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Q6MPZ6

- GCSP_BDEBA

UniProt

Q6MPZ6 - GCSP_BDEBA

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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Bdellovibrio bacteriovorus (strain ATCC 15356 / DSM 50701 / NCIB 9529 / HD100)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:Bd0692
OrganismiBdellovibrio bacteriovorus (strain ATCC 15356 / DSM 50701 / NCIB 9529 / HD100)
Taxonomic identifieri264462 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaBdellovibrionalesBdellovibrionaceaeBdellovibrio
ProteomesiUP000008080: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 958958Glycine dehydrogenase (decarboxylating)PRO_0000227095Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei705 – 7051N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi264462.Bd0692.

Structurei

3D structure databases

ProteinModelPortaliQ6MPZ6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiFDSRPYS.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6MPZ6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKIADLSPTN EFIPRHIGPT DSDIHEMLKT LGFNSLDQMA DKVIPAQIRT
60 70 80 90 100
THAYADVGNG ISEHGLLNHL KQMVSKNKVY KNYIGMGYHD TITPTVIQRN
110 120 130 140 150
IFENPVWYTA YTPYQPEISQ GRLEALLNFQ TMIADLNGME IANASLLDEG
160 170 180 190 200
TAAAEAMFMA HSLCKNKANA FVVSPDMHPH VIEVIGTRAE PLGFEMIVMD
210 220 230 240 250
PAKYDFAKPV FGVFFQYPNT NGTVEDYAAI AKKYKDHGAL VTASTDLLAM
260 270 280 290 300
TLLTPPGEWG ADMVVGNSQR FGVPLGFGGP HAGFLATKDA FKRLMPGRLV
310 320 330 340 350
GVSVDSQGKS ALRLALQTRE QHIRREKATS NICTAQVLLA NMASMYAVYH
360 370 380 390 400
GPAGLKKIAL RVQRLTAILS AGLKKLNLEV GAGHVFDTVT VKTDKAAEII
410 420 430 440 450
AQAEKMQMNF RNYGGGKLGV SLNEATTLED VEQIWAAFNL GKAAGFTALS
460 470 480 490 500
VDESLADVTL PANLTRSTAY MTHQVFNSHH SETEMLRYIH HLQNKDLTLT
510 520 530 540 550
HSMIPLGSCT MKLNATTELV PVSWPEISKL HPFAPTAQAV GLIEMIHDLE
560 570 580 590 600
KKLCDITGFA AVSLQPNAGS QGEYAGLLVI RKYHQSRGQG HRNICLIPSS
610 620 630 640 650
AHGTNPASAA LVNMQVVVVA CDDQGNVDVA DLKAKAEQHK DNLAALMITY
660 670 680 690 700
PSTHGVFEEG IVEICKIIHD NGGQVYMDGA NMNALVGMCR PGVFGPDVSH
710 720 730 740 750
MNLHKTFSIP HGGGGPGVGP IGVGAHLAEF LPKHSLVPEA GPANGISATT
760 770 780 790 800
SAPWGSASIL PISWAYITMM GAQGLRKATL VSILSANYIA KKLEAHYPVL
810 820 830 840 850
YKGKNGLVAH ECIVDVREIK KTSGIDVTDV AKRLMDFGFH APTMSFPVAG
860 870 880 890 900
TLMIEPTESE SKKELDRFIE SMVTIRKEIA AVETGKMDKE NNALKNAPHT
910 920 930 940 950
AQMLMKPEWN HPYSREEAVY PVEWLRGNKF WPVVGRVDNA YGDRNLICSC

PSIEDYQA
Length:958
Mass (Da):104,226
Last modified:July 5, 2004 - v1
Checksum:iA21D228C935F7991
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX842647 Genomic DNA. Translation: CAE78651.1.
RefSeqiNP_967658.1. NC_005363.1.

Genome annotation databases

EnsemblBacteriaiCAE78651; CAE78651; Bd0692.
GeneIDi2734190.
KEGGibba:Bd0692.
PATRICi21076084. VBIBdeBac73187_0630.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX842647 Genomic DNA. Translation: CAE78651.1 .
RefSeqi NP_967658.1. NC_005363.1.

3D structure databases

ProteinModelPortali Q6MPZ6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 264462.Bd0692.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAE78651 ; CAE78651 ; Bd0692 .
GeneIDi 2734190.
KEGGi bba:Bd0692.
PATRICi 21076084. VBIBdeBac73187_0630.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi FDSRPYS.
OrthoDBi EOG6HMXDX.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "A predator unmasked: life cycle of Bdellovibrio bacteriovorus from a genomic perspective."
    Rendulic S., Jagtap P., Rosinus A., Eppinger M., Baar C., Lanz C., Keller H., Lambert C., Evans K.J., Goesmann A., Meyer F., Sockett R.E., Schuster S.C.
    Science 303:689-692(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15356 / DSM 50701 / NCIB 9529 / HD100.

Entry informationi

Entry nameiGCSP_BDEBA
AccessioniPrimary (citable) accession number: Q6MPZ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3