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Q6MKE9

- GCH4_BDEBA

UniProt

Q6MKE9 - GCH4_BDEBA

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Protein

GTP cyclohydrolase FolE2

Gene
folE2, Bd2446
Organism
Bdellovibrio bacteriovorus (strain ATCC 15356 / DSM 50701 / NCIB 9529 / HD100)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate By similarity.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei155 – 1551May be catalytically important By similarity

GO - Molecular functioni

  1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2 (EC:3.5.4.16)
Gene namesi
Name:folE2
Ordered Locus Names:Bd2446
OrganismiBdellovibrio bacteriovorus (strain ATCC 15356 / DSM 50701 / NCIB 9529 / HD100)
Taxonomic identifieri264462 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaBdellovibrionalesBdellovibrionaceaeBdellovibrio
ProteomesiUP000008080: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 304304GTP cyclohydrolase FolE2UniRule annotationPRO_0000147702Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi264462.Bd2446.

Structurei

3D structure databases

ProteinModelPortaliQ6MKE9.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1469.
HOGENOMiHOG000247517.
KOiK09007.
OMAiAGRTTIQ.
OrthoDBiEOG6X6RBH.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6MKE9-1 [UniParc]FASTAAdd to Basket

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MTKQSLPDVA KETHSERFAP IDWVGMGAIE LPVMLKQADG VYRIPARVDA    50
KVSLDKKPSR GIHMSRLYLL SQELLTKSEL SLGLLGTVTS EFLRTHEDLS 100
TKALVQVQFE APLVRKALKS NNQAWRSYPV ITSAFNEEGQ ISYFVEVVVT 150
YSSTCPASAA LSRQLIQDGF KQNFSTDKPL DFDVVHSWLG TPQGIVATPH 200
AQRSFARVKA EVGANYNYGD LIDIVEEALQ TAVQGAVKRE DEQEFALRNG 250
QNLMFCEDAA RRVKEALDAK ADVLDYVAEF SHVESLHPHN AVSHISKGLK 300
LRSF 304
Length:304
Mass (Da):33,804
Last modified:July 5, 2004 - v1
Checksum:iB6E56358EFA020E5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX842652 Genomic DNA. Translation: CAE80258.1.
RefSeqiNP_969265.1. NC_005363.1.

Genome annotation databases

EnsemblBacteriaiCAE80258; CAE80258; Bd2446.
GeneIDi2735923.
KEGGibba:Bd2446.
PATRICi21079356. VBIBdeBac73187_2241.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX842652 Genomic DNA. Translation: CAE80258.1 .
RefSeqi NP_969265.1. NC_005363.1.

3D structure databases

ProteinModelPortali Q6MKE9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 264462.Bd2446.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAE80258 ; CAE80258 ; Bd2446 .
GeneIDi 2735923.
KEGGi bba:Bd2446.
PATRICi 21079356. VBIBdeBac73187_2241.

Phylogenomic databases

eggNOGi COG1469.
HOGENOMi HOG000247517.
KOi K09007.
OMAi AGRTTIQ.
OrthoDBi EOG6X6RBH.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .

Family and domain databases

HAMAPi MF_01527_B. GTP_cyclohydrol_B.
InterProi IPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view ]
Pfami PF02649. GCHY-1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A predator unmasked: life cycle of Bdellovibrio bacteriovorus from a genomic perspective."
    Rendulic S., Jagtap P., Rosinus A., Eppinger M., Baar C., Lanz C., Keller H., Lambert C., Evans K.J., Goesmann A., Meyer F., Sockett R.E., Schuster S.C.
    Science 303:689-692(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15356 / DSM 50701 / NCIB 9529 / HD100.

Entry informationi

Entry nameiGCH4_BDEBA
AccessioniPrimary (citable) accession number: Q6MKE9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: July 5, 2004
Last modified: May 14, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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