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Q6MPZ6 (GCSP_BDEBA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating)

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:gcvP
Ordered Locus Names:Bd0692
OrganismBdellovibrio bacteriovorus (strain ATCC 15356 / DSM 50701 / NCIB 9529 / HD100) [Complete proteome] [HAMAP]
Taxonomic identifier264462 [NCBI]
Taxonomic lineageBacteriaProteobacteriaDeltaproteobacteriaBdellovibrionalesBdellovibrionaceaeBdellovibrio

Protein attributes

Sequence length958 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 958958Glycine dehydrogenase (decarboxylating) HAMAP-Rule MF_00711
PRO_0000227095

Amino acid modifications

Modified residue7051N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6MPZ6 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: A21D228C935F7991

FASTA958104,226
        10         20         30         40         50         60 
MKIADLSPTN EFIPRHIGPT DSDIHEMLKT LGFNSLDQMA DKVIPAQIRT THAYADVGNG 

        70         80         90        100        110        120 
ISEHGLLNHL KQMVSKNKVY KNYIGMGYHD TITPTVIQRN IFENPVWYTA YTPYQPEISQ 

       130        140        150        160        170        180 
GRLEALLNFQ TMIADLNGME IANASLLDEG TAAAEAMFMA HSLCKNKANA FVVSPDMHPH 

       190        200        210        220        230        240 
VIEVIGTRAE PLGFEMIVMD PAKYDFAKPV FGVFFQYPNT NGTVEDYAAI AKKYKDHGAL 

       250        260        270        280        290        300 
VTASTDLLAM TLLTPPGEWG ADMVVGNSQR FGVPLGFGGP HAGFLATKDA FKRLMPGRLV 

       310        320        330        340        350        360 
GVSVDSQGKS ALRLALQTRE QHIRREKATS NICTAQVLLA NMASMYAVYH GPAGLKKIAL 

       370        380        390        400        410        420 
RVQRLTAILS AGLKKLNLEV GAGHVFDTVT VKTDKAAEII AQAEKMQMNF RNYGGGKLGV 

       430        440        450        460        470        480 
SLNEATTLED VEQIWAAFNL GKAAGFTALS VDESLADVTL PANLTRSTAY MTHQVFNSHH 

       490        500        510        520        530        540 
SETEMLRYIH HLQNKDLTLT HSMIPLGSCT MKLNATTELV PVSWPEISKL HPFAPTAQAV 

       550        560        570        580        590        600 
GLIEMIHDLE KKLCDITGFA AVSLQPNAGS QGEYAGLLVI RKYHQSRGQG HRNICLIPSS 

       610        620        630        640        650        660 
AHGTNPASAA LVNMQVVVVA CDDQGNVDVA DLKAKAEQHK DNLAALMITY PSTHGVFEEG 

       670        680        690        700        710        720 
IVEICKIIHD NGGQVYMDGA NMNALVGMCR PGVFGPDVSH MNLHKTFSIP HGGGGPGVGP 

       730        740        750        760        770        780 
IGVGAHLAEF LPKHSLVPEA GPANGISATT SAPWGSASIL PISWAYITMM GAQGLRKATL 

       790        800        810        820        830        840 
VSILSANYIA KKLEAHYPVL YKGKNGLVAH ECIVDVREIK KTSGIDVTDV AKRLMDFGFH 

       850        860        870        880        890        900 
APTMSFPVAG TLMIEPTESE SKKELDRFIE SMVTIRKEIA AVETGKMDKE NNALKNAPHT 

       910        920        930        940        950 
AQMLMKPEWN HPYSREEAVY PVEWLRGNKF WPVVGRVDNA YGDRNLICSC PSIEDYQA 

« Hide

References

[1]"A predator unmasked: life cycle of Bdellovibrio bacteriovorus from a genomic perspective."
Rendulic S., Jagtap P., Rosinus A., Eppinger M., Baar C., Lanz C., Keller H., Lambert C., Evans K.J., Goesmann A., Meyer F., Sockett R.E., Schuster S.C.
Science 303:689-692(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 15356 / DSM 50701 / NCIB 9529 / HD100.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX842647 Genomic DNA. Translation: CAE78651.1.
RefSeqNP_967658.1. NC_005363.1.

3D structure databases

ProteinModelPortalQ6MPZ6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING264462.Bd0692.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAE78651; CAE78651; Bd0692.
GeneID2734190.
KEGGbba:Bd0692.
PATRIC21076084. VBIBdeBac73187_0630.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239369.
KOK00281.
OMAQTMVCDL.
OrthoDBEOG6HMXDX.
ProtClustDBPRK05367.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP_BDEBA
AccessionPrimary (citable) accession number: Q6MPZ6
Entry history
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: July 5, 2004
Last modified: February 19, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families