Q6MKE9 (GCH4_BDEBA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
GTP cyclohydrolase folE2
EC=3.5.4.16

Gene names

Name:	folE2
Ordered Locus Names:	Bd2446

Organism

Bdellovibrio bacteriovorus (strain ATCC 15356 / DSM 50701 / NCIB 9529 / HD100) [Complete proteome] [HAMAP]

Taxonomic identifier

264462 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › delta/epsilon subdivisions › Deltaproteobacteria › Bdellovibrionales › Bdellovibrionaceae › Bdellovibrio › Bdellovibrio bacteriovorus

Protein attributes

Sequence length	304 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Converts GTP to 7,8-dihydroneopterin triphosphate By similarity. HAMAP-Rule MF_01527
Catalytic activity	GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP-Rule MF_01527
Pathway	Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP-Rule MF_01527
Sequence similarities	Belongs to the GTP cyclohydrolase IV family.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	7,8-dihydroneopterin 3'-triphosphate biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	GTP cyclohydrolase I activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 304	304	GTP cyclohydrolase folE2 HAMAP-Rule MF_01527		PRO_0000147702
Sites
	Site	155	1	May be catalytically important By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6MKE9 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: B6E56358EFA020E5	FASTA	304	33,804
	10 20 30 40 50 60 MTKQSLPDVA KETHSERFAP IDWVGMGAIE LPVMLKQADG VYRIPARVDA KVSLDKKPSR 70 80 90 100 110 120 GIHMSRLYLL SQELLTKSEL SLGLLGTVTS EFLRTHEDLS TKALVQVQFE APLVRKALKS 130 140 150 160 170 180 NNQAWRSYPV ITSAFNEEGQ ISYFVEVVVT YSSTCPASAA LSRQLIQDGF KQNFSTDKPL 190 200 210 220 230 240 DFDVVHSWLG TPQGIVATPH AQRSFARVKA EVGANYNYGD LIDIVEEALQ TAVQGAVKRE 250 260 270 280 290 300 DEQEFALRNG QNLMFCEDAA RRVKEALDAK ADVLDYVAEF SHVESLHPHN AVSHISKGLK LRSF

References

[1]

"A predator unmasked: life cycle of Bdellovibrio bacteriovorus from a genomic perspective." Rendulic S., Jagtap P., Rosinus A., Eppinger M., Baar C., Lanz C., Keller H., Lambert C., Evans K.J., Goesmann A., Meyer F., Sockett R.E., Schuster S.C. Science 303:689-692(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 15356 / DSM 50701 / NCIB 9529 / HD100.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX842652 Genomic DNA. Translation: CAE80258.1.
RefSeq	NP_969265.1. NC_005363.1.
3D structure databases
ProteinModelPortal	Q6MKE9.
ModBase	Search...
Protein-protein interaction databases
STRING	264462.Bd2446.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAE80258; CAE80258; Bd2446.
GeneID	2735923.
KEGG	bba:Bd2446.
PATRIC	21079356. VBIBdeBac73187_2241.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1469.
HOGENOM	HOG000247517.
KO	K09007.
OMA	LNGQNLM.
ProtClustDB	PRK13674.
Enzyme and pathway databases
UniPathway	UPA00848; UER00151.
Family and domain databases
Gene3D	3.10.270.10. 2 hits.
HAMAP	MF_01527_B. GTP_cyclohydrol_B.
InterPro	IPR022838. GTP_cyclohydrolase_FolE2. IPR003801. GTP_cyclohydrolase_FolE2/MptA. IPR002042. Uricase. [Graphical view]
Pfam	PF02649. GCHY-1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GCH4_BDEBA

Accession

Primary (citable) accession number: Q6MKE9

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 2005
Last sequence update:	July 5, 2004
Last modified:	May 1, 2013
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program