ID   Q6MJX6_BDEBA            Unreviewed;       881 AA.
AC   Q6MJX6;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   27-MAR-2024, entry version 86.
DE   SubName: Full=Adenylate cyclase {ECO:0000313|EMBL:CAE80433.1};
DE            EC=4.6.1.1 {ECO:0000313|EMBL:CAE80433.1};
GN   Name=cyaK {ECO:0000313|EMBL:CAE80433.1};
GN   OrderedLocusNames=Bd2640 {ECO:0000313|EMBL:CAE80433.1};
OS   Bdellovibrio bacteriovorus (strain ATCC 15356 / DSM 50701 / NCIMB 9529 /
OS   HD100).
OC   Bacteria; Bdellovibrionota; Bdellovibrionia; Bdellovibrionales;
OC   Pseudobdellovibrionaceae; Bdellovibrio.
OX   NCBI_TaxID=264462 {ECO:0000313|EMBL:CAE80433.1, ECO:0000313|Proteomes:UP000008080};
RN   [1] {ECO:0000313|EMBL:CAE80433.1, ECO:0000313|Proteomes:UP000008080}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15356 / DSM 50701 / NCIMB 9529 / HD100
RC   {ECO:0000313|Proteomes:UP000008080};
RX   PubMed=14752164; DOI=10.1126/science.1093027;
RA   Rendulic S., Jagtap P., Rosinus A., Eppinger M., Baar C., Lanz C.,
RA   Keller H., Lambert C., Evans K.J., Goesmann A., Meyer F., Sockett R.E.,
RA   Schuster S.C.;
RT   "A predator unmasked: life cycle of Bdellovibrio bacteriovorus from a
RT   genomic perspective.";
RL   Science 303:689-692(2004).
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BX842653; CAE80433.1; -; Genomic_DNA.
DR   RefSeq; WP_011165036.1; NC_005363.1.
DR   AlphaFoldDB; Q6MJX6; -.
DR   STRING; 264462.Bd2640; -.
DR   KEGG; bba:Bd2640; -.
DR   eggNOG; COG2114; Bacteria.
DR   eggNOG; COG4252; Bacteria.
DR   HOGENOM; CLU_000445_85_1_7; -.
DR   Proteomes; UP000008080; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR007890; CHASE2.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   PANTHER; PTHR43081:SF16; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC; 1.
DR   PANTHER; PTHR43081; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC-RELATED; 1.
DR   Pfam; PF05226; CHASE2; 1.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   SMART; SM01080; CHASE2; 1.
DR   SMART; SM00044; CYCc; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE   4: Predicted;
KW   Lyase {ECO:0000313|EMBL:CAE80433.1}; Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008080};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        7..26
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        511..529
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        536..555
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        561..583
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          625..757
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
SQ   SEQUENCE   881 AA;  99535 MW;  F6D44C997E7D092C CRC64;
     MKTEKISILI GITVSALFMW FGFHYFKYVD TPAIQRPYSP FLEGIEVLDL RFNDIKYKLR
     PPSQSQAPVA LIAIDDASVR EIGRFPWSRE MVAEMTDNLL KLGAKSVSFD VIFAEPETSN
     PQADTAFAKV IADNPDRIVL GTFSENLIDF QPHQDLCVAE AFLATGGDQL VKINPSFAID
     EETHAIDDLN WAPLFTTLFQ TIQEREQNDL LKSLGKKSPE ELSTFQKNNL KARQSLALFE
     YCKTWLTKHD IFLSPENIAQ VETLYHDVVA EAPDLKNLKF EDLRSRIRKA YKTHPIPQYG
     EWTPNTLELQ TPANYTSSFI AQLDADGYVR RYPLFFRSGH KLGTSFIPSM ALQSFLLSGP
     YRAELKMATA KDGEKSLEQF NIYDTSKEPE IKIASYPVDG SGQLLINYYG RQMSLPYVSA
     KELFNDETTV KVTTSVMNQE SKQLVIETKE YDKKEFFKDR SLIVGATAVG LYDLRNTPLE
     ANYPGPELHL TMLANLFDKH FLKQWNQEAQ WLPVVLFVGG TALAVAWALL GSLSSLLGFV
     IFILALGALD LWLFIKNNLL VHSFLIYACA FAGFGAIQVF KYFTEEKKKK ELKSTFSKYV
     SPAVVDELLK DAANLKLGGR RERMTAFFSD VRGFTTISEK LPPEELSRVL NLYLTPMTDI
     VFKNSGTLDK YMGDAIMAFF GAPVKDPHHA AHACRCALES LVKLKELQKE FSDKGLPHID
     IGIGINTGEM SVGNMGSNIV QNYTVMGDSV NLASRLEGIN KEYGTRIVIS EFTYNDVKEA
     FTAREIDRVR VKGKLEPVRI FELVCEGAAK DKTAELMASF QMGYDLYHQK RFAEAKEVFE
     KAQTNWGAEE PVSQLYIERC QEYLDSPPPP DWDGVYVMKT K
//