQDLHNSD MKDQNFETAF EKIFLREGIK

INFVRLQKI
Length:209
Mass (Da):24,222
Last modified:July 5, 2004 - v1
Checksum:iECE3A6AE1609D92C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX842646 Genomic DNA. Translation: CAE78018.1.
RefSeqiNP_967364.1. NC_005363.1.
WP_011162959.1. NC_005363.1.

Genome annotation databases

EnsemblBacteriaiCAE78018; CAE78018; Bd0370.
GeneIDi2734260.
KEGGibba:Bd0370.
PATRICi21075500. VBIBdeBac73187_0339.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX842646 Genomic DNA. Translation: CAE78018.1 .
RefSeqi NP_967364.1. NC_005363.1.
WP_011162959.1. NC_005363.1.

3D structure databases

ProteinModelPortali Q6MQU0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 264462.Bd0370.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAE78018 ; CAE78018 ; Bd0370 .
GeneIDi 2734260.
KEGGi bba:Bd0370.
PATRICi 21075500. VBIBdeBac73187_0339.

Phylogenomic databases

eggNOGi COG0220.
KOi K03439.
OMAi DNVMTEY.
OrthoDBi EOG6K6VBC.

Enzyme and pathway databases

UniPathwayi UPA00989 .

Family and domain databases

HAMAPi MF_01057. tRNA_methyltr_TrmB.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A predator unmasked: life cycle of Bdellovibrio bacteriovorus from a genomic perspective."
    Rendulic S., Jagtap P., Rosinus A., Eppinger M., Baar C., Lanz C., Keller H., Lambert C., Evans K.J., Goesmann A., Meyer F., Sockett R.E., Schuster S.C.
    Science 303:689-692(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15356 / DSM 50701 / NCIB 9529 / HD100.

Entry informationi

Entry nameiTRMB_BDEBA
AccessioniPrimary (citable) accession number: Q6MQU0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3