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Q6MPZ6

- GCSP_BDEBA

UniProt

Q6MPZ6 - GCSP_BDEBA

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Bdellovibrio bacteriovorus (strain ATCC 15356 / DSM 50701 / NCIB 9529 / HD100)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Ordered Locus Names:Bd0692
    OrganismiBdellovibrio bacteriovorus (strain ATCC 15356 / DSM 50701 / NCIB 9529 / HD100)
    Taxonomic identifieri264462 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaBdellovibrionalesBdellovibrionaceaeBdellovibrio
    ProteomesiUP000008080: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 958958Glycine dehydrogenase (decarboxylating)PRO_0000227095Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei705 – 7051N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi264462.Bd0692.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6MPZ6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239369.
    KOiK00281.
    OMAiFDSRPYS.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q6MPZ6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKIADLSPTN EFIPRHIGPT DSDIHEMLKT LGFNSLDQMA DKVIPAQIRT    50
    THAYADVGNG ISEHGLLNHL KQMVSKNKVY KNYIGMGYHD TITPTVIQRN 100
    IFENPVWYTA YTPYQPEISQ GRLEALLNFQ TMIADLNGME IANASLLDEG 150
    TAAAEAMFMA HSLCKNKANA FVVSPDMHPH VIEVIGTRAE PLGFEMIVMD 200
    PAKYDFAKPV FGVFFQYPNT NGTVEDYAAI AKKYKDHGAL VTASTDLLAM 250
    TLLTPPGEWG ADMVVGNSQR FGVPLGFGGP HAGFLATKDA FKRLMPGRLV 300
    GVSVDSQGKS ALRLALQTRE QHIRREKATS NICTAQVLLA NMASMYAVYH 350
    GPAGLKKIAL RVQRLTAILS AGLKKLNLEV GAGHVFDTVT VKTDKAAEII 400
    AQAEKMQMNF RNYGGGKLGV SLNEATTLED VEQIWAAFNL GKAAGFTALS 450
    VDESLADVTL PANLTRSTAY MTHQVFNSHH SETEMLRYIH HLQNKDLTLT 500
    HSMIPLGSCT MKLNATTELV PVSWPEISKL HPFAPTAQAV GLIEMIHDLE 550
    KKLCDITGFA AVSLQPNAGS QGEYAGLLVI RKYHQSRGQG HRNICLIPSS 600
    AHGTNPASAA LVNMQVVVVA CDDQGNVDVA DLKAKAEQHK DNLAALMITY 650
    PSTHGVFEEG IVEICKIIHD NGGQVYMDGA NMNALVGMCR PGVFGPDVSH 700
    MNLHKTFSIP HGGGGPGVGP IGVGAHLAEF LPKHSLVPEA GPANGISATT 750
    SAPWGSASIL PISWAYITMM GAQGLRKATL VSILSANYIA KKLEAHYPVL 800
    YKGKNGLVAH ECIVDVREIK KTSGIDVTDV AKRLMDFGFH APTMSFPVAG 850
    TLMIEPTESE SKKELDRFIE SMVTIRKEIA AVETGKMDKE NNALKNAPHT 900
    AQMLMKPEWN HPYSREEAVY PVEWLRGNKF WPVVGRVDNA YGDRNLICSC 950
    PSIEDYQA 958
    Length:958
    Mass (Da):104,226
    Last modified:July 5, 2004 - v1
    Checksum:iA21D228C935F7991
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX842647 Genomic DNA. Translation: CAE78651.1.
    RefSeqiNP_967658.1. NC_005363.1.
    WP_011163253.1. NC_005363.1.

    Genome annotation databases

    EnsemblBacteriaiCAE78651; CAE78651; Bd0692.
    GeneIDi2734190.
    KEGGibba:Bd0692.
    PATRICi21076084. VBIBdeBac73187_0630.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX842647 Genomic DNA. Translation: CAE78651.1 .
    RefSeqi NP_967658.1. NC_005363.1.
    WP_011163253.1. NC_005363.1.

    3D structure databases

    ProteinModelPortali Q6MPZ6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 264462.Bd0692.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAE78651 ; CAE78651 ; Bd0692 .
    GeneIDi 2734190.
    KEGGi bba:Bd0692.
    PATRICi 21076084. VBIBdeBac73187_0630.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239369.
    KOi K00281.
    OMAi FDSRPYS.
    OrthoDBi EOG6HMXDX.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "A predator unmasked: life cycle of Bdellovibrio bacteriovorus from a genomic perspective."
      Rendulic S., Jagtap P., Rosinus A., Eppinger M., Baar C., Lanz C., Keller H., Lambert C., Evans K.J., Goesmann A., Meyer F., Sockett R.E., Schuster S.C.
      Science 303:689-692(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 15356 / DSM 50701 / NCIB 9529 / HD100.

    Entry informationi

    Entry nameiGCSP_BDEBA
    AccessioniPrimary (citable) accession number: Q6MPZ6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 7, 2006
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3