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Reviewed, UniProtKB/Swiss-Prot Q6ML19 (GLO2_BDEBA)

Last modified February 9, 2010. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Hydroxyacylglutathione hydrolase
    EC=3.1.2.6
Alternative name(s):
    Glyoxalase II
      Short name=Glx II
Gene names
Name: gloB
Ordered Locus Names: Bd2204
OrganismBdellovibrio bacteriovorus [Complete proteome] [HAMAP]
Taxonomic identifier959 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Deltaproteobacteria › Bdellovibrionales › Bdellovibrionaceae › Bdellovibrio

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Protein attributes

Sequence length251 AA.
Sequence statusComplete.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid By similarity. HAMAP MF_01374

Catalytic activity

S-(2-hydroxyacyl)glutathione + H2O = glutathione + a 2-hydroxy carboxylate. HAMAP MF_01374

Cofactor

Binds 2 zinc ions per subunit By similarity. HAMAP MF_01374

Pathway

Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 2/2. HAMAP MF_01374

Subunit structure

Monomer By similarity. HAMAP MF_01374

Sequence similarities

Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.

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Ontologies

Keywords
   LigandMetal-binding
Zinc
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular functionhydroxyacylglutathione hydrolase activity

Inferred from electronic annotation. Source: HAMAP

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 251251Hydroxyacylglutathione hydrolase HAMAP MF_01374
PRO_0000309626

Sites

Metal binding581Zinc 1 By similarity
Metal binding601Zinc 1 By similarity
Metal binding621Zinc 2 By similarity
Metal binding631Zinc 2 By similarity
Metal binding1161Zinc 1 By similarity
Metal binding1351Zinc 1 By similarity
Metal binding1351Zinc 2 By similarity
Metal binding1731Zinc 2 By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q6ML19-1 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: B181FE29F591BCCB

FASTA25128,494
        10         20         30         40         50         60 
MAKKEHVELV PIFDDNYVFI LTDDATQKAV AVDPGDAGPV IDFLRANKLD LAAILLTHHH 

        70         80         90        100        110        120 
SDHIGGVGEL KAAFDCPVYA PQKNQKQIPV ADQWLKEGDS VTCGPWDFTV MELPGHTLGH 

       130        140        150        160        170        180 
IAYWNQKHKW LFSGDVIFGL GCGRLFEGTF EQGYESLQRI KKLPPQTLIY CTHEYTKSNL 

       190        200        210        220        230        240 
EFCRILTNQD NTPITGDSEA LELYANELSN RRELNLPSVP LKLSIEESVN PFLLARDVEQ 

       250 
FRYLRELRNR Q

« Hide

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References

[1]"A predator unmasked: life cycle of Bdellovibrio bacteriovorus from a genomic perspective."
Rendulic S., Jagtap P., Rosinus A., Eppinger M., Baar C., Lanz C., Keller H., Lambert C., Evans K.J., Goesmann A., Meyer F., Sockett R.E., Schuster S.C.
Science 303:689-692(2004) [PubMed: 14752164] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 15356 / HD100 / DSM 50701 / NCIB 9529.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX842652 Genomic DNA. Translation: CAE80038.1.
RefSeqNP_969045.1.

3D structure databases

HSSPHSSP built from PDB template 1XM8 based on UniProtKB Q9SID3.
SMRQ6ML19. Positions 6-250.
ModBaseSearch...

Genome annotation databases

GeneID2734570.
KEGGbba:Bd2204.
NMPDRfig|264462.1.peg.2016.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG753931.
OMAFGHEYTL.
PhylomeDBQ6ML19.

Enzyme and pathway databases

BioCycBBAC264462:BD2204-MONOMER.
BRENDA3.1.2.6. 3459.

Family and domain databases

HAMAPMF_01374. Glyoxalase_2.
[Tree]
InterProIPR001279. Blactmase-like.
IPR017782. Hydroxyacylglutathione_Hdrlase.
[Graphical view]
SMARTSM00849. Lactamase_B. 1 hit.
[Graphical view]
TIGRFAMsTIGR03413. GSH_gloB. 1 hit.
ProtoNetSearch...

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Entry information

Entry nameGLO2_BDEBA
AccessionPrimary (citable) accession number: Q6ML19
Entry history
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: July 5, 2004
Last modified: February 9, 2010
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents