Reviewed, UniProtKB/Swiss-Prot Q6MQ48 (GCP_BDEBA)

Names and origin

Protein names

Recommended name:
    Probable O-sialoglycoprotein endopeptidase
      Short name=Glycoprotease
    EC=3.4.24.57

Gene names

Name:	gcp
Ordered Locus Names:	Bd0636

Organism

Bdellovibrio bacteriovorus [Complete proteome] [HAMAP]

Taxonomic identifier

959 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Deltaproteobacteria › Bdellovibrionales › Bdellovibrionaceae › Bdellovibrio

Protein attributes

Sequence length	345 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Hydrolysis of O-sialoglycoproteins; cleaves 31-Arg-|-Asp-32 bond in glycophorin A. Does not cleave unglycosylated proteins, desialylated glycoproteins or glycoproteins that are only N-glycosylated. HAMAP MF_01445
Cofactor	Zinc Probable.
Sequence similarities	Belongs to the peptidase M22 family.

Ontologies

Keywords
Ligand	Metal-binding Zinc
Molecular function	Hydrolase Metalloprotease Protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: InterPro
Molecular function	metalloendopeptidase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 345	345	Probable O-sialoglycoprotein endopeptidase HAMAP MF_01445		PRO_0000303279
Sites
	Metal binding	113	1	Zinc Potential
	Metal binding	117	1	Zinc Potential

Sequences

	Sequence		Length	Mass (Da)
	Q6MQ48-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: F525C0AA12C4EA65	FASTA	345	37,342
	10 20 30 40 50 60 MIERVLAIET SCDDTSVAIV DRTGWVHSVV AASQDLDHEI YGGIVPEIAA RNHSIALIPL 70 80 90 100 110 120 IEEAFKKANM NWSDVQGIAV TNRPGLIGAL IVGLVTAKSL SQAKHLPFLG VNHLEGHLLA 130 140 150 160 170 180 PFLRDDKYAP PEDFGYPYVG LAISGGHTSL YQIKGLGDYR ILGATKDDAA GECFDKFAKM 190 200 210 220 230 240 AGLGFPGGVR VDQMAKAGNP QAFEFPRSMI HDDTFDMSFS GLKSSGQRML EQLGPELVQE 250 260 270 280 290 300 RLPDLCASFQ EAIVDVLIAK LDRAAKVFRS KRVILTGGVS ANSRLRQRAQ EWADKKGYTL 310 320 330 340 VIPPLRYCTD NAAMIGYVGA LRMARGEVSA LDLGPSPQAL ASDFK

References

[1]

"A predator unmasked: life cycle of Bdellovibrio bacteriovorus from a genomic perspective." Rendulic S., Jagtap P., Rosinus A., Eppinger M., Baar C., Lanz C., Keller H., Lambert C., Evans K.J., Goesmann A., Meyer F., Sockett R.E., Schuster S.C. Science 303:689-692(2004) [PubMed: 14752164] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 15356 / HD100 / DSM 50701 / NCIB 9529.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BX842647 Genomic DNA. Translation: CAE78599.1.
RefSeq	NP_967606.1.
3D structure databases
ModBase	Search...
Protein family/group databases
MEROPS	M22.001.
Genome annotation databases
GeneID	2733591.
GenomeReviews	Gene locus Bd0636 in contig BX842601_GR.
KEGG	bba:Bd0636.
NMPDR	fig|264462.1.peg.576.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q6MQ48.
OMA	CKRALKQ.
Enzyme and pathway databases
BioCyc	BBAC264462:BD0636-MON.
BRENDA	3.4.24.57. 3459.
Family and domain databases
HAMAP	MF_01445. [Tree]
InterPro	IPR009180. Pept_M22_Osialgl. IPR000905. Peptidase_M22. IPR017860. Peptidase_M22_CS. IPR017861. Peptidase_M22_subgr. [Graphical view]
PANTHER	PTHR11735. Pept_M22_Osialgl. 1 hit.
Pfam	PF00814. Peptidase_M22. 1 hit. [Graphical view]
PRINTS	PR00789. OSIALOPTASE.
ProDom	PD002367. Peptidase_M22. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00329. gcp. 1 hit.
PROSITE	PS01016. GLYCOPROTEASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GCP_BDEBA

Accession

Primary (citable) accession number: Q6MQ48

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	July 5, 2004
Last modified:	November 3, 2009
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)