Q6MM37 (T23O_BDEBA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tryptophan 2,3-dioxygenase
Short name=TDO
EC=1.13.11.11

Alternative name(s):
Tryptamin 2,3-dioxygenase
Tryptophan oxygenase
Short name=TO
Short name=TRPO
Tryptophan pyrrolase
Tryptophanase

Gene names

Name:	kynA
Ordered Locus Names:	Bd1810

Organism

Bdellovibrio bacteriovorus (strain ATCC 15356 / DSM 50701 / NCIB 9529 / HD100) [Complete proteome] [HAMAP]

Taxonomic identifier

264462 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Deltaproteobacteria › Bdellovibrionales › Bdellovibrionaceae › Bdellovibrio

Protein attributes

Sequence length	359 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring By similarity.
Catalytic activity	L-tryptophan + O2 = N-formyl-L-kynurenine.
Cofactor	Binds 2 heme groups per tetramer By similarity.
Pathway	Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 1/2.
Subunit structure	Homotetramer By similarity.
Sequence similarities	Belongs to the tryptophan 2,3-dioxygenase family.

Ontologies

Keywords
Biological process	Tryptophan catabolism
Ligand	Heme Iron Metal-binding
Molecular function	Dioxygenase Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	protein homotetramerization Inferred from sequence or structural similarity. Source: UniProtKB tryptophan catabolic process to kynurenine Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	heme binding Inferred from sequence or structural similarity. Source: UniProtKB tryptophan 2,3-dioxygenase activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 359	359	Tryptophan 2,3-dioxygenase		PRO_0000360089
Regions
	Region	8 – 12	5	Substrate binding By similarity
	Region	38 – 42	5	Substrate binding By similarity
Sites
	Metal binding	295	1	Iron (heme axial ligand) By similarity
	Binding site	109	1	Substrate By similarity
	Binding site	116	1	Heme By similarity
	Binding site	309	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6MM37 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: FCCE2708D3A531FC	FASTA	359	41,594
	10 20 30 40 50 60 MKYPPVHYHD YLGLNPLLNA QHPKSTEYGK PAHDELLFII VHQTYELWFK QILFELDSVL 70 80 90 100 110 120 STFQKPTVAE SEMGIASARL ERIVSILKLI IGQVDVLETM TPLDFLDFRD MLYPASGFQS 130 140 150 160 170 180 YQWRLIETKL GLRIGDRLAY NQSPFYKSLS ESQQGEMLNI MNQPSLHDSV EKWLERTPFL 190 200 210 220 230 240 QGENFNFWDS YKEAVNKMFQ DDITTVKNNP RLPDEEKAKT VAGLEQTLKS FDALFDEEAF 250 260 270 280 290 300 NKLRAEGQFR LSYKAMHAAL LIQLHRDQPI LQTPFRIIRA LLDIDETMTT WRYRHALMAM 310 320 330 340 350 RMLGQKIGTG GSSGHKYLAD ATAKHKIFGD FFNLTTFFIP RSQVPPLPKA IADRMSFHY

References

[1]

"A predator unmasked: life cycle of Bdellovibrio bacteriovorus from a genomic perspective." Rendulic S., Jagtap P., Rosinus A., Eppinger M., Baar C., Lanz C., Keller H., Lambert C., Evans K.J., Goesmann A., Meyer F., Sockett R.E., Schuster S.C. Science 303:689-692(2004) [PubMed: 14752164] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 15356 / DSM 50701 / NCIB 9529 / HD100.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX842650 Genomic DNA. Translation: CAE79669.1.
RefSeq	NP_968676.1. NC_005363.1.
3D structure databases
HSSP	HSSP built from PDB template 1YW0 based on UniProtKB Q8PDA8.
ProteinModelPortal	Q6MM37.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2734918.
GenomeReviews	Gene locus Bd1810 in contig BX842601_GR.
KEGG	bba:Bd1810.
NMPDR	fig|264462.1.peg.1647.
PATRIC	21078144. VBIBdeBac73187_1641.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG647485.
OMA	VPASGFQ.
ProtClustDB	CLSK2307017.
Enzyme and pathway databases
BioCyc	BBAC264462:BD1810-MONOMER.
Family and domain databases
InterPro	IPR004981. Trp_2_3_dOase. [Graphical view]
KO	K00453.
PANTHER	PTHR10138. Trp_2_3_dOase. 1 hit.
Pfam	PF03301. Trp_dioxygenase. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

T23O_BDEBA

Accession

Primary (citable) accession number: Q6MM37

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 20, 2009
Last sequence update:	July 5, 2004
Last modified:	January 25, 2012
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program