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Q6MII5

- NADK_BDEBA

UniProt

Q6MII5 - NADK_BDEBA

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Protein
NAD kinase
Gene
nadK, Bd3172
Organism
Bdellovibrio bacteriovorus (strain ATCC 15356 / DSM 50701 / NCIB 9529 / HD100)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP By similarity.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

Divalent metal ions By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei85 – 851Proton acceptor By similarity
Binding sitei90 – 901NAD By similarity
Binding sitei187 – 1871NAD By similarity
Binding sitei189 – 1891NAD By similarity
Binding sitei224 – 2241NAD; via carbonyl oxygen By similarity
Binding sitei259 – 2591NAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi85 – 862NAD By similarity
Nucleotide bindingi159 – 1602NAD By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. NAD+ kinase activity Source: UniProtKB-HAMAP
  3. metal ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. NAD metabolic process Source: InterPro
  2. NADP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinase (EC:2.7.1.23)
Alternative name(s):
ATP-dependent NAD kinase
Gene namesi
Name:nadK
Ordered Locus Names:Bd3172
OrganismiBdellovibrio bacteriovorus (strain ATCC 15356 / DSM 50701 / NCIB 9529 / HD100)
Taxonomic identifieri264462 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaBdellovibrionalesBdellovibrionaceaeBdellovibrio
ProteomesiUP000008080: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 303303NAD kinaseUniRule annotation
PRO_0000229610Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi264462.Bd3172.

Structurei

3D structure databases

ProteinModelPortaliQ6MII5.

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.

Phylogenomic databases

eggNOGiCOG0061.
HOGENOMiHOG000227222.
KOiK00858.
OMAiTHEMLYH.
OrthoDBiEOG6PZXDR.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6MII5-1 [UniParc]FASTAAdd to Basket

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MKKSSMDKEH KQSKLVLKEN GSIGLVYRLE TAQAVSLAKK VAEFLKERGF    50
EVFTCPDQKV VAGTKAAKTK KHMDDLKLVI VLGGDGTYLR AVRLLEGRSV 100
PILGFNMGSL GFLTAHSADS CFDIIEKTLE GKMVQRPRSM IYSKILRKGK 150
VRAEYHALND MVIERGSMSQ LINTAIYSEK FLVSQVKADG FIVASPSGST 200
AYNLAAGGPI CHPESPVFVV TPVAPHSLTS RPLLFPDDRE LSFRLEGKTQ 250
KAHFIVDGQK MTELTADDEV IVSRSCYDHW MVREANHNYF HLLREKLKFG 300
DRN 303
Length:303
Mass (Da):33,807
Last modified:July 5, 2004 - v1
Checksum:i4DBF66BB2D940451
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX842654 Genomic DNA. Translation: CAE80928.1.
RefSeqiNP_969935.1. NC_005363.1.

Genome annotation databases

EnsemblBacteriaiCAE80928; CAE80928; Bd3172.
GeneIDi2736781.
KEGGibba:Bd3172.
PATRICi21080694. VBIBdeBac73187_2902.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX842654 Genomic DNA. Translation: CAE80928.1 .
RefSeqi NP_969935.1. NC_005363.1.

3D structure databases

ProteinModelPortali Q6MII5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 264462.Bd3172.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAE80928 ; CAE80928 ; Bd3172 .
GeneIDi 2736781.
KEGGi bba:Bd3172.
PATRICi 21080694. VBIBdeBac73187_2902.

Phylogenomic databases

eggNOGi COG0061.
HOGENOMi HOG000227222.
KOi K00858.
OMAi THEMLYH.
OrthoDBi EOG6PZXDR.

Family and domain databases

Gene3Di 2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPi MF_00361. NAD_kinase.
InterProi IPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view ]
PANTHERi PTHR20275. PTHR20275. 1 hit.
Pfami PF01513. NAD_kinase. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "A predator unmasked: life cycle of Bdellovibrio bacteriovorus from a genomic perspective."
    Rendulic S., Jagtap P., Rosinus A., Eppinger M., Baar C., Lanz C., Keller H., Lambert C., Evans K.J., Goesmann A., Meyer F., Sockett R.E., Schuster S.C.
    Science 303:689-692(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15356 / DSM 50701 / NCIB 9529 / HD100.

Entry informationi

Entry nameiNADK_BDEBA
AccessioniPrimary (citable) accession number: Q6MII5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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