Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q6MNP6

- NRDJ_BDEBA

UniProt

Q6MNP6 - NRDJ_BDEBA

Protein

Vitamin B12-dependent ribonucleotide reductase

Gene

nrdJ

Organism
Bdellovibrio bacteriovorus (strain ATCC 15356 / DSM 50701 / NCIB 9529 / HD100)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen By similarity.By similarity

    Catalytic activityi

    2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

    Cofactori

    5'-deoxyadenosylcobalamine (coenzyme B12).By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei127 – 1271SubstrateBy similarity
    Binding sitei200 – 2001Substrate; via amide nitrogenBy similarity
    Active sitei376 – 3761Proton acceptorBy similarity
    Active sitei378 – 3781Cysteine radical intermediateBy similarity
    Active sitei380 – 3801Proton acceptorBy similarity

    GO - Molecular functioni

    1. cobalamin binding Source: UniProtKB-KW
    2. cobalt ion binding Source: InterPro
    3. nucleotide binding Source: UniProtKB-KW
    4. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: UniProtKB-EC

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    DNA synthesis

    Keywords - Ligandi

    Cobalamin, Cobalt, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Vitamin B12-dependent ribonucleotide reductase (EC:1.17.4.1)
    Alternative name(s):
    Ribonucleoside-diphosphate reductase NrdJ
    Gene namesi
    Name:nrdJ
    Ordered Locus Names:Bd1196
    OrganismiBdellovibrio bacteriovorus (strain ATCC 15356 / DSM 50701 / NCIB 9529 / HD100)
    Taxonomic identifieri264462 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaBdellovibrionalesBdellovibrionaceaeBdellovibrio
    ProteomesiUP000008080: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 764764Vitamin B12-dependent ribonucleotide reductasePRO_0000231656Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi172 ↔ 389Redox-activeBy similarity

    Keywords - PTMi

    Disulfide bond

    Interactioni

    Protein-protein interaction databases

    STRINGi264462.Bd1196.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6MNP6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni171 – 1722Substrate bindingBy similarity
    Regioni376 – 3805Substrate bindingBy similarity
    Regioni561 – 5655Substrate bindingBy similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0209.
    HOGENOMiHOG000021771.
    KOiK00525.
    OMAiAMDCGAT.
    OrthoDBiEOG6H4K5F.

    Family and domain databases

    InterProiIPR013678. RNR_2_N.
    IPR000788. RNR_lg_C.
    IPR013344. RNR_NrdJ/NrdZ.
    [Graphical view]
    PfamiPF08471. Ribonuc_red_2_N. 1 hit.
    PF02867. Ribonuc_red_lgC. 1 hit.
    [Graphical view]
    PRINTSiPR01183. RIBORDTASEM1.
    TIGRFAMsiTIGR02504. NrdJ_Z. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q6MNP6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKKQTLHSPS YFVSGGKNPE SLFAWKNVNC EIRNRKGEVF FEMKNVEAPE    50
    GWSQLAIDIA ASKYFRKVGV PKTGHETSVR QMVDRVVKAI VASAIRQGGY 100
    FATRKEADIF AKELKFILLS QRGAFNSPVW FNAGLWEAYK AQSPSEHFAW 150
    DEKKKSIQAT KNAYERPQCS ACFIQSVDDS IESIFDLAKT EAKLFKYGSG 200
    TGSNFSKIRS KYEATGSGGK SSGLISFLEV LDKGAGAIKS GGTTRRAAKM 250
    VVVDIDHPEV LDFIDWKMRE EQKAHLLIAA GLSADFEGEA YRTVSGQNAN 300
    NSVRVSDAFM KAVEQERPWK LKARLTGKVL REIPAGEVWN RITRAAWMCA 350
    DPGIQFHDTI NKWHTCPETD IIHSSNPCSE YMFLDDSACN LASINLVKFL 400
    NDTGDFDFES FIHTARTLFV AQEILVDYSS YPTQRVAQNS HDYRPLGLGF 450
    ANLGSLLMRK GVAYDSDEGR AWAGALTSLM SGVAYLTSSE MARAKGPFAG 500
    YRKNSKSMLK VMKMHERALN QVAWKMLPAG IDKAVRNLWK GVLYNGEKYG 550
    YRNAQATVIA PTGTIGLLMD CDTTGIEPDF SLIKFKKLVG GGEIQIVNQS 600
    VDAALASLQY FEDERQAILK YVEENNSVVG APQMHPEDLP VFDTATAMPG 650
    QRVLSPESHV KMMAAVQPFI SGAISKTVNM PSTATEEDIS RIYFLAWKLG 700
    VKAVAVYRDG SKQSQPLNLK EKPKVVEEVG VPNFTMKCPE CGSDTVLTSG 750
    CYRCPNCGTT VGCS 764
    Length:764
    Mass (Da):84,408
    Last modified:July 5, 2004 - v1
    Checksum:iB9B5369BEE85DB1E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX842649 Genomic DNA. Translation: CAE79105.1.
    RefSeqiNP_968112.1. NC_005363.1.

    Genome annotation databases

    EnsemblBacteriaiCAE79105; CAE79105; Bd1196.
    GeneIDi2733233.
    KEGGibba:Bd1196.
    PATRICi21077002. VBIBdeBac73187_1082.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX842649 Genomic DNA. Translation: CAE79105.1 .
    RefSeqi NP_968112.1. NC_005363.1.

    3D structure databases

    ProteinModelPortali Q6MNP6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 264462.Bd1196.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAE79105 ; CAE79105 ; Bd1196 .
    GeneIDi 2733233.
    KEGGi bba:Bd1196.
    PATRICi 21077002. VBIBdeBac73187_1082.

    Phylogenomic databases

    eggNOGi COG0209.
    HOGENOMi HOG000021771.
    KOi K00525.
    OMAi AMDCGAT.
    OrthoDBi EOG6H4K5F.

    Family and domain databases

    InterProi IPR013678. RNR_2_N.
    IPR000788. RNR_lg_C.
    IPR013344. RNR_NrdJ/NrdZ.
    [Graphical view ]
    Pfami PF08471. Ribonuc_red_2_N. 1 hit.
    PF02867. Ribonuc_red_lgC. 1 hit.
    [Graphical view ]
    PRINTSi PR01183. RIBORDTASEM1.
    TIGRFAMsi TIGR02504. NrdJ_Z. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "A predator unmasked: life cycle of Bdellovibrio bacteriovorus from a genomic perspective."
      Rendulic S., Jagtap P., Rosinus A., Eppinger M., Baar C., Lanz C., Keller H., Lambert C., Evans K.J., Goesmann A., Meyer F., Sockett R.E., Schuster S.C.
      Science 303:689-692(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 15356 / DSM 50701 / NCIB 9529 / HD100.

    Entry informationi

    Entry nameiNRDJ_BDEBA
    AccessioniPrimary (citable) accession number: Q6MNP6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 4, 2006
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3