SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q6MPZ6

- GCSP_BDEBA

UniProt

Q6MPZ6 - GCSP_BDEBA

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Glycine dehydrogenase (decarboxylating)

Gene
gcvP, Bd0692
Organism
Bdellovibrio bacteriovorus (strain ATCC 15356 / DSM 50701 / NCIB 9529 / HD100)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcvP
Ordered Locus Names:Bd0692
OrganismiBdellovibrio bacteriovorus (strain ATCC 15356 / DSM 50701 / NCIB 9529 / HD100)
Taxonomic identifieri264462 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaBdellovibrionalesBdellovibrionaceaeBdellovibrio
ProteomesiUP000008080: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 958958Glycine dehydrogenase (decarboxylating)UniRule annotationPRO_0000227095Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei705 – 7051N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi264462.Bd0692.

Structurei

3D structure databases

ProteinModelPortaliQ6MPZ6.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiFDSRPYS.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6MPZ6-1 [UniParc]FASTAAdd to Basket

« Hide

MKIADLSPTN EFIPRHIGPT DSDIHEMLKT LGFNSLDQMA DKVIPAQIRT    50
THAYADVGNG ISEHGLLNHL KQMVSKNKVY KNYIGMGYHD TITPTVIQRN 100
IFENPVWYTA YTPYQPEISQ GRLEALLNFQ TMIADLNGME IANASLLDEG 150
TAAAEAMFMA HSLCKNKANA FVVSPDMHPH VIEVIGTRAE PLGFEMIVMD 200
PAKYDFAKPV FGVFFQYPNT NGTVEDYAAI AKKYKDHGAL VTASTDLLAM 250
TLLTPPGEWG ADMVVGNSQR FGVPLGFGGP HAGFLATKDA FKRLMPGRLV 300
GVSVDSQGKS ALRLALQTRE QHIRREKATS NICTAQVLLA NMASMYAVYH 350
GPAGLKKIAL RVQRLTAILS AGLKKLNLEV GAGHVFDTVT VKTDKAAEII 400
AQAEKMQMNF RNYGGGKLGV SLNEATTLED VEQIWAAFNL GKAAGFTALS 450
VDESLADVTL PANLTRSTAY MTHQVFNSHH SETEMLRYIH HLQNKDLTLT 500
HSMIPLGSCT MKLNATTELV PVSWPEISKL HPFAPTAQAV GLIEMIHDLE 550
KKLCDITGFA AVSLQPNAGS QGEYAGLLVI RKYHQSRGQG HRNICLIPSS 600
AHGTNPASAA LVNMQVVVVA CDDQGNVDVA DLKAKAEQHK DNLAALMITY 650
PSTHGVFEEG IVEICKIIHD NGGQVYMDGA NMNALVGMCR PGVFGPDVSH 700
MNLHKTFSIP HGGGGPGVGP IGVGAHLAEF LPKHSLVPEA GPANGISATT 750
SAPWGSASIL PISWAYITMM GAQGLRKATL VSILSANYIA KKLEAHYPVL 800
YKGKNGLVAH ECIVDVREIK KTSGIDVTDV AKRLMDFGFH APTMSFPVAG 850
TLMIEPTESE SKKELDRFIE SMVTIRKEIA AVETGKMDKE NNALKNAPHT 900
AQMLMKPEWN HPYSREEAVY PVEWLRGNKF WPVVGRVDNA YGDRNLICSC 950
PSIEDYQA 958
Length:958
Mass (Da):104,226
Last modified:July 5, 2004 - v1
Checksum:iA21D228C935F7991
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX842647 Genomic DNA. Translation: CAE78651.1.
RefSeqiNP_967658.1. NC_005363.1.
WP_011163253.1. NC_005363.1.

Genome annotation databases

EnsemblBacteriaiCAE78651; CAE78651; Bd0692.
GeneIDi2734190.
KEGGibba:Bd0692.
PATRICi21076084. VBIBdeBac73187_0630.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX842647 Genomic DNA. Translation: CAE78651.1 .
RefSeqi NP_967658.1. NC_005363.1.
WP_011163253.1. NC_005363.1.

3D structure databases

ProteinModelPortali Q6MPZ6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 264462.Bd0692.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAE78651 ; CAE78651 ; Bd0692 .
GeneIDi 2734190.
KEGGi bba:Bd0692.
PATRICi 21076084. VBIBdeBac73187_0630.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi FDSRPYS.
OrthoDBi EOG6HMXDX.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "A predator unmasked: life cycle of Bdellovibrio bacteriovorus from a genomic perspective."
    Rendulic S., Jagtap P., Rosinus A., Eppinger M., Baar C., Lanz C., Keller H., Lambert C., Evans K.J., Goesmann A., Meyer F., Sockett R.E., Schuster S.C.
    Science 303:689-692(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15356 / DSM 50701 / NCIB 9529 / HD100.

Entry informationi

Entry nameiGCSP_BDEBA
AccessioniPrimary (citable) accession number: Q6MPZ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: July 5, 2004
Last modified: September 3, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi