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Q6MKE9

- GCH4_BDEBA

UniProt

Q6MKE9 - GCH4_BDEBA

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Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Bdellovibrio bacteriovorus (strain ATCC 15356 / DSM 50701 / NCIB 9529 / HD100)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei155 – 1551May be catalytically importantUniRule annotation

GO - Molecular functioni

  1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
Gene namesi
Name:folE2UniRule annotation
Ordered Locus Names:Bd2446
OrganismiBdellovibrio bacteriovorus (strain ATCC 15356 / DSM 50701 / NCIB 9529 / HD100)
Taxonomic identifieri264462 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaBdellovibrionalesBdellovibrionaceaeBdellovibrio
ProteomesiUP000008080: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 304304GTP cyclohydrolase FolE2PRO_0000147702Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi264462.Bd2446.

Structurei

3D structure databases

ProteinModelPortaliQ6MKE9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1469.
HOGENOMiHOG000247517.
KOiK09007.
OMAiAGRTTIQ.
OrthoDBiEOG6X6RBH.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6MKE9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTKQSLPDVA KETHSERFAP IDWVGMGAIE LPVMLKQADG VYRIPARVDA
60 70 80 90 100
KVSLDKKPSR GIHMSRLYLL SQELLTKSEL SLGLLGTVTS EFLRTHEDLS
110 120 130 140 150
TKALVQVQFE APLVRKALKS NNQAWRSYPV ITSAFNEEGQ ISYFVEVVVT
160 170 180 190 200
YSSTCPASAA LSRQLIQDGF KQNFSTDKPL DFDVVHSWLG TPQGIVATPH
210 220 230 240 250
AQRSFARVKA EVGANYNYGD LIDIVEEALQ TAVQGAVKRE DEQEFALRNG
260 270 280 290 300
QNLMFCEDAA RRVKEALDAK ADVLDYVAEF SHVESLHPHN AVSHISKGLK

LRSF
Length:304
Mass (Da):33,804
Last modified:July 5, 2004 - v1
Checksum:iB6E56358EFA020E5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX842652 Genomic DNA. Translation: CAE80258.1.
RefSeqiNP_969265.1. NC_005363.1.
WP_011164861.1. NC_005363.1.

Genome annotation databases

EnsemblBacteriaiCAE80258; CAE80258; Bd2446.
GeneIDi2735923.
KEGGibba:Bd2446.
PATRICi21079356. VBIBdeBac73187_2241.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX842652 Genomic DNA. Translation: CAE80258.1 .
RefSeqi NP_969265.1. NC_005363.1.
WP_011164861.1. NC_005363.1.

3D structure databases

ProteinModelPortali Q6MKE9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 264462.Bd2446.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAE80258 ; CAE80258 ; Bd2446 .
GeneIDi 2735923.
KEGGi bba:Bd2446.
PATRICi 21079356. VBIBdeBac73187_2241.

Phylogenomic databases

eggNOGi COG1469.
HOGENOMi HOG000247517.
KOi K09007.
OMAi AGRTTIQ.
OrthoDBi EOG6X6RBH.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .

Family and domain databases

HAMAPi MF_01527_B. GTP_cyclohydrol_B.
InterProi IPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view ]
Pfami PF02649. GCHY-1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A predator unmasked: life cycle of Bdellovibrio bacteriovorus from a genomic perspective."
    Rendulic S., Jagtap P., Rosinus A., Eppinger M., Baar C., Lanz C., Keller H., Lambert C., Evans K.J., Goesmann A., Meyer F., Sockett R.E., Schuster S.C.
    Science 303:689-692(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15356 / DSM 50701 / NCIB 9529 / HD100.

Entry informationi

Entry nameiGCH4_BDEBA
AccessioniPrimary (citable) accession number: Q6MKE9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: July 5, 2004
Last modified: November 26, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3