Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q6MQ94 (DDL_BDEBA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase

EC=6.3.2.4
Alternative name(s):
D-Ala-D-Ala ligase
D-alanylalanine synthetase
Gene names
Name:ddl
Ordered Locus Names:Bd0585
OrganismBdellovibrio bacteriovorus (strain ATCC 15356 / DSM 50701 / NCIB 9529 / HD100) [Complete proteome] [HAMAP]
Taxonomic identifier264462 [NCBI]
Taxonomic lineageBacteriaProteobacteriaDeltaproteobacteriaBdellovibrionalesBdellovibrionaceaeBdellovibrio

Protein attributes

Sequence length365 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity.

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family.

Contains 1 ATP-grasp domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 365365D-alanine--D-alanine ligase HAMAP-Rule MF_00047
PRO_0000341059

Regions

Domain145 – 347203ATP-grasp
Nucleotide binding173 – 22856ATP By similarity

Sites

Metal binding3011Magnesium or manganese 1 By similarity
Metal binding3141Magnesium or manganese 1 By similarity
Metal binding3141Magnesium or manganese 2 By similarity
Metal binding3161Magnesium or manganese 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6MQ94 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 763890C901EF1BA2

FASTA36540,347
        10         20         30         40         50         60 
MSMKKIVALI FGGKSAEHEV SLRSAKNVAD ALDKDKFTPV LIGISKEGSW YRFPDMGVFT 

        70         80         90        100        110        120 
EATKIVDSAL PSKAEPVALM SLQGKPVLYS LKDHSKTAVD VAFPILHGTM GEDGTIQGLF 

       130        140        150        160        170        180 
KMVQLPFVGC GVWSSAAGMD KEIMKRLLAV AKIPNARYLL LTPHQKNDYN EIVKELGSPF 

       190        200        210        220        230        240 
FIKPANAGSS VGVHKIKTAE DFVVKLKDAF QFDTKVLAEE FIQGREVECS VMGHNHAPKA 

       250        260        270        280        290        300 
SLPGEVIPQH EFYSYEAKYI DDNGALLKIP AELSPETTKA VQKMAEQTYQ AMGCDGLTRV 

       310        320        330        340        350        360 
DFFIRPNGEL YINEINTIPG FTKISMYPKM WEASGLSYKD LISQLIQLGF EKFEGEQSLK 


TSYLD 

« Hide

References

[1]"A predator unmasked: life cycle of Bdellovibrio bacteriovorus from a genomic perspective."
Rendulic S., Jagtap P., Rosinus A., Eppinger M., Baar C., Lanz C., Keller H., Lambert C., Evans K.J., Goesmann A., Meyer F., Sockett R.E., Schuster S.C.
Science 303:689-692(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 15356 / DSM 50701 / NCIB 9529 / HD100.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX842647 Genomic DNA. Translation: CAE78553.1.
RefSeqNP_967560.1. NC_005363.1.

3D structure databases

ProteinModelPortalQ6MQ94.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING264462.Bd0585.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAE78553; CAE78553; Bd0585.
GeneID2733559.
KEGGbba:Bd0585.
PATRIC21075886. VBIBdeBac73187_0532.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1181.
HOGENOMHOG000011593.
KOK01921.
OMAQIDVIFP.
OrthoDBEOG64BQ73.

Enzyme and pathway databases

UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDDL_BDEBA
AccessionPrimary (citable) accession number: Q6MQ94
Entry history
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: July 5, 2004
Last modified: May 14, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways